SUPERFAMILY 1.75 HMM library and genome assignments server


Notch domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Notch domain [ 90192]
Superfamily:   Notch domain [ 90193]
Families:   Notch domain [ 90194]


Superfamily statistics
Genomes (149) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,121 1,266 1
Proteins 508 581 1


Functional annotation
General category Regulation
Detailed category Receptor activity

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 5.747e-10 Least Informative Direct
Biological Process (BP) developmental process 2.313e-13 Least Informative Direct
Biological Process (BP) single-organism cellular process 1.697e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 9.703e-08 Least Informative Direct
Biological Process (BP) response to stimulus 4.284e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 9.093e-05 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.6978 Least Informative Inherited
Biological Process (BP) localization 0.0538 Least Informative Inherited
Biological Process (BP) immune system process 5.549e-05 Moderately Informative Direct
Biological Process (BP) signal transduction 8.2e-07 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 7.274e-05 Moderately Informative Direct
Biological Process (BP) tissue development 0.0008149 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 7.769e-06 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 2.723e-05 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 8.57e-06 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 2.508e-05 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1.47e-05 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.0001445 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001216 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.0002371 Moderately Informative Direct
Biological Process (BP) organ development 0.003799 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2145 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.001007 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01162 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.02731 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.003417 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.08261 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.7066 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.02245 Moderately Informative Inherited
Biological Process (BP) response to wounding 5.536e-07 Informative Direct
Biological Process (BP) positive regulation of signal transduction 7.028e-09 Informative Direct
Biological Process (BP) protein transport 3.134e-06 Informative Direct
Biological Process (BP) phosphorylation 0.0004215 Informative Direct
Biological Process (BP) cell projection organization 5.849e-05 Informative Direct
Biological Process (BP) secretion by cell 6.574e-05 Informative Direct
Biological Process (BP) growth 3.914e-08 Informative Direct
Biological Process (BP) regulation of cell proliferation 3.555e-05 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0009715 Informative Direct
Biological Process (BP) generation of neurons 5.605e-07 Informative Direct
Biological Process (BP) negative regulation of developmental process 4.67e-06 Informative Direct
Biological Process (BP) cardiovascular system development 3.213e-10 Informative Direct
Biological Process (BP) regulation of nervous system development 0.1178 Informative Inherited
Biological Process (BP) regulation of cell development 0.779 Informative Inherited
Biological Process (BP) tube development 0.00201 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.01524 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.003862 Informative Inherited
Biological Process (BP) epithelium development 0.136 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.001393 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.02737 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.002682 Informative Inherited
Biological Process (BP) negative regulation of gene expression 0.002185 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 0.001017 Informative Inherited
Biological Process (BP) pattern specification process 1.765e-05 Highly Informative Direct
Biological Process (BP) glial cell differentiation 0.0002441 Highly Informative Direct
Biological Process (BP) limb morphogenesis 1.68e-08 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.0006112 Highly Informative Direct
Biological Process (BP) negative regulation of cell differentiation 1.625e-06 Highly Informative Direct
Biological Process (BP) developmental growth 0.0004485 Highly Informative Direct
Biological Process (BP) stem cell development 9.761e-05 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2.24e-06 Highly Informative Direct
Biological Process (BP) neuron projection development 0.939 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.01002 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1685 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-dependent 0.00334 Highly Informative Inherited
Molecular Function (MF) binding 0.008158 Least Informative Inherited
Molecular Function (MF) receptor activity 3.226e-05 Informative Direct
Cellular Component (CC) membrane 1.368e-06 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0004158 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.08673 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.01009 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0003581 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.0001002 Moderately Informative Direct
Cellular Component (CC) endomembrane system 8.219e-10 Moderately Informative Direct
Cellular Component (CC) organelle membrane 7.55e-06 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.222 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.04029 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01362 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 3.991e-11 Informative Direct
Cellular Component (CC) cell surface 7.16e-07 Informative Direct
Cellular Component (CC) integral to membrane 3.036e-05 Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.001628Least InformativeInherited
Disease Ontology (DO)organ system cancer0.05336Least InformativeInherited
Disease Ontology (DO)benign neoplasm5.558e-05Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0001901Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.02431Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0731Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm6.978e-07InformativeDirect
Disease Ontology (DO)urinary system cancer2.016e-05InformativeDirect
Disease Ontology (DO)hemorrhagic disease2.559e-05InformativeDirect
Disease Ontology (DO)cell type benign neoplasm3.291e-05InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0.0006751InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0.003219InformativeInherited
Disease Ontology (DO)skin hemangioma4.332e-13Highly InformativeDirect
Disease Ontology (DO)hemangioma3.279e-09Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia1.873e-08Highly InformativeDirect
Disease Ontology (DO)purpura2.234e-06Highly InformativeDirect
Disease Ontology (DO)liver carcinoma0.0004139Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.2411Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the aortic valve1.973e-05InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.0001538InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01388Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.02992Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03916Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.0002491Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.001176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.00471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.006045Moderately InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.008011Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.01995Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.04015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.2345Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3967Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning3.625e-05InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0002162InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.0004015InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.0006115InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.0008694InformativeDirect
Mammalian Phenotype (MP)abnormal skin appearance0.001242InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.009945InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.06322InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.08271InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.1155InformativeInherited
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology4.278e-07Highly InformativeDirect
Mammalian Phenotype (MP)scaly skin1.094e-06Highly InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence3.776e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal sebaceous gland morphology9.613e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hair follicle morphology0.0001015Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pericardium morphology0.000316Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0007563Highly InformativeDirect
Mammalian Phenotype (MP)edema0.001379Highly InformativeInherited

Document: MP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Transferases for other substituted phosphate groups0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0Moderately InformativeDirect
Biological processTranscription regulation0Moderately InformativeDirect
Biological processAngiogenesis0InformativeDirect
Biological processNotch signaling pathway0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus2.163e-12Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainSignal3.194e-09Least InformativeDirect
DomainANK repeat0InformativeDirect
DomainEGF-like domain0InformativeDirect
Molecular functionCalcium1.946e-14Moderately InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000800 SSF90193 Protein matches
Abstract The Notch domain is also called the 'DSL' domain or the Lin-12/Notch repeat (LNR). The LNR region is present only in Notch related proteins C-terminal to EGF repeats. The lin-12/Notch proteins act as transmembrane receptors for intercellular signals that specify cell fates during animal development. In response to a ligand, proteolytic cleavages release the intracellular domain of Notch, which then gains access to the nucleus and acts as a transcriptional co-activator [PubMed3119223]. The LNR region is supposed to negatively regulate the Lin-12/Notch proteins activity. It is a triplication of an around 35-40 amino acids module present on the extracellular part of the protein [PubMed7697721, PubMed8139658]. Each module contains six cysteine residues engaged in three disulphide bonds and three conserved aspartate and asparagine residues [PubMed3119223]. The biochemical characterization of a recombinantly expressed LIN-12.1 module from the human Notch1 receptor indicate that the disulphide bonds are formed between the first and fifth, second and fourth, and third and sixth cysteines. The formation of this particular disulphide isomer is favored by the presence of Ca2+, which is also required to maintain the structural integrity of the rLIN-12.1 module. The conserved aspartate and asparagine residues are likely to be important for Ca2+ binding, and thereby contribute to the native fold.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Notch domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Notch domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]