SUPERFAMILY 1.75 HMM library and genome assignments server


F1F0 ATP synthase subunit C superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Transmembrane helix hairpin [ 81334] (5)
Superfamily:   F1F0 ATP synthase subunit C [ 81333]
Families:   F1F0 ATP synthase subunit C [ 81332]


Superfamily statistics
Genomes (3,200) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,285 26,768 4
Proteins 5,621 23,375 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.00088583.404e-06Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0087180.1234Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0026560.2889Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0096220.5226Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0044980.3795Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.020380.456Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0025780.27Least InformativeInherited
Biological Process (BP)biosynthetic process0.0220.7465Least InformativeInherited
Biological Process (BP)organophosphate metabolic process3.097e-050.0008994Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process1.08e-050.0001809Moderately InformativeDirect
Biological Process (BP)ion transport0.0019912.798e-07Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0004770.04481Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0042190.01356Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0016520.03689Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00094250.03695Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0013820.03648Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0022740.06763Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process4.031e-050.001178Moderately InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process1.023e-097.103e-08InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process1.018e-077.015e-07InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process1.859e-072.769e-06InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process2.754e-071.698e-06InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process2.137e-050.0001583InformativeDirect
Biological Process (BP)transmembrane transport1.073e-052.083e-08InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process6.629e-061.042e-05InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process2.798e-061.092e-06InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.006890.02164InformativeInherited
Biological Process (BP)hydrogen transport5.697e-110Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate biosynthetic process0.0006620.0001157Highly InformativeDirect
Biological Process (BP)purine nucleoside triphosphate biosynthetic process5.56e-065.065e-06Highly InformativeDirect
Biological Process (BP)purine ribonucleoside monophosphate metabolic process1.861e-104.451e-08Highly InformativeDirect
Biological Process (BP)ribonucleoside triphosphate biosynthetic process2.861e-067.188e-06Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate metabolic process4.271e-084.217e-07Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation transport2.457e-107.226e-05Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0022471.276e-05Least InformativeInherited
Molecular Function (MF)transporter activity8.35e-061.562e-15Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances5.339e-103.223e-13InformativeDirect
Molecular Function (MF)active transmembrane transporter activity1.55e-082.718e-07InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity5.451e-090InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity8.762e-070.4253InformativeInherited
Molecular Function (MF)hydrogen ion transmembrane transporter activity6.234e-110Highly InformativeDirect
Molecular Function (MF)ATPase activity, coupled to transmembrane movement of ions5.164e-138.977e-15Highly InformativeDirect
Cellular Component (CC)membrane8.802e-050Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00045540Least InformativeDirect
Cellular Component (CC)protein complex0.00010320Least InformativeDirect
Cellular Component (CC)intrinsic to membrane0.58461Moderately InformativeInherited
Cellular Component (CC)integral to membrane0.00060522.666e-08InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 3.404e-06 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1234 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2889 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5226 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3795 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.456 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.27 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7465 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0738 Least Informative Inherited
Biological Process (BP) ion transport 2.798e-07 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0008994 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001809 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0001289 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.04481 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01356 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.06763 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.03689 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.03695 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.03648 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.001178 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002424 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 7.103e-08 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 7.015e-07 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 2.769e-06 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 1.698e-06 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0001583 Informative Direct
Biological Process (BP) cation homeostasis 1.61e-14 Informative Direct
Biological Process (BP) cellular chemical homeostasis 9.148e-15 Informative Direct
Biological Process (BP) transmembrane transport 2.083e-08 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 1.042e-05 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 1.092e-06 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.02164 Informative Inherited
Biological Process (BP) hydrogen transport 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0001157 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate biosynthetic process 5.065e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 4.451e-08 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate biosynthetic process 7.188e-06 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 4.217e-07 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 7.226e-05 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 4.483e-08 Highly Informative Direct
Biological Process (BP) lysosome organization 0.04718 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1.276e-05 Least Informative Direct
Molecular Function (MF) transporter activity 1.562e-15 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 3.223e-13 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 2.718e-07 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.4253 Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 8.977e-15 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 5.906e-10 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0004824 Least Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.001335 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.002801 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 2.666e-08 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) mitochondrial membrane part 2.115e-05 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 6.61e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001063Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect9.186e-06Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0003339Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0003563Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.001082Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.002231Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.01583Moderately InformativeInherited
Worm Phenotype (WP)receptor mediated endocytosis defective1.005e-06InformativeDirect
Worm Phenotype (WP)somatic gonad development variant4.277e-06InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant1.419e-05InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant1.781e-05InformativeDirect
Worm Phenotype (WP)cell division variant0.007906InformativeInherited
Worm Phenotype (WP)germ cell compartment anucleate1.874e-07Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant5.642e-07Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant1.79e-06Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant6.26e-06Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant1.249e-05Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)nutrient utilization0Moderately InformativeDirect
Yeast Phenotype (YP)lifespan0InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)utilization of carbon source0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)metal resistance0Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide modification0Highly InformativeDirect
Yeast Phenotype (YP)alkaline pH resistance0Highly InformativeDirect
Yeast Phenotype (YP)respiratory growth0Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0Highly InformativeDirect
Yeast Phenotype (YP)desiccation resistance0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skin0InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage0InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid4.601e-12Moderately InformativeDirect
Cellular componentMitochondrion2.541e-11Moderately InformativeDirect
Cellular componentCell membrane0.01767Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane7.095e-06InformativeDirect
Coding sequence diversityRNA editing2.169e-06Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionLipid-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002379 SSF81333 Protein matches
Abstract

The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [PubMed11309608, PubMed15629643].

This entry represents subunit C (also called subunit 9, or proteolipid in F-ATPases, or the 16 kDa proteolipid in V-ATPases) found in the F0 or V0 complex of F- and V-ATPases, respectively. In F-ATPases, ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor [PubMed14630314].

In V-ATPases, there are three proteolipid subunits (c, c and c) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [PubMed15951435, PubMed14635779].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F1F0 ATP synthase subunit C domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the F1F0 ATP synthase subunit C superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]