SUPERFAMILY 1.75 HMM library and genome assignments server


Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   open-sided beta-meander [ 51086] (2)
Superfamily:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82185]
Families:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82186]


Superfamily statistics
Genomes (1,045) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,291 23,214 8
Proteins 6,022 13,854 8


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) localization 0.2637 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.5781 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9182 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.9687 Least Informative Inherited
Biological Process (BP) regulation of signal transduction 0.811 Moderately Informative Inherited
Biological Process (BP) system process 0.005519 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.444 Moderately Informative Inherited
Biological Process (BP) cellular lipid metabolic process 0.01772 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.5314 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.06257 Moderately Informative Inherited
Biological Process (BP) regulation of phosphate metabolic process 0.05026 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.8194 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.09388 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.8924 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.08231 Moderately Informative Inherited
Biological Process (BP) ion transport 0.06373 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4151 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.004043 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 3.605e-05 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0001141 Informative Direct
Biological Process (BP) metal ion transport 0.000401 Informative Direct
Biological Process (BP) single-organism behavior 2.789e-05 Informative Direct
Biological Process (BP) glycerolipid metabolic process 7.996e-06 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0003421 Informative Direct
Biological Process (BP) regulation of ion transport 0.002151 Informative Inherited
Biological Process (BP) cation homeostasis 0.001822 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001471 Informative Inherited
Biological Process (BP) regulation of system process 0.003223 Informative Inherited
Biological Process (BP) phosphorylation 0.02112 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.001327 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.01831 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.004378 Informative Inherited
Biological Process (BP) protein methylation 1.76e-05 Highly Informative Direct
Biological Process (BP) calcium ion transport 2.559e-06 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 2.727e-05 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 8.728e-06 Highly Informative Direct
Biological Process (BP) lipid modification 3.71e-07 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 4.835e-06 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 1.919e-06 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 7.348e-08 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 3.427e-05 Highly Informative Direct
Biological Process (BP) neuromuscular process 7.337e-05 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.27e-06 Highly Informative Direct
Biological Process (BP) positive regulation of Ras GTPase activity 0.07208 Highly Informative Inherited
Biological Process (BP) learning or memory 0.06619 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.03851 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.5235 Moderately Informative Inherited
Molecular Function (MF) enzyme regulator activity 0.005351 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.000628 Informative Direct
Molecular Function (MF) GTPase regulator activity 1.422e-05 Informative Direct
Molecular Function (MF) enzyme binding 0.009158 Informative Inherited
Molecular Function (MF) kinase activity 0.0467 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.02883 Informative Inherited
Molecular Function (MF) small GTPase regulator activity 9.948e-07 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1.878e-07 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 6.365e-05 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 7.98e-07 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.01736 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6836 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5322 Least Informative Inherited
Cellular Component (CC) membrane 0.1721 Least Informative Inherited
Cellular Component (CC) protein complex 0.2124 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 2.42e-05 Moderately Informative Direct
Cellular Component (CC) cell projection 2.469e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.008085 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.00272 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 7.637e-05 Informative Direct
Cellular Component (CC) neuron projection 0.4368 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 5.288e-06 Highly Informative Direct
Cellular Component (CC) dendrite 1.356e-07 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.1114Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1.562e-07Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0001651Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase2.584e-13InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.01217InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.01817InformativeInherited
Mammalian Phenotype (MP)abnormal exploration in a new environment6.231e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.01117Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1.901e-07Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.1111Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase2.084e-13InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentEndoplasmic reticulum5.503e-12Moderately InformativeDirect
Cellular componentChromosome1.56e-07InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.1711Least InformativeInherited
Post-translational modificationKinase6.229e-05Moderately InformativeDirect
Post-translational modificationActivator0.0003694Moderately InformativeDirect
Post-translational modificationChromatin regulator1.266e-06InformativeDirect
Post-translational modificationPhosphoprotein0.0001533Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]