SUPERFAMILY 1.75 HMM library and genome assignments server

Mitochondrial cytochrome c oxidase subunit IV superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Single transmembrane helix [ 81407] (38)
Superfamily:   Mitochondrial cytochrome c oxidase subunit IV [ 81406]
Families:   Mitochondrial cytochrome c oxidase subunit IV [ 81405]


Superfamily statistics
Genomes (366) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 580 740 1
Proteins 580 736 1


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.017850.1587Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.056350.06455Least InformativeInherited
Biological Process (BP)localization0.00018030.001256Least InformativeInherited
Biological Process (BP)ion transport0.0000000017660.000000006815Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.000000062520.00000004457Moderately InformativeDirect
Biological Process (BP)monovalent inorganic cation transport0.0000000000000063590.0000000000000406InformativeDirect
Biological Process (BP)energy derivation by oxidation of organic compounds0.00000000027460.00000000004502InformativeDirect
Biological Process (BP)ion transmembrane transport0.00000000000037850.000000000004129InformativeDirect
Biological Process (BP)electron transport chain0.0000000012390.0000000004874Highly InformativeDirect
Biological Process (BP)hydrogen ion transmembrane transport00Highly InformativeDirect
Molecular Function (MF)transporter activity0.0000000028410.000000007685Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity0.000000069040.00000001595Moderately InformativeDirect
Molecular Function (MF)electron carrier activity00InformativeDirect
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.0000000000000020.00000000000001064InformativeDirect
Molecular Function (MF)heme-copper terminal oxidase activity00Highly InformativeDirect
Molecular Function (MF)hydrogen ion transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor10Highly InformativeInherited
Cellular Component (CC)membrane0.000034990.0003268Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.0001150.0002657Least InformativeDirect
Cellular Component (CC)protein complex0.0019410.01392Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.000097550.002637Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.00071330.002405Least InformativeInherited
Cellular Component (CC)organelle envelope0.0000000036570.00000000006986Moderately InformativeDirect
Cellular Component (CC)mitochondrial part0.0000000010390.00000000002426Moderately InformativeDirect
Cellular Component (CC)mitochondrial membrane part0.000008010.0000001435InformativeDirect
Cellular Component (CC)respiratory chain0.0000000025780.00000000005387InformativeDirect
Cellular Component (CC)respiratory chain complex IV0.0000000051050.000000000008413Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.1587 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.06455 Least Informative Inherited
Biological Process (BP) localization 0.001256 Least Informative Inherited
Biological Process (BP) ion transport 0.000000006815 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00000004457 Moderately Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0000000000000406 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.00000000004502 Informative Direct
Biological Process (BP) ion transmembrane transport 0.000000000004129 Informative Direct
Biological Process (BP) electron transport chain 0.0000000004874 Highly Informative Direct
Biological Process (BP) hydrogen ion transmembrane transport 0 Highly Informative Direct
Molecular Function (MF) transporter activity 0.000000007685 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.00000001595 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.00000000000001064 Informative Direct
Molecular Function (MF) heme-copper terminal oxidase activity 0 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 0 Highly Informative Direct
Cellular Component (CC) membrane 0.0003268 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0002657 Least Informative Direct
Cellular Component (CC) protein complex 0.01392 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.002637 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.002405 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.00000000006986 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.00000000002426 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.0000001435 Informative Direct
Cellular Component (CC) respiratory chain 0.00000000005387 Informative Direct
Cellular Component (CC) respiratory chain complex IV 0.000000000008413 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a heme group of donors0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a heme group of donors0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane0.0000000001058InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Post-translational modificationAcetylation0.0000000000002361Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004203 SSF81406 Protein matches
Abstract Cytochrome c oxidase, a 13 sub-unit complex is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit IV. The Dictyostelium discoideum (Slime mould) member of this family is called COX VI. The Saccharomyces cerevisiae protein YGX6_YEAST appears to be the yeast COX IV subunit.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial cytochrome c oxidase subunit IV domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial cytochrome c oxidase subunit IV superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]