SUPERFAMILY 1.75 HMM library and genome assignments server


Aquaporin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Aquaporin-like [ 81339]
Superfamily:   Aquaporin-like [ 81338]
Families:   Aquaporin-like [ 56895] (4)


Superfamily statistics
Genomes (2,145) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 8,870 27,911 8
Proteins 8,767 27,859 8


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus3.818e-050.0008329Least InformativeDirect
Biological Process (BP)localization00Least InformativeDirect
Biological Process (BP)biosynthetic process0.14010.3453Least InformativeInherited
Biological Process (BP)single-organism cellular process0.12580.9161Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.80091Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.53171Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.8081Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.69491Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.83850.9509Least InformativeInherited
Biological Process (BP)regulation of cellular process0.97841Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0079470.6267Least InformativeInherited
Biological Process (BP)multicellular organismal process9.915e-080.04971Least InformativeInherited
Biological Process (BP)developmental process5.719e-050.807Least InformativeInherited
Biological Process (BP)system process5.799e-101.333e-12Moderately InformativeDirect
Biological Process (BP)response to abiotic stimulus7.615e-072.91e-07Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus5.237e-070.0002094Moderately InformativeDirect
Biological Process (BP)regulation of biological quality1.121e-095.396e-07Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound2.528e-055.271e-05Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0015570.4264Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.023010.1026Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.0020650.01078Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.028760.07837Moderately InformativeInherited
Biological Process (BP)response to organic substance0.067310.8458Moderately InformativeInherited
Biological Process (BP)regulation of localization0.0011070.03697Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.1121Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.041510.08419Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.36780.9692Moderately InformativeInherited
Biological Process (BP)nucleobase-containing small molecule metabolic process0.014320.05553Moderately InformativeInherited
Biological Process (BP)multi-organism process0.0003030.005898Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0032810.4024Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.16091Moderately InformativeInherited
Biological Process (BP)organelle organization0.073930.4733Moderately InformativeInherited
Biological Process (BP)nervous system development0.82670.9949Moderately InformativeInherited
Biological Process (BP)organic substance transport0.90180.326Moderately InformativeInherited
Biological Process (BP)ion transport0.43320.6855Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.00220.002415Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.020320.1367Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.0038450.07007Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.018360.1351Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.017540.08042Moderately InformativeInherited
Biological Process (BP)organ development1.479e-060.004926Moderately InformativeInherited
Biological Process (BP)nucleotide biosynthetic process1.122e-068.4e-06InformativeDirect
Biological Process (BP)response to hormone stimulus5.841e-050.0001579InformativeDirect
Biological Process (BP)response to inorganic substance3.965e-075.503e-11InformativeDirect
Biological Process (BP)response to lipid2.884e-062.844e-06InformativeDirect
Biological Process (BP)regulation of system process8.047e-050.0009418InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process2.656e-091.498e-07InformativeDirect
Biological Process (BP)regulation of body fluid levels1.18e-130InformativeDirect
Biological Process (BP)regulation of secretion0.00057550.0008623InformativeDirect
Biological Process (BP)positive regulation of transport8.939e-070.0001049InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process7.242e-070.0006437InformativeDirect
Biological Process (BP)transmembrane transport00InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process4.1e-081.887e-07InformativeDirect
Biological Process (BP)metal ion transport0.00067060.0485InformativeInherited
Biological Process (BP)response to organic cyclic compound0.0046710.01841InformativeInherited
Biological Process (BP)cellular response to endogenous stimulus0.25250.39InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.041010.1391InformativeInherited
Biological Process (BP)cellular response to nitrogen compound2.088e-050.001701InformativeInherited
Biological Process (BP)response to organonitrogen compound0.012590.08997InformativeInherited
Biological Process (BP)response to oxidative stress0.025430.03835InformativeInherited
Biological Process (BP)regulation of cell proliferation0.00060770.06216InformativeInherited
Biological Process (BP)purine ribonucleotide metabolic process0.00011470.002209InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.002270.01659InformativeInherited
Biological Process (BP)positive regulation of developmental process8.889e-060.007276InformativeInherited
Biological Process (BP)negative regulation of cell death3.349e-050.001911InformativeInherited
Biological Process (BP)nitrogen compound transport0.011490.0001857InformativeInherited
Biological Process (BP)central nervous system development0.01010.03343InformativeInherited
Biological Process (BP)cytoskeleton organization0.081590.2498InformativeInherited
Biological Process (BP)actin filament-based process0.00075470.01557InformativeInherited
Biological Process (BP)anion transport0.034867.921e-05InformativeInherited
Biological Process (BP)response to nutrient levels0.77250.7307InformativeInherited
Biological Process (BP)response to light stimulus5.892e-070.2014InformativeInherited
Biological Process (BP)sensory organ development0.00018590.002702InformativeInherited
Biological Process (BP)response to hypoxia6.311e-068.382e-05Highly InformativeDirect
Biological Process (BP)calcium ion transport2.645e-068.496e-05Highly InformativeDirect
Biological Process (BP)establishment or maintenance of cell polarity2.075e-060.0002856Highly InformativeDirect
Biological Process (BP)digestion3.768e-084.482e-09Highly InformativeDirect
Biological Process (BP)carbohydrate transport2.262e-100Highly InformativeDirect
Biological Process (BP)response to UV4.59e-119.565e-09Highly InformativeDirect
Biological Process (BP)response to water deprivation3.527e-055.636e-09Highly InformativeDirect
Biological Process (BP)response to purine-containing compound3.543e-095.391e-08Highly InformativeDirect
Biological Process (BP)gas transport3.581e-071.827e-13Highly InformativeDirect
Biological Process (BP)inorganic anion transport4.589e-058.146e-07Highly InformativeDirect
Biological Process (BP)organic hydroxy compound transport9.311e-120Highly InformativeDirect
Biological Process (BP)one-carbon compound transport00Highly InformativeDirect
Biological Process (BP)telencephalon development9.922e-081.429e-07Highly InformativeDirect
Biological Process (BP)cellular response to reactive oxygen species5.798e-053.784e-06Highly InformativeDirect
Biological Process (BP)amide transport5.249e-081.735e-08Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic process1.159e-050.0006826Highly InformativeDirect
Biological Process (BP)regulation of angiogenesis8.15e-108.018e-08Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus8.725e-117.021e-12Highly InformativeDirect
Biological Process (BP)modification of morphology or physiology of other organism involved in symbiotic interaction6.572e-114.414e-08Highly InformativeDirect
Biological Process (BP)cellular response to steroid hormone stimulus2.603e-081.482e-09Highly InformativeDirect
Biological Process (BP)cellular response to radiation2.523e-054.328e-05Highly InformativeDirect
Biological Process (BP)response to alcohol5.214e-072.606e-06Highly InformativeDirect
Biological Process (BP)response to salt stress0.24050.1645Highly InformativeInherited
Biological Process (BP)cellular response to metal ion0.026060.03115Highly InformativeInherited
Biological Process (BP)response to hydrogen peroxide0.025270.08086Highly InformativeInherited
Biological Process (BP)monovalent inorganic cation transport0.0011720.03866Highly InformativeInherited
Biological Process (BP)cellular response to starvation0.1670.01586Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus0.12180.01997Highly InformativeInherited
Biological Process (BP)transition metal ion transport10.1414Highly InformativeInherited
Molecular Function (MF)binding0.95661Least InformativeInherited
Molecular Function (MF)transporter activity00Moderately InformativeDirect
Molecular Function (MF)anion transmembrane transporter activity08.265e-15InformativeDirect
Molecular Function (MF)metal ion transmembrane transporter activity0.0046310.4068InformativeInherited
Molecular Function (MF)inorganic cation transmembrane transporter activity7.819e-110.1019InformativeInherited
Molecular Function (MF)organic cation transmembrane transporter activity00Highly InformativeDirect
Molecular Function (MF)organic hydroxy compound transmembrane transporter activity5.691e-050Highly InformativeDirect
Molecular Function (MF)carbohydrate transmembrane transporter activity0.0010662.675e-09Highly InformativeInherited
Molecular Function (MF)cation channel activity1.847e-060.03022Highly InformativeInherited
Molecular Function (MF)ion gated channel activity1.858e-050.85Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.91630.5296Least InformativeInherited
Cellular Component (CC)intracellular organelle part0.13280.6537Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.041030.3327Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum0.00017860.000897Moderately InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection4.685e-050.0008078Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.002960.004197Moderately InformativeInherited
Cellular Component (CC)organelle envelope0.0024640.0002083Moderately InformativeInherited
Cellular Component (CC)nuclear part0.043710.9354Moderately InformativeInherited
Cellular Component (CC)organelle membrane0.02150.005217Moderately InformativeInherited
Cellular Component (CC)nuclear envelope1.424e-073.427e-06InformativeDirect
Cellular Component (CC)cell junction8.722e-052.518e-05InformativeDirect
Cellular Component (CC)vacuolar part3.43e-066.088e-05InformativeDirect
Cellular Component (CC)plastid0.0020340.0001316InformativeInherited
Cellular Component (CC)brush border2.126e-101.676e-09Highly InformativeDirect
Cellular Component (CC)basolateral plasma membrane4.545e-059.559e-06Highly InformativeDirect
Cellular Component (CC)apical plasma membrane1.434e-151.589e-15Highly InformativeDirect
Cellular Component (CC)nuclear membrane3.104e-096.637e-09Highly InformativeDirect
Cellular Component (CC)sarcolemma2.69e-050.0008379Highly InformativeDirect
Cellular Component (CC)symplast2.202e-055.084e-06Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.044330.005367Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.0008329 Least Informative Direct
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0.3453 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.9161 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.9509 Least Informative Inherited
Biological Process (BP) regulation of cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.6267 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.04971 Least Informative Inherited
Biological Process (BP) developmental process 0.807 Least Informative Inherited
Biological Process (BP) system process 1.333e-12 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 2.91e-07 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.0002094 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 5.396e-07 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 5.271e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.4264 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.1026 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.01078 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.07837 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.8458 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.03697 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.07499 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9957 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.08419 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.9692 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.05553 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.005898 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4024 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.4733 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9949 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.326 Moderately Informative Inherited
Biological Process (BP) ion transport 0.6855 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.002415 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1367 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.07007 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1351 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.08042 Moderately Informative Inherited
Biological Process (BP) organ development 0.004926 Moderately Informative Inherited
Biological Process (BP) anion transport 7.921e-05 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 8.4e-06 Informative Direct
Biological Process (BP) response to hormone stimulus 0.0001579 Informative Direct
Biological Process (BP) response to inorganic substance 5.503e-11 Informative Direct
Biological Process (BP) hexose metabolic process 0.0009095 Informative Direct
Biological Process (BP) response to lipid 2.844e-06 Informative Direct
Biological Process (BP) regulation of system process 0.0009418 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.498e-07 Informative Direct
Biological Process (BP) regulation of body fluid levels 0 Informative Direct
Biological Process (BP) regulation of secretion 0.0008623 Informative Direct
Biological Process (BP) positive regulation of transport 0.0001049 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.0006437 Informative Direct
Biological Process (BP) transmembrane transport 0 Informative Direct
Biological Process (BP) nitrogen compound transport 0.0001857 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.887e-07 Informative Direct
Biological Process (BP) metal ion transport 0.0485 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01841 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.39 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1391 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001701 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.08997 Informative Inherited
Biological Process (BP) response to oxidative stress 0.03835 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.06216 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 0.002209 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.01659 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.007276 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.001911 Informative Inherited
Biological Process (BP) central nervous system development 0.03343 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.2498 Informative Inherited
Biological Process (BP) actin filament-based process 0.01557 Informative Inherited
Biological Process (BP) response to nutrient levels 0.7307 Informative Inherited
Biological Process (BP) response to light stimulus 0.2014 Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0.001766 Informative Inherited
Biological Process (BP) sensory organ development 0.002702 Informative Inherited
Biological Process (BP) response to hypoxia 8.382e-05 Highly Informative Direct
Biological Process (BP) glycolysis 0.0001833 Highly Informative Direct
Biological Process (BP) calcium ion transport 8.496e-05 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.0002856 Highly Informative Direct
Biological Process (BP) digestion 4.482e-09 Highly Informative Direct
Biological Process (BP) carbohydrate transport 0 Highly Informative Direct
Biological Process (BP) response to UV 9.565e-09 Highly Informative Direct
Biological Process (BP) response to water deprivation 5.636e-09 Highly Informative Direct
Biological Process (BP) response to purine-containing compound 5.391e-08 Highly Informative Direct
Biological Process (BP) gas transport 1.827e-13 Highly Informative Direct
Biological Process (BP) inorganic anion transport 8.146e-07 Highly Informative Direct
Biological Process (BP) organic hydroxy compound transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0 Highly Informative Direct
Biological Process (BP) telencephalon development 1.429e-07 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 3.784e-06 Highly Informative Direct
Biological Process (BP) amide transport 1.735e-08 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic process 0.0006826 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 8.018e-08 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 7.021e-12 Highly Informative Direct
Biological Process (BP) modification of morphology or physiology of other organism involved in symbiotic interaction 4.414e-08 Highly Informative Direct
Biological Process (BP) cellular response to steroid hormone stimulus 1.482e-09 Highly Informative Direct
Biological Process (BP) cellular response to radiation 4.328e-05 Highly Informative Direct
Biological Process (BP) response to alcohol 2.606e-06 Highly Informative Direct
Biological Process (BP) response to salt stress 0.1645 Highly Informative Inherited
Biological Process (BP) cellular response to metal ion 0.03115 Highly Informative Inherited
Biological Process (BP) response to hydrogen peroxide 0.08086 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.03866 Highly Informative Inherited
Biological Process (BP) cellular response to starvation 0.01586 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 0.01997 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.1414 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transporter activity 0 Moderately Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 8.265e-15 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 0.4068 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 0.1019 Informative Inherited
Molecular Function (MF) organic cation transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) carbohydrate transmembrane transporter activity 2.675e-09 Highly Informative Direct
Molecular Function (MF) organic hydroxy compound transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) cation channel activity 0.03022 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.85 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.5296 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.6537 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3327 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0.000897 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0.0002083 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0008078 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.004197 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.9354 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.005217 Moderately Informative Inherited
Cellular Component (CC) nuclear envelope 3.427e-06 Informative Direct
Cellular Component (CC) plastid 0.0001316 Informative Direct
Cellular Component (CC) cell junction 2.518e-05 Informative Direct
Cellular Component (CC) vacuolar part 6.088e-05 Informative Direct
Cellular Component (CC) brush border 1.676e-09 Highly Informative Direct
Cellular Component (CC) basolateral plasma membrane 9.559e-06 Highly Informative Direct
Cellular Component (CC) apical plasma membrane 1.589e-15 Highly Informative Direct
Cellular Component (CC) nuclear membrane 6.637e-09 Highly Informative Direct
Cellular Component (CC) sarcolemma 0.0008379 Highly Informative Direct
Cellular Component (CC) symplast 5.084e-06 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.005367 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1762Least InformativeInherited
Disease Ontology (DO)sensory system disease0.000359Moderately InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0004504InformativeDirect
Disease Ontology (DO)auditory system disease0.002591InformativeInherited
Disease Ontology (DO)labyrinthine disease6.413e-10Highly InformativeDirect
Disease Ontology (DO)colonic disease0.0007112Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.0009781Least InformativeDirect
Mammalian Phenotype (MP)renal/urinary system phenotype0.0003241Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lipid homeostasis0.03264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis9.515e-05InformativeDirect
Mammalian Phenotype (MP)abnormal urination0.005523InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.1183InformativeInherited
Mammalian Phenotype (MP)polyuria4.386e-08Highly InformativeDirect
Mammalian Phenotype (MP)increased blood osmolality4.628e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating glycerol level0.0009433Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.0007885Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.6617Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.9348Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue8.144e-06InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0007892InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.0008458InformativeDirect
Plant ANatomical entity (PAN)lateral root1.032e-05Highly InformativeDirect
Plant ANatomical entity (PAN)plant axis elongation zone0.0001294Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05303Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processGlycerol metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasmic vesicle9.641e-16Moderately InformativeDirect
Cellular componentGolgi apparatus5.625e-08Moderately InformativeDirect
Cellular componentCell junction5.047e-05Moderately InformativeDirect
Cellular componentVacuole0InformativeDirect
DomainRepeat0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationEye lens protein0Highly InformativeDirect
Post-translational modificationPhosphoprotein5.925e-07Least InformativeDirect
Post-translational modificationAcetylation0.0002665Least InformativeDirect
Post-translational modificationGlycoprotein0.0004633Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000425 SSF81338 Protein matches
Abstract

A number of transmembrane (TM) channel proteins can be grouped together on the basis of sequence similarities [PubMed8325040, PubMed2014003, PubMed1715617, PubMed7529436].

These include:

  • Mammalian major intrinsic protein (MIP). MIP is the major component of lens fibre gap junctions.
  • Mammalian aquaporins [PubMed7529436]. These proteins form water- specific channels that provide the plasma membranes of red cells and kidney prox imal and collecting tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • Soybean nodulin-26, a major component of the peribacteroid membrane induced during nodulation in legume roots after Rhizobium infection.
  • Plants tonoplast intrinsic proteins (TIP). There are various isoforms of TIP : alpha (seed), gamma, Rt (root), and Wsi (water-stress induced). These proteins may allow the diffusion of water, amino acids and/or peptides from the tonoplas t interior to the cytoplasm..
  • Bacterial glycerol facilitator protein (gene glpF), which facilitates the mo vement of glycerol across the cytoplasmic membrane.
  • Salmonella typhimurium propanediol diffusion fac ilitator (gene pduF).
  • Yeast FPS1, a glycerol uptake/efflux facilitator protein.
  • Drosophila neurogenic protein 'big brain' (bib). This protein may mediate in tercellular communication; it may functions by allowing the transport of certain molecules(s) and thereby sending a signal for an exodermal cell to become an ep idermoblast instead of a neuroblast.
  • Yeast hypothetical protein YFL054c.
  • A hypothetical protein from the pepX region of Lactococ cus lactis.

MIP family proteins are thought to contain 6 TM domains. Sequence analysis suggests that the proteins may have arisen through tandem, intragenic duplication from an ancestral protein that contained 3 TM domains [].

Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates a ttached to lipids or proteins [PubMed11845000]. Aquaporin-CHIP (Aquaporin 1) belo ngs to the Colton blood group system and is associated with Co(a/b) antigen.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Aquaporin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Aquaporin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]