SUPERFAMILY 1.75 HMM library and genome assignments server

Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain [ 118370]
Families:   Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain [ 118371]


Superfamily statistics
Genomes (118) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 342 361 2
Proteins 342 361 2


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000000001234 Least Informative Direct
Biological Process (BP) developmental process 0.000004564 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000995 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00001494 Least Informative Direct
Biological Process (BP) response to stimulus 0.00005269 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.2038 Least Informative Inherited
Biological Process (BP) nervous system development 0.00000000001869 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000000007248 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000000004198 Moderately Informative Direct
Biological Process (BP) organelle organization 0.00000007276 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000005877 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0002972 Moderately Informative Direct
Biological Process (BP) tissue development 0.03201 Moderately Informative Inherited
Biological Process (BP) actin filament-based process 0 Informative Direct
Biological Process (BP) cytoskeleton organization 0 Informative Direct
Biological Process (BP) locomotion 0.00000000000001435 Informative Direct
Biological Process (BP) generation of neurons 0.0000000000001225 Informative Direct
Biological Process (BP) cell projection organization 0.0000000000002282 Informative Direct
Biological Process (BP) cellular component movement 0.0000000002002 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.000000006445 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000001554 Informative Direct
Biological Process (BP) epithelium development 0.0000001082 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000004917 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000003197 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00001476 Informative Direct
Biological Process (BP) tube development 0.00006155 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00006329 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00007398 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0005575 Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) cell part morphogenesis 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0000000000002101 Highly Informative Direct
Biological Process (BP) epithelial tube formation 0.0000000000003094 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.000000004688 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000000005015 Highly Informative Direct
Biological Process (BP) neural tube development 0.000000008053 Highly Informative Direct
Biological Process (BP) neuron projection development 0.007556 Highly Informative Inherited
Molecular Function (MF) binding 0.00000007123 Least Informative Direct
Molecular Function (MF) protein domain specific binding 0.00000000000000752 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.002024 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8982 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7729 Least Informative Inherited
Cellular Component (CC) cell projection 0.00000000000005076 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.00001025 Moderately Informative Direct
Cellular Component (CC) cytosol 0.00004689 Moderately Informative Direct
Cellular Component (CC) cell leading edge 0 Informative Direct
Cellular Component (CC) cell junction 0.00000000000005615 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000005606 Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)hemorrhage0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect
Mammalian Phenotype (MP)abnormal brain development0InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0InformativeDirect
Mammalian Phenotype (MP)ectopic neuron0InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain ventricle morphology0Highly InformativeDirect
Mammalian Phenotype (MP)edema0Highly InformativeDirect
Mammalian Phenotype (MP)ectopic cortical neuron0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neurite morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain pia mater morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0Highly InformativeDirect
Mammalian Phenotype (MP)complete lethality throughout fetal growth and development0Highly InformativeDirect

Document: MP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentCell junction0.00000000001933Moderately InformativeDirect
DomainCoiled coil0.00000001034Moderately InformativeDirect
DomainSH3-binding0InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0.000000000001345Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · UniProtKB KeyWords (KW) · Internal database links ]