SUPERFAMILY 1.75 HMM library and genome assignments server


Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,135) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,465 0 8
Proteins 8,374 0 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus1.743e-050.0002878Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)biosynthetic process0.11380.2882Least InformativeInherited
Biological Process (BP)single-organism cellular process0.13020.9726Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.76161Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.48731Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.75991Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.64661Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.78440.8959Least InformativeInherited
Biological Process (BP)regulation of cellular process0.9551Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0051630.5192Least InformativeInherited
Biological Process (BP)multicellular organismal process6.035e-080.03147Least InformativeInherited
Biological Process (BP)developmental process3.905e-050.6298Least InformativeInherited
Biological Process (BP)system process5.229e-101.012e-13Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus7.249e-072.528e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus4.019e-070.0001444Moderately InformativeDirect
Biological Process (BP)homeostatic process1.393e-051.04e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound2.493e-054.989e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0012990.3706Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.01750.08603Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0021450.01043Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.030420.07282Moderately InformativeInherited
Biological Process (BP)response to organic substance0.059630.8025Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00080730.02748Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.091521Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.0320.07074Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.32990.9689Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.01040.04596Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00014550.003054Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0025210.4827Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.14071Moderately InformativeInherited
Biological Process (BP)organelle organization0.075250.4417Moderately InformativeInherited
Biological Process (BP)nervous system development0.82320.9218Moderately InformativeInherited
Biological Process (BP)organic substance transport0.92040.3569Moderately InformativeInherited
Biological Process (BP)ion transport0.54070.7835Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0015420.001653Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.015460.1054Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0027610.05154Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.013260.1028Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.013230.05963Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.77811Moderately InformativeInherited
Biological Process (BP)organ development1.318e-060.003409Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process7.313e-075.717e-06InformativeDirect
Biological Process (BP)response to hormone stimulus4.9e-050.0001344InformativeDirect
Biological Process (BP)response to inorganic substance4.158e-075.392e-11InformativeDirect
Biological Process (BP)response to lipid2.492e-062.787e-06InformativeDirect
Biological Process (BP)regulation of system process6.734e-050.0006541InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process2.695e-091.306e-07InformativeDirect
Biological Process (BP)regulation of body fluid levels1.229e-130InformativeDirect
Biological Process (BP)regulation of secretion0.00042250.0007546InformativeDirect
Biological Process (BP)positive regulation of transport4.972e-077.073e-05InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process5.675e-070.0005255InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process4.715e-081.369e-07InformativeDirect
Biological Process (BP)metal ion transport0.00067380.04431InformativeInherited
Biological Process (BP)response to organic cyclic compound0.0056470.02004InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.28410.4248InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.038140.1366InformativeInherited
Biological Process (BP)cellular response to nitrogen compound1.873e-050.001702InformativeInherited
Biological Process (BP)response to organonitrogen compound0.014720.09842InformativeInherited
Biological Process (BP)response to oxidative stress0.026340.03528InformativeInherited
Biological Process (BP)regulation of cell proliferation0.00055550.0529InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process7.55e-050.001842InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0023490.0137InformativeInherited
Biological Process (BP)positive regulation of developmental process7.709e-060.006103InformativeInherited
Biological Process (BP)negative regulation of cell death2.644e-050.001396InformativeInherited
Biological Process (BP)regulation of apoptotic process0.00057760.03062InformativeInherited
Biological Process (BP)nitrogen compound transport0.013240.0002215InformativeInherited
Biological Process (BP)central nervous system development0.0091810.03982InformativeInherited
Biological Process (BP)cytoskeleton organization0.084070.2479InformativeInherited
Biological Process (BP)actin filament-based process0.00073730.01372InformativeInherited
Biological Process (BP)anion transport0.094170.0003991InformativeInherited
Biological Process (BP)response to nutrient levels0.75140.7147InformativeInherited
Biological Process (BP)response to light stimulus5.345e-070.2026InformativeInherited
Biological Process (BP)sensory organ development0.00016060.002781InformativeInherited
Biological Process (BP)response to hypoxia3.478e-066.243e-05Highly InformativeDirect
Biological Process (BP)calcium ion transport2.711e-067.324e-05Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity2.18e-060.0002687Highly InformativeDirect
Biological Process (BP)digestion4.05e-084.579e-09Highly InformativeDirect
Biological Process (BP)carbohydrate transport2.279e-100Highly InformativeDirect
Biological Process (BP)purine ribonucleotide biosynthetic process1.689e-107.342e-09Highly InformativeDirect
Biological Process (BP)response to UV4.04e-117.538e-09Highly InformativeDirect
Biological Process (BP)response to water deprivation4.321e-056.985e-09Highly InformativeDirect
Biological Process (BP)response to purine-containing compound3.943e-094.363e-08Highly InformativeDirect
Biological Process (BP)gas transport1.645e-078.236e-14Highly InformativeDirect
Biological Process (BP)inorganic anion transport3.64e-055.523e-07Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport1.099e-110Highly InformativeDirect
Biological Process (BP)one-carbon compound transport00Highly InformativeDirect
Biological Process (BP)telencephalon development7.598e-081.428e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species5.636e-053.221e-06Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism6.227e-071.132e-05Highly InformativeDirect
Biological Process (BP)amide transport5.685e-081.638e-08Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process9.001e-060.0005126Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism6.519e-081.421e-05Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis7.807e-106.554e-08Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus3.266e-081.007e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation2.818e-054.28e-05Highly InformativeDirect
Biological Process (BP)cellular response to alcohol0.00023112.897e-05Highly InformativeDirect
Biological Process (BP)ion transmembrane transport0.27861Highly InformativeInherited
Biological Process (BP)response to corticosteroid stimulus0.011960.0004357Highly InformativeInherited
Biological Process (BP)response to salt stress0.23210.1467Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.031520.02936Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.025460.08261Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.015820.1746Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.1540.01359Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.12030.06451Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1411Highly InformativeInherited
Molecular Function (MF)binding0.90441Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity07.724e-14InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.00046730.1416InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity1.131e-080.1494InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity6.754e-163.8e-14Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity5.937e-050Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0012481.66e-08Highly InformativeInherited
Molecular Function (MF)cation channel activity2.032e-070.005512Highly InformativeInherited
Molecular Function (MF)ion gated channel activity7.199e-060.7406Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.89780.4309Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.1330.6053Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.044520.2702Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00015770.0006931Moderately InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0022790.002718Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0025850.0001821Moderately InformativeInherited
Cellular Component (CC)nuclear part0.044930.9224Moderately InformativeInherited
Cellular Component (CC)cell projection4.114e-050.001615Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.025010.005907Moderately InformativeInherited
Cellular Component (CC)nuclear envelope1.585e-072.778e-06InformativeDirect
Cellular Component (CC)vacuolar part3.504e-065.171e-05InformativeDirect
Cellular Component (CC)plastid0.0021360.0001051InformativeInherited
Cellular Component (CC)brush border3.14e-101.231e-09Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane4.936e-052.331e-05Highly InformativeDirect
Cellular Component (CC)apical plasma membrane1.486e-151.608e-15Highly InformativeDirect
Cellular Component (CC)nuclear membrane2.961e-096.135e-09Highly InformativeDirect
Cellular Component (CC)symplast1.882e-053.877e-06Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.043970.009744Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0002878 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.2882 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9726 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.8959 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5192 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03147 Least Informative Inherited
Biological Process (BP) developmental process 0.6298 Least Informative Inherited
Biological Process (BP) system process 1.012e-13 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 2.528e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0001444 Moderately Informative Direct
Biological Process (BP) homeostatic process 1.04e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 4.989e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3706 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.08603 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01043 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07282 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8025 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02748 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.06541 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9667 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.07074 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9689 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.04596 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.003054 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4827 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4417 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9218 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.3569 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7835 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001653 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1054 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.05154 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1028 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05963 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.003409 Moderately Informative Inherited
Biological Process (BP) anion transport 0.0003991 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 5.717e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001344 Informative Direct
Biological Process (BP) response to inorganic substance 5.392e-11 Informative Direct
Biological Process (BP) hexose metabolic process 0.0008092 Informative Direct
Biological Process (BP) response to lipid 2.787e-06 Informative Direct
Biological Process (BP) regulation of system process 0.0006541 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.306e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of secretion 0.0007546 Informative Direct
Biological Process (BP) positive regulation of transport 7.073e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0005255 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0002215 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.369e-07 Informative Direct
Biological Process (BP) metal ion transport 0.04431 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.02004 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4248 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1366 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001702 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09842 Informative Inherited
Biological Process (BP) response to oxidative stress 0.03528 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.0529 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.001842 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0137 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.006103 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001396 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.03062 Informative Inherited
Biological Process (BP) central nervous system development 0.03982 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.2479 Informative Inherited
Biological Process (BP) actin filament-based process 0.01372 Informative Inherited
Biological Process (BP) response to nutrient levels 0.7147 Informative Inherited
Biological Process (BP) response to light stimulus 0.2026 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001553 Informative Inherited
Biological Process (BP) sensory organ development 0.002781 Informative Inherited
Biological Process (BP) response to hypoxia 6.243e-05 Highly Informative Direct
Biological Process (BP) glycolysis 0.0001901 Highly Informative Direct
Biological Process (BP) calcium ion transport 7.324e-05 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002687 Highly Informative Direct
Biological Process (BP) digestion 4.579e-09 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 7.342e-09 Highly Informative Direct
Biological Process (BP) response to UV 7.538e-09 Highly Informative Direct
Biological Process (BP) response to water deprivation 6.985e-09 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 4.363e-08 Highly Informative Direct
Biological Process (BP) gas transport 8.236e-14 Highly Informative Direct
Biological Process (BP) inorganic anion transport 5.523e-07 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 1.428e-07 Highly Informative Direct
Biological Process (BP) response to corticosteroid stimulus 0.0004357 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 3.221e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 1.132e-05 Highly Informative Direct
Biological Process (BP) amide transport 1.638e-08 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0005126 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 1.421e-05 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 6.554e-08 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 1.007e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.28e-05 Highly Informative Direct
Biological Process (BP) cellular response to alcohol 2.897e-05 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) response to salt stress 0.1467 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.02936 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.08261 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.1746 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.01359 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.06451 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1411 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 7.724e-14 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.1416 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1494 Informative Inherited
Molecular Function (MF) organic cation transmembrane transporter activity 3.8e-14 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 1.66e-08 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.005512 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.7406 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.4309 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6053 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2702 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0006931 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0001821 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.002718 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9224 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001615 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.005907 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 2.778e-06 Informative Direct
Cellular Component (CC) plastid 0.0001051 Informative Direct
Cellular Component (CC) vacuolar part 5.171e-05 Informative Direct
Cellular Component (CC) brush border 1.231e-09 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 2.331e-05 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.608e-15 Highly Informative Direct
Cellular Component (CC) nuclear membrane 6.135e-09 Highly Informative Direct
Cellular Component (CC) symplast 3.877e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.009744 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.3017Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0008943Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.003219Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.0002276InformativeDirect
Disease Ontology (DO)auditory system disease0.005461InformativeInherited
Disease Ontology (DO)colonic disease0.0007963Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0009617Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0003419Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03276Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.0001032InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.005543InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1178InformativeInherited
Mammalian Phenotype (MP)polyuria4.61e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.797e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0009658Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007885Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6617Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9348Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue8.144e-06InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0007892InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008458InformativeDirect
Plant ANatomical entity (PAN)lateral root1.032e-05Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001294Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05303Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle9.618e-16Moderately InformativeDirect
Cellular componentGolgi apparatus5.427e-08Moderately InformativeDirect
Cellular componentCell junction5.068e-05Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein5.904e-07Least InformativeDirect
Post-translational modificationAcetylation0.0002442Least InformativeDirect
Post-translational modificationGlycoprotein0.0004703Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]