SUPERFAMILY 1.75 HMM library and genome assignments server

TAFH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   TAFH domain-like [ 158552]
Superfamily:   TAFH domain-like [ 158553]
Families:   TAFH domain-like [ 158554] (2)


Superfamily statistics
Genomes (137) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 635 635 3
Proteins 632 634 3


Functional annotation
Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0000000005417 Least Informative Direct
Biological Process (BP) developmental process 0.00000008705 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.00001467 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.4686 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.006008 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.01962 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.04764 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.00688 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.006174 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.004618 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.01084 Least Informative Inherited
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000004439 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.000005304 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.000005408 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.000005423 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.00001607 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.00002278 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00002499 Moderately Informative Direct
Biological Process (BP) gene expression 0.00004757 Moderately Informative Direct
Biological Process (BP) nervous system development 0.1256 Moderately Informative Inherited
Biological Process (BP) transcription, DNA-dependent 0.000000009871 Informative Direct
Biological Process (BP) generation of neurons 0.00001345 Informative Direct
Biological Process (BP) transcription from RNA polymerase II promoter 0.0000000005292 Highly Informative Direct
Molecular Function (MF) binding 0.000000001649 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.000000194 Moderately Informative Direct
Molecular Function (MF) DNA binding 0.000000004081 Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.000000007914 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.00001956 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.4844 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.00033 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.2106 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)hematologic cancer0Moderately InformativeDirect

Document: DO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0.0000000001607Moderately InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainZinc-finger0.000000004162Moderately InformativeDirect
DomainCoiled coil0.00000005106Moderately InformativeDirect
Molecular functionZinc0.0000000158Least InformativeDirect
Molecular functionMetal-binding0.0002172Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TAFH domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the TAFH domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · UniProtKB KeyWords (KW) · Internal database links ]