SUPERFAMILY 1.75 HMM library and genome assignments server

Metal cation-transporting ATPase, ATP-binding domain N superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Metal cation-transporting ATPase, ATP-binding domain N [ 81661]
Superfamily:   Metal cation-transporting ATPase, ATP-binding domain N [ 81660]
Families:   Metal cation-transporting ATPase, ATP-binding domain N [ 81659] (4)


Superfamily statistics
Genomes (2,191) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 14,767 34,983 4
Proteins 14,741 34,944 4


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.001781 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.3438 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1269 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01095 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0000000004897 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0007154 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.8761 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2655 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.5545 Moderately Informative Inherited
Biological Process (BP) organ development 0.7246 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2285 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.002696 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1076 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8906 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.7847 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.4657 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7885 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8543 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.001546 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.00775 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.3842 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.008651 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.1114 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1195 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) ion transmembrane transport 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) metal ion transport 0.0000000000006153 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.0000000001861 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000000515 Informative Direct
Biological Process (BP) single-organism membrane organization 0.000000002511 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.00000001101 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000145 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.00000001712 Informative Direct
Biological Process (BP) blood circulation 0.0000000466 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000006488 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.00000009693 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.0000002514 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.000002841 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.00002357 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002993 Informative Direct
Biological Process (BP) sensory organ development 0.0008 Informative Direct
Biological Process (BP) embryonic organ development 0.0009771 Informative Direct
Biological Process (BP) muscle system process 0.3442 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.2639 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.3448 Informative Inherited
Biological Process (BP) response to lipid 0.5543 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1938 Informative Inherited
Biological Process (BP) epithelium development 0.367 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.8528 Informative Inherited
Biological Process (BP) cation homeostasis 0.001405 Informative Inherited
Biological Process (BP) neurological system process 0.7519 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01161 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.3392 Informative Inherited
Biological Process (BP) central nervous system development 0.009233 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.3619 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) response to inorganic substance 0.2035 Informative Inherited
Biological Process (BP) response to light stimulus 0.04691 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.1859 Informative Inherited
Biological Process (BP) gland development 0.135 Informative Inherited
Biological Process (BP) regulation of body fluid levels 0.00376 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.02701 Informative Inherited
Biological Process (BP) generation of neurons 0.5057 Informative Inherited
Biological Process (BP) synaptic transmission 0.1749 Informative Inherited
Biological Process (BP) organophosphate ester transport 0.00000000000007575 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0000000000005355 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.000000000006314 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.0000000003383 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.0000000004079 Highly Informative Direct
Biological Process (BP) purine ribonucleoside catabolic process 0.000000000785 Highly Informative Direct
Biological Process (BP) purine ribonucleotide catabolic process 0.000000001032 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.00000001993 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0000001985 Highly Informative Direct
Biological Process (BP) response to drug 0.0000008831 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.000006941 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.00001556 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.00001704 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00001951 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.00004979 Highly Informative Direct
Biological Process (BP) adult behavior 0.00008826 Highly Informative Direct
Biological Process (BP) epidermis development 0.00009146 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0001702 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.0002959 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0.0005114 Highly Informative Direct
Biological Process (BP) ear development 0.0005301 Highly Informative Direct
Biological Process (BP) body fluid secretion 0.0005943 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00073 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0007833 Highly Informative Direct
Biological Process (BP) coagulation 0.0008545 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.2269 Highly Informative Inherited
Biological Process (BP) sensory perception 0.3676 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.007013 Highly Informative Inherited
Biological Process (BP) response to transition metal nanoparticle 0.001691 Highly Informative Inherited
Biological Process (BP) learning or memory 0.01193 Highly Informative Inherited
Biological Process (BP) wound healing 0.0097 Highly Informative Inherited
Biological Process (BP) hemostasis 0.7974 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 1 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.004511 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.1901 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.0202 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.385 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.7995 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.2682 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.000000000008736 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.0000000001865 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00005816 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0003482 Moderately Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.0000000000004178 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000000009038 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000000004446 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.000002941 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.005922 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 1 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.00156 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.007973 Highly Informative Inherited
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.255 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.1875 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.006091 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) membrane region 0.00000283 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.000004844 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.00001649 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.009404 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.00000000000001464 Informative Direct
Cellular Component (CC) transporter complex 0.0000002656 Informative Direct
Cellular Component (CC) vacuolar part 0.000004175 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.000004477 Informative Direct
Cellular Component (CC) contractile fiber part 0.000172 Informative Direct
Cellular Component (CC) integral component of membrane 0.000901 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Informative Inherited
Cellular Component (CC) sarcoplasmic reticulum 0.00000000001283 Highly Informative Direct
Cellular Component (CC) sarcomere 0.0000001984 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.00002449 Highly Informative Direct
Cellular Component (CC) trans-Golgi network 0.0001206 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0006275 Highly Informative Direct
Cellular Component (CC) integral component of plasma membrane 0.8736 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000000007761Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.03133Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0002815InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00137Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1559Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)lipid metabolism variant0.06673InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant0.00000000006327Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.0000000247Highly InformativeDirect
Worm Phenotype (WP)lipid composition variant0.0000001572Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndosome0.0000001893Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001554Least InformativeDirect
DiseaseDisease mutation0.0000001182Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.0000002523InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metal cation-transporting ATPase, ATP-binding domain N domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Metal cation-transporting ATPase, ATP-binding domain N superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]