SUPERFAMILY 1.75 HMM library and genome assignments server

I/LWEQ domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   I/LWEQ domain [ 109884]
Superfamily:   I/LWEQ domain [ 109885]
Families:   I/LWEQ domain [ 109886] (2)


Superfamily statistics
Genomes (350) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,667 1,826 3
Proteins 877 1,040 3


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.00000001744 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000002247 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.9563 Least Informative Inherited
Biological Process (BP) developmental process 0.5011 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01851 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) organelle organization 0.00000000117 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.125 Moderately Informative Inherited
Biological Process (BP) organ development 0.3772 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.01537 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.2227 Moderately Informative Inherited
Biological Process (BP) reproduction 0.02168 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.001526 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.04931 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.09188 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1118 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01455 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.413 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.000000000364 Informative Direct
Biological Process (BP) actin filament-based process 0.000000004427 Informative Direct
Biological Process (BP) biological adhesion 0.000000697 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000513 Informative Direct
Biological Process (BP) tube development 0.0003862 Informative Direct
Biological Process (BP) muscle structure development 0.0005316 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000662 Informative Direct
Biological Process (BP) tissue morphogenesis 0.001371 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 0.004815 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.004013 Informative Inherited
Biological Process (BP) organ morphogenesis 0.01594 Informative Inherited
Biological Process (BP) epithelium development 0.01004 Informative Inherited
Biological Process (BP) single organism reproductive process 0.01446 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.0379 Informative Inherited
Biological Process (BP) sexual reproduction 0.0579 Informative Inherited
Biological Process (BP) locomotion 0.00113 Informative Inherited
Biological Process (BP) cellular component movement 0.008477 Informative Inherited
Biological Process (BP) localization of cell 0.1193 Informative Inherited
Biological Process (BP) cell junction organization 0.000000000003647 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.000001406 Highly Informative Direct
Biological Process (BP) maintenance of location 0.000001408 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000005035 Highly Informative Direct
Biological Process (BP) respiratory system development 0.00001172 Highly Informative Direct
Biological Process (BP) female gamete generation 0.00003797 Highly Informative Direct
Biological Process (BP) muscle organ development 0.00006264 Highly Informative Direct
Biological Process (BP) post-embryonic organ development 0.0001015 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 0.0001502 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.003909 Highly Informative Inherited
Molecular Function (MF) binding 0.0006678 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000001478 Informative Direct
Molecular Function (MF) receptor binding 0.0006322 Informative Direct
Molecular Function (MF) protein complex binding 0.0000002559 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.00001568 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.09784 Least Informative Inherited
Cellular Component (CC) membrane 0.2021 Least Informative Inherited
Cellular Component (CC) endomembrane system 0.0003085 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000531 Moderately Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) cell cortex 0.00003419 Informative Direct
Cellular Component (CC) adherens junction 0 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0.00000004768 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processEndocytosis0.0000000000001654InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane0.00008626Least InformativeDirect
Cellular componentCytoskeleton0.0000000000002059Moderately InformativeDirect
Cellular componentCell junction0.000000003417Moderately InformativeDirect
DomainCoiled coil0.00000007133Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationPhosphoprotein0.0006566Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a I/LWEQ domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the I/LWEQ domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]