SUPERFAMILY 1.75 HMM library and genome assignments server

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Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (547) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 77,986 118,221 43
Proteins 76,656 117,052 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.000029940Least InformativeDirect
Biological Process (BP)regulation of cellular process0.00000000031690Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)system process00Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)regulation of localization0.64930.000000000000001938Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.23610.001086Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.77221Moderately InformativeInherited
Biological Process (BP)regulation of biological quality10.06059Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)ion transport10.3653Moderately InformativeInherited
Biological Process (BP)organic substance transport10.8872Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process10.02372Moderately InformativeInherited
Biological Process (BP)gene expression11Moderately InformativeInherited
Biological Process (BP)RNA metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.19880.0000005054Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.68020Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.85860.1957Moderately InformativeInherited
Biological Process (BP)response to organic substance10.00004172Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.14031Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.0021970Moderately InformativeInherited
Biological Process (BP)immune system process0.10610.003948Moderately InformativeInherited
Biological Process (BP)blood circulation0.0004470InformativeDirect
Biological Process (BP)response to wounding0.00047960InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.0000060950InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.000082160InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00012390InformativeDirect
Biological Process (BP)locomotion0.000052980.0000000002249InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00048080InformativeDirect
Biological Process (BP)regulation of secretion0.000000003350InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.00076510InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.0000004150InformativeDirect
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.0064360.0000001322InformativeInherited
Biological Process (BP)positive regulation of transport0.0058150InformativeInherited
Biological Process (BP)regulation of protein localization0.91880.3051InformativeInherited
Biological Process (BP)cation homeostasis0.10620.000005886InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.68430InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.81241InformativeInherited
Biological Process (BP)response to lipid10.6772InformativeInherited
Biological Process (BP)response to cytokine stimulus0.13140.008165InformativeInherited
Biological Process (BP)nitrogen compound transport10.9161InformativeInherited
Biological Process (BP)regulation of hormone levels0.88551InformativeInherited
Biological Process (BP)secretion by cell0.85490.02662InformativeInherited
Biological Process (BP)regulation of system process0.023560InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport11InformativeInherited
Biological Process (BP)transcription, DNA-dependent0.0062251InformativeInherited
Biological Process (BP)regulation of immune effector process0.13171InformativeInherited
Biological Process (BP)regulation of cell activation11InformativeInherited
Biological Process (BP)positive regulation of immune system process0.050051InformativeInherited
Biological Process (BP)regulation of immune response0.13871InformativeInherited
Biological Process (BP)regulation of cytokine production0.13190.00002166InformativeInherited
Biological Process (BP)regulation of cell cycle process0.75371InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.030110.00000000009588InformativeInherited
Biological Process (BP)regulation of body fluid levels0.73160.00001188InformativeInherited
Biological Process (BP)response to light stimulus0.033920.001731InformativeInherited
Biological Process (BP)cellular component movement0.31751InformativeInherited
Biological Process (BP)sexual reproduction0.81071InformativeInherited
Biological Process (BP)single organism reproductive process11InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.85780.5426InformativeInherited
Biological Process (BP)cellular process involved in reproduction11InformativeInherited
Biological Process (BP)localization of cell0.014140.000000009659InformativeInherited
Biological Process (BP)defense response0.61870InformativeInherited
Biological Process (BP)regulation of defense response0.099230.00002296InformativeInherited
Biological Process (BP)regulation of growth11InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis0.0000065950Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000014360Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)sensory perception00Highly InformativeDirect
Biological Process (BP)regulation of blood pressure0.000015430Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.000000048070Highly InformativeDirect
Biological Process (BP)regulation of cyclic nucleotide metabolic process0.00000028720Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade0.00000011050Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0000026290Highly InformativeDirect
Biological Process (BP)regulation of peptide transport0.0000038050.0004035Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion0.062080Highly InformativeInherited
Biological Process (BP)regulation of cytokine secretion0.062590.00004116Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus11Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway0.89651Highly InformativeInherited
Biological Process (BP)response to drug11Highly InformativeInherited
Biological Process (BP)hormone transport0.004020.00000000001568Highly InformativeInherited
Biological Process (BP)signal release0.042590.05117Highly InformativeInherited
Biological Process (BP)regulation of exocytosis0.65681Highly InformativeInherited
Biological Process (BP)transcription from RNA polymerase II promoter0.000022881Highly InformativeInherited
Biological Process (BP)positive regulation of cell activation0.6521Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.59841Highly InformativeInherited
Biological Process (BP)regulation of cell division0.23150.3837Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.4681Highly InformativeInherited
Biological Process (BP)hemostasis0.046431Highly InformativeInherited
Biological Process (BP)wound healing0.96981Highly InformativeInherited
Biological Process (BP)coagulation0.45940.205Highly InformativeInherited
Biological Process (BP)regulation of amine transport0.033410.0000000009958Highly InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.27811Highly InformativeInherited
Biological Process (BP)regulation of acute inflammatory response0.067860.8198Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.14861Highly InformativeInherited
Biological Process (BP)positive regulation of response to external stimulus0.10210.0000001044Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.0019530.0783Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway11Highly InformativeInherited
Biological Process (BP)regulation of multicellular organism growth0.063090.01172Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)receptor activity00InformativeDirect
Molecular Function (MF)amide binding0.000019250InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)lipid binding0.36870.0005737InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity0.00000058450Highly InformativeDirect
Molecular Function (MF)odorant binding00Highly InformativeDirect
Molecular Function (MF)peptide binding0.0000097150Highly InformativeDirect
Molecular Function (MF)hormone binding0.000021980Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.21530.001146Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection0.03950.0000001015Moderately InformativeInherited
Cellular Component (CC)organelle membrane11Moderately InformativeInherited
Cellular Component (CC)endosome0.00039720.00000000002478InformativeDirect
Cellular Component (CC)integral to membrane0.00000014490.00000000000004807InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane00InformativeDirect
Cellular Component (CC)integral to plasma membrane0.00000019240.0000000000001044Highly InformativeDirect
Cellular Component (CC)cilium part0.000000000000010860.000000001009Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.15310.9719Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.00004172 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000000000001938 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000005054 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.1957 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.3653 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.06059 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001086 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.02372 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8872 Moderately Informative Inherited
Biological Process (BP) organ development 0.1866 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003948 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.07079 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.00002166 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00000001072 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) response to bacterium 0.0003548 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000002341 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00000000009588 Informative Direct
Biological Process (BP) regulation of defense response 0.00002296 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) locomotion 0.0000000002249 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000003823 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000002118 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.0000001322 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000000008076 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00001188 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000002996 Informative Direct
Biological Process (BP) localization of cell 0.000000009659 Informative Direct
Biological Process (BP) cation homeostasis 0.000005886 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of nervous system development 0.06028 Informative Inherited
Biological Process (BP) regulation of protein localization 0.3051 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.006464 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001419 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.008165 Informative Inherited
Biological Process (BP) metal ion transport 0.01044 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.2321 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.5321 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.2661 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5426 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.08419 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1054 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.004546 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.03883 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1417 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.616 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9161 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.4953 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.4028 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3921 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.3346 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) response to lipid 0.6772 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.8411 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) central nervous system development 0.3372 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) lipid localization 0.5149 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.001731 Informative Inherited
Biological Process (BP) secretion by cell 0.02662 Informative Inherited
Biological Process (BP) protein transport 0.832 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001899 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.9127 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.4342 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.009445 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) immune effector process 0.2377 Informative Inherited
Biological Process (BP) leukocyte activation 0.03792 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) angiogenesis 0.0004577 Highly Informative Direct
Biological Process (BP) behavioral fear response 0.00002464 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0000000001536 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000000000000009148 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) digestion 0.0000000000241 Highly Informative Direct
Biological Process (BP) sensory perception 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.00000000204 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0 Highly Informative Direct
Biological Process (BP) hormone transport 0.00000000001568 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.0006969 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.0000002757 Highly Informative Direct
Biological Process (BP) adult behavior 0.0000001219 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.000000000001084 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.0000001044 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000000000004989 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.000000000000001938 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.0000001932 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000000007422 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0009144 Highly Informative Direct
Biological Process (BP) amide transport 0.00006114 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.0000000001834 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.00000000000004119 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.000001603 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 0.00000001896 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0000937 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00004116 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.0007349 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0000000000004264 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.00000000000003296 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00000000003695 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.00000584 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0.0000000009958 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0002247 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.00000003585 Highly Informative Direct
Biological Process (BP) regulation of peptide transport 0.0004035 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0003634 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000002164 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.0765 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.2765 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.00701 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.01205 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.4722 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.1341 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.04871 Highly Informative Inherited
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.07926 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.03115 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.007143 Highly Informative Inherited
Biological Process (BP) signal release 0.05117 Highly Informative Inherited
Biological Process (BP) placenta development 0.3964 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.3393 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.003354 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.06473 Highly Informative Inherited
Biological Process (BP) response to drug 1 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 1 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1805 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.02078 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.005215 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.007758 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.3837 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1031 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) coagulation 0.205 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.007897 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.1336 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.07224 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.1074 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.7074 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 1 Highly Informative Inherited
Biological Process (BP) protein import 0.3764 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.2605 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.08151 Highly Informative Inherited
Biological Process (BP) nuclear import 0.09398 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.07186 Highly Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 0.8198 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.0783 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.6285 Highly Informative Inherited
Biological Process (BP) vascular process in circulatory system 0.01183 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.01172 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.002582 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0005737 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.4325 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0.000008756 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 0.0000000000001346 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0.001146 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.05978 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.1506 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000001015 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endosome 0.00000000002478 Informative Direct
Cellular Component (CC) cell surface 0.0001004 Informative Direct
Cellular Component (CC) integral to membrane 0.00000000000004807 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) synapse part 0.00002537 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.09118 Informative Inherited
Cellular Component (CC) integral to plasma membrane 0.0000000000001044 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0006124 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000000003618 Highly Informative Direct
Cellular Component (CC) cilium part 0.000000001009 Highly Informative Direct
Cellular Component (CC) dendrite 0.01934 Highly Informative Inherited
Cellular Component (CC) cell projection membrane 0.9719 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.07709 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6324Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000002498Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.05781Moderately InformativeInherited
Disease Ontology (DO)migraine0.00003683InformativeDirect
Disease Ontology (DO)overnutrition0.00004936InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1958InformativeInherited
Disease Ontology (DO)substance dependence0.3374InformativeInherited
Disease Ontology (DO)eating disorder0.000007083Highly InformativeDirect
Disease Ontology (DO)anxiety disorder0.00002665Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.008138Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.07717Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1051Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1324Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3916Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype1Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0000118Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.00006689Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.04523Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.06963Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.09043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.1107Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.2028Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2065Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.2576Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.2802Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.3124Moderately InformativeInherited
Mammalian Phenotype (MP)renal/urinary system phenotype0.3274Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.3349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.374Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.4821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.7841Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.8498Moderately InformativeInherited
Mammalian Phenotype (MP)