SUPERFAMILY 1.75 HMM library and genome assignments server

Calcium ATPase, transduction domain A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Calcium ATPase, transduction domain A [ 81653]
Families:   Calcium ATPase, transduction domain A [ 81652]


Superfamily statistics
Genomes (3,046) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,731 90,075 2
Proteins 25,573 89,686 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.001421 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4503 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.3246 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.01492 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000007033 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00004363 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.0003575 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.02637 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.7261 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.03066 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.526 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.918 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.9504 Moderately Informative Inherited
Biological Process (BP) organ development 0.3731 Moderately Informative Inherited
Biological Process (BP) tissue development 0.06633 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.818 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2644 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.544 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7794 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.528 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.002199 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.05194 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1954 Moderately Informative Inherited
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) ion transmembrane transport 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000000515 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 0.000000002746 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.00000000562 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000000007444 Informative Direct
Biological Process (BP) metal ion transport 0.00000001696 Informative Direct
Biological Process (BP) organophosphate catabolic process 0.0000000529 Informative Direct
Biological Process (BP) single-organism membrane organization 0.0000001411 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.0000003142 Informative Direct
Biological Process (BP) response to inorganic substance 0.000001544 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000001581 Informative Direct
Biological Process (BP) blood circulation 0.00001183 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.00001351 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00001408 Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0001075 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001703 Informative Direct
Biological Process (BP) cation homeostasis 0.0004042 Informative Direct
Biological Process (BP) positive regulation of transport 0.0005554 Informative Direct
Biological Process (BP) muscle system process 0.2478 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.2472 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.2521 Informative Inherited
Biological Process (BP) response to lipid 0.5602 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1409 Informative Inherited
Biological Process (BP) epithelium development 0.1532 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7299 Informative Inherited
Biological Process (BP) neurological system process 0.5956 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.129 Informative Inherited
Biological Process (BP) embryonic organ development 0.003941 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2373 Informative Inherited
Biological Process (BP) central nervous system development 0.0041 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.4725 Informative Inherited
Biological Process (BP) biological adhesion 0.3603 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.1081 Informative Inherited
Biological Process (BP) single-organism behavior 0.5275 Informative Inherited
Biological Process (BP) gland development 0.01182 Informative Inherited
Biological Process (BP) sensory organ development 0.004404 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.07838 Informative Inherited
Biological Process (BP) generation of neurons 0.448 Informative Inherited
Biological Process (BP) synaptic transmission 0.2986 Informative Inherited
Biological Process (BP) response to transition metal nanoparticle 0.00000000000002089 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 0.00000000001034 Highly Informative Direct
Biological Process (BP) regulation of muscle system process 0.0000000001062 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.0000000003232 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.00000003357 Highly Informative Direct
Biological Process (BP) epidermis development 0.00000004031 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 0.0000001096 Highly Informative Direct
Biological Process (BP) phenol-containing compound metabolic process 0.0000001131 Highly Informative Direct
Biological Process (BP) body fluid secretion 0.0000008428 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.00005187 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 0.00009839 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0.000348 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0004123 Highly Informative Direct
Biological Process (BP) ear development 0.0005301 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0006347 Highly Informative Direct
Biological Process (BP) adult behavior 0.0009553 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.8772 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02557 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.2829 Highly Informative Inherited
Biological Process (BP) sensory perception 0.2611 Highly Informative Inherited
Biological Process (BP) sodium ion transport 0.004551 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.005456 Highly Informative Inherited
Biological Process (BP) cell adhesion 0.2585 Highly Informative Inherited
Biological Process (BP) learning or memory 0.02219 Highly Informative Inherited
Biological Process (BP) coagulation 0.00168 Highly Informative Inherited
Biological Process (BP) wound healing 0.02428 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2868 Highly Informative Inherited
Biological Process (BP) purine ribonucleoside catabolic process 0.04842 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide catabolic process 0.06918 Highly Informative Inherited
Biological Process (BP) ribonucleoside triphosphate catabolic process 0.2711 Highly Informative Inherited
Biological Process (BP) purine nucleoside triphosphate catabolic process 0.3146 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.009905 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.3455 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.04438 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.2074 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.9143 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1914 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000000000002922 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00000000001025 Moderately Informative Direct
Molecular Function (MF) cation binding 0.00000005811 Moderately Informative Direct
Molecular Function (MF) anion binding 0.1358 Moderately Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000000000000007683 Informative Direct
Molecular Function (MF) nucleotide binding 0.00000000000000844 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.000000000005836 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.00001605 Highly Informative Direct
Molecular Function (MF) copper ion binding 0.00002854 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 0.0000524 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 0.00008383 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.01217 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.1089 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.01219 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.1855 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0002291 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0319 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.0000009575 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0.000005554 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00004323 Moderately Informative Direct
Cellular Component (CC) vesicle 0.01707 Moderately Informative Inherited
Cellular Component (CC) membrane region 0.001059 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuolar part 0.0000002123 Informative Direct
Cellular Component (CC) transporter complex 0.000001778 Informative Direct
Cellular Component (CC) integral component of membrane 0.000002698 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.0008017 Informative Direct
Cellular Component (CC) contractile fiber part 0.001683 Informative Inherited
Cellular Component (CC) intrinsic component of plasma membrane 0.6875 Informative Inherited
Cellular Component (CC) trans-Golgi network 0.00000000000001464 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 0.00000000003927 Highly Informative Direct
Cellular Component (CC) sarcomere 0.000007784 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0009467 Highly Informative Direct
Cellular Component (CC) cell body 0.008751 Highly Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0.4212 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase0.0000000000001039Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase0.000000000006865Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase0.0000000004443Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase0.000000007143Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.01517Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003764InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007914Least InformativeDirect
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant0.000000002482Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive0.0000000186Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0001175Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.002441Least InformativeInherited
Plant ANatomical entity (PAN)flower0.03196Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.04703Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.0000005963InformativeDirect
Plant ANatomical entity (PAN)parenchyma cell0.000000003406Highly InformativeDirect
Plant ANatomical entity (PAN)anther0.0005621Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0002813Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

DrugBank ATC (DB)

(show details)
DB termFDR (all)SDDB levelAnnotation (direct or inherited)
Drugbank ATC_code (DB)alimentary tract and metabolism0Least InformativeDirect
Drugbank ATC_code (DB)drugs for acid related disorders0InformativeDirect

Document: DB annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport0.00000000001115InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport0.00000000005253Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell membrane0.0000000003752Moderately InformativeDirect
Cellular componentEndosome0.00004492Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001092Least InformativeDirect
DiseaseDisease mutation0.000008845Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration0.00001429InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transduction domain A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transduction domain A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · DrugBank ATC (DB) · UniProtKB KeyWords (KW) · Internal database links ]