SUPERFAMILY 1.75 HMM library and genome assignments server


Calcium ATPase, transduction domain A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   Calcium ATPase, transduction domain A [ 81653]
Families:   Calcium ATPase, transduction domain A [ 81652]


Superfamily statistics
Genomes (3,045) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 25,691 90,075 2
Proteins 25,533 89,686 2


Functional annotation
General category Processes_IC
Detailed category Ion metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 3.339e-11 Least Informative Direct
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9425 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5091 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.02628 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.4009 Least Informative Inherited
Biological Process (BP) ion transport 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 5.843e-07 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 4.124e-05 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 9.006e-05 Moderately Informative Direct
Biological Process (BP) organonitrogen compound catabolic process 0.0002383 Moderately Informative Direct
Biological Process (BP) organic cyclic compound catabolic process 0.0006235 Moderately Informative Direct
Biological Process (BP) system process 0.0009887 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.7806 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.9732 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.1504 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.002425 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.4699 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.369 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.3251 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003885 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5091 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8971 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.8251 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.3196 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.132 Moderately Informative Inherited
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) lipid localization 0 Informative Direct
Biological Process (BP) regulation of ion transport 3.91e-10 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 1.51e-09 Informative Direct
Biological Process (BP) metal ion transport 1.52e-09 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 4.234e-09 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 5.58e-09 Informative Direct
Biological Process (BP) glycosyl compound catabolic process 3.76e-08 Informative Direct
Biological Process (BP) organophosphate catabolic process 1.846e-07 Informative Direct
Biological Process (BP) cellular membrane organization 7.483e-07 Informative Direct
Biological Process (BP) response to inorganic substance 9.133e-07 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 9.398e-07 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 1.009e-06 Informative Direct
Biological Process (BP) blood circulation 1.075e-05 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 3.509e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0001286 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002815 Informative Direct
Biological Process (BP) cation homeostasis 0.0003553 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0004817 Informative Direct
Biological Process (BP) muscle system process 0.1198 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.2356 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.3703 Informative Inherited
Biological Process (BP) response to lipid 0.5283 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.7761 Informative Inherited
Biological Process (BP) generation of neurons 0.4213 Informative Inherited
Biological Process (BP) cell projection organization 1 Informative Inherited
Biological Process (BP) embryonic organ development 0.003626 Informative Inherited
Biological Process (BP) sensory organ development 0.003962 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.7777 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.0743 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.8952 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 0.9781 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) actin filament-based process 1 Informative Inherited
Biological Process (BP) gland development 0.001502 Informative Inherited
Biological Process (BP) central nervous system development 0.003338 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2132 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7969 Informative Inherited
Biological Process (BP) biological adhesion 0.3777 Informative Inherited
Biological Process (BP) response to other organism 0.2958 Informative Inherited
Biological Process (BP) response to light stimulus 0.1014 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.01441 Informative Inherited
Biological Process (BP) response to wounding 0.4208 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3698 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1328 Informative Inherited
Biological Process (BP) synaptic transmission 0.2648 Informative Inherited
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) organophosphate ester transport 1.805e-13 Highly Informative Direct
Biological Process (BP) lactation 1.92e-12 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 2.195e-10 Highly Informative Direct
Biological Process (BP) ER-nucleus signaling pathway 9.878e-08 Highly Informative Direct
Biological Process (BP) ATP metabolic process 2.647e-07 Highly Informative Direct
Biological Process (BP) locomotory behavior 3.069e-07 Highly Informative Direct
Biological Process (BP) embryonic organ morphogenesis 9.05e-05 Highly Informative Direct
Biological Process (BP) neuromuscular process 0.0002474 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.0003538 Highly Informative Direct
Biological Process (BP) response to toxic substance 0.0004992 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate catabolic process 0.0005173 Highly Informative Direct
Biological Process (BP) ear development 0.0005414 Highly Informative Direct
Biological Process (BP) adult behavior 0.000829 Highly Informative Direct
Biological Process (BP) hydrogen transport 0.0008441 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.03192 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.2405 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.1966 Highly Informative Inherited
Biological Process (BP) cellular calcium ion homeostasis 0.02457 Highly Informative Inherited
Biological Process (BP) maintenance of location 0.06965 Highly Informative Inherited
Biological Process (BP) sensory perception 0.01664 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 1 Highly Informative Inherited
Biological Process (BP) calcium ion transport 0.008567 Highly Informative Inherited
Biological Process (BP) transition metal ion homeostasis 0.9293 Highly Informative Inherited
Biological Process (BP) cell adhesion 1 Highly Informative Inherited
Biological Process (BP) learning or memory 0.8111 Highly Informative Inherited
Biological Process (BP) coagulation 0.001453 Highly Informative Inherited
Biological Process (BP) wound healing 0.02279 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.2836 Highly Informative Inherited
Biological Process (BP) retina development in camera-type eye 0.009328 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.3253 Highly Informative Inherited
Biological Process (BP) regulation of neurotransmitter levels 0.8934 Highly Informative Inherited
Biological Process (BP) neurotransmitter transport 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1271 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0 Moderately Informative Direct
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) cation binding 9.99e-08 Moderately Informative Direct
Molecular Function (MF) anion binding 0.09561 Moderately Informative Inherited
Molecular Function (MF) purine ribonucleoside binding 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleotide binding 6.038e-15 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 8.96e-15 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 2.329e-10 Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0 Highly Informative Direct
Molecular Function (MF) copper ion binding 2.953e-05 Highly Informative Direct
Molecular Function (MF) calcium ion binding 3.443e-05 Highly Informative Direct
Molecular Function (MF) calcium ion transmembrane transporter activity 6.728e-05 Highly Informative Direct
Molecular Function (MF) transition metal ion transmembrane transporter activity 8.696e-05 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.01175 Highly Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.2062 Highly Informative Inherited
Molecular Function (MF) lipid transporter activity 0.01094 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.2347 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1.909e-05 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.4805 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 2.468e-13 Moderately Informative Direct
Cellular Component (CC) organelle membrane 5.096e-07 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 6.433e-05 Moderately Informative Direct
Cellular Component (CC) vesicle 0.0201 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuolar part 1.831e-07 Informative Direct
Cellular Component (CC) contractile fiber part 0.001201 Informative Inherited
Cellular Component (CC) integral to membrane 0.003688 Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0.8306 Informative Inherited
Cellular Component (CC) trans-Golgi network 8.985e-15 Highly Informative Direct
Cellular Component (CC) sarcoplasmic reticulum 3.17e-11 Highly Informative Direct
Cellular Component (CC) sarcomere 7.177e-06 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000707 Highly Informative Direct
Cellular Component (CC) cell body 0.007872 Highly Informative Inherited
Cellular Component (CC) integral to plasma membrane 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembran0InformativeDirect
Enzyme Commission (EC)Potassium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Calcium-transporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Proton-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipid-translocating ATPase0Highly InformativeDirect
Enzyme Commission (EC)Copper-exporting ATPase0Highly InformativeDirect
Enzyme Commission (EC)Sodium/potassium-exchanging ATPase0Highly InformativeDirect
Enzyme Commission (EC)Cu(+) exporting ATPase1.039e-13Highly InformativeDirect
Enzyme Commission (EC)Cadmium-exporting ATPase6.865e-12Highly InformativeDirect
Enzyme Commission (EC)Hydrogen/potassium-exchanging ATPase4.443e-10Highly InformativeDirect
Enzyme Commission (EC)Zinc-exporting ATPase7.143e-09Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)muscle phenotype0.01443Moderately InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.0003685InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007914Least InformativeDirect
Worm Phenotype (WP)chemical response variant0.007528Moderately InformativeInherited
Worm Phenotype (WP)nicotine response variant0.009701InformativeInherited
Worm Phenotype (WP)cell membrane morphology variant2.482e-09Highly InformativeDirect
Worm Phenotype (WP)nicotine hypersensitive1.86e-08Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0001175Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0.002441Least InformativeInherited
Plant ANatomical entity (PAN)flower0.03196Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure0.04703Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.06103Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue5.963e-07InformativeDirect
Plant ANatomical entity (PAN)parenchyma cell3.406e-09Highly InformativeDirect
Plant ANatomical entity (PAN)anther0.0005621Highly InformativeDirect
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.0002813Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; catalyzing transmembrane movement of substances0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processLipid transport1.145e-11InformativeDirect
Biological processCalcium transport0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processSodium transport5.506e-11Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCell membrane2.847e-10Moderately InformativeDirect
Cellular componentEndosome4.18e-05Moderately InformativeDirect
Cellular componentSarcoplasmic reticulum0Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0001036Least InformativeDirect
DiseaseDisease mutation8.203e-06Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionCalmodulin-binding0InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionPotassium0InformativeDirect
Molecular functionSodium0InformativeDirect
Molecular functionCadmium0Highly InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationNitration1.445e-05InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calcium ATPase, transduction domain A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Calcium ATPase, transduction domain A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]