SUPERFAMILY 1.75 HMM library and genome assignments server


Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (506) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 71,605 96,641 43
Proteins 70,620 95,800 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)regulation of cellular process1.234e-090Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00053940Least InformativeDirect
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)system process00Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.35710.0006726Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.88341Moderately InformativeInherited
Biological Process (BP)homeostatic process0.44550Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.006380.991Moderately InformativeInherited
Biological Process (BP)regulation of localization11.773e-14Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)ion transport10.2331Moderately InformativeInherited
Biological Process (BP)organic substance transport10.925Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process10.005324Moderately InformativeInherited
Biological Process (BP)gene expression11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)RNA metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.40311.276e-07Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.69540Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process10.3867Moderately InformativeInherited
Biological Process (BP)response to organic substance10.00014Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.02020Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)immune system process0.54720.02641Moderately InformativeInherited
Biological Process (BP)regulation of purine nucleotide metabolic process1.057e-060InformativeDirect
Biological Process (BP)positive regulation of signal transduction2.196e-060InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade8.014e-050InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00027890InformativeDirect
Biological Process (BP)regulation of cytokine production0.60220.0002459InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.82436.657e-08InformativeInherited
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.048521.712e-06InformativeInherited
Biological Process (BP)cation homeostasis0.11752.962e-06InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.14570InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)positive regulation of transport0.70310InformativeInherited
Biological Process (BP)response to cytokine stimulus0.061980.003975InformativeInherited
Biological Process (BP)nitrogen compound transport10.9958InformativeInherited
Biological Process (BP)secretion by cell0.81360.04293InformativeInherited
Biological Process (BP)regulation of hormone levels0.87351InformativeInherited
Biological Process (BP)cell-cell signaling11InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.022110InformativeInherited
Biological Process (BP)regulation of secretion0.0019720InformativeInherited
Biological Process (BP)transcription, DNA-dependent0.0054111InformativeInherited
Biological Process (BP)regulation of immune effector process0.77071InformativeInherited
Biological Process (BP)positive regulation of immune system process0.1441InformativeInherited
Biological Process (BP)regulation of immune response0.43621InformativeInherited
Biological Process (BP)regulation of cell cycle11InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.094492.873e-09InformativeInherited
Biological Process (BP)regulation of system process0.16670InformativeInherited
Biological Process (BP)response to light stimulus0.027710.002247InformativeInherited
Biological Process (BP)locomotion0.001945.358e-09InformativeInherited
Biological Process (BP)localization of cell0.14366.687e-07InformativeInherited
Biological Process (BP)cellular component movement0.61531InformativeInherited
Biological Process (BP)sexual reproduction0.78661InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.84750.3533InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.99581InformativeInherited
Biological Process (BP)single organism reproductive process11InformativeInherited
Biological Process (BP)response to wounding0.01530InformativeInherited
Biological Process (BP)defense response0.78340InformativeInherited
Biological Process (BP)regulation of growth11InformativeInherited
Biological Process (BP)blood circulation0.10940InformativeInherited
Biological Process (BP)sensory perception00Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)detection of light stimulus5.626e-080Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade1.071e-070Highly InformativeDirect
Biological Process (BP)regulation of cyclic nucleotide metabolic process1.811e-070Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis2.031e-050Highly InformativeDirect
Biological Process (BP)inflammatory response6.312e-050Highly InformativeDirect
Biological Process (BP)regulation of ERK1 and ERK2 cascade0.00047960Highly InformativeDirect
Biological Process (BP)regulation of protein secretion0.30341.708e-08Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus11Highly InformativeInherited
Biological Process (BP)positive regulation of secretion0.30550.000131Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway0.74361Highly InformativeInherited
Biological Process (BP)response to drug11Highly InformativeInherited
Biological Process (BP)hormone transport0.0042811.135e-09Highly InformativeInherited
Biological Process (BP)signal release0.043190.09552Highly InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport11Highly InformativeInherited
Biological Process (BP)transcription from RNA polymerase II promoter2.222e-051Highly InformativeInherited
Biological Process (BP)positive regulation of cell activation0.52751Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.33731Highly InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.24791Highly InformativeInherited
Biological Process (BP)activation of immune response0.035150.8111Highly InformativeInherited
Biological Process (BP)immune response-regulating signaling pathway11Highly InformativeInherited
Biological Process (BP)regulation of multicellular organism growth0.063320.01455Highly InformativeInherited
Biological Process (BP)regulation of blood pressure0.050150Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)receptor activity00InformativeDirect
Molecular Function (MF)amide binding9.299e-050InformativeDirect
Molecular Function (MF)lipid binding0.37120.0006408InformativeInherited
Molecular Function (MF)odorant binding00Highly InformativeDirect
Molecular Function (MF)G-protein coupled receptor activity1.675e-060Highly InformativeDirect
Molecular Function (MF)peptide binding5.003e-050Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.22260.004256Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intrinsic to membrane00Moderately InformativeDirect
Cellular Component (CC)plasma membrane part00Moderately InformativeDirect
Cellular Component (CC)cell projection0.17870.0001976Moderately InformativeInherited
Cellular Component (CC)organelle membrane11Moderately InformativeInherited
Cellular Component (CC)intrinsic to plasma membrane00InformativeDirect
Cellular Component (CC)integral to membrane08.634e-15InformativeDirect
Cellular Component (CC)endosome0.00026895.201e-12InformativeDirect
Cellular Component (CC)cilium00Highly InformativeDirect
Cellular Component (CC)early endosome2.205e-100.0005478Highly InformativeDirect
Cellular Component (CC)integral to plasma membrane5.924e-102.496e-14Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.18380.8803Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0006726 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.276e-07 Moderately Informative Direct
Biological Process (BP) homeostatic process 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.773e-14 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00014 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.3867 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.2331 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.9993 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.991 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.005324 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.5803 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.925 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.02641 Moderately Informative Inherited
Biological Process (BP) organ development 0.1079 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02195 Moderately Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) locomotion 5.358e-09 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 1.712e-06 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 2.873e-09 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) cation homeostasis 2.962e-06 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 2.353e-06 Informative Direct
Biological Process (BP) localization of cell 6.687e-07 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) regulation of ion transport 2.506e-10 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) regulation of locomotion 9.814e-13 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0002459 Informative Direct
Biological Process (BP) regulation of cellular component movement 1.471e-07 Informative Direct
Biological Process (BP) regulation of defense response 0.0004869 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 6.657e-08 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.428e-05 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 5.629e-10 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 1.08e-06 Informative Direct
Biological Process (BP) response to bacterium 0.0007359 Informative Direct
Biological Process (BP) regulation of nervous system development 0.08844 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.06166 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.00193 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.003975 Informative Inherited
Biological Process (BP) metal ion transport 0.006208 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2283 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.4437 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.185 Informative Inherited
Biological Process (BP) muscle structure development 0.9931 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3533 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1185 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.002542 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.02172 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9958 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.5173 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.5751 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.1316 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1176 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1578 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) response to lipid 0.9972 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.03808 Informative Inherited
Biological Process (BP) regulation of nucleotide catabolic process 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.8401 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) lipid localization 0.8913 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.002247 Informative Inherited
Biological Process (BP) secretion by cell 0.04293 Informative Inherited
Biological Process (BP) protein transport 0.8267 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.002097 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.3901 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.3478 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.0132 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) cell activation 0.06465 Informative Inherited
Biological Process (BP) immune effector process 0.1464 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 1 Informative Inherited
Biological Process (BP) cell-cell signaling 1 Informative Inherited
Biological Process (BP) sensory perception 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) regulation of ERK1 and ERK2 cascade 0 Highly Informative Direct
Biological Process (BP) hormone transport 1.135e-09 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 4.735e-13 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 3.746e-15 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0003549 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 8.442e-12 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) regulation of inflammatory response 3.717e-10 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 1.412e-10 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 2.456e-10 Highly Informative Direct
Biological Process (BP) leukocyte migration 1.671e-10 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.749e-09 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 6.643e-11 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 3.662e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 9.316e-05 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 6.303e-08 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 4.209e-08 Highly Informative Direct
Biological Process (BP) regulation of protein secretion 1.708e-08 Highly Informative Direct
Biological Process (BP) positive regulation of secretion 0.000131 Highly Informative Direct
Biological Process (BP) digestion 1.855e-11 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.732e-13 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 5.863e-09 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 1.243e-06 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) response to alkaloid 0 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 6.519e-09 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 1.041e-07 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 1.839e-07 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 9.922e-07 Highly Informative Direct
Biological Process (BP) adult behavior 8.336e-06 Highly Informative Direct
Biological Process (BP) regulation of wound healing 5.256e-05 Highly Informative Direct
Biological Process (BP) negative regulation of neuron death 0.0001841 Highly Informative Direct
Biological Process (BP) amide transport 0.0002268 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0002391 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.000513 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0007337 Highly Informative Direct
Biological Process (BP) positive regulation of protein transport 0.8397 Highly Informative Inherited
Biological Process (BP) regulation of transporter activity 0.01976 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.09976 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.005669 Highly Informative Inherited
Biological Process (BP) cellular response to alcohol 0.9247 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.3319 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.02923 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 1 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.04898 Highly Informative Inherited
Biological Process (BP) cell proliferation 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.0255 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) regulation of actin cytoskeleton organization 0.4475 Highly Informative Inherited
Biological Process (BP) tissue homeostasis 0.01155 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.00412 Highly Informative Inherited
Biological Process (BP) signal release 0.09552 Highly Informative Inherited
Biological Process (BP) placenta development 0.3792 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.3742 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular catabolic process 0.6196 Highly Informative Inherited
Biological Process (BP) response to drug 1 Highly Informative Inherited
Biological Process (BP) regulation of neuron apoptotic process 0.04709 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1599 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.0919 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.01289 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 0.306 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.09843 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) coagulation 0.2349 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.1222 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.01644 Highly Informative Inherited
Biological Process (BP) regulation of phospholipase activity 0.001177 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.09323 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.6084 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 1 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.07899 Highly Informative Inherited
Biological Process (BP) nuclear import 0.09137 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.2475 Highly Informative Inherited
Biological Process (BP) protein import 0.3556 Highly Informative Inherited
Biological Process (BP) peptidyl-tyrosine modification 0.3929 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide biosynthetic process 0.09558 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.09768 Highly Informative Inherited
Biological Process (BP) activation of immune response 0.8111 Highly Informative Inherited
Biological Process (BP) immune response-regulating signaling pathway 1 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.4938 Highly Informative Inherited
Biological Process (BP) vascular process in circulatory system 0.006684 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.01455 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.003725 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) lipid binding 0.0006408 Informative Direct
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) receptor binding 0.5521 Informative Inherited
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) steroid binding 8.798e-06 Highly Informative Direct
Molecular Function (MF) drug binding 1.068e-13 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0.004256 Highly Informative Inherited
Molecular Function (MF) ion gated channel activity 0.9465 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) phospholipase activity 0.01836 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.04759 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0001976 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) integral to membrane 8.634e-15 Informative Direct
Cellular Component (CC) endosome 5.201e-12 Informative Direct
Cellular Component (CC) synapse part 1.525e-06 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.02836 Informative Inherited
Cellular Component (CC) cilium 0 Highly Informative Direct
Cellular Component (CC) early endosome 0.0005478 Highly Informative Direct
Cellular Component (CC) integral to plasma membrane 2.496e-14 Highly Informative Direct
Cellular Component (CC) receptor complex 1.787e-13 Highly Informative Direct
Cellular Component (CC) nuclear membrane 6.896e-06 Highly Informative Direct
Cellular Component (CC) neuron spine 0.007681 Highly Informative Inherited
Cellular Component (CC) dendrite 0.112 Highly Informative Inherited
Cellular Component (CC) axon part 0.08281 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.8803 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.05524 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5508Least InformativeInherited
Disease Ontology (DO)disease of mental health2.903e-07Moderately InformativeDirect
Disease Ontology (DO)lung disease8.755e-05Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.003383Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.025Moderately InformativeInherited
Disease Ontology (DO)brain disease0.1863Moderately InformativeInherited
Disease Ontology (DO)musculoskeletal system disease0.3862Moderately InformativeInherited
Disease Ontology (DO)overnutrition2.675e-06InformativeDirect
Disease Ontology (DO)migraine1.109e-05InformativeDirect
Disease Ontology (DO)arthritis0.0004522InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2136InformativeInherited
Disease Ontology (DO)substance dependence0.3273InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.4661InformativeInherited
Disease Ontology (DO)eating disorder1.05e-05Highly InformativeDirect
Disease Ontology (DO)anxiety disorder0.0001731Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.01343Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.0001078Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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