SUPERFAMILY 1.75 HMM library and genome assignments server

Multidrug efflux transporter AcrB transmembrane domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Multidrug efflux transporter AcrB transmembrane domain [ 82865]
Superfamily:   Multidrug efflux transporter AcrB transmembrane domain [ 82866]
Families:   Multidrug efflux transporter AcrB transmembrane domain [ 82867]


Superfamily statistics
Genomes (2,957) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 38,137 196,921 4
Proteins 21,580 111,633 2


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000000000005584 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000008577 Least Informative Direct
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 0.9872 Least Informative Inherited
Biological Process (BP) response to stimulus 0.07717 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.4948 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.00000000002941 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.000000008206 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000051 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0004647 Moderately Informative Direct
Biological Process (BP) reproductive process 0.2663 Moderately Informative Inherited
Biological Process (BP) gene expression 0.8264 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.7676 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04758 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.2641 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5965 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1993 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.2404 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.08931 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.08879 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4023 Moderately Informative Inherited
Biological Process (BP) lipid localization 0.0000002512 Informative Direct
Biological Process (BP) protein maturation 0.00001169 Informative Direct
Biological Process (BP) organic hydroxy compound transport 0.00001252 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.0001022 Informative Direct
Biological Process (BP) secretion by cell 0.0007217 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0009183 Informative Direct
Biological Process (BP) negative regulation of signaling 0.003635 Informative Inherited
Biological Process (BP) protein transport 0.46 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.6095 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.001004 Informative Inherited
Biological Process (BP) organic hydroxy compound biosynthetic process 0.01305 Informative Inherited
Biological Process (BP) response to drug 0.0000000000008874 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.000005066 Highly Informative Direct
Biological Process (BP) sterol transport 0.00001918 Highly Informative Direct
Biological Process (BP) sterol metabolic process 0.02731 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0.0000000006682 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.06629 Moderately Informative Inherited
Molecular Function (MF) lipid binding 0.004445 Informative Inherited
Molecular Function (MF) steroid binding 0.00000002957 Highly Informative Direct
Molecular Function (MF) alcohol binding 0.00000004267 Highly Informative Direct
Cellular Component (CC) membrane 0.00000005555 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7675 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6346 Least Informative Inherited
Cellular Component (CC) plasma membrane part 0.0000000004039 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0.000000048 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000002371 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.001964 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.1444 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.0000000000004949 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0000003028 Informative Direct
Cellular Component (CC) lytic vacuole 0.00001601 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.00008528 Informative Direct
Cellular Component (CC) integral component of membrane 0.0004052 Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000000367 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.00002419 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Hydroxymethylglutaryl-CoA reductase (NADPH)0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)artery disease0.002015Moderately InformativeInherited
Disease Ontology (DO)coronary artery disease0.00003199InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.4306Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5887Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03157Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1186Moderately InformativeInherited
Mammalian Phenotype (MP)decreased cholesterol level0.0005158Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.2004Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.3628Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00002722Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.07812Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.3135Moderately InformativeInherited
Worm Phenotype (WP)body length variant0InformativeDirect
Worm Phenotype (WP)body width variant0InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.004353InformativeInherited
Worm Phenotype (WP)alimentary system morphology variant0Highly InformativeDirect
Worm Phenotype (WP)body vacuole0Highly InformativeDirect
Worm Phenotype (WP)molt variant0Highly InformativeDirect
Worm Phenotype (WP)male tail development variant0.00000000001482Highly InformativeDirect
Worm Phenotype (WP)small0.00000000002109Highly InformativeDirect
Worm Phenotype (WP)cell secretion variant0.00000006926Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.0003851Highly InformativeDirect
Worm Phenotype (WP)osmotic integrity variant0.001349Highly InformativeInherited
Worm Phenotype (WP)alae morphology variant0.0995Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)digestive system0Least InformativeDirect
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)trunk0Least InformativeDirect
Zebrafish Anatomy (ZA)portion of tissue0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)head0.4809Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical space0Moderately InformativeDirect
Zebrafish Anatomy (ZA)suspensorium0.00008556Moderately InformativeDirect
Zebrafish Anatomy (ZA)oral region0.0001469Moderately InformativeDirect
Zebrafish Anatomy (ZA)paired fin0.0002051Moderately InformativeDirect
Zebrafish Anatomy (ZA)skeletal element0.008337Moderately InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.02092Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.1202Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.2494Moderately InformativeInherited
Zebrafish Anatomy (ZA)hyosymplectic cartilage0.000002503InformativeDirect
Zebrafish Anatomy (ZA)heart primordium0.000003323InformativeDirect
Zebrafish Anatomy (ZA)acellular anatomical structure0.000006InformativeDirect
Zebrafish Anatomy (ZA)ventral hyoid arch0.000092InformativeDirect
Zebrafish Anatomy (ZA)inner ear0.0003163InformativeDirect

Document: ZA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processLipid metabolism0.0007094Moderately InformativeDirect
Biological processSteroid metabolism0InformativeDirect
Biological processAntibiotic resistance0.000009404InformativeDirect
Biological processLipid biosynthesis1InformativeInherited
Biological processCholesterol metabolism0Highly InformativeDirect
Biological processTranslocation0Highly InformativeDirect
Biological processSteroid biosynthesis0.0000000000492Highly InformativeDirect
Biological processSterol biosynthesis1Highly InformativeInherited
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationGlycoprotein0.000000005183Least InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)cofactor metabolism0.09095Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0.0000003151Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0.0001125Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0.0001135Moderately InformativeDirect
UniPathway (UP)(R)-mevalonate metabolism0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Multidrug efflux transporter AcrB transmembrane domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Multidrug efflux transporter AcrB transmembrane domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]