SUPERFAMILY 1.75 HMM library and genome assignments server

Doublecortin (DC) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Doublecortin (DC) [ 89837]
Families:   Doublecortin (DC) [ 89838] (2)


Superfamily statistics
Genomes (196) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,983 1,983 4
Proteins 1,199 1,214 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.00000001377 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000001488 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000004135 Least Informative Direct
Biological Process (BP) localization 0.00001691 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.05388 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.002852 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8464 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1667 Least Informative Inherited
Biological Process (BP) cell differentiation 0.000000000000003707 Moderately Informative Direct
Biological Process (BP) nervous system development 0.0000000273 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00002923 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000125 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001297 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.002254 Moderately Informative Inherited
Biological Process (BP) organ development 0.1067 Moderately Informative Inherited
Biological Process (BP) tissue development 0.8779 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.1661 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002662 Moderately Informative Inherited
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cell projection organization 0 Informative Direct
Biological Process (BP) localization of cell 0.00000000000001246 Informative Direct
Biological Process (BP) locomotion 0.00000000000004707 Informative Direct
Biological Process (BP) cellular component movement 0.000000000006373 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0000000001825 Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000000006283 Informative Direct
Biological Process (BP) growth 0.000000001376 Informative Direct
Biological Process (BP) phosphorylation 0.000000022 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00000008943 Informative Direct
Biological Process (BP) organelle assembly 0.00001122 Informative Direct
Biological Process (BP) response to light stimulus 0.00001574 Informative Direct
Biological Process (BP) microtubule-based process 0.00002068 Informative Direct
Biological Process (BP) central nervous system development 0.00002522 Informative Direct
Biological Process (BP) organ morphogenesis 0.1391 Informative Inherited
Biological Process (BP) sensory organ development 0.007624 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3677 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.003773 Informative Inherited
Biological Process (BP) cell projection morphogenesis 0 Highly Informative Direct
Biological Process (BP) cell growth 0.00000000000001071 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000000002805 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.0000000004052 Highly Informative Direct
Biological Process (BP) developmental growth 0.000000002484 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.0000001887 Highly Informative Direct
Biological Process (BP) cilium organization 0.0001289 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0006338 Highly Informative Direct
Biological Process (BP) neuron projection development 0.4687 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.003401 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.001685 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0003051 Least Informative Direct
Molecular Function (MF) binding 0.4992 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000211 Moderately Informative Direct
Molecular Function (MF) protein complex binding 0.000000000005314 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.000000000009893 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000009905 Informative Direct
Molecular Function (MF) kinase activity 0.00000003311 Informative Direct
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000000003915 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.000000101 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0001079 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01513 Least Informative Inherited
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000000000000006018 Moderately Informative Direct
Cellular Component (CC) synapse 0.00000004578 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.432 Informative Inherited
Cellular Component (CC) microtubule associated complex 0.0000003396 Highly Informative Direct
Cellular Component (CC) ciliary part 0.00007106 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal genital system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of male external genitalia0InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic male external genitalia0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of eye movement0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02253Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0009244Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.5755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon morphology0.01167InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.0009634Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000004787Moderately InformativeDirect
Biological processNeurogenesis0.000000000000002773InformativeDirect
Biological processSensory transduction0.0000000000001987InformativeDirect
Biological processVision0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Cellular componentCytoplasm0.01734Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMicrotubule0.000000000006092InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.001994Least InformativeInherited
Post-translational modificationKinase0.00000000000747Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000001372Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0.00000000139Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Doublecortin (DC) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Doublecortin (DC) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]