SUPERFAMILY 1.75 HMM library and genome assignments server


Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,144) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,869 27,911 8
Proteins 8,766 27,859 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus2.684e-050.0005493Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)biosynthetic process0.11740.3084Least InformativeInherited
Biological Process (BP)single-organism cellular process0.13360.976Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.77051Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.49671Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.77261Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.65721Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.7930.9188Least InformativeInherited
Biological Process (BP)regulation of cellular process0.96181Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0067590.5863Least InformativeInherited
Biological Process (BP)multicellular organismal process8.993e-080.04355Least InformativeInherited
Biological Process (BP)developmental process5.192e-050.6935Least InformativeInherited
Biological Process (BP)system process5.133e-101.398e-13Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus7.21e-072.536e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus5.295e-070.0001939Moderately InformativeDirect
Biological Process (BP)homeostatic process1.419e-051.049e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound2.377e-054.632e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0013040.3944Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.017880.09097Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0020320.009843Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.028820.07232Moderately InformativeInherited
Biological Process (BP)response to organic substance0.065240.8311Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00087120.03173Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.095881Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.032780.07497Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.33330.9701Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.010970.04925Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00021520.004186Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.002670.5134Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.0011390.05615Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.1451Moderately InformativeInherited
Biological Process (BP)organelle organization0.07570.4497Moderately InformativeInherited
Biological Process (BP)nervous system development0.81950.9208Moderately InformativeInherited
Biological Process (BP)organic substance transport0.91210.3503Moderately InformativeInherited
Biological Process (BP)ion transport0.43490.7025Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0016550.001872Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.015840.1116Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0028270.05512Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.013990.1096Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.013540.06408Moderately InformativeInherited
Biological Process (BP)organ development1.39e-060.004346Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process7.606e-076.408e-06InformativeDirect
Biological Process (BP)response to hormone stimulus6.606e-050.0001693InformativeDirect
Biological Process (BP)response to inorganic substance3.711e-074.538e-11InformativeDirect
Biological Process (BP)response to lipid2.364e-062.585e-06InformativeDirect
Biological Process (BP)regulation of system process7.124e-050.0007416InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process2.692e-091.333e-07InformativeDirect
Biological Process (BP)regulation of body fluid levels1.333e-130InformativeDirect
Biological Process (BP)regulation of secretion0.00043640.0007643InformativeDirect
Biological Process (BP)positive regulation of transport5.68e-078.657e-05InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process5.905e-070.0005847InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process4.51e-081.511e-07InformativeDirect
Biological Process (BP)metal ion transport0.00065490.04641InformativeInherited
Biological Process (BP)response to organic cyclic compound0.0052040.01938InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.24610.377InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.039120.1357InformativeInherited
Biological Process (BP)cellular response to nitrogen compound2.001e-050.0017InformativeInherited
Biological Process (BP)response to organonitrogen compound0.013230.09341InformativeInherited
Biological Process (BP)response to oxidative stress0.025890.0364InformativeInherited
Biological Process (BP)positive regulation of cell proliferation1.851e-050.002341InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process7.638e-050.001926InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0022780.01448InformativeInherited
Biological Process (BP)positive regulation of developmental process7.656e-060.006519InformativeInherited
Biological Process (BP)negative regulation of cell death3.089e-050.001616InformativeInherited
Biological Process (BP)nitrogen compound transport0.012590.0002184InformativeInherited
Biological Process (BP)central nervous system development0.0088920.04039InformativeInherited
Biological Process (BP)cytoskeleton organization0.083950.2551InformativeInherited
Biological Process (BP)actin filament-based process0.00075370.01459InformativeInherited
Biological Process (BP)anion transport0.074650.0002369InformativeInherited
Biological Process (BP)response to nutrient levels0.7610.7175InformativeInherited
Biological Process (BP)response to light stimulus5.417e-070.2026InformativeInherited
Biological Process (BP)sensory organ development0.00016460.002743InformativeInherited
Biological Process (BP)response to hypoxia5.179e-067.465e-05Highly InformativeDirect
Biological Process (BP)calcium ion transport2.73e-068.411e-05Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity2.22e-060.0002929Highly InformativeDirect
Biological Process (BP)digestion3.847e-084.563e-09Highly InformativeDirect
Biological Process (BP)carbohydrate transport2.165e-100Highly InformativeDirect
Biological Process (BP)purine ribonucleotide biosynthetic process1.714e-108.137e-09Highly InformativeDirect
Biological Process (BP)response to UV4.111e-118.554e-09Highly InformativeDirect
Biological Process (BP)response to water deprivation3.886e-056.586e-09Highly InformativeDirect
Biological Process (BP)response to purine-containing compound3.786e-095.711e-08Highly InformativeDirect
Biological Process (BP)gas transport3.039e-071.552e-13Highly InformativeDirect
Biological Process (BP)inorganic anion transport8.853e-051.649e-06Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport1.045e-110Highly InformativeDirect
Biological Process (BP)one-carbon compound transport00Highly InformativeDirect
Biological Process (BP)telencephalon development7.058e-081.549e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species5.631e-053.262e-06Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism7.611e-071.157e-05Highly InformativeDirect
Biological Process (BP)amide transport5.527e-081.637e-08Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process1.043e-050.0005847Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism1.942e-072.248e-05Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis7.903e-107.447e-08Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus8.471e-116.117e-12Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus3.04e-081.346e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation2.589e-054.215e-05Highly InformativeDirect
Biological Process (BP)response to alcohol5.692e-072.694e-06Highly InformativeDirect
Biological Process (BP)ion transmembrane transport0.31851Highly InformativeInherited
Biological Process (BP)response to salt stress0.2320.1448Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.030880.03025Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.024280.08266Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.01560.1736Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.15310.01379Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.12150.06219Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1373Highly InformativeInherited
Molecular Function (MF)binding0.92971Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity07.537e-15InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.0044620.4039InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity7.198e-110.1009InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity6.02e-050Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0012671.586e-08Highly InformativeInherited
Molecular Function (MF)cation channel activity1.89e-060.03061Highly InformativeInherited
Molecular Function (MF)ion gated channel activity1.906e-050.8512Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.9110.4966Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.13110.6397Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.03990.3108Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.0001730.0008237Moderately InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0020630.00253Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0024430.0001961Moderately InformativeInherited
Cellular Component (CC)nuclear part0.04470.9373Moderately InformativeInherited
Cellular Component (CC)cell projection3.36e-050.001512Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.021310.00514Moderately InformativeInherited
Cellular Component (CC)nuclear envelope1.514e-073.269e-06InformativeDirect
Cellular Component (CC)vacuolar part3.382e-065.734e-05InformativeDirect
Cellular Component (CC)plastid0.0020540.0001228InformativeInherited
Cellular Component (CC)brush border2.881e-101.146e-09Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane4.858e-052.078e-05Highly InformativeDirect
Cellular Component (CC)apical plasma membrane1.461e-151.61e-15Highly InformativeDirect
Cellular Component (CC)nuclear membrane2.794e-096.512e-09Highly InformativeDirect
Cellular Component (CC)sarcolemma2.966e-050.0008718Highly InformativeDirect
Cellular Component (CC)symplast2.028e-054.398e-06Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.043190.01194Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0005493 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.3084 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.976 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9188 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5863 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.04355 Least Informative Inherited
Biological Process (BP) developmental process 0.6935 Least Informative Inherited
Biological Process (BP) system process 1.398e-13 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 2.536e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0001939 Moderately Informative Direct
Biological Process (BP) homeostatic process 1.049e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 4.632e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3944 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.09097 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.009843 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07232 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8311 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.03173 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.06945 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.07497 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9701 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.04925 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.004186 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5134 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.05615 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4497 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9208 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3503 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7025 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001872 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1116 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.05512 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1096 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.06408 Moderately Informative Inherited
Biological Process (BP) organ development 0.004346 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0002369 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 6.408e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001693 Informative Direct
Biological Process (BP) response to inorganic substance 4.538e-11 Informative Direct
Biological Process (BP) hexose metabolic process 0.0008504 Informative Direct
Biological Process (BP) response to lipid 2.585e-06 Informative Direct
Biological Process (BP) regulation of system process 0.0007416 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.333e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of secretion 0.0007643 Informative Direct
Biological Process (BP) positive regulation of transport 8.657e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0005847 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0002184 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.511e-07 Informative Direct
Biological Process (BP) metal ion transport 0.04641 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01938 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.377 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1357 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.0017 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09341 Informative Inherited
Biological Process (BP) response to oxidative stress 0.0364 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.002341 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.001926 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01448 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.006519 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001616 Informative Inherited
Biological Process (BP) central nervous system development 0.04039 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.2551 Informative Inherited
Biological Process (BP) actin filament-based process 0.01459 Informative Inherited
Biological Process (BP) response to nutrient levels 0.7175 Informative Inherited
Biological Process (BP) response to light stimulus 0.2026 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001639 Informative Inherited
Biological Process (BP) sensory organ development 0.002743 Informative Inherited
Biological Process (BP) response to hypoxia 7.465e-05 Highly Informative Direct
Biological Process (BP) glycolysis 0.0001791 Highly Informative Direct
Biological Process (BP) calcium ion transport 8.411e-05 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002929 Highly Informative Direct
Biological Process (BP) digestion 4.563e-09 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 8.137e-09 Highly Informative Direct
Biological Process (BP) response to UV 8.554e-09 Highly Informative Direct
Biological Process (BP) response to water deprivation 6.586e-09 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 5.711e-08 Highly Informative Direct
Biological Process (BP) gas transport 1.552e-13 Highly Informative Direct
Biological Process (BP) inorganic anion transport 1.649e-06 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 1.549e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 3.262e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.157e-05 Highly Informative Direct
Biological Process (BP) amide transport 1.637e-08 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0005847 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 2.248e-05 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 7.447e-08 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 6.117e-12 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 1.346e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.215e-05 Highly Informative Direct
Biological Process (BP) response to alcohol 2.694e-06 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.1448 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.03025 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.08266 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.1736 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.01379 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.06219 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1373 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 7.537e-15 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.4039 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1009 Informative Inherited
Molecular Function (MF) organic cation transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 1.586e-08 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.03061 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.8512 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.4966 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6397 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3108 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0008237 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0001961 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00253 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9373 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001512 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.00514 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 3.269e-06 Informative Direct
Cellular Component (CC) plastid 0.0001228 Informative Direct
Cellular Component (CC) vacuolar part 5.734e-05 Informative Direct
Cellular Component (CC) brush border 1.146e-09 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 2.078e-05 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.61e-15 Highly Informative Direct
Cellular Component (CC) nuclear membrane 6.512e-09 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0008718 Highly Informative Direct
Cellular Component (CC) symplast 4.398e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.01194 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.2476Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0009518Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.003239Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.0002264InformativeDirect
Disease Ontology (DO)auditory system disease0.005597InformativeInherited
Disease Ontology (DO)colonic disease0.0008475Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0009485Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0003336Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.0001015InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.005981InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1178InformativeInherited
Mammalian Phenotype (MP)polyuria4.479e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.702e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0009562Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007885Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6617Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9348Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue8.144e-06InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0007892InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008458InformativeDirect
Plant ANatomical entity (PAN)lateral root1.032e-05Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001294Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05303Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle9.63e-16Moderately InformativeDirect
Cellular componentGolgi apparatus5.339e-08Moderately InformativeDirect
Cellular componentCell junction5.023e-05Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein5.694e-07Least InformativeDirect
Post-translational modificationAcetylation0.0002645Least InformativeDirect
Post-translational modificationGlycoprotein0.0004436Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]