SUPERFAMILY 1.75 HMM library and genome assignments server

Please note: Superfamily is currently under maintenance and some functionality may be limited. Please bear with us as we fix these problems.


Doublecortin (DC) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-Grasp (ubiquitin-like) [ 54235] (14)
Superfamily:   Doublecortin (DC) [ 89837]
Families:   Doublecortin (DC) [ 89838] (2)


Superfamily statistics
Genomes (195) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,982 1,983 4
Proteins 1,198 1,214 4


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) developmental process 0.00000001391 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000004036 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000002413 Least Informative Direct
Biological Process (BP) localization 0.00001127 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.002753 Least Informative Inherited
Biological Process (BP) response to stimulus 0.8419 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.002499 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.05271 Least Informative Inherited
Biological Process (BP) cell differentiation 0.000000000000003741 Moderately Informative Direct
Biological Process (BP) nervous system development 0.00000001957 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.00001926 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00002808 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.00007661 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.000128 Moderately Informative Direct
Biological Process (BP) organ development 0.1209 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002311 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.002529 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3898 Moderately Informative Inherited
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) cell projection organization 0.000000000000001931 Informative Direct
Biological Process (BP) localization of cell 0.00000000000001772 Informative Direct
Biological Process (BP) locomotion 0.00000000000005088 Informative Direct
Biological Process (BP) cellular component movement 0.0000000002541 Informative Direct
Biological Process (BP) growth 0.000000001395 Informative Direct
Biological Process (BP) phosphorylation 0.000000005145 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000004182 Informative Direct
Biological Process (BP) response to light stimulus 0.00001525 Informative Direct
Biological Process (BP) central nervous system development 0.00002014 Informative Direct
Biological Process (BP) microtubule-based process 0.00008212 Informative Direct
Biological Process (BP) sensory organ development 0.007379 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1412 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.004998 Informative Inherited
Biological Process (BP) cell part morphogenesis 0.000000000000001931 Highly Informative Direct
Biological Process (BP) cell growth 0.0000000000001408 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0.0000000002791 Highly Informative Direct
Biological Process (BP) eye morphogenesis 0.000000000394 Highly Informative Direct
Biological Process (BP) developmental growth 0.000000002363 Highly Informative Direct
Biological Process (BP) retina development in camera-type eye 0.000000188 Highly Informative Direct
Biological Process (BP) neuron projection development 0.4867 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.002211 Highly Informative Inherited
Biological Process (BP) cell projection assembly 0.003417 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.000108 Least Informative Direct
Molecular Function (MF) binding 0.4793 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.0000002108 Moderately Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.00000000001048 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000009888 Informative Direct
Molecular Function (MF) kinase activity 0.00000003395 Informative Direct
Molecular Function (MF) tubulin binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0000000004028 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.1677 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.00306 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.01596 Least Informative Inherited
Cellular Component (CC) cell projection 0.00000000000002463 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0000008242 Moderately Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.000000001661 Informative Direct
Cellular Component (CC) microtubule associated complex 0.0000000005784 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of higher mental function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal genital system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of male external genitalia0InformativeDirect
Phenotypic Abnormality (PA)Hypoplastic male external genitalia0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pyramidal motor function0InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of eye movement0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02188Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0008658Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.5734Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cerebrum morphology0.004895InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus morphology0.0009733Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDifferentiation0.0000004607Moderately InformativeDirect
Biological processNeurogenesis0.000000000000002776InformativeDirect
Biological processSensory transduction0.0000000000001906InformativeDirect
Biological processVision0Highly InformativeDirect
Biological processCilium biogenesis/degradation0Highly InformativeDirect
Cellular componentCytoplasm0.01733Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentMicrotubule0.000000000006123InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.001995Least InformativeInherited
Post-translational modificationKinase0.000000000007412Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000001383Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0.000000001349Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Doublecortin (DC) domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Doublecortin (DC) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]