SUPERFAMILY 1.75 HMM library and genome assignments server

G protein-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Coiled coil proteins [ 57942] (7)
Fold:   Parallel coiled-coil [ 57943] (34)
Superfamily:   G protein-binding domain [ 103652] (2)
Families:   RhoA-binding domain [ 103653]
  Rabaptin-5 [ 118367]


Superfamily statistics
Genomes (130) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 568 648 4
Proteins 432 499 4


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.00005144 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00001061 Least Informative Direct
Biological Process (BP) localization 0.000202 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000008082 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.5715 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.007862 Least Informative Inherited
Biological Process (BP) response to stimulus 0.006941 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.03427 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.08139 Least Informative Inherited
Biological Process (BP) organelle organization 0.000001548 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00001009 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0000838 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000000002737 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.3017 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.004508 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.6759 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1522 Moderately Informative Inherited
Biological Process (BP) tissue development 0.001458 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.003328 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02054 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.2416 Moderately Informative Inherited
Biological Process (BP) apoptotic process 0.00000852 Informative Direct
Biological Process (BP) cellular component movement 0.000006636 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00003046 Informative Direct
Biological Process (BP) microtubule-based process 0.0006472 Informative Direct
Biological Process (BP) phosphorylation 0.0002979 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000008705 Informative Direct
Biological Process (BP) actin filament-based process 0.0000000001661 Informative Direct
Biological Process (BP) cell projection organization 0.00000001082 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0003328 Informative Direct
Biological Process (BP) regulation of organelle organization 0.000000003704 Informative Direct
Biological Process (BP) locomotion 0.0000007812 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.000000003266 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.00003527 Informative Direct
Biological Process (BP) generation of neurons 0.0000002926 Informative Direct
Biological Process (BP) tissue morphogenesis 0.00002965 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0000000001524 Informative Direct
Biological Process (BP) localization of cell 0.0001294 Informative Direct
Biological Process (BP) epithelium development 0.0000000008894 Informative Direct
Biological Process (BP) intracellular signal transduction 0.05318 Informative Inherited
Biological Process (BP) protein phosphorylation 0.00008182 Highly Informative Direct
Biological Process (BP) small GTPase mediated signal transduction 0.0000000006875 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000008825 Highly Informative Direct
Biological Process (BP) morphogenesis of embryonic epithelium 0.0000113 Highly Informative Direct
Biological Process (BP) regulation of cell adhesion 0.0000002269 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0000001103 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.9894 Highly Informative Inherited
Molecular Function (MF) binding 0.00007656 Least Informative Direct
Molecular Function (MF) transferase activity 0.0002465 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000002623 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.0000007119 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0002784 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.578 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.001194 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.006445 Moderately Informative Inherited
Cellular Component (CC) cell leading edge 0.0000008939 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.7154 Informative Inherited
Cellular Component (CC) centrosome 0.000217 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.0005282Least InformativeDirect
Biological processApoptosis0.00000000000001406Moderately InformativeDirect
Biological processProtein transport0.000000000005594Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processBiological rhythms0.000000000002387InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentMembrane0.0009849Least InformativeDirect
Cellular componentEndosome0.00000000000001161Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000000009172Moderately InformativeDirect
Cellular componentCell projection0.0000000001681Moderately InformativeDirect
Cellular componentCell membrane0.000000004334Moderately InformativeDirect
Cellular componentGolgi apparatus0.000000008888Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.000001412Moderately InformativeDirect
Molecular functionZinc0.00000006976Least InformativeDirect
Molecular functionNucleotide-binding0.0002671Least InformativeDirect
Molecular functionMagnesium0.000000004546Moderately InformativeDirect
Molecular functionATP-binding0.00004503Moderately InformativeDirect
Post-translational modificationTransferase0.00006747Least InformativeDirect
Post-translational modificationKinase0.000000000007089Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationAcetylation0.00000134Least InformativeDirect
Post-translational modificationPhosphoprotein0.00008766Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a G protein-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the G protein-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]