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Kix domain of CBP (creb binding protein) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Kix domain of CBP (creb binding protein) [ 47039]
Superfamily:   Kix domain of CBP (creb binding protein) [ 47040]
Families:   Kix domain of CBP (creb binding protein) [ 47041]

 Superfamily statistics
Genomes (159) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 471 373 2
Proteins 453 359 2

 Functional annotation
General category Regulation
Detailed category DNA-binding

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 1.749e-08 Least Informative Direct
Biological Process (BP) regulation of cellular process 6.767e-06 Least Informative Direct
Biological Process (BP) developmental process 3.233e-05 Least Informative Direct
Biological Process (BP) multicellular organismal process 9.978e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002804 Least Informative Direct
Biological Process (BP) protein metabolic process 0.0006975 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.006185 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1368 Least Informative Inherited
Biological Process (BP) positive regulation of metabolic process 5.594e-13 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 1.002e-10 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1.572e-10 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 1.691e-10 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 1.743e-10 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 3.511e-09 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 4.777e-08 Moderately Informative Direct
Biological Process (BP) organelle organization 5.017e-05 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.009503 Moderately Informative Inherited
Biological Process (BP) positive regulation of gene expression 2.076e-15 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 4.008e-15 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 4.008e-15 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 4.008e-15 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 7.835e-15 Informative Direct
Biological Process (BP) peptidyl-amino acid modification 2.442e-14 Informative Direct
Biological Process (BP) chromosome organization 3.171e-12 Informative Direct
Biological Process (BP) peptidyl-lysine modification 0 Highly Informative Direct
Biological Process (BP) histone modification 0 Highly Informative Direct
Biological Process (BP) internal protein amino acid acetylation 0 Highly Informative Direct
Molecular Function (MF) transferase activity 2.619e-09 Least Informative Direct
Molecular Function (MF) binding 1.466e-05 Least Informative Direct
Molecular Function (MF) protein binding 7.556e-08 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.004206 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.004788 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) DNA binding 8.419e-09 Informative Direct
Molecular Function (MF) acetyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.231e-13 Highly Informative Direct
Molecular Function (MF) chromatin binding 8.017e-09 Highly Informative Direct
Cellular Component (CC) protein complex 7.405e-08 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 5.454e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.006345 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 2.146e-09 Moderately Informative Direct
Cellular Component (CC) nuclear part 8.15e-05 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 1.843e-05 Informative Direct
Cellular Component (CC) transcription factor complex 1.403e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation2.557e-12Moderately InformativeDirect
Cellular componentNucleus1.418e-10Least InformativeDirect
DomainRepeat1.952e-06Least InformativeDirect
DomainBromodomain0Highly InformativeDirect
Molecular functionZinc1.055e-06Least InformativeDirect
Molecular functionMetal-binding0.0009726Least InformativeDirect
Molecular functionZinc-finger1.216e-09Moderately InformativeDirect
Post-translational modificationActivator7.629e-12Moderately InformativeDirect
Post-translational modificationPhosphoprotein3.364e-05Least InformativeDirect
Post-translational modificationIsopeptide bond9.37e-12Moderately InformativeDirect
Post-translational modificationMethylation4.425e-10Moderately InformativeDirect
Post-translational modificationUbl conjugation5.919e-10Moderately InformativeDirect
Post-translational modificationAcetylation4.808e-08Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR003101 SSF47040 Protein matches
Abstract

The nuclear factor CREB activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner [PubMed9413984]. This provides a model for activator:coactivator interactions. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kix domain of CBP (creb binding protein) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Kix domain of CBP (creb binding protein) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.