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Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (2,190) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,732 34,983 4
Proteins 14,706 34,944 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000000000004747 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01097 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.402 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1201 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000003285 Moderately Informative Direct
Biological Process (BP) system process 0.000001144 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00003305 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0003263 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0009511 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.89 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1173 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7499 Moderately Informative Inherited
Biological Process (BP) organ development 0.746 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7701 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4584 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7735 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.648 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.005375 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.2822 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2592 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1044 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1373 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) metal ion transport 0.0000000000001209 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.00000000002181 Informative Direct
Biological Process (BP) regulation of ion transport 0.0000000003676 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000000003701 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000001137 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000002549 Informative Direct
Biological Process (BP) blood circulation 0.00000004562 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000006266 Informative Direct
Biological Process (BP) cellular membrane organization 0.00000006932 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000007332 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000002898 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.000006494 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00002349 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002869 Informative Direct
Biological Process (BP) sensory organ development 0.0008031 Informative Direct
Biological Process (BP) embryonic organ development 0.0009607 Informative Direct
Biological Process (BP) muscle system process 0.1032 Informative Inherited
Biological Process (BP) cation homeostasis 0.001592 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3403 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.4847 Informative Inherited
Biological Process (BP) response to lipid 0.5486 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.646 Informative Inherited
Biological Process (BP) generation of neurons 0.4993 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.9291 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02682 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.9805 Informative Inherited
Biological Process (BP) single-organism behavior 0.02039 Informative Inherited
Biological Process (BP) gland development 0.04546 Informative Inherited
Biological Process (BP) central nervous system development 0.008712 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3317 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.2836 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2017 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.04655 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.003282 Informative Inherited
Biological Process (BP) response to wounding 0.2548 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.839 Informative Inherited
Biological Process (BP) epithelium development 0.5513 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1954 Informative Inherited
Biological Process (BP) synaptic transmission 0.1473 Informative Inherited
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0.000000000000001938 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000000000002458 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0000000000005588 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.000000000007501 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.0000000003505 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.0000000004226 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.0000000008145 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.00000000107 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.000000001201 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.00000001938 Highly Informative Direct
Biological Process (BP) lactation 0.0000001766 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.000001106 Highly Informative Direct
Biological Process (BP) response to drug 0.000001222 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00001645 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00002013 Highly Informative Direct
Biological Process (BP) adult behavior 0.00009679 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0001571 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0001633 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0004502 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0005083 Highly Informative Direct
Biological Process (BP) ear development 0.0005411 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.0007211 Highly Informative Direct
Biological Process (BP) coagulation 0.0008773 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.01534 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.0186 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.381 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.06033 Highly Informative Inherited
Biological Process (BP) sensory perception 0.01452 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.006997 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.4751 Highly Informative Inherited
Biological Process (BP) wound healing 0.009824 Highly Informative Inherited
Biological Process (BP) hemostasis 0.7977 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.004532 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1916 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.7888 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 0.9924 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.2399 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00005672 Moderately Informative Direct
Molecular Function (MF) anion binding 0.00035 Moderately Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.0000000000004279 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000000008894 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.000000001485 Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000004441 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.000004061 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.005791 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.001371 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.01191 Highly Informative Inherited
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.2566 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001115 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.6259 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000003769 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0.01136 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00000000000006555 Informative Direct
Cellular Component (CC) vacuolar part 0.000003496 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.000006924 Informative Direct
Cellular Component (CC) contractile fiber part 0.0001088 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 1 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 0.00000000001356 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0000001973 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.00002201 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.00003109 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.0001095 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0005711 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000000007761Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.03133Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0002815InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00137Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1559Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.06673InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant0.00000000006327Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.0000000247Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.0000001572Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0.0000001893Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001554Least InformativeDirect
DiseaseDisease mutation0.0000001182Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0000002523InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]