Gated mechanosensitive channel superfamily
|General category ||coiled coil|
|Detailed category ||The code refers to alpha-helical barrels. These are a type of structure which frequently contain coiled-coils.|
Document: Function annotation of SCOP domain superfamilies
UniProtKB KeyWords (KW)(show details)
Highlighted in gray are those with FDR_all>0.001
Document: KW annotation of SCOP domains
|Cross references ||IPR001185 SSF81330 Protein matches|
|Abstract ||Mechanosensitive ion channels (MscL) play a critical role in transducing physical stresses
at the cell membrane into an electrochemical response. MscL is a protein which forms a
channel organised as a homopentamer, with each subunit containing two transmembrane
regions . Prokaryotes harbor a
large-conductance mechanosensitive channel (gene mscL) that opens in response to stretch
forces in the membrane lipid bilayer and may participate in the regulation of osmotic
pressure changes within the cell .|
PDBeMotif information about ligands, sequence and structure motifs
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Internal database links
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
Alignments of sequences to 1 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
Browse and view proteins in genomes which have
different domain combinations including a Gated mechanosensitive channel domain.
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
There are 1 hidden Markov models representing the Gated mechanosensitive channel superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · UniProtKB KeyWords (KW) · Internal database links ]