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STAT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   STAT [ 47655]
Families:   STAT [ 47656] (3)


Superfamily statistics
Genomes (162) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 706 960 3
Proteins 696 949 3


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000006842 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.00000006849 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000176 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0002396 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003329 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00133 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.004667 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.008251 Least Informative Inherited
Biological Process (BP) localization 0.001174 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.000000000000005576 Moderately Informative Direct
Biological Process (BP) reproduction 0.00000000000001772 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.00000000000003117 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.000000000002423 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000000000004474 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.00000000001318 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00000000005604 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0000000001649 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.0000000006429 Moderately Informative Direct
Biological Process (BP) gene expression 0.0000000006927 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.00000002344 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.00000005715 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00000007363 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00000009701 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000002491 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00002782 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.007124 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.02656 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7822 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7797 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4898 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.5975 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8809 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.005588 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7674 Moderately Informative Inherited
Biological Process (BP) system process 0.01702 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8816 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of apoptotic process 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.000000000000003741 Informative Direct
Biological Process (BP) apoptotic process 0.00000000000001083 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.00000000000004112 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.0000000000007851 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.000000000002102 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000001288 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 0.0000000004687 Informative Direct
Biological Process (BP) regulation of growth 0.000000007135 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.00000004614 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.00000008456 Informative Direct
Biological Process (BP) response to hormone stimulus 0.000000109 Informative Direct
Biological Process (BP) lipid localization 0.0000001199 Informative Direct
Biological Process (BP) response to organonitrogen compound 0.0000005384 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.0000007301 Informative Direct
Biological Process (BP) phosphorylation 0.000001138 Informative Direct
Biological Process (BP) generation of neurons 0.000001535 Informative Direct
Biological Process (BP) defense response 0.000001577 Informative Direct
Biological Process (BP) immune response 0.000002831 Informative Direct
Biological Process (BP) gland development 0.000004279 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.000007462 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0.00001272 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.00004255 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.00006068 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.00009038 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0002279 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0004944 Informative Direct
Biological Process (BP) regulation of defense response 0.0005149 Informative Direct
Biological Process (BP) protein localization to organelle 0.0006677 Informative Direct
Biological Process (BP) sensory organ development 0.0007376 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.054 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1255 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.002111 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.002743 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1199 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.009688 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.0504 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.005966 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01429 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01164 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00804 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.009141 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.00849 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.006404 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.006478 Informative Inherited
Biological Process (BP) response to lipid 0.8822 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.8465 Informative Inherited
Biological Process (BP) leukocyte activation 0.003818 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1962 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.004594 Informative Inherited
Biological Process (BP) response to other organism 0.8499 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.06469 Informative Inherited
Biological Process (BP) protein transport 0.006216 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.08279 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01143 Informative Inherited
Biological Process (BP) reproductive system development 0.07148 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.000000000000003741 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.00000000000006861 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000000000003292 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0000000000003648 Highly Informative Direct
Biological Process (BP) lactation 0.0000000000004558 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.000000000001657 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 0.000000000002218 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.000000000002778 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000001426 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000000001431 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 0.000000004283 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000001272 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.00000001413 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 0.00000001892 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000002218 Highly Informative Direct
Biological Process (BP) renal system development 0.00000002908 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.00000004383 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.0000001537 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0000001565 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000002381 Highly Informative Direct
Biological Process (BP) stem cell proliferation 0.0000002451 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.0000003858 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000007505 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 0.0000007856 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000009316 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.000001297 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0.000002632 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.000003326 Highly Informative Direct
Biological Process (BP) gonad development 0.000003437 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000005939 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.000008534 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.00000864 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00001736 Highly Informative Direct
Biological Process (BP) nuclear import 0.00007332 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00008188 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001111 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0001204 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0002376 Highly Informative Direct
Biological Process (BP) protein import 0.0003479 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.004772 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.003895 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.01857 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2239 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001061 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.003406 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.01686 Highly Informative Inherited
Biological Process (BP) stem cell development 0.006686 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.002474 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.001417 Highly Informative Inherited
Molecular Function (MF) binding 0.00000004364 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0000000000003152 Informative Direct
Molecular Function (MF) enzyme binding 0.000001181 Informative Direct
Molecular Function (MF) molecular transducer activity 0.000003536 Informative Direct
Molecular Function (MF) receptor binding 0.06969 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.0000000003888 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.000001842 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0.0000867 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03528 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.9037 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000000002705 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0005133 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.475 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.615 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.001792 Informative Inherited
Cellular Component (CC) dendrite 0.00001048 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04545Least InformativeInherited
Disease Ontology (DO)organ system cancer0.08609Least InformativeInherited
Disease Ontology (DO)lung disease0.00007835Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001709Moderately InformativeInherited
Disease Ontology (DO)leukemia0.009882Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7537Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001365InformativeDirect
Disease Ontology (DO)chronic leukemia0.00008532InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0001093InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1352InformativeInherited
Disease Ontology (DO)viral infectious disease0.2718InformativeInherited
Disease Ontology (DO)mumps0.000000005273Highly InformativeDirect
Disease Ontology (DO)colitis0.000000187Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001148Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01491Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07387Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1078Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.000009689Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0005677Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008371Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.002498Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01304Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03712Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.03817Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2595Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3138Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3248Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level0.00000000775InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.0000000128InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000002437InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.000007418InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001674InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003954InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0004211InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0005086InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0009311InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0009545InformativeDirect
Mammalian Phenotype (MP)abnormal circulating triglyceride level0.0009948InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.001819InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002542InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.007927InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008258InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05181InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.0533InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06103InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1444InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.1567InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2299InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3105InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.4425InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.4499InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.6482InformativeInherited
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000003066Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.000001828Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000002376Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity0.000004788Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.00000746Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.00001131Highly InformativeDirect
Mammalian Phenotype (MP)enlarged liver0.00002189Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003739Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.00005784Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001126Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0001422Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas secretion0.0001862Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002006Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0003045Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor incidence0.0003527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive T cell differentiation0.0003767Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004692Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0006985Highly InformativeDirect
Mammalian Phenotype (MP)increased body weight0.0009697Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002775Highly InformativeInherited
Mammalian Phenotype (MP)abnormal body fat mass0.003345Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.04693Highly InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.0000000004377Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000003266Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00005939Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015988 SSF47655 Protein matches
Abstract

This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a STAT domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the STAT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]