SUPERFAMILY 1.75 HMM library and genome assignments server


Radical SAM enzymes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
Superfamily:   Radical SAM enzymes [ 102114] (3)
Families:   Biotin synthase [ 102115]
  Oxygen-independent coproporphyrinogen III oxidase HemN [ 102118]
  MoCo biosynthesis proteins [ 110388]


Superfamily statistics
Genomes (2,440) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 36,221 112,453 3
Proteins 35,988 112,000 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00013440.0004544Least InformativeDirect
Biological Process (BP)heterocycle metabolic process1.157e-051.22e-05Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process3.331e-058.228e-05Least InformativeDirect
Biological Process (BP)nitrogen compound metabolic process0.010020.00825Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.14760.307Least InformativeInherited
Biological Process (BP)regulation of cellular process11Least InformativeInherited
Biological Process (BP)protein metabolic process0.51260.6402Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.98751Least InformativeInherited
Biological Process (BP)multicellular organismal process11Least InformativeInherited
Biological Process (BP)developmental process0.97381Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)heterocycle biosynthetic process4.567e-144.008e-15Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.00048790.0001499Moderately InformativeDirect
Biological Process (BP)cofactor metabolic process6.09e-150Moderately InformativeDirect
Biological Process (BP)organic cyclic compound biosynthetic process1.228e-133.329e-14Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process5.94e-053.727e-08Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.07270.1637Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.48771Moderately InformativeInherited
Biological Process (BP)regulation of localization0.059670.3853Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.58791Moderately InformativeInherited
Biological Process (BP)organ development0.20381Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.85980.7574Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.045030.005818Moderately InformativeInherited
Biological Process (BP)immune system process0.17411Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.49161Moderately InformativeInherited
Biological Process (BP)regulation of cell communication0.091261Moderately InformativeInherited
Biological Process (BP)regulation of signaling0.088081Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.36411Moderately InformativeInherited
Biological Process (BP)cell differentiation0.27321Moderately InformativeInherited
Biological Process (BP)multi-organism process0.097690.5895Moderately InformativeInherited
Biological Process (BP)cellular lipid metabolic process0.26680.1559Moderately InformativeInherited
Biological Process (BP)lipid biosynthetic process0.27240.05754Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.054581Moderately InformativeInherited
Biological Process (BP)vitamin metabolic process0.00046431.598e-05InformativeDirect
Biological Process (BP)sulfur compound biosynthetic process2.829e-062.854e-08InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.00011116.105e-06InformativeDirect
Biological Process (BP)immune effector process0.00049360.02919InformativeInherited
Biological Process (BP)defense response0.030510.2056InformativeInherited
Biological Process (BP)regulation of secretion0.00011240.02899InformativeInherited
Biological Process (BP)regulation of protein localization0.00010040.0214InformativeInherited
Biological Process (BP)positive regulation of signal transduction0.0017320.3659InformativeInherited
Biological Process (BP)cell activation0.000110.06404InformativeInherited
Biological Process (BP)hematopoietic or lymphoid organ development4.306e-050.08998InformativeInherited
Biological Process (BP)response to other organism0.0026060.05341InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.61620.01365InformativeInherited
Biological Process (BP)fatty acid metabolic process0.03150.002815InformativeInherited
Biological Process (BP)regulation of immune response0.0052620.1789InformativeInherited
Biological Process (BP)positive regulation of immune system process0.0014490.08691InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process6.203e-050.08793InformativeInherited
Biological Process (BP)regulation of cytokine production3.517e-050.01259InformativeInherited
Biological Process (BP)regulation of immune effector process3.773e-060.001733InformativeInherited
Biological Process (BP)positive regulation of cytokine production3.8e-070.0001485Highly InformativeDirect
Biological Process (BP)positive regulation of immune effector process4.02e-082.976e-05Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte mediated immunity4.02e-081.656e-05Highly InformativeDirect
Biological Process (BP)positive regulation of adaptive immune response1.672e-106.091e-07Highly InformativeDirect
Biological Process (BP)response to virus2.143e-060.0006055Highly InformativeDirect
Biological Process (BP)lymphocyte differentiation3.351e-070.0006401Highly InformativeDirect
Biological Process (BP)molybdopterin cofactor biosynthetic process9.119e-053.085e-13Highly InformativeDirect
Biological Process (BP)regulation of protein secretion2.252e-078.368e-05Highly InformativeDirect
Biological Process (BP)negative regulation of secretion6.782e-083.456e-05Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport1.095e-072.688e-05Highly InformativeDirect
Biological Process (BP)T cell activation4.584e-070.001183Highly InformativeInherited
Biological Process (BP)regulation of adaptive immune response based on somatic recombination of immune receptors built from11.17e-05Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity0.3560.2813Least InformativeInherited
Molecular Function (MF)protein binding11Moderately InformativeInherited
Molecular Function (MF)ligase activity, forming carbon-nitrogen bonds0.0025650.005949InformativeInherited
Molecular Function (MF)sulfurtransferase activity1.598e-121.374e-05Highly InformativeDirect
Molecular Function (MF)metal cluster binding00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)lipid particle2.52e-060.0001534Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.0004544 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.22e-05 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 8.228e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.00825 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.307 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.6402 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.92 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 4.008e-15 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0001499 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 3.329e-14 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 3.727e-08 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.1637 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3853 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.005818 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.7574 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.5895 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.1559 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.05754 Moderately Informative Inherited
Biological Process (BP) cellular amino acid metabolic process 0.111 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.6472 Moderately Informative Inherited
Biological Process (BP) gene expression 0.56 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9941 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) tRNA metabolic process 7.685e-05 Informative Direct
Biological Process (BP) vitamin metabolic process 1.598e-05 Informative Direct
Biological Process (BP) RNA modification 0.0004565 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.0006556 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 2.854e-08 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 6.105e-06 Informative Direct
Biological Process (BP) immune effector process 0.02919 Informative Inherited
Biological Process (BP) defense response 0.2056 Informative Inherited
Biological Process (BP) regulation of secretion 0.02899 Informative Inherited
Biological Process (BP) regulation of protein localization 0.0214 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.3659 Informative Inherited
Biological Process (BP) cell activation 0.06404 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.08998 Informative Inherited
Biological Process (BP) response to other organism 0.05341 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 0.01365 Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.002815 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.001897 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 0.02686 Informative Inherited
Biological Process (BP) organonitrogen compound catabolic process 0.7815 Informative Inherited
Biological Process (BP) ncRNA processing 0.001938 Informative Inherited
Biological Process (BP) regulation of immune response 0.1789 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.08691 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.08793 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.01259 Informative Inherited
Biological Process (BP) regulation of immune effector process 0.001733 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.2572 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.09885 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0001485 Highly Informative Direct
Biological Process (BP) positive regulation of immune effector process 2.976e-05 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte mediated immunity 1.656e-05 Highly Informative Direct
Biological Process (BP) positive regulation of adaptive immune response 6.091e-07 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 1.17e-05 Highly Informative Direct
Biological Process (BP) tRNA modification 2.864e-06 Highly Informative Direct
Biological Process (BP) response to virus 0.0006055 Highly Informative Direct
Biological Process (BP) lymphocyte differentiation 0.0006401 Highly Informative Direct
Biological Process (BP) molybdopterin cofactor biosynthetic process 3.085e-13 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 8.368e-05 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 3.456e-05 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 2.688e-05 Highly Informative Direct
Biological Process (BP) T cell activation 0.001183 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.2813 Least Informative Inherited
Molecular Function (MF) protein binding 1 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.008431 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.002382 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0.005949 Informative Inherited
Molecular Function (MF) sulfurtransferase activity 1.374e-05 Highly Informative Direct
Molecular Function (MF) intramolecular transferase activity 1.425e-07 Highly Informative Direct
Molecular Function (MF) protein kinase regulator activity 4.318e-11 Highly Informative Direct
Molecular Function (MF) metal cluster binding 0 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) nucleoplasm part 0.01582 Informative Inherited
Cellular Component (CC) lipid particle 0.0001534 Highly Informative Direct
Cellular Component (CC) transcription elongation factor complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.4974Moderately InformativeInherited
Enzyme Commission (EC)With other acceptors0InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase2.909e-12InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups1InformativeInherited
Enzyme Commission (EC)Other oxidoreductases0.009866Highly InformativeInherited

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases4.55e-07Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0Moderately InformativeDirect
Enzyme Commission (EC)Carbon-carbon lyases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases (mutases)1InformativeInherited
Enzyme Commission (EC)With other acceptors0Highly InformativeDirect
Enzyme Commission (EC)Sulfurtransferases0Highly InformativeDirect
Enzyme Commission (EC)Other carbon-carbon lyases0Highly InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase1.816e-11Highly InformativeDirect
Enzyme Commission (EC)Transferring nitrogenous groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processrRNA processing0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processNitrogen fixation0.0001279InformativeDirect
Biological processMolybdenum cofactor biosynthesis0Highly InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentLipid droplet5.667e-05Highly InformativeDirect
DomainTransit peptide1.467e-12Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding1Least InformativeInherited
Molecular functionIron0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular function4Fe-4S0InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Molecular functionS-adenosyl-L-methionine0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationLyase1.442e-06Moderately InformativeDirect
Post-translational modificationMethyltransferase2.304e-08InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)cofactor metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)purine metabolism1Moderately InformativeInherited
UniPathway (UP)purine base metabolism5.975e-13InformativeDirect
UniPathway (UP)tRNA modification1InformativeInherited
UniPathway (UP)quinone cofactor biosynthesis1InformativeInherited
UniPathway (UP)biotin biosynthesis0Highly InformativeDirect
UniPathway (UP)molybdopterin biosynthesis0Highly InformativeDirect
UniPathway (UP)protein lipoylation0Highly InformativeDirect
UniPathway (UP)pyrroloquinoline quinone biosynthesis0Highly InformativeDirect
UniPathway (UP)purine base biosynthesis8.92e-15Highly InformativeDirect
UniPathway (UP)tRNA post-transcriptional modification6.063e-10Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Radical SAM enzymes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Radical SAM enzymes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]