SUPERFAMILY 1.75 HMM library and genome assignments server


Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,097) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 7,622 13,970 8
Proteins 7,572 13,939 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus2.699e-050.0007423Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)biosynthetic process0.12960.3079Least InformativeInherited
Biological Process (BP)single-organism cellular process0.16440.9733Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.79441Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.52781Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.80081Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.68831Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.83070.9244Least InformativeInherited
Biological Process (BP)regulation of cellular process0.96661Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0062830.5332Least InformativeInherited
Biological Process (BP)multicellular organismal process8.481e-080.03312Least InformativeInherited
Biological Process (BP)developmental process5.066e-050.6449Least InformativeInherited
Biological Process (BP)system process3.926e-108.593e-14Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus6.368e-076.513e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus4.838e-070.0001154Moderately InformativeDirect
Biological Process (BP)homeostatic process1.084e-052.893e-06Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound2.384e-055.172e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0013420.3723Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.019970.09261Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0022180.005475Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.030030.07143Moderately InformativeInherited
Biological Process (BP)response to organic substance0.064010.8208Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00074790.02614Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.094841Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.036330.07624Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.36090.9669Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.011670.04814Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00018390.003391Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0024040.4888Moderately InformativeInherited
Biological Process (BP)regulation of programmed cell death0.0012230.05306Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.15221Moderately InformativeInherited
Biological Process (BP)organelle organization0.063960.4167Moderately InformativeInherited
Biological Process (BP)nervous system development0.82350.9166Moderately InformativeInherited
Biological Process (BP)organic substance transport0.9430.5325Moderately InformativeInherited
Biological Process (BP)ion transport0.70750.7928Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0018440.001887Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.017110.1159Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.003140.05834Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.014550.1115Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.015130.0679Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.75331Moderately InformativeInherited
Biological Process (BP)organ development9.336e-070.006396Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process6.903e-075.906e-06InformativeDirect
Biological Process (BP)response to hormone stimulus5.166e-050.0001478InformativeDirect
Biological Process (BP)response to inorganic substance3.97e-075.336e-11InformativeDirect
Biological Process (BP)response to lipid1.965e-062.653e-06InformativeDirect
Biological Process (BP)regulation of system process7.017e-050.0006865InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process2.012e-091.125e-07InformativeDirect
Biological Process (BP)regulation of body fluid levels1.21e-130InformativeDirect
Biological Process (BP)regulation of secretion0.00037040.0007896InformativeDirect
Biological Process (BP)positive regulation of transport3.961e-076.09e-05InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process4.144e-070.0005477InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process3.883e-081.298e-07InformativeDirect
Biological Process (BP)metal ion transport00.001566InformativeInherited
Biological Process (BP)response to organic cyclic compound0.0052680.01837InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.27560.4146InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.032990.1341InformativeInherited
Biological Process (BP)cellular response to nitrogen compound1.908e-050.001596InformativeInherited
Biological Process (BP)response to organonitrogen compound0.015820.09165InformativeInherited
Biological Process (BP)response to oxidative stress0.026720.02318InformativeInherited
Biological Process (BP)positive regulation of cell proliferation1.617e-050.002093InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process8.931e-050.001872InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0028050.01431InformativeInherited
Biological Process (BP)positive regulation of developmental process8.937e-060.006096InformativeInherited
Biological Process (BP)negative regulation of cell death2.789e-050.001433InformativeInherited
Biological Process (BP)nitrogen compound transport0.037610.0007994InformativeInherited
Biological Process (BP)central nervous system development0.0092240.03916InformativeInherited
Biological Process (BP)cytoskeleton organization0.091690.2437InformativeInherited
Biological Process (BP)actin filament-based process0.00072270.01286InformativeInherited
Biological Process (BP)anion transport0.16220.00215InformativeInherited
Biological Process (BP)response to nutrient levels0.73970.7218InformativeInherited
Biological Process (BP)response to light stimulus5.499e-070.205InformativeInherited
Biological Process (BP)sensory organ development0.00015870.002654InformativeInherited
Biological Process (BP)response to hypoxia4.257e-063.98e-05Highly InformativeDirect
Biological Process (BP)calcium ion transport2.413e-067.699e-05Highly InformativeDirect
Biological Process (BP)response to osmotic stress1.235e-130Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity2.004e-060.0002388Highly InformativeDirect
Biological Process (BP)digestion4.863e-085.949e-09Highly InformativeDirect
Biological Process (BP)carbohydrate transport7.57e-100Highly InformativeDirect
Biological Process (BP)purine ribonucleotide biosynthetic process1.513e-106.505e-09Highly InformativeDirect
Biological Process (BP)response to UV5.841e-111.071e-08Highly InformativeDirect
Biological Process (BP)response to water deprivation4.954e-054.946e-09Highly InformativeDirect
Biological Process (BP)response to purine-containing compound3.665e-094.053e-08Highly InformativeDirect
Biological Process (BP)inorganic anion transport0.00015612.58e-06Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport6.117e-110Highly InformativeDirect
Biological Process (BP)telencephalon development6.722e-081.35e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species4.099e-051.798e-06Highly InformativeDirect
Biological Process (BP)amide transport5.862e-086.116e-09Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis1.08e-097.565e-08Highly InformativeDirect
Biological Process (BP)positive regulation of secretion3.753e-054.761e-05Highly InformativeDirect
Biological Process (BP)interaction with symbiont4.035e-141.017e-13Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction2.024e-112.887e-08Highly InformativeDirect
Biological Process (BP)cellular response to organic cyclic compound6.386e-082.187e-07Highly InformativeDirect
Biological Process (BP)cellular response to radiation3.503e-054.262e-05Highly InformativeDirect
Biological Process (BP)cellular response to alcohol0.0002662.727e-05Highly InformativeDirect
Biological Process (BP)ion transmembrane transport0.47531Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.05040.4097Highly InformativeInherited
Biological Process (BP)response to corticosteroid stimulus0.014990.0004583Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.028260.03002Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.027230.08869Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.15030.01357Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.11650.06538Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1874Highly InformativeInherited
Molecular Function (MF)binding0.90261Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity01.391e-11InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity1.424e-060.5251InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity8.574e-100.007426InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity2.007e-121.182e-10Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity5.014e-052.318e-14Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0011213.011e-07Highly InformativeInherited
Molecular Function (MF)ion channel activity0.14151Highly InformativeInherited
Molecular Function (MF)ion gated channel activity1.869e-060.6653Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.97440.5208Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.10850.5737Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.058710.2431Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00019310.0006744Moderately InformativeDirect
Cellular Component (CC)plasma membrane part00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0023950.002411Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0036170.0001506Moderately InformativeInherited
Cellular Component (CC)nuclear part0.016180.6996Moderately InformativeInherited
Cellular Component (CC)cell projection5.743e-050.004636Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.037360.0135Moderately InformativeInherited
Cellular Component (CC)nuclear envelope1.774e-071.24e-06InformativeDirect
Cellular Component (CC)vacuolar part4.298e-065.959e-05InformativeDirect
Cellular Component (CC)plastid0.0027310.0001786InformativeInherited
Cellular Component (CC)brush border4.013e-107.809e-10Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane7.533e-051.837e-05Highly InformativeDirect
Cellular Component (CC)apical plasma membrane2.676e-152.972e-15Highly InformativeDirect
Cellular Component (CC)nuclear membrane5.587e-103.766e-10Highly InformativeDirect
Cellular Component (CC)symplast2.687e-056.213e-06Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.049810.02611Highly InformativeInherited
Cellular Component (CC)vacuolar membrane0.0056120.04877Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0007423 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.3079 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9733 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9244 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5332 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.03312 Least Informative Inherited
Biological Process (BP) developmental process 0.6449 Least Informative Inherited
Biological Process (BP) system process 8.593e-14 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 6.513e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0001154 Moderately Informative Direct
Biological Process (BP) homeostatic process 2.893e-06 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 5.172e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3723 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.09261 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.005475 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07143 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8208 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.02614 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.07123 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.07624 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9669 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.04814 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.003391 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4888 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.05306 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4167 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9166 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5325 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7928 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001887 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1159 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.05834 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1115 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.0679 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.006396 Moderately Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 5.906e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001478 Informative Direct
Biological Process (BP) response to inorganic substance 5.336e-11 Informative Direct
Biological Process (BP) hexose metabolic process 0.000912 Informative Direct
Biological Process (BP) response to lipid 2.653e-06 Informative Direct
Biological Process (BP) regulation of system process 0.0006865 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.125e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of secretion 0.0007896 Informative Direct
Biological Process (BP) positive regulation of transport 6.09e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0005477 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0007994 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.298e-07 Informative Direct
Biological Process (BP) metal ion transport 0.001566 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01837 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4146 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1341 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001596 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.09165 Informative Inherited
Biological Process (BP) response to oxidative stress 0.02318 Informative Inherited
Biological Process (BP) positive regulation of cell proliferation 0.002093 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.001872 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01431 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.006096 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001433 Informative Inherited
Biological Process (BP) central nervous system development 0.03916 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.2437 Informative Inherited
Biological Process (BP) actin filament-based process 0.01286 Informative Inherited
Biological Process (BP) anion transport 0.00215 Informative Inherited
Biological Process (BP) response to nutrient levels 0.7218 Informative Inherited
Biological Process (BP) response to light stimulus 0.205 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001517 Informative Inherited
Biological Process (BP) sensory organ development 0.002654 Informative Inherited
Biological Process (BP) response to hypoxia 3.98e-05 Highly Informative Direct
Biological Process (BP) glycolysis 0.0001771 Highly Informative Direct
Biological Process (BP) calcium ion transport 7.699e-05 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002388 Highly Informative Direct
Biological Process (BP) digestion 5.949e-09 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 6.505e-09 Highly Informative Direct
Biological Process (BP) response to UV 1.071e-08 Highly Informative Direct
Biological Process (BP) response to water deprivation 4.946e-09 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 4.053e-08 Highly Informative Direct
Biological Process (BP) inorganic anion transport 2.58e-06 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 1.35e-07 Highly Informative Direct
Biological Process (BP) response to corticosteroid stimulus 0.0004583 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 1.798e-06 Highly Informative Direct
Biological Process (BP) amide transport 6.116e-09 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 7.565e-08 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 4.761e-05 Highly Informative Direct
Biological Process (BP) interaction with symbiont 1.017e-13 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 2.887e-08 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 2.187e-07 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.262e-05 Highly Informative Direct
Biological Process (BP) cellular response to alcohol 2.727e-05 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.03002 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.08869 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.4097 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.01357 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.06538 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1874 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 1.391e-11 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.5251 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.007426 Informative Inherited
Molecular Function (MF) organic cation transmembrane transporter activity 1.182e-10 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 3.011e-07 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 2.318e-14 Highly Informative Direct
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.6653 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.5208 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.5737 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.2431 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.0006744 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0001506 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.002411 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.6996 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.004636 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.0135 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 1.24e-06 Informative Direct
Cellular Component (CC) plastid 0.0001786 Informative Direct
Cellular Component (CC) vacuolar part 5.959e-05 Informative Direct
Cellular Component (CC) brush border 7.809e-10 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 1.837e-05 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 2.972e-15 Highly Informative Direct
Cellular Component (CC) nuclear membrane 3.766e-10 Highly Informative Direct
Cellular Component (CC) symplast 6.213e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.02611 Highly Informative Inherited
Cellular Component (CC) vacuolar membrane 0.04877 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.3078Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0008848Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.003227Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.0002278InformativeDirect
Disease Ontology (DO)auditory system disease0.005478InformativeInherited
Disease Ontology (DO)colonic disease0.0007958Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0009223Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0003304Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.0001049InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.005158InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.03254InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1159InformativeInherited
Mammalian Phenotype (MP)polyuria4.015e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.878e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0009085Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007885Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6617Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9348Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue8.144e-06InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0007892InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008458InformativeDirect
Plant ANatomical entity (PAN)lateral root1.032e-05Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001294Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05303Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle6.373e-16Moderately InformativeDirect
Cellular componentGolgi apparatus5.312e-08Moderately InformativeDirect
Cellular componentCell junction4.581e-05Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein5.872e-07Least InformativeDirect
Post-translational modificationAcetylation0.0002601Least InformativeDirect
Post-translational modificationGlycoprotein0.0004594Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]