SUPERFAMILY 1.75 HMM library and genome assignments server


Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   open-sided beta-meander [ 51086] (2)
Superfamily:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82185]
Families:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82186]


Superfamily statistics
Genomes (1,045) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,291 23,214 8
Proteins 6,022 13,854 8


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.2509 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.559 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8903 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9604 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8197 Moderately Informative Inherited
Biological Process (BP) system process 0.005185 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4307 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.01584 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.5109 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.05727 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.04638 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.8127 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.08812 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8802 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.07608 Moderately Informative Inherited
Biological Process (BP) ion transport 0.06442 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4058 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.7391 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 3.34e-05 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 9.211e-05 Informative Direct
Biological Process (BP) metal ion transport 0.0003798 Informative Direct
Biological Process (BP) cellular cation homeostasis 0.0006552 Informative Direct
Biological Process (BP) single-organism behavior 2.412e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 7.457e-06 Informative Direct
Biological Process (BP) metal ion homeostasis 0.0005731 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0002864 Informative Direct
Biological Process (BP) regulation of ion transport 0.002154 Informative Inherited
Biological Process (BP) regulation of system process 0.002931 Informative Inherited
Biological Process (BP) phosphorylation 0.02075 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001133 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.0175 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.004068 Informative Inherited
Biological Process (BP) protein methylation 1.627e-05 Highly Informative Direct
Biological Process (BP) calcium ion transport 2.493e-06 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 2.561e-05 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 8.023e-06 Highly Informative Direct
Biological Process (BP) lipid modification 3.21e-07 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 5.004e-06 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 1.828e-06 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 6.732e-08 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 3.011e-05 Highly Informative Direct
Biological Process (BP) neuromuscular process 7.424e-05 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.037e-06 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 0.06889 Highly Informative Inherited
Biological Process (BP) learning or memory 0.07166 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.03419 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.5329 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.005029 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0006194 Informative Direct
Molecular Function (MF) GTPase regulator activity 1.27e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.008303 Informative Inherited
Molecular Function (MF) kinase activity 0.04451 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.02767 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 8.361e-07 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1.708e-07 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 5.626e-05 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 5.985e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.01546 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6745 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5184 Least Informative Inherited
Cellular Component (CC) membrane 0.1474 Least Informative Inherited
Cellular Component (CC) protein complex 0.202 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 2.261e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 1.876e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.007771 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.002662 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 7.721e-05 Informative Direct
Cellular Component (CC) neuron projection 0.437 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 5.289e-06 Highly Informative Direct
Cellular Component (CC) dendrite 1.197e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.1114Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1.562e-07Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0001651Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase2.584e-13InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.01204InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.01825InformativeInherited
Mammalian Phenotype (MP)abnormal exploration in a new environment6.295e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.01116Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1.911e-07Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.1111Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase2.092e-13InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentEndoplasmic reticulum5.503e-12Moderately InformativeDirect
Cellular componentChromosome1.56e-07InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.1711Least InformativeInherited
Post-translational modificationKinase6.229e-05Moderately InformativeDirect
Post-translational modificationActivator0.0003694Moderately InformativeDirect
Post-translational modificationChromatin regulator1.266e-06InformativeDirect
Post-translational modificationPhosphoprotein0.0001533Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]