SUPERFAMILY 1.75 HMM library and genome assignments server


Subunits of heterodimeric actin filament capping protein Capz superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Subunits of heterodimeric actin filament capping protein Capz [ 90095]
Superfamily:   Subunits of heterodimeric actin filament capping protein Capz [ 90096] (2)
Families:   Capz alpha-1 subunit [ 90097]
  Capz beta-1 subunit [ 90100]


Superfamily statistics
Genomes (417) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,167 1,068 2
Proteins 1,144 1,060 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process1.206e-082.834e-06Least InformativeDirect
Biological Process (BP)regulation of cellular process7.732e-122.485e-07Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)developmental process0.00010560.02612Least InformativeInherited
Biological Process (BP)multicellular organismal process8.614e-060.005345Least InformativeInherited
Biological Process (BP)regulation of signal transduction1.606e-050.0003877Moderately InformativeDirect
Biological Process (BP)cell differentiation9.595e-080.0001719Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process1.393e-067.346e-07Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization00Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.061220.4367Moderately InformativeInherited
Biological Process (BP)nervous system development0.004140.006586Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.870.5956Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.074040.2746Moderately InformativeInherited
Biological Process (BP)organelle organization0.031950.04581Moderately InformativeInherited
Biological Process (BP)cytoskeleton organization6.364e-111.254e-09InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade5.226e-097.062e-08InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis2.77e-073.23e-05InformativeDirect
Biological Process (BP)cell projection organization4.536e-050.0008754InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis00InformativeDirect
Biological Process (BP)generation of neurons1.081e-073.845e-05InformativeDirect
Biological Process (BP)negative regulation of cellular component organization00InformativeDirect
Biological Process (BP)muscle structure development6.971e-081.352e-07InformativeDirect
Biological Process (BP)regulation of anatomical structure size00InformativeDirect
Biological Process (BP)cell projection assembly1.398e-089.123e-10Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization00Highly InformativeDirect
Biological Process (BP)neuron projection development1.159e-101.397e-07Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization00Highly InformativeDirect
Biological Process (BP)negative regulation of protein complex disassembly00Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly1.368e-120Highly InformativeDirect
Biological Process (BP)muscle fiber development01.605e-14Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization00Highly InformativeDirect
Biological Process (BP)regulation of protein depolymerization00Highly InformativeDirect
Molecular Function (MF)binding3.959e-070.0001415Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)actin filament binding7.247e-063.933e-07Highly InformativeDirect
Molecular Function (MF)tubulin binding0.22070.3244Highly InformativeInherited
Cellular Component (CC)membrane3.85e-063.181e-05Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle01.143e-14Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00028727.922e-07Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.431e-050.0002619Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoskeleton2.339e-105.013e-11Moderately InformativeDirect
Cellular Component (CC)vesicle3.109e-067.854e-08Moderately InformativeDirect
Cellular Component (CC)cell projection0.003030.007343Moderately InformativeInherited
Cellular Component (CC)cell-cell junction00InformativeDirect
Cellular Component (CC)cell cortex00InformativeDirect
Cellular Component (CC)actin cytoskeleton5.348e-121.521e-15InformativeDirect
Cellular Component (CC)secretory granule0.0001911.562e-06InformativeDirect
Cellular Component (CC)cell leading edge1.26e-088.645e-09InformativeDirect
Cellular Component (CC)contractile fiber part2.922e-083.6e-08InformativeDirect
Cellular Component (CC)sarcomere5.272e-151.689e-14Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton00Highly InformativeDirect
Cellular Component (CC)cell-cell contact zone4.924e-054.495e-06Highly InformativeDirect
Cellular Component (CC)sperm part1.538e-140Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 2.834e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 2.485e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.02612 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.005345 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0003877 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0001719 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 7.346e-07 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.9175 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.4367 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.006586 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5956 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2746 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.04581 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 1.254e-09 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 7.062e-08 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 3.23e-05 Informative Direct
Biological Process (BP) cell projection organization 0.0008754 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) generation of neurons 3.845e-05 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) muscle structure development 1.352e-07 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) cell projection assembly 9.123e-10 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 1.397e-07 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0 Highly Informative Direct
Biological Process (BP) muscle fiber development 1.605e-14 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein depolymerization 0 Highly Informative Direct
Molecular Function (MF) binding 0.0001415 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) actin filament binding 3.933e-07 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.3244 Highly Informative Inherited
Cellular Component (CC) membrane 3.181e-05 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1.143e-14 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 7.922e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0002619 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 5.013e-11 Moderately Informative Direct
Cellular Component (CC) vesicle 7.854e-08 Moderately Informative Direct
Cellular Component (CC) cell projection 0.007343 Moderately Informative Inherited
Cellular Component (CC) cell-cell junction 0 Informative Direct
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 1.521e-15 Informative Direct
Cellular Component (CC) secretory granule 1.562e-06 Informative Direct
Cellular Component (CC) cell leading edge 8.645e-09 Informative Direct
Cellular Component (CC) contractile fiber part 3.6e-08 Informative Direct
Cellular Component (CC) sarcomere 1.689e-14 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 4.495e-06 Highly Informative Direct
Cellular Component (CC) sperm part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomach0Highly InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.0004389Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Subunits of heterodimeric actin filament capping protein Capz domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Subunits of heterodimeric actin filament capping protein Capz superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]