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Doublecortin (DC) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Doublecortin (DC) [ 89837]
Families:   Doublecortin (DC) [ 89838] (2)

Superfamily statistics
Genomes (170) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 1,766 1,584 4
Proteins 1,067 962 4

 Functional annotation
General category Regulation
Detailed category Signal transduction

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 1.568e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.194e-07 Least Informative Direct
Biological Process (BP) multicellular organismal process 4.269e-07 Least Informative Direct
Biological Process (BP) localization 0.0001131 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.005841 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.01025 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.1257 Least Informative Inherited
Biological Process (BP) cell differentiation 1.792e-13 Moderately Informative Direct
Biological Process (BP) nervous system development 9.121e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 4.989e-05 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0001804 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002579 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0004861 Moderately Informative Direct
Biological Process (BP) organ development 0.08776 Moderately Informative Inherited
Biological Process (BP) system process 0.1325 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9813 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.2871 Moderately Informative Inherited
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cell projection organization 5.086e-14 Informative Direct
Biological Process (BP) localization of cell 5.683e-13 Informative Direct
Biological Process (BP) locomotion 5.773e-12 Informative Direct
Biological Process (BP) cellular component movement 1.168e-10 Informative Direct
Biological Process (BP) growth 1.322e-08 Informative Direct
Biological Process (BP) protein phosphorylation 1.408e-08 Informative Direct
Biological Process (BP) central nervous system development 3.474e-05 Informative Direct
Biological Process (BP) microtubule-based process 4.066e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.083e-05 Informative Direct
Biological Process (BP) sensory organ development 0.005084 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1089 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.006458 Informative Inherited
Biological Process (BP) cell growth 9.287e-13 Highly Informative Direct
Biological Process (BP) eye morphogenesis 6.018e-10 Highly Informative Direct
Biological Process (BP) sensory perception 9.3e-10 Highly Informative Direct
Biological Process (BP) developmental growth 6.984e-09 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 6.777e-08 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0004995 Highly Informative Direct
Biological Process (BP) photoreceptor cell differentiation 0.001272 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.002855 Highly Informative Inherited
Biological Process (BP) axonogenesis 0.05997 Highly Informative Inherited
Molecular Function (MF) transferase activity 9.172e-05 Least Informative Direct
Molecular Function (MF) binding 0.5549 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1.79e-07 Moderately Informative Direct
Molecular Function (MF) protein binding 0.04103 Moderately Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 3.508e-12 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 7.596e-09 Informative Direct
Molecular Function (MF) kinase activity 2.565e-08 Informative Direct
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 9.173e-10 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.01353 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.004354 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.0147 Least Informative Inherited
Cellular Component (CC) cell projection 5.782e-10 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1.067e-06 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 2.176e-09 Informative Direct
Cellular Component (CC) cell projection part 0.0003566 Informative Direct
Cellular Component (CC) nonmotile primary cilium 0 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 8.925e-10 Highly Informative Direct
Cellular Component (CC) cilium part 1.113e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02438Least InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.5544Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.004943InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus layer morphology1.652e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation3.687e-07Moderately InformativeDirect
Biological processNeurogenesis1.603e-15InformativeDirect
Biological processSensory transduction1.803e-13InformativeDirect
Biological processVision0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Cellular componentCytoplasm0.01606Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMicrotubule6.083e-12InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.00176Least InformativeInherited
Post-translational modificationKinase6.858e-12Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.244e-06Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein2.423e-09Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Doublecortin (DC) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Doublecortin (DC) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

Please send feedback, comments or questions to superfamily@cs.bris.ac.uk or use the feedback form.

© Copyright 2013 The SUPERFAMILY authors and Julian Gough.