SUPERFAMILY 1.75 HMM library and genome assignments server


Doublecortin (DC) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Doublecortin (DC) [ 89837]
Families:   Doublecortin (DC) [ 89838] (2)


Superfamily statistics
Genomes (189) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,855 1,983 4
Proteins 1,128 1,214 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 6.62e-09 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.915e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.147e-07 Least Informative Direct
Biological Process (BP) localization 7.241e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002842 Least Informative Inherited
Biological Process (BP) response to stimulus 0.7741 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.001945 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.04282 Least Informative Inherited
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) nervous system development 1.92e-08 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 1.883e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 2.158e-05 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 5.367e-05 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.0001267 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.005178 Moderately Informative Inherited
Biological Process (BP) organ development 0.1201 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.001911 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3873 Moderately Informative Inherited
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cell projection organization 1.922e-15 Informative Direct
Biological Process (BP) localization of cell 1.761e-14 Informative Direct
Biological Process (BP) locomotion 2.935e-14 Informative Direct
Biological Process (BP) growth 1.555e-10 Informative Direct
Biological Process (BP) cellular component movement 2.738e-10 Informative Direct
Biological Process (BP) phosphorylation 4.003e-09 Informative Direct
Biological Process (BP) cellular component morphogenesis 4.214e-06 Informative Direct
Biological Process (BP) response to light stimulus 1.219e-05 Informative Direct
Biological Process (BP) central nervous system development 1.819e-05 Informative Direct
Biological Process (BP) microtubule-based process 7.971e-05 Informative Direct
Biological Process (BP) sensory organ development 0.00764 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1446 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.004866 Informative Inherited
Biological Process (BP) cell growth 1.46e-13 Highly Informative Direct
Biological Process (BP) tissue homeostasis 8.847e-13 Highly Informative Direct
Biological Process (BP) protein phosphorylation 2.205e-10 Highly Informative Direct
Biological Process (BP) eye morphogenesis 3.351e-10 Highly Informative Direct
Biological Process (BP) developmental growth 2.65e-09 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 2.085e-07 Highly Informative Direct
Biological Process (BP) microtubule cytoskeleton organization 0.0006025 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.06146 Highly Informative Inherited
Biological Process (BP) photoreceptor cell differentiation 0.002446 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.003039 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0914 Highly Informative Inherited
Biological Process (BP) axon development 0.06344 Highly Informative Inherited
Molecular Function (MF) binding 0.3983 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1.439e-07 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 1.012e-11 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 7.035e-09 Informative Direct
Molecular Function (MF) kinase activity 2.366e-08 Informative Direct
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 2.808e-10 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.1481 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.002432 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01268 Least Informative Inherited
Cellular Component (CC) cell projection 1.06e-14 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 5.852e-07 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 1.231e-09 Informative Direct
Cellular Component (CC) nonmotile primary cilium 0 Highly Informative Direct
Cellular Component (CC) microtubule associated complex 6.368e-10 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal genital system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of male external genitalia0InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic male external genitalia0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of eye movement0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0221Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0008704Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.5708Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.004873InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.000972Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation4.632e-07Moderately InformativeDirect
Biological processNeurogenesis2.773e-15InformativeDirect
Biological processSensory transduction1.931e-13InformativeDirect
Biological processVision0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Cellular componentCytoplasm0.01752Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMicrotubule6.198e-12InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.001991Least InformativeInherited
Post-translational modificationKinase7.44e-12Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.396e-06Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein1.343e-09Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Doublecortin (DC) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Doublecortin (DC) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]