SUPERFAMILY 1.75 HMM library and genome assignments server

FAS1 domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   FAS1 domain [ 82152]
Superfamily:   FAS1 domain [ 82153]
Families:   FAS1 domain [ 82154] (2)


Superfamily statistics
Genomes (918) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,958 9,877 3
Proteins 4,474 5,915 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0001866 Least Informative Direct
Biological Process (BP) developmental process 0.001439 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3349 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.05479 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cell differentiation 0.6253 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4442 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2069 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.002157 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.002034 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.4479 Moderately Informative Inherited
Biological Process (BP) biological adhesion 0.000000001163 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.000001021 Informative Direct
Biological Process (BP) cell wall organization or biogenesis 0.0001585 Informative Direct
Biological Process (BP) generation of neurons 0.00068 Informative Direct
Biological Process (BP) cell projection organization 0.001237 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.04221 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.004653 Informative Inherited
Biological Process (BP) extracellular matrix organization 0.0000000001526 Highly Informative Direct
Biological Process (BP) cell adhesion 0.000000000654 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.00001886 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.0001177 Highly Informative Direct
Biological Process (BP) neuron projection development 0.1339 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.01638 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.0077 Moderately Informative Inherited
Cellular Component (CC) membrane 0.0000006016 Least Informative Direct
Cellular Component (CC) extracellular region part 0.00000000002153 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00006066 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.0001011 Moderately Informative Direct
Cellular Component (CC) extracellular matrix 0.00000000000003132 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0.05038 Informative Inherited
Cellular Component (CC) anchored component of membrane 0 Highly Informative Direct
Cellular Component (CC) proteinaceous extracellular matrix 0.000007931 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0InformativeDirect
Xenopus ANatomical entity (XAN)adipose tissue0Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell adhesion0.000000000004626InformativeDirect
Cellular componentMembrane0.000007759Least InformativeDirect
Cellular componentSecreted0.000004003Moderately InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentExtracellular matrix0.000003146InformativeDirect
DomainSignal0Least InformativeDirect
DomainEGF-like domain0.00001911InformativeDirect
DomainLaminin EGF-like domain0.00000000002609Highly InformativeDirect
Post-translational modificationReceptor0.0003614Moderately InformativeDirect
Post-translational modificationGlycoprotein0.00000000000008856Least InformativeDirect
Post-translational modificationProteoglycan0InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0.000000000003267Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000782 SSF82153 Protein matches
Abstract

The FAS1 or BIgH3 domain is an extracellular module of about 140 amino acid residues. It has been suggested that the FAS1 domain represents an ancient cell adhesion domain common to plants and animals [PubMed7925267]; related FAS1 domains are also found in bacteria [PubMed7822037]. Most FAS1 domain containing proteins are GPI anchored and contain two or four copies of the domain. FAS1 domains of BIgH3 protein mediate cell adhesion throught an interaction with alpha3/beta1 integrin. A short motif (EPDIM), located on the C-teminal side of the fourth domain, is essential for the binding to integrin [PubMed10906123]. The crystal structure of two FAS1 domains (FAS1 3-4) of a fas1 protein have been solved [PubMed12575939]. Each domain consists of seven-stranded wedge and at least five alpha helices. Two well-ordered N-acetylglucosamine moities attached to a conserved asparagine are located in the interface region between the two FAS1 domains.

Some of the proteins containing a FAS1 domain are listed below:
  • Drosophila fasciclin I (fas1) protein. A cell adhesion molecule involved in axon guidance. It is attached to the membrane by a GPI-anchor (4 copies).
  • Human TGF-beta induced Ig-H3 (BIgH3) protein. Mutation in its FAS1 domains result in corneal distrophy, due to the deposition of insoluble protein aggregates (4 copies).
  • Arabidopsis fasciclin-like arabinogalactan proteins (2 copies).
  • Volvox major cell adhesion protein (2 copies).
  • Bacterial immunogenic protein MPT70 (1 copy).
  • Human extracellular matrix protein periostin (4 copies).
  • Mammalian stabilin protein (7 copies).

  • InterPro database


    PDBeMotif information about ligands, sequence and structure motifs
    Cross references PDB entries
    Ligand binding statistics
    Nucleic-acid binding statistics
    Occurrence of secondary structure elements
    Occurrence of small 3D structural motifs

    PDBeMotif resource

    Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

    Internal database links

    Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


    Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


    Browse and view proteins in genomes which have different domain combinations including a FAS1 domain domain.


    Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


    Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

    There are 3 hidden Markov models representing the FAS1 domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


    Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]