Multidrug efflux transporter AcrB transmembrane domain superfamily

SCOP classification

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:	Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:	Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Families:	Multidrug efflux transporter AcrB transmembrane domain [ 82867]

Superfamily statistics

	Genomes (2,276)	Uniprot 2013_05	PDB chains (SCOP 1.75)
Domains	29,893	92,758	4
Proteins	16,955	53,330	2

Functional annotation

General category	Processes_IC
Detailed category	Transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)

	GO term	FDR (all)	SDFO level	Annotation (direct or inherited)
Biological Process (BP)	localization	5.897e-13	Least Informative	Direct
Biological Process (BP)	multicellular organismal process	0.0003444	Least Informative	Direct
Biological Process (BP)	response to stimulus	0.06605	Least Informative	Inherited
Biological Process (BP)	protein metabolic process	1	Least Informative	Inherited
Biological Process (BP)	developmental process	1	Least Informative	Inherited
Biological Process (BP)	regulation of cellular process	1	Least Informative	Inherited
Biological Process (BP)	single-organism cellular process	0.8505	Least Informative	Inherited
Biological Process (BP)	single-organism metabolic process	0.2437	Least Informative	Inherited
Biological Process (BP)	organic cyclic compound metabolic process	0.5544	Least Informative	Inherited
Biological Process (BP)	biosynthetic process	1	Least Informative	Inherited
Biological Process (BP)	homeostatic process	2.278e-05	Moderately Informative	Direct
Biological Process (BP)	monocarboxylic acid metabolic process	0.0004	Moderately Informative	Direct
Biological Process (BP)	organic hydroxy compound metabolic process	0.001647	Moderately Informative	Inherited
Biological Process (BP)	gene expression	0.8493	Moderately Informative	Inherited
Biological Process (BP)	regulation of response to stimulus	0.1645	Moderately Informative	Inherited
Biological Process (BP)	negative regulation of cellular process	0.9795	Moderately Informative	Inherited
Biological Process (BP)	regulation of cell communication	0.07552	Moderately Informative	Inherited
Biological Process (BP)	regulation of signaling	0.2949	Moderately Informative	Inherited
Biological Process (BP)	anatomical structure morphogenesis	0.1079	Moderately Informative	Inherited
Biological Process (BP)	single-organism developmental process	1	Moderately Informative	Inherited
Biological Process (BP)	multi-organism process	0.8075	Moderately Informative	Inherited
Biological Process (BP)	regulation of localization	0.05854	Moderately Informative	Inherited
Biological Process (BP)	organic substance transport	0.8998	Moderately Informative	Inherited
Biological Process (BP)	macromolecule localization	0.4342	Moderately Informative	Inherited
Biological Process (BP)	signal transduction	0.3363	Moderately Informative	Inherited
Biological Process (BP)	cellular localization	0.01554	Moderately Informative	Inherited
Biological Process (BP)	small molecule biosynthetic process	0.3635	Moderately Informative	Inherited
Biological Process (BP)	organic cyclic compound biosynthetic process	0.3896	Moderately Informative	Inherited
Biological Process (BP)	lipid biosynthetic process	0.007646	Moderately Informative	Inherited
Biological Process (BP)	transmembrane transport	0	Informative	Direct
Biological Process (BP)	steroid metabolic process	0	Informative	Direct
Biological Process (BP)	lipid transport	9.342e-07	Informative	Direct
Biological Process (BP)	organic hydroxy compound biosynthetic process	3.313e-05	Informative	Direct
Biological Process (BP)	negative regulation of cell communication	0.0002912	Informative	Direct
Biological Process (BP)	alcohol metabolic process	0.0003193	Informative	Direct
Biological Process (BP)	negative regulation of response to stimulus	0.0007699	Informative	Direct
Biological Process (BP)	response to other organism	0.3077	Informative	Inherited
Biological Process (BP)	negative regulation of signaling	0.01021	Informative	Inherited
Biological Process (BP)	secretion	0.6147	Informative	Inherited
Biological Process (BP)	protein transport	0.9575	Informative	Inherited
Biological Process (BP)	response to drug	0	Highly Informative	Direct
Biological Process (BP)	lipid homeostasis	0	Highly Informative	Direct
Biological Process (BP)	alcohol biosynthetic process	1.079e-06	Highly Informative	Direct
Biological Process (BP)	organic hydroxy compound transport	4.631e-06	Highly Informative	Direct
Biological Process (BP)	steroid biosynthetic process	1.248e-05	Highly Informative	Direct
Biological Process (BP)	symbiosis, encompassing mutualism through parasitism	3.765e-05	Highly Informative	Direct
Biological Process (BP)	negative regulation of signal transduction	0.0409	Highly Informative	Inherited
Biological Process (BP)	sterol metabolic process	0.1057	Highly Informative	Inherited
Molecular Function (MF)	binding	1	Least Informative	Inherited
Molecular Function (MF)	transporter activity	1.669e-08	Moderately Informative	Direct
Molecular Function (MF)	organic cyclic compound binding	1	Moderately Informative	Inherited
Molecular Function (MF)	lipid binding	0.005563	Informative	Inherited
Molecular Function (MF)	steroid binding	1.962e-08	Highly Informative	Direct
Molecular Function (MF)	alcohol binding	4.214e-08	Highly Informative	Direct
Cellular Component (CC)	membrane	4.526e-07	Least Informative	Direct
Cellular Component (CC)	cytoplasmic part	1	Least Informative	Inherited
Cellular Component (CC)	intracellular organelle part	1	Least Informative	Inherited
Cellular Component (CC)	intracellular membrane-bounded organelle	1	Least Informative	Inherited
Cellular Component (CC)	endomembrane system	2.749e-09	Moderately Informative	Direct
Cellular Component (CC)	plasma membrane	7.663e-08	Moderately Informative	Direct
Cellular Component (CC)	endoplasmic reticulum	2.211e-07	Moderately Informative	Direct
Cellular Component (CC)	organelle envelope	1.548e-05	Moderately Informative	Direct
Cellular Component (CC)	intrinsic to membrane	0.01546	Moderately Informative	Inherited
Cellular Component (CC)	nuclear part	0.4065	Moderately Informative	Inherited
Cellular Component (CC)	nuclear envelope	1.872e-12	Informative	Direct
Cellular Component (CC)	integral to membrane	5.003e-12	Informative	Direct
Cellular Component (CC)	external encapsulating structure	1.339e-05	Informative	Direct
Cellular Component (CC)	intrinsic to plasma membrane	0.0004702	Informative	Direct
Cellular Component (CC)	vacuole	0.01103	Informative	Inherited
Cellular Component (CC)	perinuclear region of cytoplasm	4.741e-10	Highly Informative	Direct
Cellular Component (CC)	cell wall	1.761e-06	Highly Informative	Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEO level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0	Least Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Moderately Informative	Direct
Enzyme Commission (EC)	Hydroxymethylglutaryl-CoA reductase (NADPH)	0	Highly Informative	Direct

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)

	DO term	FDR (all)	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	heart disease	0.0003976	Moderately Informative	Direct

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)

	HP term	FDR (all)	SDHP level	Annotation (direct or inherited)
Phenotypic Abnormality (PA)	Abnormality of the integument	0	Least Informative	Direct
Phenotypic Abnormality (PA)	Abnormality of the central nervous system	0	Least Informative	Direct

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)

	MP term	FDR (all)	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal homeostasis	0.2184	Least Informative	Inherited
Mammalian Phenotype (MP)	abnormal lipid level	0.01537	Moderately Informative	Inherited
Mammalian Phenotype (MP)	abnormal cholesterol level	0.001983	Informative	Inherited
Mammalian Phenotype (MP)	decreased cholesterol level	0.0003627	Highly Informative	Direct

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)

	WP term	FDR (all)	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	larval development variant	0	Least Informative	Direct
Worm Phenotype (WP)	cell physiology variant	0.2004	Least Informative	Inherited
Worm Phenotype (WP)	organism environmental stimulus response variant	0.3628	Least Informative	Inherited
Worm Phenotype (WP)	organism segment morphology variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	locomotion variant	0	Moderately Informative	Direct
Worm Phenotype (WP)	reproductive system morphology variant	2.722e-05	Moderately Informative	Direct
Worm Phenotype (WP)	chemical response variant	0.07812	Moderately Informative	Inherited
Worm Phenotype (WP)	early embryonic lethal	0.3135	Moderately Informative	Inherited
Worm Phenotype (WP)	body length variant	0	Informative	Direct
Worm Phenotype (WP)	body width variant	0	Informative	Direct
Worm Phenotype (WP)	chemotaxis variant	0.004353	Informative	Inherited
Worm Phenotype (WP)	alimentary system morphology variant	0	Highly Informative	Direct
Worm Phenotype (WP)	body vacuole	0	Highly Informative	Direct
Worm Phenotype (WP)	molt variant	0	Highly Informative	Direct
Worm Phenotype (WP)	male tail development variant	1.482e-11	Highly Informative	Direct
Worm Phenotype (WP)	small	2.109e-11	Highly Informative	Direct
Worm Phenotype (WP)	cell secretion variant	6.926e-08	Highly Informative	Direct
Worm Phenotype (WP)	negative chemotaxis variant	0.0003851	Highly Informative	Direct
Worm Phenotype (WP)	osmotic integrity variant	0.001349	Highly Informative	Inherited
Worm Phenotype (WP)	alae morphology variant	0.0995	Highly Informative	Inherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)

	FA term	FDR (all)	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organ system	0	Least Informative	Direct
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	Least Informative	Inherited
Fly Anatomy (FA)	head	0	Moderately Informative	Direct

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)

	ZA term	FDR (all)	SDZA level	Annotation (direct or inherited)
Zebrafish Anatomy (ZA)	nervous system	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	portion of tissue	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	multi-tissue structure	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	cavitated compound organ	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	cell	0	Least Informative	Direct
Zebrafish Anatomy (ZA)	head	0.4542	Least Informative	Inherited
Zebrafish Anatomy (ZA)	digestive system	0	Moderately Informative	Direct
Zebrafish Anatomy (ZA)	trunk	0	Moderately Informative	Direct
Zebrafish Anatomy (ZA)	skeletal element	0.003911	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	pharyngeal arch	0.01002	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	cranium	0.01086	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	surface structure	0.03777	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	anatomical cluster	0.1009	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	eye	0.2117	Moderately Informative	Inherited
Zebrafish Anatomy (ZA)	dorsal hyoid arch	3.036e-05	Informative	Direct
Zebrafish Anatomy (ZA)	pharyngeal arch cartilage	0.0002686	Informative	Direct
Zebrafish Anatomy (ZA)	paired fin	0.0004906	Informative	Direct
Zebrafish Anatomy (ZA)	retinal neural layer	0.01003	Informative	Inherited
Zebrafish Anatomy (ZA)	cardiovascular system	0.09694	Informative	Inherited
Zebrafish Anatomy (ZA)	heart primordium	7.5e-07	Highly Informative	Direct
Zebrafish Anatomy (ZA)	hyosymplectic cartilage	2.697e-06	Highly Informative	Direct
Zebrafish Anatomy (ZA)	acellular anatomical structure	1.883e-05	Highly Informative	Direct
Zebrafish Anatomy (ZA)	ventral hyoid arch	0.000145	Highly Informative	Direct
Zebrafish Anatomy (ZA)	inner ear	0.0005222	Highly Informative	Direct
Zebrafish Anatomy (ZA)	retinal ganglion cell layer	0.0008997	Highly Informative	Direct

Document: ZA annotation of SCOP domains

Enzyme Commission (EC)

(show details)

	EC term	FDR (all)	SDEC level	Annotation (direct or inherited)
Enzyme Commission (EC)	Oxidoreductases	0	Least Informative	Direct
Enzyme Commission (EC)	Acting on the CH-OH group of donors	0	Moderately Informative	Direct
Enzyme Commission (EC)	With NAD(+) or NADP(+) as acceptor	0	Informative	Direct

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)

	KW term	FDR (all)	SDKW level	Annotation (direct or inherited)
Biological process	Transport	0	Least Informative	Direct
Biological process	Protein transport	0	Moderately Informative	Direct
Biological process	Lipid metabolism	0.0006306	Moderately Informative	Direct
Biological process	Steroid metabolism	0	Informative	Direct
Biological process	Antibiotic resistance	9.229e-06	Informative	Direct
Biological process	Lipid biosynthesis	1	Informative	Inherited
Biological process	Translocation	0	Highly Informative	Direct
Biological process	Steroid biosynthesis	4.663e-11	Highly Informative	Direct
Cellular component	Membrane	0	Least Informative	Direct
Cellular component	Cell membrane	0	Moderately Informative	Direct
Cellular component	Cell inner membrane	0	Informative	Direct
Domain	Transmembrane	0	Least Informative	Direct
Post-translational modification	Glycoprotein	2.51e-09	Least Informative	Direct
Post-translational modification	Isopeptide bond	0.0009059	Moderately Informative	Direct

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)

	UP term	FDR (all)	SDUP level	Annotation (direct or inherited)
UniPathway (UP)	cofactor metabolism	0.08976	Least Informative	Inherited
UniPathway (UP)	metabolic intermediate biosynthesis	3.233e-07	Moderately Informative	Direct
UniPathway (UP)	(R)-mevalonate biosynthesis	0	Highly Informative	Direct

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Multidrug efflux transporter AcrB transmembrane domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

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Multidrug efflux transporter AcrB transmembrane domain superfamily