SUPERFAMILY 1.75 HMM library and genome assignments server

Transmembrane di-heme cytochromes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Heme-binding four-helical bundle [ 81344] (3)
Superfamily:   Transmembrane di-heme cytochromes [ 81342] (2)
Families:   Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [ 81642] (2)
  Formate dehydrogenase N, cytochrome (gamma) subunit [ 75645]


Superfamily statistics
Genomes (1,902) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,448 167,695 8
Proteins 6,446 167,592 8


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.2050.05303Least InformativeInherited
Biological Process (BP)oxidation-reduction process0.00016560.0000000009841Moderately InformativeDirect
Molecular Function (MF)electron carrier activity0.0000000000060740InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.9985 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.05303 Least Informative Inherited
Biological Process (BP) localization 0.1174 Least Informative Inherited
Biological Process (BP) ion transport 0.00009097 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000000009841 Moderately Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.00000001052 Informative Direct
Biological Process (BP) energy derivation by oxidation of organic compounds 0.000000003528 Informative Direct
Biological Process (BP) ion transmembrane transport 0.002833 Informative Inherited
Biological Process (BP) electron transport chain 0.00000000676 Highly Informative Direct
Biological Process (BP) hydrogen ion transmembrane transport 0.00007165 Highly Informative Direct
Molecular Function (MF) transporter activity 0.0007344 Moderately Informative Direct
Molecular Function (MF) oxidoreductase activity 0.000003357 Moderately Informative Direct
Molecular Function (MF) electron carrier activity 0 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.00000009838 Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0.0000000003482 Highly Informative Direct
Cellular Component (CC) protein complex 0.01001 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.0431 Least Informative Inherited
Cellular Component (CC) membrane 0.03786 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.9745 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00518 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.000719 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.001195 Moderately Informative Inherited
Cellular Component (CC) oxidoreductase complex 0.0000000002985 Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processElectron transport0InformativeDirect
Biological processPhotosynthesis0InformativeDirect
Biological processRespiratory chain0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentThylakoid0InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Coding sequence diversityRNA editing0.00000002797Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionHeme0InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transmembrane di-heme cytochromes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transmembrane di-heme cytochromes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]