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Neurotransmitter-gated ion-channel transmembrane pore superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Neurotransmitter-gated ion-channel transmembrane pore [ 90111]
Superfamily:   Neurotransmitter-gated ion-channel transmembrane pore [ 90112]
Families:   Neurotransmitter-gated ion-channel transmembrane pore [ 90113] (4)


Superfamily statistics
Genomes (205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,732 8,728 8
Proteins 7,559 8,593 8


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.0094150Least InformativeInherited
Biological Process (BP)multicellular organismal process0.014370Least InformativeInherited
Biological Process (BP)single-organism cellular process0.026050Least InformativeInherited
Biological Process (BP)system process0.000027470Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.039840.0001798Moderately InformativeInherited
Biological Process (BP)single-organism behavior0.0000000049230.00004222InformativeDirect
Biological Process (BP)synaptic transmission0.00000015470InformativeDirect
Biological Process (BP)regulation of membrane potential0.000000023520Highly InformativeDirect
Cellular Component (CC)membrane0.0011770Least InformativeInherited
Cellular Component (CC)synapse part0.000000048220InformativeDirect
Cellular Component (CC)postsynaptic membrane0.000000000011230.00000374Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) developmental process 0.04075 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0001798 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000000001909 Moderately Informative Direct
Biological Process (BP) signal transduction 0.0000000001702 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0000001924 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001261 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3692 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7238 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.5585 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6809 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4448 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8323 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005808 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.6149 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3953 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01819 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1124 Moderately Informative Inherited
Biological Process (BP) single-organism behavior 0.00004222 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) regulation of secretion 0.000000000004869 Informative Direct
Biological Process (BP) regulation of system process 0.00000006648 Informative Direct
Biological Process (BP) regulation of ion transport 0.00000112 Informative Direct
Biological Process (BP) leukocyte activation 0.0007599 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.03613 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.6042 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6506 Informative Inherited
Biological Process (BP) protein oligomerization 0.0103 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.003596 Informative Inherited
Biological Process (BP) regulation of cell development 0.005285 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.008409 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01475 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.05137 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.06356 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1172 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01544 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.3562 Informative Inherited
Biological Process (BP) locomotion 0.003049 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.1787 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002521 Informative Inherited
Biological Process (BP) response to light stimulus 0.006404 Informative Inherited
Biological Process (BP) secretion by cell 0.6677 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6148 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) muscle system process 0.4854 Informative Inherited
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0.0000000000008539 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.000000001558 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.000000003165 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0.00000000644 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00000002302 Highly Informative Direct
Biological Process (BP) B cell activation 0.00000002601 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00002175 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.00004017 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0002632 Highly Informative Direct
Biological Process (BP) exocytosis 0.0005626 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.02763 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1459 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.3371 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.7775 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.004368 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.7222 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.007733 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.02672 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.003646 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.08073 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.9681 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.5892 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.0000000000005657 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0.00000000000000752 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.04695 Informative Inherited
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.000008692 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000002694 Moderately Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) neuron projection 0.0000003657 Informative Direct
Cellular Component (CC) postsynaptic membrane 0.00000374 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) cell body 0.00000003969 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of mental health0.000000000007942Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.4186Moderately InformativeInherited
Disease Ontology (DO)substance dependence0.000000000003471InformativeDirect
Disease Ontology (DO)schizophrenia0.0005014InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1086InformativeInherited
Disease Ontology (DO)cocaine dependence0.0000004718Highly InformativeDirect
Disease Ontology (DO)autistic disorder0.0000009512Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.00009831Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdomen0.08517Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.133Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of head and neck0.5256Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.878Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9092Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.003024Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.003952Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04615Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1251Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.1413Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.2886Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4122Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.6575Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.0001348InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.0005926InformativeDirect
Phenotypic Abnormality (PA)Joint dislocation0.0008539InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the voice0.001109InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.001772InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.00284InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01066InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ribs0.01241InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01687InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.0303InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cervical spine0.04002InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the neck0.04307InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.05194InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the curvature of the vertebral column0.05852InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebrae0.06324InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.281InformativeInherited
Phenotypic Abnormality (PA)Abdominal symptom0.3126InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the intestine0.5461InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents0.0000000003035Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness0.0000000003035Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals0.000000002283Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy0.000000009461Highly InformativeDirect
Phenotypic Abnormality (PA)Multiple pterygia0.00000003924Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry0.0000001011Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0.0000001011Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized amyoplasia0.0000001189Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement0.0000001671Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita0.0000001979Highly InformativeDirect
Phenotypic Abnormality (PA)Popliteal pterygium0.0000002821Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of placental membranes0.0000002821Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign0.0000008019Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal cervical curvature0.000001123Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement0.000001288Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0.000002309Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability0.000002577Highly InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic heart0.00000576Highly InformativeDirect
Phenotypic Abnormality (PA)Malignant hyperthermia0.00000576Highly InformativeDirect
Phenotypic Abnormality (PA)Poor suck0.000007932Highly InformativeDirect
Phenotypic Abnormality (PA)Thin ribs0.00002274Highly InformativeDirect
Phenotypic Abnormality (PA)Cystic hygroma0.0000283Highly InformativeDirect
Phenotypic Abnormality (PA)Vertebral fusion0.00007297Highly InformativeDirect
Phenotypic Abnormality (PA)Bulbar palsy0.00009303Highly InformativeDirect
Phenotypic Abnormality (PA)Short thorax0.0001692Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal malrotation0.0002136Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary hypoplasia0.0002391Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00000000289Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9591Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.001466Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.1288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1346Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.3966Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5311Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8223Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.00001915InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.002306InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004532InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.004898InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.004898InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.007795InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01298InformativeInherited
Mammalian Phenotype (MP)seizures0.01996InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.03516InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.06335InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08339InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08647InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.145InformativeInherited
Mammalian Phenotype (MP)urinary incontinence0.00000002576Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.0000001992Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder0.0000007009Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology0.000003713Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures0.00001616Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis0.00001765Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex0.00002299Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission0.00005184Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pupil morphology0.00006962Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception0.00007844Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open0.00009269Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0001082Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001378Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.0002162Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.0003153Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.000495Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.000524Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.00924Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.01092Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.03174Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1107Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3101Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0000000000002736Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000000004156Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.00001422Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.001275Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant0.00003373InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002419InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0003623InformativeDirect
Worm Phenotype (WP)neuron development variant0.01251InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant0.000001637Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant0.000002574Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0001783Highly InformativeDirect
Worm Phenotype (WP)organism starvation response variant0.002109Highly InformativeInherited
Worm Phenotype (WP)pesticide response variant0.006343Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.03953Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant0.00000003636Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.00009457Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.0058Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.000258InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation0.000000000002072Least InformativeDirect
DiseaseEpilepsy0.000000005261InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate0.0000000000483Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006029 SSF90112 Protein matches
Abstract

This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Neurotransmitter-gated ion-channel transmembrane pore domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Neurotransmitter-gated ion-channel transmembrane pore superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


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