SUPERFAMILY 1.75 HMM library and genome assignments server

L27 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   L27 domain [ 101287]
Superfamily:   L27 domain [ 101288]
Families:   L27 domain [ 101289] (5)


Superfamily statistics
Genomes (141) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,687 1,767 10
Proteins 1,484 1,537 10


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0000000002858 Least Informative Direct
Biological Process (BP) localization 0.00000002433 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0000004777 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000005182 Least Informative Direct
Biological Process (BP) developmental process 0.000001023 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.09449 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.1515 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.2089 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.2659 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.08286 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.8369 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.08412 Least Informative Inherited
Biological Process (BP) response to stimulus 0.9659 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0.000000007769 Moderately Informative Direct
Biological Process (BP) system process 0.0000001459 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000005372 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.000002877 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000007126 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001884 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0002478 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.001079 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6488 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.001608 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.6551 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.02504 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.0747 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.04659 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.04942 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.06624 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1232 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.0019 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.004061 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.001515 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.1154 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.5628 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2775 Moderately Informative Inherited
Biological Process (BP) immune system process 0.1285 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.0000000000009583 Informative Direct
Biological Process (BP) biological adhesion 0.000000003527 Informative Direct
Biological Process (BP) phosphorylation 0.00000006716 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.00000007614 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000002974 Informative Direct
Biological Process (BP) growth 0.000003588 Informative Direct
Biological Process (BP) muscle tissue development 0.000009995 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00001748 Informative Direct
Biological Process (BP) leukocyte activation 0.00006489 Informative Direct
Biological Process (BP) immune effector process 0.0000789 Informative Direct
Biological Process (BP) epithelium development 0.000088 Informative Direct
Biological Process (BP) cellular membrane organization 0.0001315 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0001419 Informative Direct
Biological Process (BP) regulation of cell activation 0.000153 Informative Direct
Biological Process (BP) regulation of kinase activity 0.0004964 Informative Direct
Biological Process (BP) regulation of growth 0.0004966 Informative Direct
Biological Process (BP) positive regulation of transport 0.0006411 Informative Direct
Biological Process (BP) regulation of ion transport 0.000713 Informative Direct
Biological Process (BP) regulation of cell development 0.0007289 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.000776 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0008217 Informative Direct
Biological Process (BP) tissue morphogenesis 0.002138 Informative Inherited
Biological Process (BP) tube development 0.01398 Informative Inherited
Biological Process (BP) regulation of system process 0.01679 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.00398 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.00664 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.0146 Informative Inherited
Biological Process (BP) synaptic transmission 0.03082 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.01308 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.008743 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3071 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02533 Informative Inherited
Biological Process (BP) embryonic organ development 0.005303 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.02401 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.002675 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.01467 Informative Inherited
Biological Process (BP) actin filament-based process 0.1093 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.01505 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.003352 Informative Inherited
Biological Process (BP) secretion by cell 0.003696 Informative Inherited
Biological Process (BP) muscle system process 0.03496 Informative Inherited
Biological Process (BP) immune response 0.005135 Informative Inherited
Biological Process (BP) sensory organ development 0.02386 Informative Inherited
Biological Process (BP) cell junction organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of leukocyte activation 0.000000009445 Highly Informative Direct
Biological Process (BP) regulation of striated muscle cell differentiation 0.00000001266 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 0.00000007976 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000001945 Highly Informative Direct
Biological Process (BP) leukocyte mediated immunity 0.0000002369 Highly Informative Direct
Biological Process (BP) regulation of mononuclear cell proliferation 0.0000002395 Highly Informative Direct
Biological Process (BP) respiratory system development 0.0000002988 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000001477 Highly Informative Direct
Biological Process (BP) developmental growth 0.000002388 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0.000002483 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 0.000003323 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000003813 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 0.000005207 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000007746 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.000009222 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.000009587 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00001831 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.00002757 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 0.00003005 Highly Informative Direct
Biological Process (BP) regulation of developmental growth 0.00003511 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0000605 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0.0001247 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.0001486 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.0001983 Highly Informative Direct
Biological Process (BP) renal system development 0.002277 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.005127 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.007513 Highly Informative Inherited
Biological Process (BP) signal release 0.01515 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.01502 Highly Informative Inherited
Molecular Function (MF) binding 0.00000000000961 Least Informative Direct
Molecular Function (MF) transferase activity 0.0008288 Least Informative Direct
Molecular Function (MF) structural molecule activity 0.00000007541 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000007836 Moderately Informative Direct
Molecular Function (MF) kinase activity 0.00000009379 Informative Direct
Molecular Function (MF) enzyme binding 0.4439 Informative Inherited
Molecular Function (MF) nucleobase-containing compound kinase activity 0 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000000000109 Highly Informative Direct
Molecular Function (MF) kinase binding 0.00004207 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.001173 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1124 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00005059 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001841 Moderately Informative Direct
Cellular Component (CC) vesicle 0.001408 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.07934 Moderately Informative Inherited
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) extracellular matrix 0.0000009086 Informative Direct
Cellular Component (CC) extracellular membrane-bounded organelle 0.001108 Informative Inherited
Cellular Component (CC) neuron projection 0.8905 Informative Inherited
Cellular Component (CC) extracellular matrix part 0.00000000194 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0000007059 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0000008065 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.0000622 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.3741Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.004267Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.05955Moderately InformativeInherited
Mammalian Phenotype (MP)preweaning lethality0.1962Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.0001501InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.04621InformativeInherited
Mammalian Phenotype (MP)abnormal excitatory postsynaptic currents0.0001345Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0002469Highly InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.005485Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00822Least InformativeInherited
Biological processProtein transport0.000000001484Moderately InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0002665Moderately InformativeDirect
Cellular componentSynapse1InformativeInherited
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
Cellular componentTight junction0Highly InformativeDirect
Cellular componentSynaptosome0.0000002384Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSH3 domain0InformativeDirect
Post-translational modificationPhosphoprotein0.00000000003969Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a L27 domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the L27 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]