SUPERFAMILY 1.75 HMM library and genome assignments server

GroEL equatorial domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GroEL equatorial domain-like [ 48591]
Superfamily:   GroEL equatorial domain-like [ 48592] (2)
Families:   GroEL chaperone, ATPase domain [ 48593]
  Group II chaperonin (CCT, TRIC), ATPase domain [ 48596]


Superfamily statistics
Genomes (3,192) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 11,282 42,500 29
Proteins 10,850 41,164 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process0.00016070.000000001094Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0079630.000000000000005594Least InformativeInherited
Biological Process (BP)single-organism cellular process0.000035260.1622Least InformativeInherited
Biological Process (BP)localization0.0016420.0000000000006871Least InformativeInherited
Biological Process (BP)reproduction0.0000001630Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.00012120.00000000009137Moderately InformativeDirect
Biological Process (BP)cellular component biogenesis0.00038920.000000009527Moderately InformativeDirect
Biological Process (BP)sexual reproduction0.00000000093470.00000000000007996InformativeDirect
Biological Process (BP)single organism reproductive process0.0000005040InformativeDirect
Biological Process (BP)cellular process involved in reproduction0.000000025580InformativeDirect
Biological Process (BP)fertilization0.00015510Highly InformativeDirect
Cellular Component (CC)protein complex0.00034420.00004081Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0000014220Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.0055321Least InformativeInherited
Cellular Component (CC)cytosol0.19710Moderately InformativeInherited
Cellular Component (CC)vesicle0.0049810.000004301Moderately InformativeInherited
Cellular Component (CC)secretory granule0.00000026420.000002376InformativeDirect
Cellular Component (CC)cell body0.00000029760Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000000001094 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000000005488 Least Informative Direct
Biological Process (BP) localization 0.0000000000006871 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000000005594 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) developmental process 0.8996 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1622 Least Informative Inherited
Biological Process (BP) reproduction 0 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.000003158 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00000000009137 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.000000009527 Moderately Informative Direct
Biological Process (BP) organelle organization 0.05648 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9459 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.06273 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.001192 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.04069 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3729 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3019 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2363 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.4389 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.4089 Moderately Informative Inherited
Biological Process (BP) carbohydrate biosynthetic process 0.00002539 Informative Direct
Biological Process (BP) hexose metabolic process 0.0001401 Informative Direct
Biological Process (BP) sexual reproduction 0.00000000000007996 Informative Direct
Biological Process (BP) single organism reproductive process 0 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000559 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0008616 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0 Informative Direct
Biological Process (BP) mitotic cell cycle 0.001573 Informative Inherited
Biological Process (BP) cell cycle process 0.5059 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.006 Informative Inherited
Biological Process (BP) microtubule-based process 0.002033 Informative Inherited
Biological Process (BP) organelle assembly 0.003687 Informative Inherited
Biological Process (BP) cellular component morphogenesis 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.045 Informative Inherited
Biological Process (BP) cell projection organization 0.7131 Informative Inherited
Biological Process (BP) proteolysis 1 Informative Inherited
Biological Process (BP) protein catabolic process 0.734 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.6137 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) nucleobase-containing compound catabolic process 0.005005 Informative Inherited
Biological Process (BP) carbohydrate derivative catabolic process 0.001834 Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.009943 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.9012 Informative Inherited
Biological Process (BP) epithelium development 0.04227 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 1 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.09796 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.01304 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) mitosis 0.000004377 Highly Informative Direct
Biological Process (BP) spermatogenesis 0.0003893 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.000003517 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.00008162 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.0001265 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.00001208 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.00007475 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.0001336 Highly Informative Direct
Biological Process (BP) response to heat 0.000000009026 Highly Informative Direct
Biological Process (BP) fertilization 0 Highly Informative Direct
Biological Process (BP) proteasomal protein catabolic process 0.0001727 Highly Informative Direct
Biological Process (BP) cilium organization 0.000000003302 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0001112 Highly Informative Direct
Biological Process (BP) monosaccharide biosynthetic process 0.000001066 Highly Informative Direct
Biological Process (BP) response to cadmium ion 0.0004104 Highly Informative Direct
Biological Process (BP) spindle organization 0.002345 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.1888 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.001288 Highly Informative Inherited
Molecular Function (MF) binding 0.0001519 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0.003612 Informative Inherited
Molecular Function (MF) unfolded protein binding 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.00004081 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001023 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytosol 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000004301 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.006813 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.003651 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.249 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.538 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.0006403 Informative Direct
Cellular Component (CC) secretory granule 0.000002376 Informative Direct
Cellular Component (CC) plastid 0.5235 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.0003101 Highly Informative Direct
Cellular Component (CC) cell body 0 Highly Informative Direct
Cellular Component (CC) sperm part 0.000000004383 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.006914Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.003294InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.00000008859Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.0662Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.1032Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.005444Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.006737Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.01552Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal genital system morphology0.04345Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04431Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.04457Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.0865Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.1035Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.1469Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving the skeleton0.1574Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the globe0.1615Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2065Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digit0.309Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7596Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the autonomic nervous system0.0001029InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the biliary system0.0009095InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.001243InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia affecting the eye0.001243InformativeInherited
Phenotypic Abnormality (PA)Puberty and gonadal disorders0.00143InformativeInherited
Phenotypic Abnormality (PA)Hypoplastic male external genitalia0.002076InformativeInherited
Phenotypic Abnormality (PA)Abnormality of female internal genitalia0.004341InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.004398InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.004802InformativeInherited
Phenotypic Abnormality (PA)Abnormality of phalanx of finger0.007085InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.009204InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.009698InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cornea0.009949InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.01382InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eyelid0.02082InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.02165InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hair0.02424InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the feet0.02871InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.03212InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the fundus0.03571InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.06549InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.06683InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.07275InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coordination0.3137InformativeInherited
Phenotypic Abnormality (PA)Congenital primary aphakia0.0000002274Highly InformativeDirect
Phenotypic Abnormality (PA)Nephrogenic diabetes insipidus0.0000002274Highly InformativeDirect
Phenotypic Abnormality (PA)Medial flaring of the eyebrow0.0000002274Highly InformativeDirect
Phenotypic Abnormality (PA)Genital tract atresia0.000000689Highly InformativeDirect
Phenotypic Abnormality (PA)Poor coordination0.000000689Highly InformativeDirect
Phenotypic Abnormality (PA)Asthma0.000006627Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased testicular size0.000006627Highly InformativeDirect
Phenotypic Abnormality (PA)Dental crowding0.000008473Highly InformativeDirect
Phenotypic Abnormality (PA)Astigmatism0.00001323Highly InformativeDirect
Phenotypic Abnormality (PA)Retinal dystrophy0.00001634Highly InformativeDirect
Phenotypic Abnormality (PA)Polycystic ovaries0.00002177Highly InformativeDirect
Phenotypic Abnormality (PA)Hypodontia0.00002177Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.00002177Highly InformativeDirect
Phenotypic Abnormality (PA)Short foot0.0000283Highly InformativeDirect
Phenotypic Abnormality (PA)Postaxial polydactyly0.00003343Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the vagina0.00003633Highly InformativeDirect
Phenotypic Abnormality (PA)Nephrotic syndrome0.00003923Highly InformativeDirect
Phenotypic Abnormality (PA)Hirsutism0.00003923Highly InformativeDirect
Phenotypic Abnormality (PA)Biliary tract abnormality0.00004225Highly InformativeDirect
Phenotypic Abnormality (PA)Multicystic kidney dysplasia0.00008008Highly InformativeDirect
Phenotypic Abnormality (PA)Micropenis0.00008008Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the enteric ganglia0.00008552Highly InformativeDirect
Phenotypic Abnormality (PA)Retinitis pigmentosa0.00009552Highly InformativeDirect
Phenotypic Abnormality (PA)Specific learning disability0.0001065Highly InformativeDirect
Phenotypic Abnormality (PA)Hypogonadism0.0001068Highly InformativeDirect
Phenotypic Abnormality (PA)Hand polydactyly0.0001724Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic failure0.0001982Highly InformativeDirect
Phenotypic Abnormality (PA)Finger syndactyly0.0002711Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal electroretinogram0.0004821Highly InformativeDirect
Phenotypic Abnormality (PA)Hypertrichosis0.0004996Highly InformativeDirect
Phenotypic Abnormality (PA)Short neck0.0008865Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiac ventricle0.001568Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the 5th finger0.001641Highly InformativeInherited
Phenotypic Abnormality (PA)Duplication involving bones of the feet0.004387Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.004678Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of eye movement0.00663Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.01706Highly InformativeInherited
Phenotypic Abnormality (PA)Gait disturbance0.08973Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000002487Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00006128Least InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0000000001645Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0000000001818Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0000001073Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.0000002173Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.0000005425Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000001838Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.002616Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.0229Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0.2232Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000152InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.00000000000196InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00000000004552InformativeDirect
Worm Phenotype (WP)germline nuclear positioning variant0.0000000002187InformativeDirect
Worm Phenotype (WP)receptor mediated endocytosis defective0.0000000869InformativeDirect
Worm Phenotype (WP)pigmentation variant0.0000002813InformativeDirect
Worm Phenotype (WP)transgene expression increased0.000000441InformativeDirect
Worm Phenotype (WP)protruding vulva0.0000005867InformativeDirect
Worm Phenotype (WP)sick0.0001812InformativeDirect
Worm Phenotype (WP)cell corpse number variant0.09631InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.1336InformativeInherited
Worm Phenotype (WP)cell division variant0.1777InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.7481InformativeInherited
Worm Phenotype (WP)oocytes small0.00000000000000187Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000004889Highly InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.000000655Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00004001Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0006864Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0.003842Least InformativeInherited
Zebrafish Anatomy (ZA)solid compound organ0.0001648Moderately InformativeDirect
Zebrafish Anatomy (ZA)liver and biliary system0.0001696Moderately InformativeDirect
Zebrafish Anatomy (ZA)gut0.0005599Moderately InformativeDirect
Zebrafish Anatomy (ZA)immune system0.0006536Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.01895Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skin0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal muscle0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect
Xenopus ANatomical entity (XAN)oviduct0InformativeDirect
Xenopus ANatomical entity (XAN)hematological system0.00004188InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0004186InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0008341InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.008532InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.00004337Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000004755InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0002307InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainTransit peptide0.000001091Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008950 SSF48592 Protein matches
Abstract

Partially folded polypeptide chains, either newly made by ribosomes or emerging from mature proteins unfolded by stress, run the risk of aggregating with one another to the detriment of the organism. Folding of newly synthesised polypeptides in the crowded cellular environment requires the assistance of molecular chaperone proteins, such as the large bacterial chaperonins GroEL and GroES.

GroEL and GroES prevent aggregation by encapsulating individual chains within the so-called ┐Anfinsen cage┐ provided by the GroEL┐GroES complex, where they can fold in isolation from one another [PubMed12654267]. GroEL consists of two heptameric rings of identical ATPase subunits stacked back to back, containing a cage in each ring. Each subunit consists of three domains. The equatorial domain contains the nucleotide binding site and is connected by a flexible intermediate domain with the apical domain. The latter presents several hydrophobic amino-acid side chains at the top of the ring, orientated towards the cavity of the cage. These side chains are involved in binding either a partially folded polypeptide chain or a single molecule of GroES.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL equatorial domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL equatorial domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]