SUPERFAMILY 1.75 HMM library and genome assignments server


Multidrug efflux transporter AcrB transmembrane domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:   Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Families:   Multidrug efflux transporter AcrB transmembrane domain [ 82867]


Superfamily statistics
Genomes (2,955) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,075 196,921 4
Proteins 21,529 111,633 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 1.336e-12 Least Informative Direct
Biological Process (BP) multicellular organismal process 2.562e-05 Least Informative Direct
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9757 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09365 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9206 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.2238 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4557 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0.0001207 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0001772 Moderately Informative Direct
Biological Process (BP) gene expression 0.7636 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.6721 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2304 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04417 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2337 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.6817 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.2639 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.08202 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.01119 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.3655 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.003061 Moderately Informative Inherited
Biological Process (BP) single-organism biosynthetic process 0.08446 Moderately Informative Inherited
Biological Process (BP) lipid biosynthetic process 0.004998 Moderately Informative Inherited
Biological Process (BP) transmembrane transport 4.416e-08 Informative Direct
Biological Process (BP) lipid localization 1.958e-07 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001711 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003934 Informative Direct
Biological Process (BP) negative regulation of signaling 0.006066 Informative Inherited
Biological Process (BP) secretion by cell 0.001616 Informative Inherited
Biological Process (BP) protein transport 0.929 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.001102 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.005018 Informative Inherited
Biological Process (BP) response to drug 5.5e-13 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 1.886e-06 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 6.07e-06 Highly Informative Direct
Biological Process (BP) alcohol biosynthetic process 0.001207 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.03156 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 5.931e-10 Moderately Informative Direct
Molecular Function (MF) lipid binding 0.004029 Informative Inherited
Molecular Function (MF) steroid binding 2.144e-08 Highly Informative Direct
Molecular Function (MF) alcohol binding 4.355e-08 Highly Informative Direct
Cellular Component (CC) membrane 3.829e-08 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7402 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4595 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 9.286e-11 Moderately Informative Direct
Cellular Component (CC) plasma membrane 1.65e-08 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 4.239e-08 Moderately Informative Direct
Cellular Component (CC) organelle envelope 2.282e-06 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.002337 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2157 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 4.621e-13 Informative Direct
Cellular Component (CC) integral to membrane 5.109e-13 Informative Direct
Cellular Component (CC) external encapsulating structure 2.838e-07 Informative Direct
Cellular Component (CC) lytic vacuole 1.439e-05 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0.0001804 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 2.941e-10 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethylglutaryl-CoA reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.002025Moderately InformativeInherited
Disease Ontology (DO)coronary artery disease3.212e-05InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.4261Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6131Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03172Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.116Moderately InformativeInherited
Mammalian Phenotype (MP)decreased cholesterol level0.0005222Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.2004Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3628Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant2.722e-05Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.07812Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3135Moderately InformativeInherited
Worm Phenotype (WP)body length variant0InformativeDirect
Worm Phenotype (WP)body width variant0InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.004353InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0Highly InformativeDirect
Worm Phenotype (WP)body vacuole0Highly InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)male tail development variant1.482e-11Highly InformativeDirect
Worm Phenotype (WP)small2.109e-11Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant6.926e-08Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0003851Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.001349Highly InformativeInherited
Worm Phenotype (WP)alae morphology variant0.0995Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)head0.4903Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical space0Moderately InformativeDirect
Zebrafish Anatomy (ZA)suspensorium9.203e-05Moderately InformativeDirect
Zebrafish Anatomy (ZA)skeletal element0.008614Moderately InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.02145Moderately InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.0528Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1207Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.2551Moderately InformativeInherited
Zebrafish Anatomy (ZA)hyosymplectic cartilage2.674e-06InformativeDirect
Zebrafish Anatomy (ZA)heart primordium3.346e-06InformativeDirect
Zebrafish Anatomy (ZA)acellular anatomical structure6.41e-06InformativeDirect
Zebrafish Anatomy (ZA)ventral hyoid arch9.855e-05InformativeDirect
Zebrafish Anatomy (ZA)inner ear0.0003175InformativeDirect

Document: ZA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processLipid metabolism0.0007117Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processAntibiotic resistance9.429e-06InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processTranslocation0Highly InformativeDirect
Biological processSteroid biosynthesis4.964e-11Highly InformativeDirect
Biological processSterol biosynthesis1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationGlycoprotein4.742e-09Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor biosynthesis0Moderately InformativeDirect
UniPathway (UP)heterocycle metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Multidrug efflux transporter AcrB transmembrane domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]