SUPERFAMILY 1.75 HMM library and genome assignments server

Citrate synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Citrate synthase [ 48255]
Superfamily:   Citrate synthase [ 48256]
Families:   Citrate synthase [ 48257]


Superfamily statistics
Genomes (2,549) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,375 26,635 13
Proteins 5,349 26,611 13


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.72320.86Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.044050.03139Least InformativeInherited
Biological Process (BP)cofactor metabolic process0.025530.00000000003755Moderately InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.00012250.00005522InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.000000000061340.00000000255InformativeDirect
Biological Process (BP)acyl-CoA metabolic process0.00000024910Highly InformativeDirect
Biological Process (BP)aerobic respiration0.0000000000060410Highly InformativeDirect
Biological Process (BP)thioester biosynthetic process0.0000000041550Highly InformativeDirect
Molecular Function (MF)transferase activity0.000000088990Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Cellular Component (CC)cytoplasmic part0.00000004070Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.86 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.03139 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000000001466 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.00000000003755 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.7429 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4373 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.01331 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.00678 Moderately Informative Inherited
Biological Process (BP) cellular aldehyde metabolic process 0.00003103 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0009092 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.00005522 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00000000255 Informative Direct
Biological Process (BP) lipid catabolic process 0.0004483 Informative Direct
Biological Process (BP) acyl-CoA metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) thioester biosynthetic process 0 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000000000006088 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.4228 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.00000000000001474 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0000000002383 Moderately Informative Direct
Cellular Component (CC) mitochondrial matrix 0 Informative Direct
Cellular Component (CC) microbody 0.0009342 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0.00005061Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.00008178InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)citric acid0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.0003547Moderately InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processLipid biosynthesis0.0000001325InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0.0000000249InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcetylation0.00001067Least InformativeDirect
Post-translational modificationIsopeptide bond0.000002007Moderately InformativeDirect
Post-translational modificationMethylation0.000157Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0002764Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)carbohydrate metabolism0Least InformativeDirect
UniPathway (UP)organic acid metabolism0.000226Moderately InformativeDirect
UniPathway (UP)tricarboxylic acid cycle0InformativeDirect
UniPathway (UP)organic acid degradation0.00003066InformativeDirect
UniPathway (UP)propanoate metabolism0.000000000001279Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Citrate synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Citrate synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]