SUPERFAMILY 1.75 HMM library and genome assignments server


Mitochondrial cytochrome c oxidase subunit IV superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Single transmembrane helix [ 81407] (38)
Superfamily:   Mitochondrial cytochrome c oxidase subunit IV [ 81406]
Families:   Mitochondrial cytochrome c oxidase subunit IV [ 81405]


Superfamily statistics
Genomes (366) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 580 740 1
Proteins 580 736 1


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.01850.01211Least InformativeInherited
Biological Process (BP)energy derivation by oxidation of organic compounds0.00015270.0004231InformativeDirect
Biological Process (BP)electron transport chain5.146e-050.0001734Highly InformativeDirect
Molecular Function (MF)transporter activity2.798e-097.582e-09Moderately InformativeDirect
Molecular Function (MF)oxidoreductase activity6.635e-081.519e-08Moderately InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity1.262e-148.887e-13InformativeDirect
Molecular Function (MF)heme-copper terminal oxidase activity00Highly InformativeDirect
Molecular Function (MF)hydrogen ion transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor10Highly InformativeInherited
Cellular Component (CC)membrane3.23e-050.0003121Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00012080.0002537Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00069990.002676Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.00012770.003419Least InformativeInherited
Cellular Component (CC)protein complex0.0019780.0145Least InformativeInherited
Cellular Component (CC)organelle membrane7.379e-086.91e-09Moderately InformativeDirect
Cellular Component (CC)organelle envelope3.376e-096.432e-11Moderately InformativeDirect
Cellular Component (CC)mitochondrial part9.885e-102.208e-11Moderately InformativeDirect
Cellular Component (CC)mitochondrial membrane part8.342e-061.511e-07InformativeDirect
Cellular Component (CC)respiratory chain2.603e-095.478e-11InformativeDirect
Cellular Component (CC)respiratory chain complex IV5.224e-098.768e-12Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.01211 Least Informative Inherited
Biological Process (BP) energy derivation by oxidation of organic compounds 0.0004231 Informative Direct
Biological Process (BP) electron transport chain 0.0001734 Highly Informative Direct
Molecular Function (MF) transporter activity 7.582e-09 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 1.519e-08 Moderately Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 8.887e-13 Informative Direct
Molecular Function (MF) heme-copper terminal oxidase activity 0 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 0 Highly Informative Direct
Cellular Component (CC) membrane 0.0003121 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0002537 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.002676 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.003419 Least Informative Inherited
Cellular Component (CC) protein complex 0.0145 Least Informative Inherited
Cellular Component (CC) organelle membrane 6.91e-09 Moderately Informative Direct
Cellular Component (CC) organelle envelope 6.432e-11 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 2.208e-11 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 1.511e-07 Informative Direct
Cellular Component (CC) respiratory chain 5.478e-11 Informative Direct
Cellular Component (CC) respiratory chain complex IV 8.768e-12 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a heme group of donors0Highly InformativeDirect

Document: EC annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on a heme group of donors0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion inner membrane1.096e-10InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Post-translational modificationAcetylation2.343e-13Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004203 SSF81406 Protein matches
Abstract Cytochrome c oxidase, a 13 sub-unit complex is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit IV. The Dictyostelium discoideum (Slime mould) member of this family is called COX VI. The Saccharomyces cerevisiae protein YGX6_YEAST appears to be the yeast COX IV subunit.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial cytochrome c oxidase subunit IV domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial cytochrome c oxidase subunit IV superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Yeast Phenotype (YP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]