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  Home > SCOP hierarchy > Protein serine/threonine phosphatase 2C, C-terminal domain superfamily


Protein serine/threonine phosphatase 2C, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Another 3-helical bundle [ 81602] (5)
Superfamily:   Protein serine/threonine phosphatase 2C, C-terminal domain [ 81601]
Families:   Protein serine/threonine phosphatase 2C, C-terminal domain [ 81600]

 Superfamily statistics
Genomes (102) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 290 284 1
Proteins 290 284 1

 Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 4.434e-08 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.522e-06 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.0006421 Least Informative Direct
Biological Process (BP) cellular protein modification process 6.691e-10 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 4.588e-10 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 2.661e-05 Moderately Informative Direct
Biological Process (BP) regulation of signaling 1.21e-05 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 8.936e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.06221 Moderately Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.0002303 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0.0001357 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003839 Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 3.184e-09 Least Informative Direct
Molecular Function (MF) binding 0.1866 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 7.321e-14 Moderately Informative Direct
Molecular Function (MF) protein binding 0.00898 Moderately Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentNucleus9.473e-05Least InformativeDirect
Coding sequence diversityAlternative splicing8.53e-07Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationPhosphoprotein0.0001541Least InformativeDirect
Post-translational modificationMyristate1.333e-12InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR012911 SSF81601 Protein matches
Abstract

Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain [PubMed9003755].


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein serine/threonine phosphatase 2C, C-terminal domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Protein serine/threonine phosphatase 2C, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.