SUPERFAMILY 1.75 HMM library and genome assignments server


Roadblock/LC7 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   Roadblock/LC7 domain [ 103196]
Families:   Roadblock/LC7 domain [ 103197] (4)


Superfamily statistics
Genomes (617) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 2,040 2,985 13
Proteins 2,037 2,979 13


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process1.598e-151.833e-07Least InformativeDirect
Biological Process (BP)localization3.099e-158.753e-12Least InformativeDirect
Biological Process (BP)response to stimulus4.26e-105.817e-06Least InformativeDirect
Biological Process (BP)single-organism cellular process9.61e-104.802e-06Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.45881Least InformativeInherited
Biological Process (BP)regulation of cell communication00Moderately InformativeDirect
Biological Process (BP)regulation of signaling00Moderately InformativeDirect
Biological Process (BP)response to organic substance00Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus00Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus3.099e-150Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus3.099e-154.008e-15Moderately InformativeDirect
Biological Process (BP)macromolecule localization4.432e-142.268e-12Moderately InformativeDirect
Biological Process (BP)cellular localization2.762e-131.385e-13Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process5.033e-126.532e-11Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound1.978e-112.567e-12Moderately InformativeDirect
Biological Process (BP)response to organic nitrogen00InformativeDirect
Biological Process (BP)cellular response to nitrogen compound00InformativeDirect
Biological Process (BP)cellular response to endogenous stimulus00InformativeDirect
Biological Process (BP)cellular response to oxygen-containing compound1.195e-140InformativeDirect
Biological Process (BP)positive regulation of signal transduction1.591e-112.15e-11InformativeDirect
Biological Process (BP)growth4.761e-082.859e-06InformativeDirect
Biological Process (BP)microtubule-based process1.019e-065.935e-06InformativeDirect
Biological Process (BP)regulation of anatomical structure size2.131e-063.777e-05InformativeDirect
Biological Process (BP)cellular component movement2.14e-050.0003006InformativeDirect
Biological Process (BP)protein localization to organelle11InformativeInherited
Biological Process (BP)response to acid00Highly InformativeDirect
Biological Process (BP)microtubule-based movement3.049e-111.178e-10Highly InformativeDirect
Biological Process (BP)cell growth2.207e-095.628e-09Highly InformativeDirect
Biological Process (BP)regulation of cellular component size0.00049550.0005372Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.013750.01246Least InformativeInherited
Molecular Function (MF)binding4.374e-080.00303Least InformativeInherited
Molecular Function (MF)enzyme regulator activity00Moderately InformativeDirect
Molecular Function (MF)structural molecule activity00Moderately InformativeDirect
Molecular Function (MF)protein binding01.431e-09Moderately InformativeDirect
Molecular Function (MF)GTPase regulator activity00InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity6.427e-084.187e-07InformativeDirect
Molecular Function (MF)guanyl-nucleotide exchange factor activity00Highly InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)intracellular organelle part04.667e-15Least InformativeDirect
Cellular Component (CC)membrane3.582e-089.816e-06Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.059340.0004287Least InformativeInherited
Cellular Component (CC)intracellular non-membrane-bounded organelle0.087280.3189Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)organelle membrane5.065e-150Moderately InformativeDirect
Cellular Component (CC)cytoskeleton6.104e-131.176e-09Moderately InformativeDirect
Cellular Component (CC)endosome00InformativeDirect
Cellular Component (CC)microtubule cytoskeleton02.465e-13InformativeDirect
Cellular Component (CC)vacuole0.022050.006906InformativeInherited
Cellular Component (CC)membrane raft00Highly InformativeDirect
Cellular Component (CC)endosomal part00Highly InformativeDirect
Cellular Component (CC)late endosome00Highly InformativeDirect
Cellular Component (CC)microtubule associated complex4.79e-087.165e-09Highly InformativeDirect
Cellular Component (CC)lysosome7.245e-064.367e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.833e-07 Least Informative Direct
Biological Process (BP) localization 8.753e-12 Least Informative Direct
Biological Process (BP) response to stimulus 5.817e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 4.802e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 4.008e-15 Moderately Informative Direct
Biological Process (BP) macromolecule localization 2.268e-12 Moderately Informative Direct
Biological Process (BP) cellular localization 1.385e-13 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 6.532e-11 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 2.567e-12 Moderately Informative Direct
Biological Process (BP) response to organic nitrogen 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 0 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 2.15e-11 Informative Direct
Biological Process (BP) growth 2.859e-06 Informative Direct
Biological Process (BP) microtubule-based process 5.935e-06 Informative Direct
Biological Process (BP) regulation of anatomical structure size 3.777e-05 Informative Direct
Biological Process (BP) cellular component movement 0.0003006 Informative Direct
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) response to acid 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 1.178e-10 Highly Informative Direct
Biological Process (BP) cell growth 5.628e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular component size 0.0005372 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.01246 Least Informative Inherited
Molecular Function (MF) binding 0.00303 Least Informative Inherited
Molecular Function (MF) enzyme regulator activity 0 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) protein binding 1.431e-09 Moderately Informative Direct
Molecular Function (MF) GTPase regulator activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 4.187e-07 Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 4.667e-15 Least Informative Direct
Cellular Component (CC) membrane 9.816e-06 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0004287 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.3189 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1.176e-09 Moderately Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.465e-13 Informative Direct
Cellular Component (CC) vacuole 0.006906 Informative Inherited
Cellular Component (CC) membrane raft 0 Highly Informative Direct
Cellular Component (CC) endosomal part 0 Highly Informative Direct
Cellular Component (CC) late endosome 0 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 7.165e-09 Highly Informative Direct
Cellular Component (CC) lysosome 4.367e-06 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male genitalia0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane7.885e-07Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCytoskeleton4.741e-06Moderately InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentMicrotubule1.188e-07InformativeDirect
Post-translational modificationAcetylation2.945e-05Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Roadblock/LC7 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Roadblock/LC7 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]