SUPERFAMILY 1.75 HMM library and genome assignments server

Antigen MPT63/MPB63 (immunoprotective extracellular protein) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Antigen MPT63/MPB63 (immunoprotective extracellular protein) [ 81982]
Families:   Antigen MPT63/MPB63 (immunoprotective extracellular protein) [ 81983]

Superfamily statistics
Genomes (65) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 110 471 1
Proteins 110 471 1

Functional annotation
General category Other
Detailed category Unknown function

Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR015250 SSF81982 Protein matches

This domain, found in bacterial proteins, assumes a beta-sandwich structure consisting of two antiparallel beta-sheets (similar to an immunoglobulin-like fold), and an additional small, antiparallel beta-sheet. The longer-stranded beta-sheet is made up of four antiparallel beta-strands. The shorter-stranded beta-sheet consists of five beta-strands, four of which form an antiparallel beta-sheet. The exact function of this domain is unknown, though a putative role includes involvement in host-bacterial interactions involved in endocytosis or phagocytosis, possibly during bacterial internalisation [PubMed12441386].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Antigen MPT63/MPB63 (immunoprotective extracellular protein) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Antigen MPT63/MPB63 (immunoprotective extracellular protein) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]