SUPERFAMILY 1.75 HMM library and genome assignments server


STAT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   STAT [ 47655]
Families:   STAT [ 47656] (3)


Superfamily statistics
Genomes (162) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 706 960 3
Proteins 696 949 3


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 7.273e-11 Least Informative Direct
Biological Process (BP) regulation of metabolic process 7.672e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 1.77e-07 Least Informative Direct
Biological Process (BP) biosynthetic process 0.0002421 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003335 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.001336 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.004666 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.008284 Least Informative Inherited
Biological Process (BP) localization 0.001252 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) organ development 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 3.755e-15 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 7.347e-15 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 1.086e-14 Moderately Informative Direct
Biological Process (BP) reproduction 1.778e-14 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 3.459e-14 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 2.386e-12 Moderately Informative Direct
Biological Process (BP) response to organic substance 5.098e-12 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.813e-11 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 9.461e-11 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 1.957e-10 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 6.372e-10 Moderately Informative Direct
Biological Process (BP) gene expression 6.93e-10 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 4.907e-08 Moderately Informative Direct
Biological Process (BP) multi-organism process 8.739e-08 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.164e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 3.234e-07 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.628e-05 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.007261 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.0279 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7647 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.7862 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 0.4857 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.6146 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8733 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.00553 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.7561 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.2049 Moderately Informative Inherited
Biological Process (BP) system process 0.01769 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8843 Moderately Informative Inherited
Biological Process (BP) regulation of peptidase activity 0 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) transcription, DNA-dependent 0 Informative Direct
Biological Process (BP) response to cytokine stimulus 0 Informative Direct
Biological Process (BP) negative regulation of developmental process 0 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 3.755e-15 Informative Direct
Biological Process (BP) apoptotic process 1.086e-14 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.447e-14 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 7.851e-13 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 1.38e-12 Informative Direct
Biological Process (BP) intracellular signal transduction 1.481e-11 Informative Direct
Biological Process (BP) regulation of mitotic cell cycle 4.766e-10 Informative Direct
Biological Process (BP) regulation of growth 7.372e-09 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 5.222e-08 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 9.515e-08 Informative Direct
Biological Process (BP) response to hormone stimulus 1.068e-07 Informative Direct
Biological Process (BP) lipid localization 1.169e-07 Informative Direct
Biological Process (BP) regulation of cell activation 4.21e-07 Informative Direct
Biological Process (BP) response to organonitrogen compound 4.948e-07 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 9.291e-07 Informative Direct
Biological Process (BP) response to bacterium 9.808e-07 Informative Direct
Biological Process (BP) phosphorylation 1.13e-06 Informative Direct
Biological Process (BP) defense response 1.498e-06 Informative Direct
Biological Process (BP) generation of neurons 1.566e-06 Informative Direct
Biological Process (BP) immune response 2.724e-06 Informative Direct
Biological Process (BP) gland development 4.619e-06 Informative Direct
Biological Process (BP) regulation of body fluid levels 7.236e-06 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 1.271e-05 Informative Direct
Biological Process (BP) multi-multicellular organism process 4.263e-05 Informative Direct
Biological Process (BP) cellular ketone metabolic process 5.92e-05 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 8.452e-05 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0.0002418 Informative Direct
Biological Process (BP) regulation of defense response 0.0004989 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0005372 Informative Direct
Biological Process (BP) protein localization to organelle 0.0006838 Informative Direct
Biological Process (BP) sensory organ development 0.0007487 Informative Direct
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.05272 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1244 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.00203 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.002783 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1204 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.008997 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.05191 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.006535 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.01539 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01165 Informative Inherited
Biological Process (BP) single organism reproductive process 0.008299 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.008856 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.007936 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.006606 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.006368 Informative Inherited
Biological Process (BP) response to lipid 0.8923 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.8335 Informative Inherited
Biological Process (BP) leukocyte activation 0.003808 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1925 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.00488 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.06312 Informative Inherited
Biological Process (BP) protein transport 0.006208 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.08147 Informative Inherited
Biological Process (BP) organ morphogenesis 0.0115 Informative Inherited
Biological Process (BP) reproductive system development 0.07142 Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of endopeptidase activity 0 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 3.755e-15 Highly Informative Direct
Biological Process (BP) mesenchyme development 6.719e-14 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 2.869e-13 Highly Informative Direct
Biological Process (BP) female pregnancy 3.851e-13 Highly Informative Direct
Biological Process (BP) lactation 4.249e-13 Highly Informative Direct
Biological Process (BP) ovulation cycle process 1.003e-12 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 2.618e-12 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.674e-12 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 1.459e-10 Highly Informative Direct
Biological Process (BP) cellular response to peptide 1.567e-09 Highly Informative Direct
Biological Process (BP) leukocyte homeostasis 4.203e-09 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.194e-08 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 1.334e-08 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 2.082e-08 Highly Informative Direct
Biological Process (BP) renal system development 2.835e-08 Highly Informative Direct
Biological Process (BP) eye morphogenesis 4.671e-08 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 1.445e-07 Highly Informative Direct
Biological Process (BP) regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.656e-07 Highly Informative Direct
Biological Process (BP) stem cell proliferation 2.083e-07 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 2.373e-07 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 3.489e-07 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 7.022e-07 Highly Informative Direct
Biological Process (BP) positive regulation of defense response 7.548e-07 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 9.462e-07 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 1.151e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 2.278e-06 Highly Informative Direct
Biological Process (BP) gonad development 3.404e-06 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 3.457e-06 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 6.571e-06 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 8.839e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 1.007e-05 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 1.581e-05 Highly Informative Direct
Biological Process (BP) nuclear import 7.449e-05 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 8.083e-05 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001072 Highly Informative Direct
Biological Process (BP) positive regulation of growth 0.0001259 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.0002301 Highly Informative Direct
Biological Process (BP) protein import 0.0003508 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.004467 Highly Informative Inherited
Biological Process (BP) negative regulation of locomotion 0.003668 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 1 Highly Informative Inherited
Biological Process (BP) glial cell differentiation 0.01835 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.2266 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.001115 Highly Informative Inherited
Biological Process (BP) positive regulation of leukocyte proliferation 0.003301 Highly Informative Inherited
Biological Process (BP) response to lipopolysaccharide 0.0166 Highly Informative Inherited
Biological Process (BP) stem cell development 0.006589 Highly Informative Inherited
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.002464 Highly Informative Inherited
Biological Process (BP) development of primary female sexual characteristics 0.001404 Highly Informative Inherited
Molecular Function (MF) binding 4.957e-08 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0 Moderately Informative Direct
Molecular Function (MF) DNA binding 0 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 0 Informative Direct
Molecular Function (MF) protein dimerization activity 3.033e-13 Informative Direct
Molecular Function (MF) enzyme binding 1.216e-06 Informative Direct
Molecular Function (MF) molecular transducer activity 3.549e-06 Informative Direct
Molecular Function (MF) receptor binding 0.06941 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 3.85e-10 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 2.174e-06 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 8.469e-05 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03484 Highly Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.8997 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 2.607e-09 Moderately Informative Direct
Cellular Component (CC) cytosol 0.0005385 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.4681 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.6262 Moderately Informative Inherited
Cellular Component (CC) neuron projection 0.001966 Informative Inherited
Cellular Component (CC) dendrite 1.136e-05 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.04628Least InformativeInherited
Disease Ontology (DO)organ system cancer0.08676Least InformativeInherited
Disease Ontology (DO)obstructive lung disease1.501e-05Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001737Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01773Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7545Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease1.373e-06InformativeDirect
Disease Ontology (DO)glomerulonephritis0.0001088InformativeDirect
Disease Ontology (DO)myeloid leukemia0.135InformativeInherited
Disease Ontology (DO)viral infectious disease0.2717InformativeInherited
Disease Ontology (DO)mumps5.262e-09Highly InformativeDirect
Disease Ontology (DO)colitis1.874e-07Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome1.15e-05Highly InformativeDirect
Disease Ontology (DO)chronic leukemia1.167e-05Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.01516Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07681Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.1089Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell-mediated immunity0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukopoiesis0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level9.695e-06Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.0003461Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0005665Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008538Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.002536Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01363Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03166Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03793Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.03837Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2576Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3381Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin level7.287e-09InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level1.245e-08InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion2.346e-07InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology7.661e-06InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001714InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0004218InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0004962InformativeDirect
Mammalian Phenotype (MP)abnormal antigen presentation0.0009244InformativeDirect
Mammalian Phenotype (MP)abnormal respiration0.0009703InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.001876InformativeInherited
Mammalian Phenotype (MP)abnormal female genitalia morphology0.002697InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.008275InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.008622InformativeInherited
Mammalian Phenotype (MP)abnormal cell proliferation0.02044InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05451InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05562InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.06273InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1501InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.1582InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2359InformativeInherited
Mammalian Phenotype (MP)abnormal sex gland morphology0.3039InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.4415InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.4539InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.6504InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology1.778e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules3.052e-07Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion1.97e-06Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis2.369e-06Highly InformativeDirect
Mammalian Phenotype (MP)impaired natural killer cell mediated cytotoxicity5.17e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level6.962e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number1.157e-05Highly InformativeDirect
Mammalian Phenotype (MP)obese2.394e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology3.776e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level5.598e-05Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001204Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0001566Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0003126Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor incidence0.0003536Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.00049Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002972Highly InformativeInherited
Mammalian Phenotype (MP)abnormal body fat mass0.003275Highly InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.0114Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus size0.04692Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08199Highly InformativeInherited

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm4.354e-10Least InformativeDirect
DomainSH2 domain0InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein3.235e-06Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation6.234e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015988 SSF47655 Protein matches
Abstract

This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a STAT domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the STAT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]