SUPERFAMILY 1.75 HMM library and genome assignments server

Bacterial adhesins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   Bacterial adhesins [ 49401] (6)
Families:   Collagen-binding domain of adhesin [ 49402]
  Fibrinogen-binding domain [ 89210] (2)
  Pilus subunits [ 49405] (8)
  PapG adhesin receptor-binding domain [ 63680]
  F17c-type adhesin [ 89215] (2)
  Dr-family adhesin [ 110075]

Superfamily statistics
Genomes (860) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 9,679 166,188 39
Proteins 7,605 130,316 34

Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.000000000018880.0000003499Least InformativeDirect
Biological Process (BP)multi-organism process0.003390Moderately InformativeInherited
Biological Process (BP)biological adhesion00InformativeDirect
Biological Process (BP)cell adhesion00Highly InformativeDirect
Biological Process (BP)multi-organism cellular process0.0000067440Highly InformativeDirect
Cellular Component (CC)cell projection0.0000011540.002521Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.0000003499 Least Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) biological adhesion 0 Informative Direct
Biological Process (BP) locomotion 0.01107 Informative Inherited
Biological Process (BP) growth 0.009779 Informative Inherited
Biological Process (BP) cell adhesion 0 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0 Highly Informative Direct
Biological Process (BP) interaction with host 0.8725 Highly Informative Inherited
Cellular Component (CC) cell projection 0.002521 Moderately Informative Inherited
Cellular Component (CC) external encapsulating structure 0.000000003779 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0InformativeDirect
Biological processVirulence0InformativeDirect
Cellular componentMembrane1Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentGPI-anchor0.00000000000712InformativeDirect
Cellular componentCell wall0Highly InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionCalcium0.0000000000000959Moderately InformativeDirect
Molecular functionLectin0.00000001564InformativeDirect
Post-translational modificationPeptidoglycan-anchor0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008966 SSF49401 Protein matches

The bacterial adhesion domain is found in adhesin proteins, which form part of the adhesive pilus found on the cell surface. Adhesin proteins are important for receptor binding to host cells during pathogenesis. For example, the Escherichia coli PapG adhesin at the tip of the P pilus is necessary for attachment to the human kidney receptor during pyelonephritis pathogenesis [PubMed11440716]. The bacterial adhesion domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology and is a sub-class of the immunoglobin-like fold. Members of this structural superfamily include:

  • Collagen-binding domain of adhesion [PubMed9334749].
  • Fibrinogen-binding domain, which is found in both fibrinogen-binding adhesion SdrG and in clumping factor A; these proteins contain a duplication of this domain, where each copy of this fold displays a variation in the core structure [PubMed14567919].
  • Pilus subunits, such as mannose-specific adhesion FimH (duplication of this domain), PapK pilus subunit (similar to C-terminal domain of FimH), PapE pilus subunit, and F1 capsule antigen Caf1 [PubMed12010488].
  • PapG adhesion receptor-binding domain [PubMed11440716].
  • F17c-type adhesions, such as fimbrail adhesion F17-AG lectin domain, and fimbrial lectin GafD [PubMed12864853].
  • Dr-family adhesion Afa-III [PubMed15331605].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Bacterial adhesins domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the Bacterial adhesins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]