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F1F0 ATP synthase subunit C superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Transmembrane helix hairpin [ 81334] (5)
Superfamily:   F1F0 ATP synthase subunit C [ 81333]
Families:   F1F0 ATP synthase subunit C [ 81332]


Superfamily statistics
Genomes (3,200) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,285 26,768 4
Proteins 5,621 23,375 4


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)localization0.00088580.000003404Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0087180.1234Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process0.0026560.2889Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0096220.5226Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process0.0044980.3795Least InformativeInherited
Biological Process (BP)single-organism metabolic process0.020380.456Least InformativeInherited
Biological Process (BP)heterocycle metabolic process0.0025780.27Least InformativeInherited
Biological Process (BP)biosynthetic process0.0220.7465Least InformativeInherited
Biological Process (BP)organophosphate metabolic process0.000030970.0008994Moderately InformativeDirect
Biological Process (BP)nucleobase-containing small molecule metabolic process0.00001080.0001809Moderately InformativeDirect
Biological Process (BP)ion transport0.0019910.0000002798Moderately InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process0.0004770.04481Moderately InformativeInherited
Biological Process (BP)organonitrogen compound biosynthetic process0.0042190.01356Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process0.0016520.03689Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process0.00094250.03695Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process0.0013820.03648Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.0022740.06763Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process0.000040310.001178Moderately InformativeInherited
Biological Process (BP)nucleoside monophosphate metabolic process0.0000000010230.00000007103InformativeDirect
Biological Process (BP)nucleoside triphosphate metabolic process0.00000010180.0000007015InformativeDirect
Biological Process (BP)purine ribonucleotide metabolic process0.00000018590.000002769InformativeDirect
Biological Process (BP)purine ribonucleoside metabolic process0.00000027540.000001698InformativeDirect
Biological Process (BP)ribose phosphate biosynthetic process0.000021370.0001583InformativeDirect
Biological Process (BP)transmembrane transport0.000010730.00000002083InformativeDirect
Biological Process (BP)purine-containing compound biosynthetic process0.0000066290.00001042InformativeDirect
Biological Process (BP)glycosyl compound biosynthetic process0.0000027980.000001092InformativeDirect
Biological Process (BP)nucleotide biosynthetic process0.006890.02164InformativeInherited
Biological Process (BP)hydrogen transport0.000000000056970Highly InformativeDirect
Biological Process (BP)nucleoside monophosphate biosynthetic process0.0006620.0001157Highly InformativeDirect
Biological Process (BP)purine nucleoside triphosphate biosynthetic process0.000005560.000005065Highly InformativeDirect
Biological Process (BP)purine ribonucleoside monophosphate metabolic process0.00000000018610.00000004451Highly InformativeDirect
Biological Process (BP)ribonucleoside triphosphate biosynthetic process0.0000028610.000007188Highly InformativeDirect
Biological Process (BP)purine ribonucleoside triphosphate metabolic process0.000000042710.0000004217Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation transport0.00000000024570.00007226Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.0022470.00001276Least InformativeInherited
Molecular Function (MF)transporter activity0.000008350.000000000000001562Moderately InformativeDirect
Molecular Function (MF)hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances0.00000000053390.0000000000003223InformativeDirect
Molecular Function (MF)active transmembrane transporter activity0.00000001550.0000002718InformativeDirect
Molecular Function (MF)inorganic cation transmembrane transporter activity0.0000000054510InformativeDirect
Molecular Function (MF)nucleoside-triphosphatase activity0.00000087620.4253InformativeInherited
Molecular Function (MF)hydrogen ion transmembrane transporter activity0.000000000062340Highly InformativeDirect
Molecular Function (MF)ATPase activity, coupled to transmembrane movement of ions0.00000000000051640.000000000000008977Highly InformativeDirect
Cellular Component (CC)membrane0.000088020Least InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.00045540Least InformativeDirect
Cellular Component (CC)protein complex0.00010320Least InformativeDirect
Cellular Component (CC)intrinsic to membrane0.58461Moderately InformativeInherited
Cellular Component (CC)integral to membrane0.00060520.00000002666InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.000003404 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1234 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.2889 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.5226 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.3795 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.456 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.27 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.7465 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0738 Least Informative Inherited
Biological Process (BP) ion transport 0.0000002798 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0.0008994 Moderately Informative Direct
Biological Process (BP) nucleobase-containing small molecule metabolic process 0.0001809 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0001289 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0.04481 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 0.01356 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.06763 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.03689 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.03695 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.03648 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 0.001178 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.002424 Moderately Informative Inherited
Biological Process (BP) nucleoside monophosphate metabolic process 0.00000007103 Informative Direct
Biological Process (BP) nucleoside triphosphate metabolic process 0.0000007015 Informative Direct
Biological Process (BP) purine ribonucleotide metabolic process 0.000002769 Informative Direct
Biological Process (BP) purine ribonucleoside metabolic process 0.000001698 Informative Direct
Biological Process (BP) ribose phosphate biosynthetic process 0.0001583 Informative Direct
Biological Process (BP) cation homeostasis 0.0000000000000161 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.000000000000009148 Informative Direct
Biological Process (BP) transmembrane transport 0.00000002083 Informative Direct
Biological Process (BP) purine-containing compound biosynthetic process 0.00001042 Informative Direct
Biological Process (BP) glycosyl compound biosynthetic process 0.000001092 Informative Direct
Biological Process (BP) nucleotide biosynthetic process 0.02164 Informative Inherited
Biological Process (BP) hydrogen transport 0 Highly Informative Direct
Biological Process (BP) nucleoside monophosphate biosynthetic process 0.0001157 Highly Informative Direct
Biological Process (BP) purine nucleoside triphosphate biosynthetic process 0.000005065 Highly Informative Direct
Biological Process (BP) purine ribonucleoside monophosphate metabolic process 0.00000004451 Highly Informative Direct
Biological Process (BP) ribonucleoside triphosphate biosynthetic process 0.000007188 Highly Informative Direct
Biological Process (BP) purine ribonucleoside triphosphate metabolic process 0.0000004217 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation transport 0.00007226 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0.00000004483 Highly Informative Direct
Biological Process (BP) lysosome organization 0.04718 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.00001276 Least Informative Direct
Molecular Function (MF) transporter activity 0.000000000000001562 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.0000000000003223 Informative Direct
Molecular Function (MF) active transmembrane transporter activity 0.0000002718 Informative Direct
Molecular Function (MF) inorganic cation transmembrane transporter activity 0 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 0.4253 Informative Inherited
Molecular Function (MF) hydrogen ion transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) ATPase activity, coupled to transmembrane movement of ions 0.000000000000008977 Highly Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000000005906 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0004824 Least Informative Direct
Cellular Component (CC) organelle membrane 0 Moderately Informative Direct
Cellular Component (CC) mitochondrial part 0.001335 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 0.002801 Moderately Informative Inherited
Cellular Component (CC) intrinsic to membrane 1 Moderately Informative Inherited
Cellular Component (CC) integral to membrane 0.00000002666 Informative Direct
Cellular Component (CC) vacuolar part 0 Informative Direct
Cellular Component (CC) mitochondrial membrane part 0.00002115 Informative Direct
Cellular Component (CC) mitochondrial proton-transporting ATP synthase complex 0.0000000661 Highly Informative Direct

Document: GO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001063Least InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000009186Moderately InformativeDirect
Worm Phenotype (WP)cell organization biogenesis variant0.0003339Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.0003563Moderately InformativeDirect
Worm Phenotype (WP)gametogenesis variant0.001082Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.002231Moderately InformativeInherited
Worm Phenotype (WP)cell death variant0.01583Moderately InformativeInherited
Worm Phenotype (WP)receptor mediated endocytosis defective0.000001005InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.000004277InformativeDirect
Worm Phenotype (WP)meiotic chromosome organization variant0.00001419InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00001781InformativeDirect
Worm Phenotype (WP)cell division variant0.007906InformativeInherited
Worm Phenotype (WP)germ cell compartment anucleate0.0000001874Highly InformativeDirect
Worm Phenotype (WP)oocyte septum formation variant0.0000005642Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00000179Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.00000626Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.00001249Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)morphology0Moderately InformativeDirect
Yeast Phenotype (YP)nutrient utilization0Moderately InformativeDirect
Yeast Phenotype (YP)lifespan0InformativeDirect
Yeast Phenotype (YP)chemical compound accumulation0InformativeDirect
Yeast Phenotype (YP)utilization of carbon source0InformativeDirect
Yeast Phenotype (YP)vegetative growth0InformativeDirect
Yeast Phenotype (YP)subcellular morphology0InformativeDirect
Yeast Phenotype (YP)metal resistance0Highly InformativeDirect
Yeast Phenotype (YP)protein/peptide modification0Highly InformativeDirect
Yeast Phenotype (YP)alkaline pH resistance0Highly InformativeDirect
Yeast Phenotype (YP)respiratory growth0Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0Highly InformativeDirect
Yeast Phenotype (YP)desiccation resistance0Highly InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)visual system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skin0InformativeDirect
Xenopus ANatomical entity (XAN)heart0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)spleen0InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0Moderately InformativeDirect
Plant structure DEvelopment stage (PDE)L mature pollen stage0InformativeDirect
Plant structure DEvelopment stage (PDE)M germinated pollen stage0InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processIon transport0Moderately InformativeDirect
Biological processATP synthesis0Highly InformativeDirect
Biological processHydrogen ion transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentPlastid0.000000000004601Moderately InformativeDirect
Cellular componentMitochondrion0.00000000002541Moderately InformativeDirect
Cellular componentCell membrane0.01767Moderately InformativeInherited
Cellular componentThylakoid0InformativeDirect
Cellular componentVacuole0InformativeDirect
Cellular componentCell inner membrane0.000007095InformativeDirect
Coding sequence diversityRNA editing0.000002169Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionLipid-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002379 SSF81333 Protein matches
Abstract

The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [PubMed11309608, PubMed15629643].

This entry represents subunit C (also called subunit 9, or proteolipid in F-ATPases, or the 16 kDa proteolipid in V-ATPases) found in the F0 or V0 complex of F- and V-ATPases, respectively. In F-ATPases, ten C subunits form an oligomeric ring that makes up the F0 rotor. The flux of protons through the ATPase channel drives the rotation of the C subunit ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the C subunit ring of F0. The sequential protonation and deprotonation of Asp61 of subunit C is coupled to the stepwise movement of the rotor [PubMed14630314].

In V-ATPases, there are three proteolipid subunits (c, c and c) that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [PubMed15951435, PubMed14635779].

More information about this protein can be found at Protein of the Month: ATP Synthases.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a F1F0 ATP synthase subunit C domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the F1F0 ATP synthase subunit C superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]