SUPERFAMILY 1.75 HMM library and genome assignments server

Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,146) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,919 27,911 8
Proteins 8,799 27,859 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000035010.000831Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.82971Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.82441Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.16471Least InformativeInherited
Biological Process (BP)regulation of cellular process0.99711Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000000048190.02695Least InformativeInherited
Biological Process (BP)developmental process0.00005840.8064Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0085730.6838Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.56121Least InformativeInherited
Biological Process (BP)biosynthetic process0.13810.3448Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.72071Least InformativeInherited
Biological Process (BP)response to abiotic stimulus0.00000076610.0000003038Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00000059550.0002152Moderately InformativeDirect
Biological Process (BP)regulation of biological quality0.00000000088940.0000004219Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000027060.00005878Moderately InformativeDirect
Biological Process (BP)carbohydrate derivative metabolic process0.028830.1221Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.030110.07836Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0023060.002444Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0021160.01171Moderately InformativeInherited
Biological Process (BP)response to organic substance0.074710.8585Moderately InformativeInherited
Biological Process (BP)response to external stimulus0.0012050.03283Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.19120.2511Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0040750.07158Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.16521Moderately InformativeInherited
Biological Process (BP)regulation of localization0.001240.04141Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.049770.09924Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0015690.4293Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0019430.3238Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00032390.01236Moderately InformativeInherited
Biological Process (BP)single-organism organelle organization0.096530.9378Moderately InformativeInherited
Biological Process (BP)nervous system development0.85131Moderately InformativeInherited
Biological Process (BP)organ development0.0000011330.004424Moderately InformativeInherited
Biological Process (BP)organic substance transport0.82670.2469Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.018180.08193Moderately InformativeInherited
Biological Process (BP)ion transport11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.019110.1374Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.42150.9768Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.021130.1391Moderately InformativeInherited
Biological Process (BP)response to acid chemical0.00000000025240.00000000004355InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.0000011080.000008303InformativeDirect
Biological Process (BP)response to inorganic substance0.00000042650.00000000005728InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.00000000088650InformativeDirect
Biological Process (BP)response to lipid0.000002790.000002945InformativeDirect
Biological Process (BP)regulation of system process0.0000029410.00003198InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.0000000018990.0000001101InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00000000000013910InformativeDirect
Biological Process (BP)regulation of secretion0.00063530.000856InformativeDirect
Biological Process (BP)positive regulation of transport0.0000014870.0001528InformativeDirect
Biological Process (BP)cellular response to external stimulus0.00000013990.00000000006046InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000000034330.000000186InformativeDirect
Biological Process (BP)ion transmembrane transport0.92241InformativeInherited
Biological Process (BP)metal ion transport0.000036990.006272InformativeInherited
Biological Process (BP)response to organonitrogen compound0.011780.08872InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.000019380.001688InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.0072860.004265InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.040510.1408InformativeInherited
Biological Process (BP)response to oxidative stress0.025680.04175InformativeInherited
Biological Process (BP)response to organic cyclic compound0.0045740.0187InformativeInherited
Biological Process (BP)regulation of cell proliferation0.00063490.06386InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0001440.0453InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.00022110.003564InformativeInherited
Biological Process (BP)positive regulation of developmental process0.000021310.01346InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0020790.01554InformativeInherited
Biological Process (BP)sensory organ development0.000064540.001511InformativeInherited
Biological Process (BP)nitrogen compound transport0.0085790.0001148InformativeInherited
Biological Process (BP)actin filament-based process0.000053720.005484InformativeInherited
Biological Process (BP)cytoskeleton organization0.069060.206InformativeInherited
Biological Process (BP)central nervous system development0.01130.03626InformativeInherited
Biological Process (BP)anion transport0.0066930.00001876InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.020370.1621InformativeInherited
Biological Process (BP)response to nutrient levels0.78090.7412InformativeInherited
Biological Process (BP)response to light stimulus0.00000056890.1981InformativeInherited
Biological Process (BP)response to hypoxia0.0000074540.0001182Highly InformativeDirect
Biological Process (BP)calcium ion transport0.0000019970.00006985Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.00000013990.00009051Highly InformativeDirect
Biological Process (BP)digestion0.000000046020.000000006013Highly InformativeDirect
Biological Process (BP)carbohydrate transport0.0000000014480Highly InformativeDirect
Biological Process (BP)response to UV0.000000000056510.00000001182Highly InformativeDirect
Biological Process (BP)response to water deprivation0.000035870.000000006442Highly InformativeDirect
Biological Process (BP)response to purine-containing compound0.0000000034920.00000005183Highly InformativeDirect
Biological Process (BP)gas transport0.0000010450.0000000000004894Highly InformativeDirect
Biological Process (BP)inorganic anion transport0.000036270.000005493Highly InformativeDirect
Biological Process (BP)one-carbon compound transport00Highly InformativeDirect
Biological Process (BP)telencephalon development0.00000013320.000000177Highly InformativeDirect
Biological Process (BP)secretion by tissue0.0000037980.000003367Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.000057440.000003729Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism0.00000092180.00000915Highly InformativeDirect
Biological Process (BP)amide transport0.00000018110.00000005789Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.00000038990.00003928Highly InformativeDirect
Biological Process (BP)positive regulation of angiogenesis0.00000000010340.0000000009177Highly InformativeDirect
Biological Process (BP)response to glucocorticoid0.00000000010340.000000000008078Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.000000032510.000000001651Highly InformativeDirect
Biological Process (BP)cellular response to radiation0.000034610.00006155Highly InformativeDirect
Biological Process (BP)response to alcohol0.00000054010.000002708Highly InformativeDirect
Biological Process (BP)response to transition metal nanoparticle0.0000025830.0000005692Highly InformativeDirect
Biological Process (BP)anion transmembrane transport0.021060.001807Highly InformativeInherited
Biological Process (BP)response to salt stress0.24050.1632Highly InformativeInherited
Biological Process (BP)cellular response to acid chemical0.00027830.001703Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.025980.03173Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.024950.08137Highly InformativeInherited
Biological Process (BP)response to carbohydrate0.12050.02017Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1411Highly InformativeInherited
Molecular Function (MF)binding0.96231Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity00.00000000000001064InformativeDirect
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.0000000000092560.000000001388InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.026580.6818InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)inorganic anion transmembrane transporter activity0.00000083720.0000005016Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity0.00011168.141e-16Highly InformativeDirect
Molecular Function (MF)gated channel activity11Highly InformativeInherited
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0015710.000000008064Highly InformativeInherited
Molecular Function (MF)cation channel activity0.0000020090.03193Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.84730.5352Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.060320.6159Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.026080.4679Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00015870.000902Moderately InformativeDirect
Cellular Component (CC)plasma membrane part00Moderately InformativeDirect
Cellular Component (CC)membrane region0.000000000018940.0000000001963Moderately InformativeDirect
Cellular Component (CC)cell projection0.000057880.001087Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle0.4180.6862Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0021090.0002031Moderately InformativeInherited
Cellular Component (CC)nuclear part0.049990.8388Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.0000080380.00001494InformativeDirect
Cellular Component (CC)cell junction0.000084490.00002439InformativeDirect
Cellular Component (CC)vacuolar part0.0000028720.00005295InformativeDirect
Cellular Component (CC)plasma membrane region00InformativeDirect
Cellular Component (CC)plastid0.0019340.0001296InformativeInherited
Cellular Component (CC)brush border0.00000000017340.000000001292Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane0.0000000000071750.0000000002325Highly InformativeDirect
Cellular Component (CC)apical plasma membrane00Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.0000000036320.00000001006Highly InformativeDirect
Cellular Component (CC)sarcolemma0.000023870.0007108Highly InformativeDirect
Cellular Component (CC)symplast0.000021750.000004988Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.040070.004287Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000831 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02695 Least Informative Inherited
Biological Process (BP) developmental process 0.8064 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6838 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3448 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.0000003038 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002152 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000004219 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00005878 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.1221 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07836 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002444 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01171 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.03283 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.2511 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.07158 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8585 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04141 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.09924 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4293 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3238 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01236 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.9378 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.004424 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2469 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.08193 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1374 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9768 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1391 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.07721 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.5611 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9998 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.04071 Moderately Informative Inherited
Biological Process (BP) response to acid chemical 0.00000000004355 Informative Direct
Biological Process (BP) anion transport 0.00001876 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.000008303 Informative Direct
Biological Process (BP) response to inorganic substance 0.00000000005728 Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Informative Direct
Biological Process (BP) response to lipid 0.000002945 Informative Direct
Biological Process (BP) regulation of system process 0.00003198 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0000001101 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of secretion 0.000856 Informative Direct
Biological Process (BP) positive regulation of transport 0.0001528 Informative Direct
Biological Process (BP) cellular response to external stimulus 0.00000000006046 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0001148 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000000186 Informative Direct
Biological Process (BP) ion transmembrane transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.006272 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.08872 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001688 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.004265 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1408 Informative Inherited
Biological Process (BP) response to oxidative stress 0.04175 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.0187 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.06386 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.0453 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.003564 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.01346 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01554 Informative Inherited
Biological Process (BP) sensory organ development 0.001511 Informative Inherited
Biological Process (BP) actin filament-based process 0.005484 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.206 Informative Inherited
Biological Process (BP) central nervous system development 0.03626 Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.1621 Informative Inherited
Biological Process (BP) response to nutrient levels 0.7412 Informative Inherited
Biological Process (BP) response to light stimulus 0.1981 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001803 Informative Inherited
Biological Process (BP) response to hypoxia 0.0001182 Highly Informative Direct
Biological Process (BP) glycolytic process 0.00000863 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00006985 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00009051 Highly Informative Direct
Biological Process (BP) digestion 0.000000006013 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) response to UV 0.00000001182 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.000000006442 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000005183 Highly Informative Direct
Biological Process (BP) gas transport 0.0000000000004894 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0.000005493 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 0.000000177 Highly Informative Direct
Biological Process (BP) secretion by tissue 0.000003367 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000003729 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.00000915 Highly Informative Direct
Biological Process (BP) amide transport 0.00000005789 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.00003928 Highly Informative Direct
Biological Process (BP) positive regulation of angiogenesis 0.0000000009177 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.000000000008078 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.000000001651 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.00006155 Highly Informative Direct
Biological Process (BP) response to alcohol 0.000002708 Highly Informative Direct
Biological Process (BP) response to transition metal nanoparticle 0.0000005692 Highly Informative Direct
Biological Process (BP) anion transmembrane transport 0.001807 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.1632 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.001703 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.03173 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.08137 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.02017 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1411 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.00000000000001064 Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.000000001388 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.6818 Informative Inherited
Molecular Function (MF) organic cation transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) inorganic anion transmembrane transporter activity 0.0000005016 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0.000000008064 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 8.141e-16 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.03193 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.5352 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6159 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.4679 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000902 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0002031 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) membrane region 0.0000000001963 Moderately Informative Direct
Cellular Component (CC) cell projection 0.001087 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.6862 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.8388 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.00001494 Informative Direct
Cellular Component (CC) plastid 0.0001296 Informative Direct
Cellular Component (CC) cell junction 0.00002439 Informative Direct
Cellular Component (CC) vacuolar part 0.00005295 Informative Direct
Cellular Component (CC) plasma membrane region 0 Informative Direct
Cellular Component (CC) brush border 0.000000001292 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.0000000002325 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.00000001006 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0007108 Highly Informative Direct
Cellular Component (CC) symplast 0.000004988 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.004287 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1762Least InformativeInherited
Disease Ontology (DO)sensory system disease0.000359Moderately InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0004504InformativeDirect
Disease Ontology (DO)auditory system disease0.002591InformativeInherited
Disease Ontology (DO)labyrinthine disease0.0000000006413Highly InformativeDirect
Disease Ontology (DO)colonic disease0.0007112Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0009781Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0003241Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.00009515InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.005523InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1183InformativeInherited
Mammalian Phenotype (MP)polyuria0.00000004386Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000004628Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0009433Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007885Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6617Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9348Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.000008144InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0007892InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008458InformativeDirect
Plant ANatomical entity (PAN)lateral root0.00001032Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001294Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05303Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle9.641e-16Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000005625Moderately InformativeDirect
Cellular componentCell junction0.00005047Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000005925Least InformativeDirect
Post-translational modificationAcetylation0.0002665Least InformativeDirect
Post-translational modificationGlycoprotein0.0004633Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]