SUPERFAMILY 1.75 HMM library and genome assignments server

Phospholipase C/P1 nuclease superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Phospholipase C/P1 nuclease [ 48536]
Superfamily:   Phospholipase C/P1 nuclease [ 48537] (2)
Families:   Phospholipase C [ 48538] (2)
  P1 nuclease [ 48543]


Superfamily statistics
Genomes (619) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,289 3,291 7
Proteins 1,264 3,266 7


Functional annotation
General category Processes_IC
Detailed category Phospholipid metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)hydrolase activity0.0043790.0000000128Least InformativeInherited
Molecular Function (MF)hydrolase activity, acting on ester bonds0.00010840.000114Moderately InformativeDirect
Molecular Function (MF)nuclease activity0.00000013580.00001152InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.002749 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.003012 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.004432 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.057 Least Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.000000002651 Informative Direct
Molecular Function (MF) hydrolase activity 0.0000000128 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.000114 Moderately Informative Direct
Molecular Function (MF) nuclease activity 0.00001152 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000000000002681Moderately InformativeDirect

Document: EC annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000000000892InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCytolysis0InformativeDirect
Biological processHemolysis0Highly InformativeDirect
Cellular componentSecreted0.000000005903Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.000000000002365Least InformativeDirect
Molecular functionCalcium0.00000001565Moderately InformativeDirect
Post-translational modificationHydrolase0.00000000000002457Least InformativeDirect
Post-translational modificationNuclease0.0006542Moderately InformativeDirect
Post-translational modificationToxin0.00000000000178InformativeDirect
Post-translational modificationEndonuclease0.000000000003775InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008947 SSF48537 Protein matches
Abstract

The enzymes belonging to this family are involved in phosphate ester hydrolysis and contain a triad of closely spaced zinc ions at their active centres. Both families of enzymes hydrolyse phosphodiesters. Substrates for phospholipase C are phosphatidylinositol and phosphatidylcholine, while P1 nuclease is an endonuclease hydrolysing single stranded ribo- and deoxyribonucleotides. P1 nuclease also has activity as a phosphomonoesterase against 3'-terminal phosphates of nucleotides. The Zn ions in both enzymes form almost identical trinuclear sites [PubMed1525473].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Phospholipase C/P1 nuclease domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Phospholipase C/P1 nuclease superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]