SUPERFAMILY 1.75 HMM library and genome assignments server


Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,465 27,911 8
Proteins 8,374 27,859 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus0.000017430.0002878Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)biosynthetic process0.11380.2882Least InformativeInherited
Biological Process (BP)single-organism cellular process0.13020.9726Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.76161Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.48731Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.75991Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.64661Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.78440.8959Least InformativeInherited
Biological Process (BP)regulation of cellular process0.9551Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0051630.5192Least InformativeInherited
Biological Process (BP)multicellular organismal process0.000000060350.03147Least InformativeInherited
Biological Process (BP)developmental process0.000039050.6298Least InformativeInherited
Biological Process (BP)system process0.00000000052290.0000000000001012Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus0.00000072490.0000002528Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.00000040190.0001444Moderately InformativeDirect
Biological Process (BP)homeostatic process0.000013930.0000104Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.000024930.00004989Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0012990.3706Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.01750.08603Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0021450.01043Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.030420.07282Moderately InformativeInherited
Biological Process (BP)response to organic substance0.059630.8025Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00080730.02748Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.091521Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0320.07074Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.32990.9689Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.01040.04596Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00014550.003054Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0025210.4827Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.14071Moderately InformativeInherited
Biological Process (BP)organelle organization0.075250.4417Moderately InformativeInherited
Biological Process (BP)nervous system development0.82320.9218Moderately InformativeInherited
Biological Process (BP)organic substance transport0.92040.3569Moderately InformativeInherited
Biological Process (BP)ion transport0.54070.7835Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0015420.001653Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.015460.1054Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0027610.05154Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.013260.1028Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.013230.05963Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.77811Moderately InformativeInherited
Biological Process (BP)organ development0.0000013180.003409Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.00000073130.000005717InformativeDirect
Biological Process (BP)response to hormone stimulus0.0000490.0001344InformativeDirect
Biological Process (BP)response to inorganic substance0.00000041580.00000000005392InformativeDirect
Biological Process (BP)response to lipid0.0000024920.000002787InformativeDirect
Biological Process (BP)regulation of system process0.000067340.0006541InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.0000000026950.0000001306InformativeDirect
Biological Process (BP)regulation of body fluid levels0.00000000000012290InformativeDirect
Biological Process (BP)regulation of secretion0.00042250.0007546InformativeDirect
Biological Process (BP)positive regulation of transport0.00000049720.00007073InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.00000056750.0005255InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.000000047150.0000001369InformativeDirect
Biological Process (BP)metal ion transport0.00067380.04431InformativeInherited
Biological Process (BP)response to organic cyclic compound0.0056470.02004InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.28410.4248InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.038140.1366InformativeInherited
Biological Process (BP)cellular response to nitrogen compound0.000018730.001702InformativeInherited
Biological Process (BP)response to organonitrogen compound0.014720.09842InformativeInherited
Biological Process (BP)response to oxidative stress0.026340.03528InformativeInherited
Biological Process (BP)regulation of cell proliferation0.00055550.0529InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.00007550.001842InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0023490.0137InformativeInherited
Biological Process (BP)positive regulation of developmental process0.0000077090.006103InformativeInherited
Biological Process (BP)negative regulation of cell death0.000026440.001396InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00057760.03062InformativeInherited
Biological Process (BP)nitrogen compound transport0.013240.0002215InformativeInherited
Biological Process (BP)central nervous system development0.0091810.03982InformativeInherited
Biological Process (BP)cytoskeleton organization0.084070.2479InformativeInherited
Biological Process (BP)actin filament-based process0.00073730.01372InformativeInherited
Biological Process (BP)anion transport0.094170.0003991InformativeInherited
Biological Process (BP)response to nutrient levels0.75140.7147InformativeInherited
Biological Process (BP)response to light stimulus0.00000053450.2026InformativeInherited
Biological Process (BP)sensory organ development0.00016060.002781InformativeInherited
Biological Process (BP)response to hypoxia0.0000034780.00006243Highly InformativeDirect
Biological Process (BP)calcium ion transport0.0000027110.00007324Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity0.000002180.0002687Highly InformativeDirect
Biological Process (BP)digestion0.00000004050.000000004579Highly InformativeDirect
Biological Process (BP)carbohydrate transport0.00000000022790Highly InformativeDirect
Biological Process (BP)purine ribonucleotide biosynthetic process0.00000000016890.000000007342Highly InformativeDirect
Biological Process (BP)response to UV0.00000000004040.000000007538Highly InformativeDirect
Biological Process (BP)response to water deprivation0.000043210.000000006985Highly InformativeDirect
Biological Process (BP)response to purine-containing compound0.0000000039430.00000004363Highly InformativeDirect
Biological Process (BP)gas transport0.00000016450.00000000000008236Highly InformativeDirect
Biological Process (BP)inorganic anion transport0.00003640.0000005523Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport0.000000000010990Highly InformativeDirect
Biological Process (BP)one-carbon compound transport00Highly InformativeDirect
Biological Process (BP)telencephalon development0.000000075980.0000001428Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species0.000056360.000003221Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism0.00000062270.00001132Highly InformativeDirect
Biological Process (BP)amide transport0.000000056850.00000001638Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process0.0000090010.0005126Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.000000065190.00001421Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis0.00000000078070.00000006554Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus0.000000032660.000000001007Highly InformativeDirect
Biological Process (BP)cellular response to radiation0.000028180.0000428Highly InformativeDirect
Biological Process (BP)cellular response to alcohol0.00023110.00002897Highly InformativeDirect
Biological Process (BP)ion transmembrane transport0.27861Highly InformativeInherited
Biological Process (BP)response to corticosteroid stimulus0.011960.0004357Highly InformativeInherited
Biological Process (BP)response to salt stress0.23210.1467Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.031520.02936Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.025460.08261Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.015820.1746Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.1540.01359Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.12030.06451Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1411Highly InformativeInherited
Molecular Function (MF)binding0.90441Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity00.00000000000007724InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.00046730.1416InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity0.000000011310.1494InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity6.754e-160.000000000000038Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity0.000059370Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0012480.0000000166Highly InformativeInherited
Molecular Function (MF)cation channel activity0.00000020320.005512Highly InformativeInherited
Molecular Function (MF)ion gated channel activity0.0000071990.7406Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.89780.4309Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.1330.6053Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.044520.2702Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00015770.0006931Moderately InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0022790.002718Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0025850.0001821Moderately InformativeInherited
Cellular Component (CC)nuclear part0.044930.9224Moderately InformativeInherited
Cellular Component (CC)cell projection0.000041140.001615Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.025010.005907Moderately InformativeInherited
Cellular Component (CC)nuclear envelope0.00000015850.000002778InformativeDirect
Cellular Component (CC)vacuolar part0.0000035040.00005171InformativeDirect
Cellular Component (CC)plastid0.0021360.0001051InformativeInherited
Cellular Component (CC)brush border0.0000000003140.000000001231Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane0.000049360.00002331Highly InformativeDirect
Cellular Component (CC)apical plasma membrane0.0000000000000014860.000000000000001608Highly InformativeDirect
Cellular Component (CC)nuclear membrane0.0000000029610.000000006135Highly InformativeDirect
Cellular Component (CC)symplast0.000018820.000003877Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.043970.009744Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0002878 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.2882 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9726 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8959 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5192 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03147 Least Informative Inherited
Biological Process (BP) developmental process 0.6298 Least Informative Inherited
Biological Process (BP) system process 0.0000000000001012 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.0000002528 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0001444 Moderately Informative Direct
Biological Process (BP) homeostatic process 0.0000104 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00004989 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3706 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.08603 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01043 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07282 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8025 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02748 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.06541 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9667 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.07074 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9689 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.04596 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.003054 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4827 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4417 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9218 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3569 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7835 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001653 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1054 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.05154 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1028 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05963 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.003409 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0003991 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.000005717 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001344 Informative Direct
Biological Process (BP) response to inorganic substance 0.00000000005392 Informative Direct
Biological Process (BP) hexose metabolic process 0.0008092 Informative Direct
Biological Process (BP) response to lipid 0.000002787 Informative Direct
Biological Process (BP) regulation of system process 0.0006541 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0000001306 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of secretion 0.0007546 Informative Direct
Biological Process (BP) positive regulation of transport 0.00007073 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0005255 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0002215 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.0000001369 Informative Direct
Biological Process (BP) metal ion transport 0.04431 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02004 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4248 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1366 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001702 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09842 Informative Inherited
Biological Process (BP) response to oxidative stress 0.03528 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0529 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.001842 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0137 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.006103 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001396 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.03062 Informative Inherited
Biological Process (BP) central nervous system development 0.03982 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.2479 Informative Inherited
Biological Process (BP) actin filament-based process 0.01372 Informative Inherited
Biological Process (BP) response to nutrient levels 0.7147 Informative Inherited
Biological Process (BP) response to light stimulus 0.2026 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001553 Informative Inherited
Biological Process (BP) sensory organ development 0.002781 Informative Inherited
Biological Process (BP) response to hypoxia 0.00006243 Highly Informative Direct
Biological Process (BP) glycolysis 0.0001901 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.00007324 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002687 Highly Informative Direct
Biological Process (BP) digestion 0.000000004579 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 0.000000007342 Highly Informative Direct
Biological Process (BP) response to UV 0.000000007538 Highly Informative Direct
Biological Process (BP) response to water deprivation 0.000000006985 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 0.00000004363 Highly Informative Direct
Biological Process (BP) gas transport 0.00000000000008236 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0.0000005523 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0000001428 Highly Informative Direct
Biological Process (BP) response to corticosteroid stimulus 0.0004357 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000003221 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 0.00001132 Highly Informative Direct
Biological Process (BP) amide transport 0.00000001638 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0005126 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.00001421 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.00000006554 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 0.000000001007 Highly Informative Direct
Biological Process (BP) cellular response to radiation 0.0000428 Highly Informative Direct
Biological Process (BP) cellular response to alcohol 0.00002897 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.1467 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.02936 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.08261 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.1746 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.01359 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.06451 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1411 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.00000000000007724 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.1416 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1494 Informative Inherited
Molecular Function (MF) organic cation transmembrane transporter activity 0.000000000000038 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 0.0000000166 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.005512 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.7406 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.4309 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6053 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2702 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0006931 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0001821 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.002718 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9224 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001615 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.005907 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 0.000002778 Informative Direct
Cellular Component (CC) plastid 0.0001051 Informative Direct
Cellular Component (CC) vacuolar part 0.00005171 Informative Direct
Cellular Component (CC) brush border 0.000000001231 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 0.00002331 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0.000000000000001608 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000000006135 Highly Informative Direct
Cellular Component (CC) symplast 0.000003877 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.009744 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.3017Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0008943Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.003219Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.0002276InformativeDirect
Disease Ontology (DO)auditory system disease0.005461InformativeInherited
Disease Ontology (DO)colonic disease0.0007963Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0009617Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0003419Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03276Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.0001032InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.005543InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1178InformativeInherited
Mammalian Phenotype (MP)polyuria0.0000000461Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality0.0000004797Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0009658Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007885Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6617Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9348Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.000008144InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0007892InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008458InformativeDirect
Plant ANatomical entity (PAN)lateral root0.00001032Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001294Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05303Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle9.618e-16Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000005427Moderately InformativeDirect
Cellular componentCell junction0.00005068Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein0.0000005904Least InformativeDirect
Post-translational modificationAcetylation0.0002442Least InformativeDirect
Post-translational modificationGlycoprotein0.0004703Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]