SUPERFAMILY 1.75 HMM library and genome assignments server


F1F0 ATP synthase subunit A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   F1F0 ATP synthase subunit A [ 81337]
Superfamily:   F1F0 ATP synthase subunit A [ 81336]
Families:   F1F0 ATP synthase subunit A [ 81335]


Superfamily statistics
Genomes (2,518) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,821 0 1
Proteins 2,819 0 1


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part01.352e-11Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.401e-143.14e-08Least InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial membrane part00InformativeDirect
Cellular Component (CC)mitochondrial proton-transporting ATP synthase complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.2743 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.3692 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.1954 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.2603 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.313 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.1818 Least Informative Inherited
Biological Process (BP) localization 0.5528 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001705 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.0007367 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0007558 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0009605 Moderately Informative Direct
Biological Process (BP) ion transport 0.00103 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.03067 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.005978 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.002492 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.002568 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.002585 Moderately Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 6.938e-09 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 4.499e-08 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 1.853e-07 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.038e-06 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 1.186e-06 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 2.543e-06 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 4.133e-06 Informative Direct
Biological Process (BP) transmembrane transport 5.654e-05 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.0005191 Informative Direct
Biological Process (BP) hydrogen transport 4.992e-12 Highly Informative Direct
Biological Process (BP) ATP metabolic process 6.51e-08 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 9.599e-08 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 8.103e-07 Highly Informative Direct
Biological Process (BP) ion transmembrane transport 1.604e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 2.006e-05 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.05619 Least Informative Inherited
Molecular Function (MF) transporter activity 0.001933 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 3.332e-05 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 3.463e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 7.179e-05 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.00186 Informative Inherited
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 7.695e-09 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 5.221e-08 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.352e-11 Least Informative Direct
Cellular Component (CC) intracellular organelle part 3.14e-08 Least Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.007338Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Coding sequence diversityRNA editing3.162e-05Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000568 SSF81336 Protein matches
Abstract

This entry represents subunit A (or subunit 6) found in the F0 complex of F-ATPases. This subunit is a key component of the proton channel, and may play a direct role in the translocation of protons across the membrane. Catalysis in the F1 complex depends upon the rotation of the central stalk and F0 c-ring, which in turn is driven by the flux of protons through the membrane via the interface between the F0 c-ring and subunit A. The peripheral stalk links subunit A to the external surface of the F1 domain, and is thought to act as a stator to counter the tendency of subunit A and the F1 alpha(3)beta(3) catalytic portion to rotate with the central rotary element [PubMed16045926].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F1F0 ATP synthase subunit A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the F1F0 ATP synthase subunit A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]