SUPERFAMILY 1.75 HMM library and genome assignments server

F1F0 ATP synthase subunit C superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Transmembrane helix hairpin [ 81334] (5)
Superfamily:   F1F0 ATP synthase subunit C [ 81333]
Families:   F1F0 ATP synthase subunit C [ 81332]


Superfamily statistics
Genomes (3,201) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,301 26,768 4
Proteins 5,633 23,375 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.05011Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.010260.5402Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0048410.3937Least InformativeInherited
Biological Process (BP)localization0.0010650.000005015Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0028120.2826Least InformativeInherited
Biological Process (BP)single-organism cellular process0.043250.3692Least InformativeInherited
Biological Process (BP)biosynthetic process0.021720.747Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.00290.3021Least InformativeInherited
Biological Process (BP)ion transport0.0000067310.0000008945Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.000037490.0004126Moderately InformativeDirect
Biological Process (BP)organonitrogen compound biosynthetic process0.0040720.01364Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0016350.03748Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.000049290.001504Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.00059550.05832Moderately InformativeInherited
Biological Process (BP)organophosphate metabolic process0.000037240.001127Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00094190.03757Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0022340.06852Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0013610.03707Moderately InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.0000000036560.0000001838InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process0.00000018010.000001416InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.00000031110.000004947InformativeDirect
Biological Process (BP)monovalent inorganic cation transport0.0000000039760.0008529InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00000044470.000003159InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.000017720.0001304InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.0000059770.000009362InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process0.0000025550.000001093InformativeDirect
Biological Process (BP)ion transmembrane transport0.000000047780.06853InformativeInherited
Biological Process (BP)nucleotide biosynthetic process0.0052710.01693InformativeInherited
Biological Process (BP)nucleoside monophosphate biosynthetic process0.0003760.00007581Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate biosynthetic process0.0000021790.000002607Highly InformativeDirect
Biological Process (BP)hydrogen ion transmembrane transport0.000000000066760.0005746Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0022610.00001302Least InformativeInherited
Molecular Function (MF)transporter activity0.00000850.000000000000001593Moderately InformativeDirect
Molecular Function (MF)monovalent inorganic cation transmembrane transporter activity0.0000000019420.0007751InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances0.0000000005360.0000000000003349InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.000000016210.0000003052InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity0.00000087110.426InformativeInherited
Molecular Function (MF)hydrogen ion transmembrane transporter activity0.000000000062470Highly InformativeDirect
Molecular Function (MF)ATPase activity, coupled to transmembrane movement of ions0.00000000000062150.000000000000009916Highly InformativeDirect
Cellular Component (CC)membrane0.0000880Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00036740Least InformativeDirect
Cellular Component (CC)protein complex0.00010080Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000005015 Least Informative Direct
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5402 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3937 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.2826 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.3692 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.747 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.3021 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.08673 Least Informative Inherited
Biological Process (BP) ion transport 0.0000008945 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0004126 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000114 Moderately Informative Direct
Biological Process (BP) organonitrogen compound biosynthetic process 0.01364 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.03748 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.001504 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 0.001127 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0.05832 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.03757 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.06852 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.03707 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.0000001838 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.000001416 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.000004947 Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.0008529 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000003159 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0001304 Informative Direct
Biological Process (BP) cation homeostasis 0.00000000000001071 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000000007248 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.000009362 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.000001093 Informative Direct
Biological Process (BP) ion transmembrane transport 0.06853 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 0.01693 Informative Inherited
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.00007581 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate biosynthetic process 0.000002607 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0.00000005642 Highly Informative Direct
Biological Process (BP) hydrogen ion transmembrane transport 0.0005746 Highly Informative Direct
Biological Process (BP) lysosome organization 0.04723 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00001302 Least Informative Direct
Molecular Function (MF) transporter activity 0.000000000000001593 Moderately Informative Direct
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.0007751 Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.0000000000003349 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.0000003052 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.426 Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0.000000000000009916 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000008499 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0003784 Least Informative Direct
Cellular Component (CC) organelle envelope 0.002991 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 0.4195 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.001461 Moderately Informative Inherited
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.00001862 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 0.00000006474 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001063Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000009186Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0003339Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0003563Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.001082Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.002231Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.01583Moderately InformativeInherited
Worm Phenotype (WP)receptor mediated endocytosis defective0.000001005InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.000004277InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.00001419InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00001781InformativeDirect
Worm Phenotype (WP)cell division variant0.007906InformativeInherited
Worm Phenotype (WP)germ cell compartment anucleate0.0000001874Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000005642Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000179Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.00000626Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.00001249Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)nutrient utilization0Moderately InformativeDirect
Yeast Phenotype (YP)lifespan0InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)utilization of carbon source0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)metal resistance0Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide modification0Highly InformativeDirect
Yeast Phenotype (YP)alkaline pH resistance0Highly InformativeDirect
Yeast Phenotype (YP)respiratory growth0Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0Highly InformativeDirect
Yeast Phenotype (YP)desiccation resistance0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skin0InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage0InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0.000000000004601Moderately InformativeDirect
Cellular componentMitochondrion0.00000000002541Moderately InformativeDirect
Cellular componentCell membrane0.01767Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane0.000007095InformativeDirect
Coding sequence diversityRNA editing0.000002169Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionLipid-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002379 SSF81333 Protein matches
Abstract

The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [PubMed11309608, PubMed15629643].

This entry represents subunit C (also called subunit 9, or proteolipid in F-ATPases, or the 16 kDa proteolipid in V-ATPases) found in the F0 or V0 complex of F- and V-ATPases, respectively. In F-ATPases, ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor [PubMed14630314].

In V-ATPases, there are three proteolipid subunits (c, c and c) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [PubMed15951435, PubMed14635779].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F1F0 ATP synthase subunit C domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the F1F0 ATP synthase subunit C superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]