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Protein serine/threonine phosphatase 2C, C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Another 3-helical bundle [ 81602] (5)
Superfamily:   Protein serine/threonine phosphatase 2C, C-terminal domain [ 81601]
Families:   Protein serine/threonine phosphatase 2C, C-terminal domain [ 81600]


Superfamily statistics
Genomes (117) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 326 347 1
Proteins 326 347 1


Functional annotation
General category Regulation
Detailed category Kinases/phosphatases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000000000005125 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000009964 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000004052 Least Informative Direct
Biological Process (BP) biosynthetic process 0.004368 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1206 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0003419 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000004991 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0001639 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000000001364 Moderately Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.000006592 Informative Direct
Biological Process (BP) negative regulation of cell communication 0 Informative Direct
Biological Process (BP) dephosphorylation 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0 Informative Direct
Biological Process (BP) regulation of intracellular transport 0 Informative Direct
Biological Process (BP) regulation of protein localization 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0 Informative Direct
Biological Process (BP) negative regulation of transport 0.0000000008414 Informative Direct
Biological Process (BP) protein dephosphorylation 0 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0 Highly Informative Direct
Biological Process (BP) lipoprotein metabolic process 0.00000000000008478 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.00000003435 Least Informative Direct
Molecular Function (MF) binding 0.1708 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.000000000001014 Moderately Informative Direct
Molecular Function (MF) phosphoric ester hydrolase activity 0.000000000000001562 Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0 Highly Informative Direct
Cellular Component (CC) membrane 0.00002209 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0002501 Least Informative Direct
Cellular Component (CC) cytosol 0.00000001033 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.0000001882Least InformativeDirect
Cellular componentCytoplasm0.0002354Least InformativeDirect
Cellular componentNucleus0.0003332Least InformativeDirect
Coding sequence diversityAlternative splicing0.000001331Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionMagnesium0Moderately InformativeDirect
Molecular functionManganese0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationMyristate0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR012911 SSF81601 Protein matches
Abstract

Protein phosphatase 2C (PP2C) is involved in regulating cellular responses to stress in various eukaryotes. It consists of two domains: an N-terminal catalytic domain and a C-terminal domain characteristic of mammalian PP2Cs. This domain consists of three antiparallel alpha helices, one of which packs against two corresponding alpha-helices of the N-terminal domain. The C-terminal domain does not seem to play a role in catalysis, but it may provide protein substrate specificity due to the cleft that is created between it and the catalytic domain [PubMed9003755].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Protein serine/threonine phosphatase 2C, C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Protein serine/threonine phosphatase 2C, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]