SUPERFAMILY 1.75 HMM library and genome assignments server

Subunits of heterodimeric actin filament capping protein Capz superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Subunits of heterodimeric actin filament capping protein Capz [ 90095]
Superfamily:   Subunits of heterodimeric actin filament capping protein Capz [ 90096] (2)
Families:   Capz alpha-1 subunit [ 90097]
  Capz beta-1 subunit [ 90100]


Superfamily statistics
Genomes (467) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,271 1,475 2
Proteins 1,245 1,462 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.000000013240.000003153Least InformativeDirect
Biological Process (BP)regulation of cellular process0.000000000011030.0000002832Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)developmental process0.00045690.06019Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000041940.01483Least InformativeInherited
Biological Process (BP)regulation of signal transduction0.0000025860.00009876Moderately InformativeDirect
Biological Process (BP)cell differentiation0.0000010310.0008004Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0000012820.000001003Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization00Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.00000000010060.000000000004191Moderately InformativeDirect
Biological Process (BP)nervous system development0.0088080.01278Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.96140.7691Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.029010.1574Moderately InformativeInherited
Biological Process (BP)organelle organization0.031990.04601Moderately InformativeInherited
Biological Process (BP)cytoskeleton organization0.000000000052920.000000001397InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.00000000031610.000000007175InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis00InformativeDirect
Biological Process (BP)generation of neurons0.0000015330.0002404InformativeDirect
Biological Process (BP)negative regulation of cellular component organization00InformativeDirect
Biological Process (BP)muscle structure development0.00000084120.000001131InformativeDirect
Biological Process (BP)regulation of anatomical structure size00InformativeDirect
Biological Process (BP)cell projection organization0.00033560.003832InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0045950.002739InformativeInherited
Biological Process (BP)cell projection assembly0.00000015970.00000001123Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.0000000000000032610Highly InformativeDirect
Biological Process (BP)neuron projection development0.0000000033040.000001677Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization00Highly InformativeDirect
Biological Process (BP)regulation of protein complex disassembly00Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.0000000000010240Highly InformativeDirect
Biological Process (BP)muscle fiber development0.00000000000010450.000000000001299Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization00Highly InformativeDirect
Molecular Function (MF)binding0.00000049290.0001639Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)actin filament binding0.000013830.0000008421Highly InformativeDirect
Molecular Function (MF)tubulin binding0.29950.4041Highly InformativeInherited
Cellular Component (CC)membrane0.000063450.0003903Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle00.0000000000001722Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000012090.0002714Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.001820.000008975Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoskeleton0.0000000000074650.000000000001473Moderately InformativeDirect
Cellular Component (CC)vesicle0.00022420.000005485Moderately InformativeDirect
Cellular Component (CC)cell projection0.012050.02434Moderately InformativeInherited
Cellular Component (CC)cell cortex00InformativeDirect
Cellular Component (CC)actin cytoskeleton0.00000000000056770InformativeDirect
Cellular Component (CC)cell junction00.00000000000001474InformativeDirect
Cellular Component (CC)secretory granule0.0003780.000005127InformativeDirect
Cellular Component (CC)cell leading edge0.00000018870.0000001199InformativeDirect
Cellular Component (CC)contractile fiber part0.00000035680.0000004893InformativeDirect
Cellular Component (CC)sarcomere0.00000000000035390.00000000000117Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton00Highly InformativeDirect
Cellular Component (CC)cell-cell contact zone0.00026880.00002906Highly InformativeDirect
Cellular Component (CC)sperm part0.00000000000085010Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.000003153 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000002832 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.06019 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.01483 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.00009876 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0008004 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.000001003 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000000004191 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.9225 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01278 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7691 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1574 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.04601 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.000000001397 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.000000007175 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) generation of neurons 0.0002404 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) muscle structure development 0.000001131 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0 Informative Direct
Biological Process (BP) cell projection organization 0.003832 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.002739 Informative Inherited
Biological Process (BP) cell projection assembly 0.00000001123 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000001677 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.000000000001299 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Molecular Function (MF) binding 0.0001639 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) actin filament binding 0.0000008421 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.4041 Highly Informative Inherited
Cellular Component (CC) membrane 0.0003903 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0000000000001722 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000008975 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0002714 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000000001473 Moderately Informative Direct
Cellular Component (CC) vesicle 0.000005485 Moderately Informative Direct
Cellular Component (CC) cell projection 0.02434 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0 Informative Direct
Cellular Component (CC) cell junction 0.00000000000001474 Informative Direct
Cellular Component (CC) secretory granule 0.000005127 Informative Direct
Cellular Component (CC) cell leading edge 0.0000001199 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000004893 Informative Direct
Cellular Component (CC) sarcomere 0.00000000000117 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0.00002906 Highly Informative Direct
Cellular Component (CC) sperm part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomach0Highly InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.0004896Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Subunits of heterodimeric actin filament capping protein Capz domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Subunits of heterodimeric actin filament capping protein Capz superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]