SUPERFAMILY 1.75 HMM library and genome assignments server


F1F0 ATP synthase subunit A superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   F1F0 ATP synthase subunit A [ 81337]
Superfamily:   F1F0 ATP synthase subunit A [ 81336]
Families:   F1F0 ATP synthase subunit A [ 81335]


Superfamily statistics
Genomes (2,520) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,821 33,775 1
Proteins 2,819 33,693 1


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular membrane-bounded organelle00Least InformativeDirect
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)protein complex00Least InformativeDirect
Cellular Component (CC)cytoplasmic part01.826e-11Least InformativeDirect
Cellular Component (CC)intracellular organelle part1.107e-142.566e-08Least InformativeDirect
Cellular Component (CC)mitochondrial part00Moderately InformativeDirect
Cellular Component (CC)organelle membrane00Moderately InformativeDirect
Cellular Component (CC)organelle envelope00Moderately InformativeDirect
Cellular Component (CC)mitochondrial membrane part00InformativeDirect
Cellular Component (CC)mitochondrial proton-transporting ATP synthase complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.3278 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2383 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3136 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.4357 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.3816 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2228 Least Informative Inherited
Biological Process (BP) localization 0.6151 Least Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0002533 Moderately Informative Direct
Biological Process (BP) ion transport 0.001355 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.001081 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.04022 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.001373 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.001088 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.008008 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.00343 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.003497 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.003501 Moderately Informative Inherited
Biological Process (BP) glycosyl compound biosynthetic process 1.177e-08 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 4.631e-08 Informative Direct
Biological Process (BP) nucleoside monophosphate metabolic process 2.449e-07 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 1.163e-06 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 1.727e-06 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 3.817e-06 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 5.89e-06 Informative Direct
Biological Process (BP) transmembrane transport 7.778e-05 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.000584 Informative Direct
Biological Process (BP) hydrogen transport 7.098e-12 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 1.552e-08 Highly Informative Direct
Biological Process (BP) ATP metabolic process 8.607e-08 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 1.385e-07 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 7.839e-07 Highly Informative Direct
Biological Process (BP) purine ribonucleotide biosynthetic process 2.212e-05 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.07254 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 7.847e-05 Moderately Informative Direct
Molecular Function (MF) transporter activity 0.002459 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 2.993e-05 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 4.72e-05 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 9.368e-05 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.001799 Informative Inherited
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 1.002e-08 Highly Informative Direct
Molecular Function (MF) hydrogen ion transmembrane transporter activity 6.775e-08 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1.826e-11 Least Informative Direct
Cellular Component (CC) intracellular organelle part 2.566e-08 Least Informative Direct
Cellular Component (CC) mitochondrial part 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) organelle envelope 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial membrane part 0 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPlastid0Moderately InformativeDirect
Cellular componentCell membrane0.008575Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion inner membrane0InformativeDirect
Coding sequence diversityRNA editing3.129e-05Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000568 SSF81336 Protein matches
Abstract

This entry represents subunit A (or subunit 6) found in the F0 complex of F-ATPases. This subunit is a key component of the proton channel, and may play a direct role in the translocation of protons across the membrane. Catalysis in the F1 complex depends upon the rotation of the central stalk and F0 c-ring, which in turn is driven by the flux of protons through the membrane via the interface between the F0 c-ring and subunit A. The peripheral stalk links subunit A to the external surface of the F1 domain, and is thought to act as a stator to counter the tendency of subunit A and the F1 alpha(3)beta(3) catalytic portion to rotate with the central rotary element [PubMed16045926].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F1F0 ATP synthase subunit A domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the F1F0 ATP synthase subunit A superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]