SUPERFAMILY 1.75 HMM library and genome assignments server

Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   open-sided beta-meander [ 51086] (2)
Superfamily:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82185]
Families:   Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain [ 82186]


Superfamily statistics
Genomes (1,046) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 10,461 23,214 8
Proteins 6,125 13,854 8


Functional annotation
General category Information
Detailed category Chromatin structure

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.4882 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.9781 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.952 Least Informative Inherited
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.4231 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.983 Least Informative Inherited
Biological Process (BP) developmental process 0.9505 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3456 Least Informative Inherited
Biological Process (BP) cellular localization 0.05835 Moderately Informative Inherited
Biological Process (BP) ion transport 0.1456 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.003922 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6546 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.7794 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.1041 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8223 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.7572 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.08325 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.5933 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 0.04902 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.0724 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.4193 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.08932 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.07908 Moderately Informative Inherited
Biological Process (BP) phospholipid metabolic process 0.00003666 Informative Direct
Biological Process (BP) regulation of nucleoside metabolic process 0.0001099 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0005921 Informative Direct
Biological Process (BP) single-organism behavior 0.00000753 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0.000008104 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.0003436 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0009295 Informative Direct
Biological Process (BP) metal ion transport 0.00232 Informative Inherited
Biological Process (BP) cation homeostasis 0.001753 Informative Inherited
Biological Process (BP) neurological system process 0.1257 Informative Inherited
Biological Process (BP) phosphorylation 0.03786 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.1706 Informative Inherited
Biological Process (BP) regulation of ion transport 0.002295 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.00208 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.00461 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 0.001389 Informative Inherited
Biological Process (BP) protein methylation 0.00001912 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00002782 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.00002651 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.000008746 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.0000003492 Highly Informative Direct
Biological Process (BP) lipid modification 0.0000003753 Highly Informative Direct
Biological Process (BP) regulation of Ras GTPase activity 0.000003526 Highly Informative Direct
Biological Process (BP) regulation of ion transmembrane transport 0.000002071 Highly Informative Direct
Biological Process (BP) phosphatidylinositol metabolic process 0.00000007491 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00004067 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.000001217 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.000001381 Highly Informative Direct
Biological Process (BP) learning or memory 0.1638 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 0.07443 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.3611 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring one-carbon groups 0.0003873 Informative Direct
Molecular Function (MF) enzyme binding 0.009761 Informative Inherited
Molecular Function (MF) kinase activity 0.0462 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.02878 Informative Inherited
Molecular Function (MF) guanyl-nucleotide exchange factor activity 0.0000005909 Highly Informative Direct
Molecular Function (MF) methyltransferase activity 0.0000694 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.00000087 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.6559 Least Informative Inherited
Cellular Component (CC) membrane 0.1774 Least Informative Inherited
Cellular Component (CC) protein complex 0.204 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.01833 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4597 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.00002483 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000004011 Moderately Informative Direct
Cellular Component (CC) membrane region 0.00003929 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.09144 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0.00006805 Informative Direct
Cellular Component (CC) neuron projection 0.3969 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 0.000005669 Highly Informative Direct
Cellular Component (CC) dendrite 0.0000001182 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.1114Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000001562Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0001651Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000000002584InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal emotion/affect behavior0.01242InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.01877InformativeInherited
Mammalian Phenotype (MP)abnormal exploration in a new environment0.00006275Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0.01103Least InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0000001921Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.1103Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000000002067InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentEndoplasmic reticulum0.000000000006036Moderately InformativeDirect
Cellular componentChromosome0.0000001564InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
DomainRepeat0Least InformativeDirect
Post-translational modificationTransferase0.1712Least InformativeInherited
Post-translational modificationKinase0.00006266Moderately InformativeDirect
Post-translational modificationActivator0.0003697Moderately InformativeDirect
Post-translational modificationChromatin regulator0.000001323InformativeDirect
Post-translational modificationPhosphoprotein0.0001568Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]