SUPERFAMILY 1.75 HMM library and genome assignments server

Subunits of heterodimeric actin filament capping protein Capz superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Subunits of heterodimeric actin filament capping protein Capz [ 90095]
Superfamily:   Subunits of heterodimeric actin filament capping protein Capz [ 90096] (2)
Families:   Capz alpha-1 subunit [ 90097]
  Capz beta-1 subunit [ 90100]


Superfamily statistics
Genomes (467) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,272 1,475 2
Proteins 1,246 1,462 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.000000000018560.0000003442Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00.000000000000003707Least InformativeDirect
Biological Process (BP)single-organism cellular process0.003240.007007Least InformativeInherited
Biological Process (BP)developmental process0.00046090.05998Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000029460.009959Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000030240.0001051Moderately InformativeDirect
Biological Process (BP)cell differentiation0.0000011860.0008809Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0000031970.000001575Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization00Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000000000076760.000000000003047Moderately InformativeDirect
Biological Process (BP)nervous system development0.009820.01388Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.950.7356Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.028970.1573Moderately InformativeInherited
Biological Process (BP)cytoskeleton organization0.0000000000540.000000001416InformativeDirect
Biological Process (BP)actin filament-based process0.00076890.0006062InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis00InformativeDirect
Biological Process (BP)generation of neurons0.0000016110.000247InformativeDirect
Biological Process (BP)negative regulation of cellular component organization00InformativeDirect
Biological Process (BP)muscle structure development0.00000030650.0000002661InformativeDirect
Biological Process (BP)regulation of anatomical structure size00InformativeDirect
Biological Process (BP)cell projection organization0.000060490.001553InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0042540.002485InformativeInherited
Biological Process (BP)cell projection assembly0.00000014980.000000009992Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.0000000000000032510.000000000000001913Highly InformativeDirect
Biological Process (BP)neuron projection development0.000000003810.000001732Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization00Highly InformativeDirect
Biological Process (BP)regulation of protein complex disassembly00Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.00000000000037340Highly InformativeDirect
Biological Process (BP)muscle fiber development0.0000000000000048440Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization00Highly InformativeDirect
Molecular Function (MF)binding0.00000054960.0001886Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)protein complex binding00InformativeDirect
Molecular Function (MF)actin filament binding0.0000000001020.00000000000002233Highly InformativeDirect
Molecular Function (MF)tubulin binding0.30820.4052Highly InformativeInherited
Cellular Component (CC)membrane0.000063750.0003918Least InformativeDirect
Cellular Component (CC)non-membrane-bounded organelle00.0000000000002101Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000012590.0002122Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.0019540.00001175Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0000000000024150.000000000001305Moderately InformativeDirect
Cellular Component (CC)vesicle0.00021620.000005953Moderately InformativeDirect
Cellular Component (CC)cell projection0.013210.02775Moderately InformativeInherited
Cellular Component (CC)cell cortex00InformativeDirect
Cellular Component (CC)actin cytoskeleton0.00000000000035080InformativeDirect
Cellular Component (CC)cell junction00.00000000000001464InformativeDirect
Cellular Component (CC)secretory granule0.0000000026210.000000000005538InformativeDirect
Cellular Component (CC)cell leading edge0.00000018550.000000117InformativeDirect
Cellular Component (CC)contractile fiber part0.00000037380.000000549InformativeDirect
Cellular Component (CC)acrosomal vesicle00Highly InformativeDirect
Cellular Component (CC)sarcomere0.00000000000034990.000000000001169Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton00Highly InformativeDirect
Cellular Component (CC)cell-cell contact zone0.00026770.00002898Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0000003442 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000000000000003707 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.007007 Least Informative Inherited
Biological Process (BP) developmental process 0.05998 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.009959 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.0001051 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0008809 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000001575 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000000003047 Moderately Informative Direct
Biological Process (BP) nervous system development 0.01388 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7356 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1573 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.000000001416 Informative Direct
Biological Process (BP) actin filament-based process 0.0006062 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) generation of neurons 0.000247 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) muscle structure development 0.0000002661 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) cell projection organization 0.001553 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002485 Informative Inherited
Biological Process (BP) cell projection assembly 0.000000009992 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0.000000000000001913 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000001732 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0 Highly Informative Direct
Biological Process (BP) muscle fiber development 0 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Molecular Function (MF) binding 0.0001886 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) protein complex binding 0 Informative Direct
Molecular Function (MF) actin filament binding 0.00000000000002233 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.4052 Highly Informative Inherited
Cellular Component (CC) membrane 0.0003918 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000000000002101 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001175 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0002122 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000000001305 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000005953 Moderately Informative Direct
Cellular Component (CC) cell projection 0.02775 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell junction 0.00000000000001464 Informative Direct
Cellular Component (CC) secretory granule 0.000000000005538 Informative Direct
Cellular Component (CC) cell leading edge 0.000000117 Informative Direct
Cellular Component (CC) contractile fiber part 0.000000549 Informative Direct
Cellular Component (CC) acrosomal vesicle 0 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000000000001169 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0.00002898 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomach0Highly InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.0004896Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Subunits of heterodimeric actin filament capping protein Capz domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Subunits of heterodimeric actin filament capping protein Capz superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]