SUPERFAMILY 1.75 HMM library and genome assignments server

PurS-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   PurS-like [ 109622]
Superfamily:   PurS-like [ 82697] (2)
Families:   PurS subunit of FGAM synthetase [ 82698]
  FGAM synthase PurL, PurS-like domain [ 111002]


Superfamily statistics
Genomes (2,321) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,430 13,683 4
Proteins 2,409 13,652 4


Functional annotation
General category Metabolism
Detailed category Nucleotide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) heterocycle metabolic process 0.0000003053 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.0000003511 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000006313 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.000001412 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00126 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.005611 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3614 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0000001051 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.0000008971 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.000004157 Moderately Informative Direct
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.0001176 Moderately Informative Direct
Biological Process (BP) aromatic compound biosynthetic process 0.0001299 Moderately Informative Direct
Biological Process (BP) heterocycle biosynthetic process 0.0001398 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.0002668 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0003428 Moderately Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0000004733 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.001355 Informative Inherited
Molecular Function (MF) ligase activity 0.000000000000364 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N0InformativeDirect
Enzyme Commission (EC)Phosphoribosylformylglycinamidine synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Moderately InformativeDirect
Enzyme Commission (EC)Carbon--nitrogen ligases with glutamine as amido-N-donor0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPurine biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
DomainGlutamine amidotransferase0Highly InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Post-translational modificationLigase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)aromatic compound metabolism0Least InformativeDirect
UniPathway (UP)purine metabolism0Moderately InformativeDirect
UniPathway (UP)nucleotide metabolism0Moderately InformativeDirect
UniPathway (UP)IMP biosynthesis via de novo pathway0InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PurS-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the PurS-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]