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Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)

Superfamily statistics
Genomes (1,667) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 6,850 13,970 8
Proteins 6,801 13,939 8

 Functional annotation
General category Processes_IC
Detailed category Transport

Document: Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus2.234e-050.0002167Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)biosynthetic process0.1890.3396Least InformativeInherited
Biological Process (BP)single-organism cellular process0.079570.8376Least InformativeInherited
Biological Process (BP)regulation of cellular process0.98841Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.82731Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.58121Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.84981Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.73461Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.89450.868Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0070770.4602Least InformativeInherited
Biological Process (BP)multicellular organismal process4.094e-080.02656Least InformativeInherited
Biological Process (BP)developmental process2.799e-050.5998Least InformativeInherited
Biological Process (BP)system process3.511e-103.1e-13Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus5.205e-078.782e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus1.846e-060.0003609Moderately InformativeDirect
Biological Process (BP)cellular response to stress0.0008460.0009471Moderately InformativeDirect
Biological Process (BP)homeostatic process4.133e-052.513e-05Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound1.383e-051.13e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0012990.3481Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.023550.05816Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.035350.08267Moderately InformativeInherited
Biological Process (BP)response to organic substance0.09280.7768Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.10481Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00063640.01683Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.041390.04387Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.34840.9151Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.012650.02219Moderately InformativeInherited
Biological Process (BP)multi-organism process0.00056970.005549Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0024670.4847Moderately InformativeInherited
Biological Process (BP)organelle organization0.025930.1592Moderately InformativeInherited
Biological Process (BP)nervous system development0.83410.9244Moderately InformativeInherited
Biological Process (BP)ion transport0.53380.7944Moderately InformativeInherited
Biological Process (BP)organic substance transport0.46170.1508Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0031430.002574Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.020250.09482Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0030650.04708Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.024930.1153Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.017010.05578Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.34471Moderately InformativeInherited
Biological Process (BP)organ development2.155e-100.01003Moderately InformativeInherited
Biological Process (BP)purine nucleotide metabolic process0.00016910.0005322InformativeDirect
Biological Process (BP)nucleotide biosynthetic process9.952e-077.474e-06InformativeDirect
Biological Process (BP)response to hormone stimulus0.00015050.0005425InformativeDirect
Biological Process (BP)response to inorganic substance9.329e-074.426e-10InformativeDirect
Biological Process (BP)ribose phosphate metabolic process0.00015540.0005892InformativeDirect
Biological Process (BP)metal ion transport01.158e-14InformativeDirect
Biological Process (BP)response to lipid5.238e-066.826e-06InformativeDirect
Biological Process (BP)regulation of system process3.825e-050.0006563InformativeDirect
Biological Process (BP)regulation of body fluid levels1.965e-130InformativeDirect
Biological Process (BP)positive regulation of transport2.392e-075.003e-05InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process6.143e-070.0006435InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process9.616e-082.829e-07InformativeDirect
Biological Process (BP)cellular response to nitrogen compound1.135e-050.0007814InformativeDirect
Biological Process (BP)response to organic cyclic compound0.014720.02981InformativeInherited
Biological Process (BP)response to external stimulus1.052e-050.001025InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.31320.4259InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.020250.06911InformativeInherited
Biological Process (BP)response to organic nitrogen0.010440.06173InformativeInherited
Biological Process (BP)response to oxidative stress0.021380.02711InformativeInherited
Biological Process (BP)regulation of secretion0.00067310.001109InformativeInherited
Biological Process (BP)regulation of cell proliferation0.00076420.06873InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0024030.01071InformativeInherited
Biological Process (BP)positive regulation of developmental process8.343e-060.004548InformativeInherited
Biological Process (BP)nitrogen compound transport0.0053210.0001054InformativeInherited
Biological Process (BP)secretion0.68951InformativeInherited
Biological Process (BP)central nervous system development0.01050.04094InformativeInherited
Biological Process (BP)cytoskeleton organization0.10270.3714InformativeInherited
Biological Process (BP)actin filament-based process0.000330.009873InformativeInherited
Biological Process (BP)response to light stimulus1.094e-060.2157InformativeInherited
Biological Process (BP)sensory organ development0.00016990.003359InformativeInherited
Biological Process (BP)response to hypoxia1.138e-050.0001307Highly InformativeDirect
Biological Process (BP)calcium ion transport2.349e-067.579e-05Highly InformativeDirect
Biological Process (BP)response to osmotic stress4.849e-140Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity7.149e-070.0001473Highly InformativeDirect
Biological Process (BP)digestion5.276e-086.834e-09Highly InformativeDirect
Biological Process (BP)carbohydrate transport3.162e-110Highly InformativeDirect
Biological Process (BP)response to UV1.678e-102.42e-08Highly InformativeDirect
Biological Process (BP)response to water deprivation5.919e-051.167e-08Highly InformativeDirect
Biological Process (BP)response to purine-containing compound2.199e-106.409e-10Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport7.451e-130Highly InformativeDirect
Biological Process (BP)telencephalon development6.919e-081.481e-07Highly InformativeDirect
Biological Process (BP)response to corticosteroid stimulus3.601e-101.496e-11Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species4.536e-052.023e-06Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism6.951e-073.715e-06Highly InformativeDirect
Biological Process (BP)amide transport1.204e-081.293e-09Highly InformativeDirect
Biological Process (BP)symbiosis, encompassing mutualism through parasitism2.819e-078.737e-06Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis1.693e-099.859e-08Highly InformativeDirect
Biological Process (BP)positive regulation of secretion6.815e-056.189e-05Highly InformativeDirect
Biological Process (BP)cellular response to abiotic stimulus8.46e-111.775e-07Highly InformativeDirect
Biological Process (BP)cellular response to organic cyclic compound4.166e-074.997e-07Highly InformativeDirect
Biological Process (BP)cellular response to alcohol6.482e-053.76e-06Highly InformativeDirect
Biological Process (BP)ion transmembrane transport0.10160.4939Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.040740.2597Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.049840.02901Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.012870.04005Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.15020.02327Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.12110.06412Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1999Highly InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity0.59120.0005715InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity5.675e-070.1758InformativeInherited
Molecular Function (MF)metal ion transmembrane transporter activity2.274e-090.03247InformativeInherited
Molecular Function (MF)carbohydrate transmembrane transporter activity0.00076839.039e-08Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity3.403e-060Highly InformativeDirect
Molecular Function (MF)ion channel activity0.16061Highly InformativeInherited
Molecular Function (MF)ion gated channel activity5.407e-060.7066Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.95160.7288Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.12190.8761Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.022470.569Least InformativeInherited
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.0023780.003636Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0038470.0004561Moderately InformativeInherited
Cellular Component (CC)nuclear part0.041441Moderately InformativeInherited
Cellular Component (CC)cell projection1.069e-050.001667Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.014210.004663Moderately InformativeInherited
Cellular Component (CC)nuclear envelope8.113e-084.172e-06InformativeDirect
Cellular Component (CC)vacuole1.542e-062.868e-08InformativeDirect
Cellular Component (CC)cell junction3.845e-051.222e-05InformativeDirect
Cellular Component (CC)cell projection part1.442e-050.003217InformativeInherited
Cellular Component (CC)plastid0.0027620.0004323InformativeInherited
Cellular Component (CC)brush border3.915e-104.907e-10Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane2.116e-054.316e-06Highly InformativeDirect
Cellular Component (CC)apical plasma membrane00Highly InformativeDirect
Cellular Component (CC)nuclear membrane6.631e-101.371e-09Highly InformativeDirect
Cellular Component (CC)sarcolemma2.841e-050.0005843Highly InformativeDirect
Cellular Component (CC)symplast4.941e-051.306e-05Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.0022380.004681Highly InformativeInherited
Cellular Component (CC)vacuolar membrane0.0023790.02186Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0002167 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.3396 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.8376 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.868 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.4602 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.02656 Least Informative Inherited
Biological Process (BP) developmental process 0.5998 Least Informative Inherited
Biological Process (BP) system process 3.1e-13 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 8.782e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0003609 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0009471 Moderately Informative Direct
Biological Process (BP) homeostatic process 2.513e-05 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 1.13e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3481 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.05816 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.08267 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7768 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.01683 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.04274 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9333 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.04387 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9151 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.02219 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.005549 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4847 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1592 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9244 Moderately Informative Inherited
Biological Process (BP) ion transport 0.7944 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1508 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002574 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.09482 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.04708 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1153 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.05578 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.01003 Moderately Informative Inherited
Biological Process (BP) purine nucleotide metabolic process 0.0005322 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 7.474e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0005425 Informative Direct
Biological Process (BP) response to inorganic substance 4.426e-10 Informative Direct
Biological Process (BP) ribose phosphate metabolic process 0.0005892 Informative Direct
Biological Process (BP) metal ion transport 1.158e-14 Informative Direct
Biological Process (BP) response to lipid 6.826e-06 Informative Direct
Biological Process (BP) regulation of system process 0.0006563 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) positive regulation of transport 5.003e-05 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0006435 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0001054 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 2.829e-07 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0007814 Informative Direct
Biological Process (BP) response to organic cyclic compound 0.02981 Informative Inherited
Biological Process (BP) response to external stimulus 0.001025 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.4259 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.06911 Informative Inherited
Biological Process (BP) response to organic nitrogen 0.06173 Informative Inherited
Biological Process (BP) response to oxidative stress 0.02711 Informative Inherited
Biological Process (BP) regulation of secretion 0.001109 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.06873 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01071 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.004548 Informative Inherited
Biological Process (BP) secretion 1 Informative Inherited
Biological Process (BP) central nervous system development 0.04094 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.3714 Informative Inherited
Biological Process (BP) actin filament-based process 0.009873 Informative Inherited
Biological Process (BP) anion transport 0.009457 Informative Inherited
Biological Process (BP) response to light stimulus 0.2157 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001589 Informative Inherited
Biological Process (BP) hexose metabolic process 0.001012 Informative Inherited
Biological Process (BP) sensory organ development 0.003359 Informative Inherited
Biological Process (BP) response to hypoxia 0.0001307 Highly Informative Direct
Biological Process (BP) glycolysis 0.0001647 Highly Informative Direct
Biological Process (BP) calcium ion transport 7.579e-05 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0001473 Highly Informative Direct
Biological Process (BP) digestion 6.834e-09 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) response to UV 2.42e-08 Highly Informative Direct
Biological Process (BP) response to water deprivation 1.167e-08 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 6.409e-10 Highly Informative Direct
Biological Process (BP) inorganic anion transport 0.0002863 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 1.481e-07 Highly Informative Direct
Biological Process (BP) response to corticosteroid stimulus 1.496e-11 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 2.023e-06 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism 3.715e-06 Highly Informative Direct
Biological Process (BP) amide transport 1.293e-09 Highly Informative Direct
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 8.737e-06 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 9.859e-08 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 6.189e-05 Highly Informative Direct
Biological Process (BP) cellular response to abiotic stimulus 1.775e-07 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 4.997e-07 Highly Informative Direct
Biological Process (BP) cellular response to alcohol 3.76e-06 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 0.4939 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.02901 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.04005 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.2597 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.02327 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.06412 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1999 Highly Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.0005715 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1758 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.03247 Informative Inherited
Molecular Function (MF) carbohydrate transmembrane transporter activity 9.039e-08 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.7066 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.7288 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.8761 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.569 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0004561 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.003636 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) cell projection 0.001667 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.004663 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 4.172e-06 Informative Direct
Cellular Component (CC) vacuole 2.868e-08 Informative Direct
Cellular Component (CC) plastid 0.0004323 Informative Direct
Cellular Component (CC) cell junction 1.222e-05 Informative Direct
Cellular Component (CC) cell projection part 0.003217 Informative Inherited
Cellular Component (CC) brush border 4.907e-10 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 4.316e-06 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 0 Highly Informative Direct
Cellular Component (CC) nuclear membrane 1.371e-09 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0005843 Highly Informative Direct
Cellular Component (CC) symplast 1.306e-05 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.004681 Highly Informative Inherited
Cellular Component (CC) vacuolar membrane 0.02186 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.3691Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.0009302Moderately InformativeDirect
Disease Ontology (DO)sensory system disease0.003239Moderately InformativeInherited
Disease Ontology (DO)female reproductive system disease0.0002564InformativeDirect
Disease Ontology (DO)auditory system disease0.005688InformativeInherited
Disease Ontology (DO)colonic disease0.0006381Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0007476Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0004234Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal urine homeostasis0.0001483InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.003407InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1243InformativeInherited
Mammalian Phenotype (MP)polyuria3.531e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality7.128e-07Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0.008095Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue1.495e-05InformativeDirect
Plant ANatomical entity (PAN)portion of vascular tissue0.000469InformativeDirect
Plant ANatomical entity (PAN)lateral root9.768e-06Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001218Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.04938Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle3.226e-16Moderately InformativeDirect
Cellular componentGolgi apparatus4.03e-08Moderately InformativeDirect
Cellular componentCell junction2.687e-05Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationGlycoprotein1.276e-07Least InformativeDirect
Post-translational modificationPhosphoprotein1.653e-05Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]
Please cite: Gough, J., Karplus, K., Hughey, R. and Chothia, C. (2001). "Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure." J. Mol. Biol., 313(4), 903-919.

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© Copyright 2013 The SUPERFAMILY authors and Julian Gough.