SUPERFAMILY 1.75 HMM library and genome assignments server

Guanido kinase N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Guanido kinase N-terminal domain [ 48033]
Superfamily:   Guanido kinase N-terminal domain [ 48034]
Families:   Guanido kinase N-terminal domain [ 48035] (2)


Superfamily statistics
Genomes (171) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 760 2,997 14
Proteins 723 2,925 14


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) nitrogen compound metabolic process 0.003747 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.4639 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.002331 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3317 Least Informative Inherited
Biological Process (BP) developmental process 0.599 Least Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.00000000001041 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00001246 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0004551 Moderately Informative Direct
Biological Process (BP) single-organism biosynthetic process 0.01094 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.03746 Moderately Informative Inherited
Biological Process (BP) organ development 0.104 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01716 Moderately Informative Inherited
Biological Process (BP) cellular modified amino acid metabolic process 0 Informative Direct
Biological Process (BP) central nervous system development 0.0001404 Informative Direct
Biological Process (BP) cellular modified amino acid biosynthetic process 0.006832 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0000000002871 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000000000004488 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.000000000000003838 Informative Direct
Cellular Component (CC) cytoplasmic part 0.000161 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.1964 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with a nitrogenous group as ac0InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal total tissue mass0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a nitrogenous group as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)cardiovascular system0Least InformativeDirect
Drugbank ATC_code (DB)cardiac therapy0Moderately InformativeDirect
Drugbank ATC_code (DB)other cardiac preparations0InformativeDirect
Drugbank ATC_code (DB)fosfocreatine0Highly InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMitochondrion0.000000001354Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0.00000000000001192InformativeDirect
DomainTransit peptide0.000000000004839Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationNitration0.000000000000009227InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000749 SSF48034 Protein matches
Abstract ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes [PubMed2324092, PubMed7819288] that reversibly catalyze the transfer of phosphate between ATP and various phosphogens. The enzymes belonging to this family include glycocyamine kinase , which catalyzes the transfer of phosphate from ATP to guanidoacetate; arginine kinase , which catalyzes the transfer of phosphate from ATP to arginine; taurocyamine kinase , an annelid-specific enzyme that catalyzes the transfer of phosphate from ATP to taurocyamine; lombricine kinase , an annelid-specific enzyme that catalyzes the transfer of phosphate from ATP to lombricine; Smc74, a cercaria-specific enzyme from Schistosoma mansoni [PubMed2324092]; and creatine kinase (CK) [PubMed3896131, PubMed2324105], which plays an important role in energy metabolism of vertebrates. It catalyzes the reversible transfer of high energy phosphate from ATP to creatine, generating phosphocreatine and ADP. There are at least four different, but very closely related, forms of CK. Two isozymes, M (muscle) and B (brain), are cytosolic, while the other two are mitochondrial. In sea urchins there is a flagellar isozyme, which consists of the triplication of a CK-domain. A cysteine residue is implicated in the catalytic activity of these enzymes and the region around this active site residue is highly conserved.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Guanido kinase N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Guanido kinase N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]