SUPERFAMILY 1.75 HMM library and genome assignments server


Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (1,715) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 12,731 20,261 4
Proteins 12,713 20,236 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.8864 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8821 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.07809 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5072 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001003 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.2704 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 8.186e-09 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.021e-06 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 9.798e-06 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 9.749e-05 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0001642 Moderately Informative Direct
Biological Process (BP) system process 0.0002783 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0004955 Moderately Informative Direct
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.08698 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.6054 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3583 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.9767 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6093 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.9523 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.9499 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.788 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.3463 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3751 Moderately Informative Inherited
Biological Process (BP) reproduction 0.08579 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.9383 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular cation homeostasis 3.718e-12 Informative Direct
Biological Process (BP) purine nucleotide metabolic process 4.95e-10 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 6.461e-10 Informative Direct
Biological Process (BP) organophosphate catabolic process 8.151e-08 Informative Direct
Biological Process (BP) lipid transport 8.611e-08 Informative Direct
Biological Process (BP) metal ion transport 1.279e-07 Informative Direct
Biological Process (BP) cellular membrane organization 2.521e-07 Informative Direct
Biological Process (BP) ribonucleoside metabolic process 3.858e-07 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 5.442e-07 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 2.456e-06 Informative Direct
Biological Process (BP) regulation of ion transport 3.775e-06 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 2.627e-05 Informative Direct
Biological Process (BP) blood circulation 0.0002669 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0002813 Informative Direct
Biological Process (BP) positive regulation of transport 0.0005694 Informative Direct
Biological Process (BP) generation of neurons 0.659 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) sensory organ development 0.01071 Informative Inherited
Biological Process (BP) embryonic organ development 0.02439 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9143 Informative Inherited
Biological Process (BP) response to external stimulus 0.8153 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.1135 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.03491 Informative Inherited
Biological Process (BP) single organism reproductive process 0.5957 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.1075 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) central nervous system development 0.05267 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.7414 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.8844 Informative Inherited
Biological Process (BP) response to other organism 0.07314 Informative Inherited
Biological Process (BP) response to light stimulus 0.09074 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.002377 Informative Inherited
Biological Process (BP) response to wounding 0.228 Informative Inherited
Biological Process (BP) gland development 0.1124 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.8535 Informative Inherited
Biological Process (BP) metal ion homeostasis 0.3426 Informative Inherited
Biological Process (BP) purine nucleoside metabolic process 0.2233 Informative Inherited
Biological Process (BP) nucleoside triphosphate metabolic process 0.001802 Informative Inherited
Biological Process (BP) epithelium development 0.6079 Informative Inherited
Biological Process (BP) organ morphogenesis 0.52 Informative Inherited
Biological Process (BP) synaptic transmission 0.1191 Informative Inherited
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 7.835e-15 Highly Informative Direct
Biological Process (BP) locomotory behavior 4.646e-10 Highly Informative Direct
Biological Process (BP) nucleoside triphosphate catabolic process 1.77e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 3.03e-09 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 6.072e-09 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 1.53e-08 Highly Informative Direct
Biological Process (BP) lactation 4.544e-06 Highly Informative Direct
Biological Process (BP) adult behavior 3.092e-05 Highly Informative Direct
Biological Process (BP) response to drug 0.0001776 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0002193 Highly Informative Direct
Biological Process (BP) inner ear development 0.0002373 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0002946 Highly Informative Direct
Biological Process (BP) coagulation 0.0003926 Highly Informative Direct
Biological Process (BP) epidermis development 0.0004517 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0206 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.3893 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.05222 Highly Informative Inherited
Biological Process (BP) sensory perception 0.2636 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.006276 Highly Informative Inherited
Biological Process (BP) learning or memory 0.3329 Highly Informative Inherited
Biological Process (BP) wound healing 0.007218 Highly Informative Inherited
Biological Process (BP) hemostasis 0.6722 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) nucleotide catabolic process 0.001679 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.08512 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.001991 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.6428 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.8063 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.381 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 2.331e-05 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003515 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 0.02795 Moderately Informative Inherited
Molecular Function (MF) organic cyclic compound binding 0.03548 Moderately Informative Inherited
Molecular Function (MF) protein binding 0.86 Moderately Informative Inherited
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 1.61e-14 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 1.792e-08 Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 1.993e-07 Highly Informative Direct
Molecular Function (MF) lipid transporter activity 5.715e-05 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.01152 Highly Informative Inherited
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.2247 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.841e-13 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 2.782e-07 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.8445 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 7.932e-11 Moderately Informative Direct
Cellular Component (CC) organelle membrane 3.612e-05 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.002714 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) Golgi apparatus 2.789e-11 Informative Direct
Cellular Component (CC) contractile fiber part 0.0001074 Informative Direct
Cellular Component (CC) vacuole 0.000559 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.000625 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 6.069e-13 Highly Informative Direct
Cellular Component (CC) sarcomere 8.289e-07 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 4.999e-05 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.0001577 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0004989 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.0006536 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase7.761e-13Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.04043Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.000117InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00137Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1559Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.06673InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant6.327e-11Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive2.47e-08Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant1.572e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus8.445e-09Moderately InformativeDirect
Cellular componentEndosome1.337e-05Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001048Least InformativeDirect
DiseaseDisease mutation1.883e-05Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCopper0.004834InformativeInherited
Molecular functionCalcium transport0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration2.841e-08Highly InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]