SUPERFAMILY 1.75 HMM library and genome assignments server

PAP/OAS1 substrate-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   PAP/OAS1 substrate-binding domain [ 81632]
Superfamily:   PAP/OAS1 substrate-binding domain [ 81631] (5)
Families:   Poly(A) polymerase, PAP, middle domain [ 81630]
  2'-5'-oligoadenylate synthetase 1, OAS1, second domain [ 101271]
  Archaeal tRNA CCA-adding enzyme substrate-binding domain [ 101274]
  RNA editing terminal uridyl transferase 2, RET2, domain 2 [ 140679]
  AadK C-terminal domain-like [ 158607]


Superfamily statistics
Genomes (894) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 5,868 7,984 11
Proteins 5,578 7,650 11


Functional annotation
General category Information
Detailed category RNA processing

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)binding0.045020.0000000001287Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups00Moderately InformativeDirect
Molecular Function (MF)nucleic acid binding0.0000014290.00004753Moderately InformativeDirect
Molecular Function (MF)nucleotidyltransferase activity00InformativeDirect
Molecular Function (MF)RNA binding0.00000017240InformativeDirect
Molecular Function (MF)adenylyltransferase activity00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000007242 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5619 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1051 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9738 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) gene expression 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000004705 Moderately Informative Direct
Biological Process (BP) defense response 0.0000006893 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0000008168 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.00004498 Moderately Informative Direct
Biological Process (BP) immune system process 0.00009094 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000591 Moderately Informative Direct
Biological Process (BP) organic cyclic compound biosynthetic process 0.5737 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.2734 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2304 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.1249 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.007256 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.005349 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3135 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3946 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.3036 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.3273 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.01638 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.02068 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.02296 Moderately Informative Inherited
Biological Process (BP) RNA processing 0 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.00000000007477 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000000001298 Informative Direct
Biological Process (BP) immune effector process 0.000000002455 Informative Direct
Biological Process (BP) response to cytokine 0.0000007718 Informative Direct
Biological Process (BP) nucleobase-containing compound catabolic process 0.009157 Informative Inherited
Biological Process (BP) defense response to other organism 0.1292 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.03227 Informative Inherited
Biological Process (BP) ncRNA metabolic process 0.9538 Informative Inherited
Biological Process (BP) nucleic acid phosphodiester bond hydrolysis 0.1878 Informative Inherited
Biological Process (BP) response to virus 0 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.00002482 Highly Informative Direct
Biological Process (BP) protein glycosylation 0.0002519 Highly Informative Direct
Biological Process (BP) gene silencing 0.0002663 Highly Informative Direct
Biological Process (BP) mRNA catabolic process 0.001465 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.001455 Highly Informative Inherited
Biological Process (BP) mRNA processing 0.2692 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.0000000001287 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.00004753 Moderately Informative Direct
Molecular Function (MF) cation binding 0.01402 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.3 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 0.00428 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 0.001177 Moderately Informative Inherited
Molecular Function (MF) nucleotidyltransferase activity 0 Informative Direct
Molecular Function (MF) RNA binding 0 Informative Direct
Molecular Function (MF) nucleotide binding 0.0000001125 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.000001257 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 1 Informative Inherited
Molecular Function (MF) adenylyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) ATP binding 0.00000000001671 Highly Informative Direct
Molecular Function (MF) mRNA binding 0.2009 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6099 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.002409 Least Informative Inherited
Cellular Component (CC) protein complex 0.3612 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.06231 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000002441 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0001406 Moderately Informative Direct
Cellular Component (CC) nucleoplasm part 0.0721 Informative Inherited
Cellular Component (CC) perinuclear region of cytoplasm 0.0003259 Highly Informative Direct
Cellular Component (CC) nuclear body 0.005509 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Nucleotidyltransferases0Least InformativeDirect
Enzyme Commission (EC)CCA tRNA nucleotidyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0000005657Least InformativeDirect
Worm Phenotype (WP)RNA expression variant0.00000000002283InformativeDirect
Worm Phenotype (WP)miRNA expression variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)RNA accumulation0Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.7253Least InformativeInherited
Plant ANatomical entity (PAN)radicle0.00000002246Highly InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.0006708Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0.0004336InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Nucleotidyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Polynucleotide adenylyltransferase0Highly InformativeDirect
Enzyme Commission (EC)RNA uridylyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0.02Moderately InformativeInherited
Biological processInnate immunity0InformativeDirect
Biological processtRNA processing0InformativeDirect
Biological processMitosis0.00000001295InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentEndoplasmic reticulum0.0000004127Moderately InformativeDirect
Cellular componentMitochondrion0.0006383Moderately InformativeDirect
Cellular componentMicrosome0.000001901Highly InformativeDirect
DomainZinc-finger0.0001763Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Molecular functionRNA-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationNucleotidyltransferase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0.00005782Least InformativeDirect
Post-translational modificationAcetylation0.0002781Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PAP/OAS1 substrate-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the PAP/OAS1 substrate-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]