SUPERFAMILY 1.75 HMM library and genome assignments server


Neurotransmitter-gated ion-channel transmembrane pore superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Neurotransmitter-gated ion-channel transmembrane pore [ 90111]
Superfamily:   Neurotransmitter-gated ion-channel transmembrane pore [ 90112]
Families:   Neurotransmitter-gated ion-channel transmembrane pore [ 90113] (4)


Superfamily statistics
Genomes (205) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,732 8,728 8
Proteins 7,559 8,593 8


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.0088320Least InformativeInherited
Biological Process (BP)multicellular organismal process0.014150Least InformativeInherited
Biological Process (BP)single-organism cellular process0.026560Least InformativeInherited
Biological Process (BP)system process2.632e-050Moderately InformativeDirect
Biological Process (BP)single-organism behavior4.296e-094.293e-05InformativeDirect
Biological Process (BP)synaptic transmission1.473e-070InformativeDirect
Biological Process (BP)regulation of membrane potential2.261e-080Highly InformativeDirect
Cellular Component (CC)membrane0.0011140Least InformativeInherited
Cellular Component (CC)synapse part3.855e-080InformativeDirect
Cellular Component (CC)postsynaptic membrane1.125e-117.849e-06Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) developmental process 0.03475 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.667e-11 Moderately Informative Direct
Biological Process (BP) signal transduction 2.987e-10 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 1.613e-07 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0009996 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.3538 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.6939 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.5209 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6408 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) immune system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4327 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.8153 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.005082 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.5986 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.377 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.02926 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.1464 Moderately Informative Inherited
Biological Process (BP) single-organism behavior 4.293e-05 Informative Direct
Biological Process (BP) synaptic transmission 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) response to organonitrogen compound 0 Informative Direct
Biological Process (BP) response to organic cyclic compound 0 Informative Direct
Biological Process (BP) regulation of secretion 1.978e-12 Informative Direct
Biological Process (BP) regulation of system process 5.022e-08 Informative Direct
Biological Process (BP) regulation of ion transport 1.172e-06 Informative Direct
Biological Process (BP) protein complex assembly 6.415e-05 Informative Direct
Biological Process (BP) leukocyte activation 0.000689 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.03617 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.5665 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.6444 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.003783 Informative Inherited
Biological Process (BP) regulation of cell development 0.004229 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.00724 Informative Inherited
Biological Process (BP) positive regulation of protein modification process 0.01013 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.01114 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.04273 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1199 Informative Inherited
Biological Process (BP) positive regulation of transport 0.01317 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.362 Informative Inherited
Biological Process (BP) locomotion 0.002772 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) central nervous system development 0.1698 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.001959 Informative Inherited
Biological Process (BP) response to light stimulus 0.005691 Informative Inherited
Biological Process (BP) secretion by cell 0.6599 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.6378 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) muscle system process 0.476 Informative Inherited
Biological Process (BP) regulation of membrane potential 0 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0 Highly Informative Direct
Biological Process (BP) adult behavior 0 Highly Informative Direct
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 5.522e-13 Highly Informative Direct
Biological Process (BP) response to toxic substance 9.499e-10 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.925e-09 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 5.682e-09 Highly Informative Direct
Biological Process (BP) calcium ion transport 2.185e-08 Highly Informative Direct
Biological Process (BP) B cell activation 2.256e-08 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 2.268e-05 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 4.915e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.00023 Highly Informative Direct
Biological Process (BP) exocytosis 0.0004706 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.03102 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1462 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.331 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.7805 Highly Informative Inherited
Biological Process (BP) regulation of circadian rhythm 0.004147 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.6925 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.007759 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.02222 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) sensory perception 1 Highly Informative Inherited
Biological Process (BP) fertilization 0.003026 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.07631 Highly Informative Inherited
Biological Process (BP) striated muscle contraction 0.9445 Highly Informative Inherited
Biological Process (BP) neuromuscular process 0.6076 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) cation binding 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 6.724e-14 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.0678 Informative Inherited
Molecular Function (MF) ion gated channel activity 0 Highly Informative Direct
Molecular Function (MF) amino acid binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 8.477e-13 Highly Informative Direct
Molecular Function (MF) cation channel activity 4.959e-06 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1.232e-06 Moderately Informative Direct
Cellular Component (CC) synapse part 0 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) neuron projection 2.998e-07 Informative Direct
Cellular Component (CC) postsynaptic membrane 7.849e-06 Highly Informative Direct
Cellular Component (CC) receptor complex 0 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 0 Highly Informative Direct
Cellular Component (CC) ion channel complex 0 Highly Informative Direct
Cellular Component (CC) cell body 3.045e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.002007Least InformativeInherited
Disease Ontology (DO)disease of mental health1.644e-12Moderately InformativeDirect
Disease Ontology (DO)central nervous system disease0.04341Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.39Moderately InformativeInherited
Disease Ontology (DO)substance dependence2.799e-13InformativeDirect
Disease Ontology (DO)schizophrenia0.0001408InformativeDirect
Disease Ontology (DO)leukodystrophy0.005341InformativeInherited
Disease Ontology (DO)focal epilepsy0.04831InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.06956InformativeInherited
Disease Ontology (DO)autistic disorder9.52e-08Highly InformativeDirect
Disease Ontology (DO)cocaine dependence5.382e-07Highly InformativeDirect
Disease Ontology (DO)Angelman syndrome0.0001047Highly InformativeDirect
Disease Ontology (DO)early myoclonic encephalopathy0.0001545Highly InformativeDirect
Disease Ontology (DO)Lewy body dementia0.000568Highly InformativeDirect
Disease Ontology (DO)frontal lobe epilepsy0.0008489Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2907Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9082Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01617Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.02031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle morphology0.1757Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle physiology0.4825Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.7025Moderately InformativeInherited
Phenotypic Abnormality (PA)Proximal muscle weakness0.002128InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle fibers0.003367InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.00965InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01594InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.06237InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the peripheral nervous system0.146InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.4837InformativeInherited
Phenotypic Abnormality (PA)Prolonged miniature endplate currents3.607e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Intermittent episodes of respiratory insufficiency due to muscle weakness3.607e-08Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased size of nerve terminals2.669e-07Highly InformativeDirect
Phenotypic Abnormality (PA)Muscle fiber atrophy1.642e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Weak cry7.662e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness7.662e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Decreased fetal movement8.157e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Arthrogryposis multiplex congenita9.348e-06Highly InformativeDirect
Phenotypic Abnormality (PA)Diminished movement2.362e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Gowers sign4.086e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Easy fatigability7.157e-05Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness9.527e-05Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype1.03e-09Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.9706Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.001061Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.08063Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1014Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2906Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.5617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.6635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.8212Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic3.262e-05InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.002333InformativeInherited
Mammalian Phenotype (MP)abnormal urination0.002877InformativeInherited
Mammalian Phenotype (MP)abnormal uvea morphology0.004755InformativeInherited
Mammalian Phenotype (MP)abnormal hair cell morphology0.00514InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear sensory epithelium morphology0.00514InformativeInherited
Mammalian Phenotype (MP)abnormal membranous labyrinth morphology0.01461InformativeInherited
Mammalian Phenotype (MP)seizures0.02313InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.04788InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.0771InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0774InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.08673InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.08805InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.1655InformativeInherited
Mammalian Phenotype (MP)urinary incontinence3.132e-08Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents2.105e-07Highly InformativeDirect
Mammalian Phenotype (MP)distended urinary bladder6.283e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary bladder physiology3.625e-06Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential8.966e-06Highly InformativeDirect
Mammalian Phenotype (MP)absence seizures1.903e-05Highly InformativeDirect
Mammalian Phenotype (MP)urolithiasis2.008e-05Highly InformativeDirect
Mammalian Phenotype (MP)impaired pupillary reflex2.594e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal distortion product otoacoustic emission4.952e-05Highly InformativeDirect
Mammalian Phenotype (MP)decreased chemically-elicited antinociception8.917e-05Highly InformativeDirect
Mammalian Phenotype (MP)eyelids fail to open0.0001048Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urothelium morphology0.0001227Highly InformativeDirect
Mammalian Phenotype (MP)abnormal nicotine-mediated receptor currents0.0001397Highly InformativeDirect
Mammalian Phenotype (MP)decreased prepulse inhibition0.000344Highly InformativeDirect
Mammalian Phenotype (MP)abnormal inhibitory postsynaptic currents0.0004313Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eyelid aperture0.0005068Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synapse morphology0.0008022Highly InformativeDirect
Mammalian Phenotype (MP)abnormal iris morphology0.0009739Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.01043Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron innervation pattern0.0259Highly InformativeInherited
Mammalian Phenotype (MP)impaired learning0.03245Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fear/anxiety-related behavior0.1116Highly InformativeInherited
Mammalian Phenotype (MP)abnormal avoidance learning behavior0.3182Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant2.736e-13Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant4.156e-09Least InformativeDirect
Worm Phenotype (WP)endocytic transport defect0Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant1.422e-05Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.001275Moderately InformativeInherited
Worm Phenotype (WP)electrophysiology variant3.373e-05InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002419InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0003623InformativeDirect
Worm Phenotype (WP)neuron development variant0.01251InformativeInherited
Worm Phenotype (WP)nicotine response variant0.1986InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.8078InformativeInherited
Worm Phenotype (WP)drug resistant1InformativeInherited
Worm Phenotype (WP)organism stress response variant1InformativeInherited
Worm Phenotype (WP)coelomocyte uptake defective0Highly InformativeDirect
Worm Phenotype (WP)nervous system physiology variant1.637e-06Highly InformativeDirect
Worm Phenotype (WP)sodium chloride chemotaxis variant2.574e-06Highly InformativeDirect
Worm Phenotype (WP)isothermal tracking behavior variant0.0001783Highly InformativeDirect
Worm Phenotype (WP)organism starvation response variant0.002109Highly InformativeInherited
Worm Phenotype (WP)pesticide response variant0.006343Highly InformativeInherited
Worm Phenotype (WP)osmotic integrity variant0.03953Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)chemical resistant3.977e-08Highly InformativeDirect
Fly Phenotype (FP)temperature response defective8.519e-05Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)musculature system0.005784Moderately InformativeInherited
Zebrafish Anatomy (ZA)trunk musculature0.0002605InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage0Least InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentSynapse0InformativeDirect
Cellular componentPostsynaptic cell membrane0Highly InformativeDirect
DiseaseDisease mutation1.831e-12Least InformativeDirect
DiseaseEpilepsy4.356e-09InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionChloride0Highly InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationIon channel0InformativeDirect
Post-translational modificationLigand-gated ion channel0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPalmitate4.991e-11Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006029 SSF90112 Protein matches
Abstract

This domain represents four transmembrane helices of a variety of neurotransmitter-gated ion-channels.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Neurotransmitter-gated ion-channel transmembrane pore domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Neurotransmitter-gated ion-channel transmembrane pore superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]