SUPERFAMILY 1.75 HMM library and genome assignments server


Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   open-sided beta-meander [ 51086] (2)
Superfamily:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82185]
Families:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82186]


Superfamily statistics
Genomes (1,036) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,084 23,214 8
Proteins 5,890 13,854 8


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.1825 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.4238 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8236 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.9813 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9765 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9112 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.9132 Moderately Informative Inherited
Biological Process (BP) system process 0.003481 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3684 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.01214 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4511 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.04625 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.09467 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.06891 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9645 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1441 Moderately Informative Inherited
Biological Process (BP) ion transport 0.06435 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3541 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.7386 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.0000242 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0005005 Informative Direct
Biological Process (BP) metal ion transport 0.0002738 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.0004886 Informative Direct
Biological Process (BP) single-organism behavior 0.0000147 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000005069 Informative Direct
Biological Process (BP) metal ion homeostasis 0.0004293 Informative Direct
Biological Process (BP) regulation of ion transport 0.002063 Informative Inherited
Biological Process (BP) regulation of system process 0.002236 Informative Inherited
Biological Process (BP) phosphorylation 0.01631 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.001324 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.004219 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.003219 Informative Inherited
Biological Process (BP) protein methylation 0.00001209 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000001688 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00001898 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000005634 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000002289 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.000002473 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.000001304 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000004686 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00002208 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.00006496 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.0000006144 Highly Informative Direct
Biological Process (BP) learning or memory 0.06886 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.5365 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.01362 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0006237 Informative Direct
Molecular Function (MF) GTPase regulator activity 0.00009749 Informative Direct
Molecular Function (MF) enzyme binding 0.005855 Informative Inherited
Molecular Function (MF) kinase activity 0.03507 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.02153 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.000009698 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.000002519 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 0.00004284 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.00000045 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00676 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6272 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3839 Least Informative Inherited
Cellular Component (CC) membrane 0.0628 Least Informative Inherited
Cellular Component (CC) protein complex 0.1533 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00001324 Moderately Informative Direct
Cellular Component (CC) cell projection 0.00000008485 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.007471 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.002529 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00007493 Informative Direct
Cellular Component (CC) neuron projection 0.4352 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 0.000002899 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000000719 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.1114Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000001562Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0001651Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000000002584InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.01186InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.01828InformativeInherited
Mammalian Phenotype (MP)abnormal exploration in a new environment0.00006377Highly InformativeDirect

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.01119Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0000001915Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.1112Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000000002106InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentEndoplasmic reticulum0.00000000000561Moderately InformativeDirect
Cellular componentChromosome0.0000001576InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.1711Least InformativeInherited
Post-translational modificationKinase0.00006242Moderately InformativeDirect
Post-translational modificationActivator0.0003693Moderately InformativeDirect
Post-translational modificationChromatin regulator0.000001275InformativeDirect
Post-translational modificationPhosphoprotein0.0001526Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]