SUPERFAMILY 1.75 HMM library and genome assignments server


Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,869 27,911 8
Proteins 8,766 27,859 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus3.584e-050.0007859Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)biosynthetic process0.13840.3426Least InformativeInherited
Biological Process (BP)single-organism cellular process0.12590.9662Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.79491Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.52461Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.80191Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.68891Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.83570.9528Least InformativeInherited
Biological Process (BP)regulation of cellular process0.97141Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0074940.6132Least InformativeInherited
Biological Process (BP)multicellular organismal process9.509e-080.04917Least InformativeInherited
Biological Process (BP)developmental process5.489e-050.8063Least InformativeInherited
Biological Process (BP)system process5.189e-101.205e-12Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus7.488e-072.834e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus5.166e-070.0002041Moderately InformativeDirect
Biological Process (BP)regulation of biological quality9.445e-104.574e-07Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound2.162e-054.637e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0013550.4131Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.021450.1011Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0020770.01016Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.027720.07427Moderately InformativeInherited
Biological Process (BP)response to organic substance0.065470.8376Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00098420.03513Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.10271Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.039090.08341Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.36110.9694Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.013240.05514Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00027860.005288Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0028680.3891Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.15251Moderately InformativeInherited
Biological Process (BP)organelle organization0.073320.4455Moderately InformativeInherited
Biological Process (BP)nervous system development0.81740.9922Moderately InformativeInherited
Biological Process (BP)organic substance transport0.91310.3498Moderately InformativeInherited
Biological Process (BP)ion transport0.43590.6938Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0021330.00236Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.018510.1221Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0033690.06108Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.016440.1201Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0160.07132Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.77411Moderately InformativeInherited
Biological Process (BP)organ development1.416e-060.004887Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process1.1e-068.375e-06InformativeDirect
Biological Process (BP)response to hormone stimulus5.981e-050.0001593InformativeDirect
Biological Process (BP)response to inorganic substance4.057e-075.174e-11InformativeDirect
Biological Process (BP)response to lipid2.204e-062.581e-06InformativeDirect
Biological Process (BP)regulation of system process7.651e-050.0008509InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process2.775e-091.511e-07InformativeDirect
Biological Process (BP)regulation of body fluid levels1.259e-130InformativeDirect
Biological Process (BP)regulation of secretion0.00054010.0007935InformativeDirect
Biological Process (BP)positive regulation of transport6.219e-079.563e-05InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process6.331e-070.0006325InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process4.481e-081.865e-07InformativeDirect
Biological Process (BP)metal ion transport0.00065180.04616InformativeInherited
Biological Process (BP)response to organic cyclic compound0.0049170.0188InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.2530.3847InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.038990.135InformativeInherited
Biological Process (BP)cellular response to nitrogen compound1.962e-050.001622InformativeInherited
Biological Process (BP)response to organonitrogen compound0.012890.09186InformativeInherited
Biological Process (BP)response to oxidative stress0.025170.03686InformativeInherited
Biological Process (BP)regulation of cell proliferation0.00060030.06035InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process9.229e-050.002177InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.002150.01587InformativeInherited
Biological Process (BP)positive regulation of developmental process7.957e-060.006801InformativeInherited
Biological Process (BP)regulation of apoptotic process0.0006730.0371InformativeInherited
Biological Process (BP)negative regulation of cell death3.371e-050.001829InformativeInherited
Biological Process (BP)nitrogen compound transport0.012030.0002108InformativeInherited
Biological Process (BP)central nervous system development0.0089290.03272InformativeInherited
Biological Process (BP)cytoskeleton organization0.083730.2522InformativeInherited
Biological Process (BP)actin filament-based process0.00076330.01455InformativeInherited
Biological Process (BP)anion transport0.033937.674e-05InformativeInherited
Biological Process (BP)response to nutrient levels0.77070.726InformativeInherited
Biological Process (BP)response to light stimulus5.798e-070.2034InformativeInherited
Biological Process (BP)sensory organ development0.00016540.002676InformativeInherited
Biological Process (BP)response to hypoxia5.929e-068.021e-05Highly InformativeDirect
Biological Process (BP)calcium ion transport2.805e-068.638e-05Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity1.867e-060.0002581Highly InformativeDirect
Biological Process (BP)digestion3.843e-084.547e-09Highly InformativeDirect
Biological Process (BP)carbohydrate transport1.719e-100Highly InformativeDirect
Biological Process (BP)purine ribonucleotide biosynthetic process2.278e-101.035e-08Highly InformativeDirect
Biological Process (BP)response to UV4.631e-119.555e-09Highly InformativeDirect
Biological Process (BP)response to water deprivation3.608e-055.957e-09Highly InformativeDirect
Biological Process (BP)response to purine-containing compound3.687e-095.615e-08Highly InformativeDirect
Biological Process (BP)gas transport3.608e-071.85e-13Highly InformativeDirect
Biological Process (BP)inorganic anion transport4.698e-058.232e-07Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport9.503e-120Highly InformativeDirect
Biological Process (BP)one-carbon compound transport00Highly InformativeDirect
Biological Process (BP)telencephalon development7.042e-081.305e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species5.907e-053.455e-06Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism1.343e-061.392e-05Highly InformativeDirect
Biological Process (BP)amide transport5.296e-081.569e-08Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process1.144e-050.0006637Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism4.333e-073.403e-05Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis8.201e-108.132e-08Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus8.776e-116.874e-12Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus2.966e-081.541e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation2.46e-054.021e-05Highly InformativeDirect
Biological Process (BP)response to alcohol5.346e-072.533e-06Highly InformativeDirect
Biological Process (BP)response to salt stress0.24730.166Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.025990.03018Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.023190.08082Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.0011470.03817Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.16630.01548Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.12170.02005Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1402Highly InformativeInherited
Molecular Function (MF)binding0.95471Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity07.513e-15InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.0046310.4052InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity7.93e-110.1012InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity5.78e-050Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0010662.685e-09Highly InformativeInherited
Molecular Function (MF)cation channel activity1.849e-060.03019Highly InformativeInherited
Molecular Function (MF)ion gated channel activity1.86e-050.8506Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.91320.5242Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.13160.652Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.040460.3262Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00016910.000881Moderately InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection3.956e-050.0007221Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0019680.002479Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0024630.0002068Moderately InformativeInherited
Cellular Component (CC)nuclear part0.044060.9355Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.021190.005165Moderately InformativeInherited
Cellular Component (CC)nuclear envelope1.548e-073.348e-06InformativeDirect
Cellular Component (CC)cell junction8.221e-052.534e-05InformativeDirect
Cellular Component (CC)vacuolar part3.495e-066.111e-05InformativeDirect
Cellular Component (CC)plastid0.0020550.0001325InformativeInherited
Cellular Component (CC)brush border2.55e-101.896e-09Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane4.855e-059.461e-06Highly InformativeDirect
Cellular Component (CC)apical plasma membrane1.454e-151.594e-15Highly InformativeDirect
Cellular Component (CC)nuclear membrane2.836e-096.305e-09Highly InformativeDirect
Cellular Component (CC)sarcolemma2.937e-050.0008826Highly InformativeDirect
Cellular Component (CC)symplast2.214e-055.132e-06Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.044790.005546Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0007859 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.3426 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9662 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9528 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6132 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.04917 Least Informative Inherited
Biological Process (BP) developmental process 0.8063 Least Informative Inherited
Biological Process (BP) system process 1.205e-12 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 2.834e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002041 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 4.574e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 4.637e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.4131 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1011 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01016 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07427 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8376 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.03513 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.07449 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.08341 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9694 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.05514 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.005288 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3891 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4455 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9922 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3498 Moderately Informative Inherited
Biological Process (BP) ion transport 0.6938 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.00236 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1221 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.06108 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1201 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.07132 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.004887 Moderately Informative Inherited
Biological Process (BP) anion transport 7.674e-05 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 8.375e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001593 Informative Direct
Biological Process (BP) response to inorganic substance 5.174e-11 Informative Direct
Biological Process (BP) hexose metabolic process 0.0009088 Informative Direct
Biological Process (BP) response to lipid 2.581e-06 Informative Direct
Biological Process (BP) regulation of system process 0.0008509 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.511e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of secretion 0.0007935 Informative Direct
Biological Process (BP) positive regulation of transport 9.563e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0006325 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0002108 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.865e-07 Informative Direct
Biological Process (BP) metal ion transport 0.04616 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.0188 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.3847 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.135 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001622 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09186 Informative Inherited
Biological Process (BP) response to oxidative stress 0.03686 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.06035 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.002177 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01587 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.006801 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.0371 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001829 Informative Inherited
Biological Process (BP) central nervous system development 0.03272 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.2522 Informative Inherited
Biological Process (BP) actin filament-based process 0.01455 Informative Inherited
Biological Process (BP) response to nutrient levels 0.726 Informative Inherited
Biological Process (BP) response to light stimulus 0.2034 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001752 Informative Inherited
Biological Process (BP) sensory organ development 0.002676 Informative Inherited
Biological Process (BP) response to hypoxia 8.021e-05 Highly Informative Direct
Biological Process (BP) glycolysis 0.0001817 Highly Informative Direct
Biological Process (BP) calcium ion transport 8.638e-05 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002581 Highly Informative Direct
Biological Process (BP) digestion 4.547e-09 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 1.035e-08 Highly Informative Direct
Biological Process (BP) response to UV 9.555e-09 Highly Informative Direct
Biological Process (BP) response to water deprivation 5.957e-09 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 5.615e-08 Highly Informative Direct
Biological Process (BP) gas transport 1.85e-13 Highly Informative Direct
Biological Process (BP) inorganic anion transport 8.232e-07 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 1.305e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 3.455e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.392e-05 Highly Informative Direct
Biological Process (BP) amide transport 1.569e-08 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0006637 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 3.403e-05 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 8.132e-08 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 6.874e-12 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 1.541e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.021e-05 Highly Informative Direct
Biological Process (BP) response to alcohol 2.533e-06 Highly Informative Direct
Biological Process (BP) response to salt stress 0.166 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.03018 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.08082 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.03817 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.01548 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.02005 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1402 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 7.513e-15 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.4052 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1012 Informative Inherited
Molecular Function (MF) organic cation transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 2.685e-09 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.03019 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.8506 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.5242 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.652 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3262 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000881 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0002068 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0007221 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.002479 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9355 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.005165 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 3.348e-06 Informative Direct
Cellular Component (CC) plastid 0.0001325 Informative Direct
Cellular Component (CC) cell junction 2.534e-05 Informative Direct
Cellular Component (CC) vacuolar part 6.111e-05 Informative Direct
Cellular Component (CC) brush border 1.896e-09 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 9.461e-06 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.594e-15 Highly Informative Direct
Cellular Component (CC) nuclear membrane 6.305e-09 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0008826 Highly Informative Direct
Cellular Component (CC) symplast 5.132e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.005546 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1948Least InformativeInherited
Disease Ontology (DO)sensory system disease0.0007075Moderately InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0004525InformativeDirect
Disease Ontology (DO)auditory system disease0.001437InformativeInherited
Disease Ontology (DO)labyrinthine disease6.402e-10Highly InformativeDirect
Disease Ontology (DO)colonic disease0.0007183Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0009535Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.000328Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03303Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis9.925e-05InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.005941InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1184InformativeInherited
Mammalian Phenotype (MP)polyuria4.414e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.661e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0009458Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007885Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6617Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9348Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue8.144e-06InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0007892InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008458InformativeDirect
Plant ANatomical entity (PAN)lateral root1.032e-05Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001294Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05303Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle9.63e-16Moderately InformativeDirect
Cellular componentGolgi apparatus5.339e-08Moderately InformativeDirect
Cellular componentCell junction5.023e-05Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein5.694e-07Least InformativeDirect
Post-translational modificationAcetylation0.0002645Least InformativeDirect
Post-translational modificationGlycoprotein0.0004436Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]