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Apyrase superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | Other enzymes |
Document: Function annotation of SCOP domain superfamilies
Gene Ontology (high-quality) (show details)
Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001
| GO term | FDR (singleton) | FDR (all) | IC level | SDFO level | Annotation (direct or inherited) |
| Molecular Function (MF) | pyrophosphatase activity | 3.298e-11 | 9.863e-10 | 1.298 | -- | DIRECT |
| Molecular Function (MF) | hydrolase activity, acting on acid anhydrides | 3.635e-11 | 1.018e-09 | 1.281 | -- | DIRECT |
| Molecular Function (MF) | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 3.528e-11 | 1.007e-09 | 1.281 | -- | DIRECT |
| Molecular Function (MF) | nucleoside-diphosphatase activity | 0 | 0 | 2.377 | -- | DIRECT |
| Molecular Function (MF) | calcium-dependent ATPase activity | 0 | 0 | 2.679 | -- | DIRECT |
| Molecular Function (MF) | ATPase activity, coupled | 7.535e-15 | 2.396e-10 | 1.637 | -- | DIRECT |
| Molecular Function (MF) | ATPase activity | 1.84e-14 | 0.04851 | 1.599 | -- | INHERITED FROM: ATPase activity, coupled || calcium-dependent ATPase activity |
| Molecular Function (MF) | catalytic activity | 0.001399 | 0.004467 | 0.2686 | -- | INHERITED FROM: ATPase activity, coupled || hydrolase activity || nucleoside-diphosphatase activity || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || nucleoside-triphosphatase activity || calcium-dependent ATPase activity || pyrophosphatase activity || hydrolase activity, acting on acid anhydrides |
| Molecular Function (MF) | molecular_function | 0 | 0.4915 | 0 | -- | INHERITED FROM: ATPase activity, coupled || hydrolase activity || nucleoside-diphosphatase activity || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || pyrophosphatase activity || nucleoside-triphosphatase activity || calcium-dependent ATPase activity || hydrolase activity, acting on acid anhydrides |
| Molecular Function (MF) | hydrolase activity | 1.77e-07 | 5.21e-06 | 0.6657 | Least Informative | DIRECT |
| Molecular Function (MF) | nucleoside-triphosphatase activity | 1.161e-11 | 5.816e-10 | 1.502 | Informative | DIRECT |
Document: GO annotation of SCOP domains
Gene Ontology (high-coverage) (show details)
Highlighted in gray are those with either FDR_singleton>0.001 or FDR_all>0.001
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GO term |
FDR (all) |
IC level |
SDFO level |
Annotation (direct or inherited) |
| Molecular Function (MF) |
pyrophosphatase activity |
9.863e-10 |
1.298 |
-- |
DIRECT |
| Molecular Function (MF) |
hydrolase activity, acting on acid anhydrides |
1.018e-09 |
1.281 |
-- |
DIRECT |
| Molecular Function (MF) |
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
1.007e-09 |
1.281 |
-- |
DIRECT |
| Molecular Function (MF) |
nucleoside-diphosphatase activity |
0 |
2.377 |
-- |
DIRECT |
| Molecular Function (MF) |
calcium-dependent ATPase activity |
0 |
2.679 |
-- |
DIRECT |
| Molecular Function (MF) |
ATPase activity, coupled |
2.396e-10 |
1.637 |
-- |
DIRECT |
| Molecular Function (MF) |
ATPase activity |
0.04851 |
1.599 |
-- |
INHERITED FROM: ATPase activity, coupled || calcium-dependent ATPase activity |
| Molecular Function (MF) |
catalytic activity |
0.004467 |
0.2686 |
-- |
INHERITED FROM: ATPase activity, coupled || hydrolase activity || nucleoside-diphosphatase activity || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || nucleoside-triphosphatase activity || calcium-dependent ATPase activity || pyrophosphatase activity || hydrolase activity, acting on acid anhydrides |
| Molecular Function (MF) |
molecular_function |
0.4915 |
0 |
-- |
INHERITED FROM: ATPase activity, coupled || hydrolase activity || nucleoside-diphosphatase activity || hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides || pyrophosphatase activity || nucleoside-triphosphatase activity || calcium-dependent ATPase activity || hydrolase activity, acting on acid anhydrides |
| Molecular Function (MF) |
hydrolase activity |
5.21e-06 |
0.6657 |
Least Informative |
DIRECT |
| Molecular Function (MF) |
nucleoside-triphosphatase activity |
5.816e-10 |
1.502 |
Informative |
DIRECT |
Document: GO annotation of SCOP domains
Worm Phenotype (WP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: WP annotation of SCOP domains
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: EC annotation of SCOP domains
InterPro annotation
| Cross references | IPR009283 SSF101887 Protein matches |
| Abstract | This family consists of several eukaryotic apyrase (or adenosine diphosphatase) proteins , and related nucleoside diphosphatases . The salivary apyrases of blood-feeding arthropods are nucleotide hydrolysing enzymes implicated in the inhibition of host platelet aggregation through the hydrolysis of extracellular adenosine diphosphate [ 12234496]. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Enzyme Commission (EC) ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 1 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Apyrase domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 1 hidden Markov models representing the Apyrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Enzyme Commission (EC) · Internal database links ]
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