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Subunits of heterodimeric actin filament capping protein Capz superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Subunits of heterodimeric actin filament capping protein Capz [ 90095]
Superfamily:   Subunits of heterodimeric actin filament capping protein Capz [ 90096] (2)
Families:   Capz alpha-1 subunit [ 90097]
  Capz beta-1 subunit [ 90100]


Superfamily statistics
Genomes (466) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,269 1,475 2
Proteins 1,243 1,462 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.000000013270.00000306Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0000000000092030.0000002558Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis00Least InformativeDirect
Biological Process (BP)developmental process0.00044630.06003Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000041050.01472Least InformativeInherited
Biological Process (BP)cell differentiation0.0000010330.0007908Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.0000011520.0000008557Moderately InformativeDirect
Biological Process (BP)regulation of cellular component organization00Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.000000000093180.000000000003785Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.1190.607Moderately InformativeInherited
Biological Process (BP)nervous system development0.0084540.01259Moderately InformativeInherited
Biological Process (BP)cellular component biogenesis0.96070.7638Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.06970.2857Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.00012480.001877Moderately InformativeInherited
Biological Process (BP)organelle organization0.031720.04595Moderately InformativeInherited
Biological Process (BP)cytoskeleton organization0.000000000054430.000000001397InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.00000011110.0000009873InformativeDirect
Biological Process (BP)regulation of anatomical structure morphogenesis0.00000022260.00003225InformativeDirect
Biological Process (BP)regulation of organelle organization00InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis00InformativeDirect
Biological Process (BP)generation of neurons0.0000015240.0002373InformativeDirect
Biological Process (BP)negative regulation of cellular component organization00InformativeDirect
Biological Process (BP)muscle structure development0.00000077820.0000011InformativeDirect
Biological Process (BP)cell projection organization0.0003140.003825InformativeInherited
Biological Process (BP)cell projection assembly0.00000013250.00000001014Highly InformativeDirect
Biological Process (BP)regulation of microtubule polymerization or depolymerization0.0000000000000032580Highly InformativeDirect
Biological Process (BP)neuron projection development0.000000003320.000001702Highly InformativeDirect
Biological Process (BP)regulation of actin cytoskeleton organization00Highly InformativeDirect
Biological Process (BP)regulation of protein complex disassembly00Highly InformativeDirect
Biological Process (BP)regulation of protein complex assembly0.0000000000014570Highly InformativeDirect
Biological Process (BP)muscle fiber development0.00000000000010380.000000000001231Highly InformativeDirect
Biological Process (BP)negative regulation of cytoskeleton organization00Highly InformativeDirect
Molecular Function (MF)binding0.000002050.0004442Least InformativeDirect
Molecular Function (MF)cytoskeletal protein binding00InformativeDirect
Molecular Function (MF)actin filament binding0.000013830.0000007044Highly InformativeDirect
Molecular Function (MF)tubulin binding0.29970.4052Highly InformativeInherited
Cellular Component (CC)membrane0.000038140.0002577Least InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle00.0000000000005371Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00062180.000002566Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.000022930.0004568Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoskeleton0.00000000001740.000000000003331Moderately InformativeDirect
Cellular Component (CC)vesicle0.00015670.00000369Moderately InformativeDirect
Cellular Component (CC)cell projection0.0098130.02046Moderately InformativeInherited
Cellular Component (CC)cell cortex00InformativeDirect
Cellular Component (CC)actin cytoskeleton0.0000000000013570.000000000000003092InformativeDirect
Cellular Component (CC)cell junction0.0000000000000014540.000000000003609InformativeDirect
Cellular Component (CC)secretory granule0.00038460.000004885InformativeDirect
Cellular Component (CC)cell leading edge0.00000016470.0000001006InformativeDirect
Cellular Component (CC)contractile fiber part0.00000030.0000004074InformativeDirect
Cellular Component (CC)sarcomere0.00000000000036160.000000000001188Highly InformativeDirect
Cellular Component (CC)cortical cytoskeleton00Highly InformativeDirect
Cellular Component (CC)cell-cell contact zone0.00026890.00002833Highly InformativeDirect
Cellular Component (CC)sperm part0.0000000000006280Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.00000306 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0000002558 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) developmental process 0.06003 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.01472 Least Informative Inherited
Biological Process (BP) cell differentiation 0.0007908 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000008557 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000000003785 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.9182 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.607 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01259 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7638 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.2857 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.001877 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.04595 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.000000001397 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.0000009873 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.00003225 Informative Direct
Biological Process (BP) regulation of organelle organization 0 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0 Informative Direct
Biological Process (BP) generation of neurons 0.0002373 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0 Informative Direct
Biological Process (BP) muscle structure development 0.0000011 Informative Direct
Biological Process (BP) cell projection organization 0.003825 Informative Inherited
Biological Process (BP) cell projection assembly 0.00000001014 Highly Informative Direct
Biological Process (BP) regulation of microtubule polymerization or depolymerization 0 Highly Informative Direct
Biological Process (BP) neuron projection development 0.000001702 Highly Informative Direct
Biological Process (BP) regulation of actin cytoskeleton organization 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex disassembly 0 Highly Informative Direct
Biological Process (BP) regulation of protein complex assembly 0 Highly Informative Direct
Biological Process (BP) muscle fiber development 0.000000000001231 Highly Informative Direct
Biological Process (BP) negative regulation of cytoskeleton organization 0 Highly Informative Direct
Molecular Function (MF) binding 0.0004442 Least Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0 Informative Direct
Molecular Function (MF) actin filament binding 0.0000007044 Highly Informative Direct
Molecular Function (MF) tubulin binding 0.4052 Highly Informative Inherited
Cellular Component (CC) membrane 0.0002577 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0000000000005371 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000002566 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0004568 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000000003331 Moderately Informative Direct
Cellular Component (CC) vesicle 0.00000369 Moderately Informative Direct
Cellular Component (CC) cell projection 0.02046 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.000000000000003092 Informative Direct
Cellular Component (CC) cell junction 0.000000000003609 Informative Direct
Cellular Component (CC) secretory granule 0.000004885 Informative Direct
Cellular Component (CC) cell leading edge 0.0000001006 Informative Direct
Cellular Component (CC) contractile fiber part 0.0000004074 Informative Direct
Cellular Component (CC) sarcomere 0.000000000001188 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0 Highly Informative Direct
Cellular Component (CC) cell-cell contact zone 0.00002833 Highly Informative Direct
Cellular Component (CC) sperm part 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)intestine0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)liver and biliary system0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0InformativeDirect
Xenopus ANatomical entity (XAN)tail0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect
Xenopus ANatomical entity (XAN)stomach0Highly InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0Highly InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0.0004894Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationActin capping0Highly InformativeDirect
Post-translational modificationAcetylation0Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Subunits of heterodimeric actin filament capping protein Capz domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Subunits of heterodimeric actin filament capping protein Capz superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]