SUPERFAMILY 1.75 HMM library and genome assignments server

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ISP transmembrane anchor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Single transmembrane helix [ 81407] (38)
Superfamily:   ISP transmembrane anchor [ 81502]
Families:   ISP transmembrane anchor [ 81501] (2)


Superfamily statistics
Genomes (443) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 608 749 4
Proteins 608 749 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.02265 Least Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.03651 Informative Inherited
Biological Process (BP) electron transport chain 0.0001781 Highly Informative Direct
Molecular Function (MF) transporter activity 0.00000002434 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.00000004436 Moderately Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.00000000001636 Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Cellular Component (CC) intracellular organelle part 0.0000001853 Least Informative Direct
Cellular Component (CC) membrane 0.000001832 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.000008442 Least Informative Direct
Cellular Component (CC) protein complex 0.000009241 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0001175 Least Informative Direct
Cellular Component (CC) mitochondrial part 0.0000000000003694 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.000000000001123 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000000003218 Moderately Informative Direct
Cellular Component (CC) respiratory chain 0.000000000000006088 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.000000003274 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)With a cytochrome as acceptor0Highly InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on diphenols and related substances as donors0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processRespiratory chain0.00000000005404Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionIron-sulfur0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004192 SSF81502 Protein matches
Abstract The ubiquinol cytochrome c reductase (cytochrome bc1) complex is a respiratory chain that generates an elctrochemical potential coupled to ATP synthesis. The bc1 complex contains 11 subunits, 3 respiratory subunits (cytochrome B, cytochrome C1, Rieske protein), 2 core proteins and 6 low-molecular weight proteins. Each subunit of the cytochrome bc1 complex provides a single helix (this family) to make up the transmembrane region of the complex.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ISP transmembrane anchor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the ISP transmembrane anchor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]