SUPERFAMILY 1.75 HMM library and genome assignments server


Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (547) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 77,986 118,221 43
Proteins 76,656 117,052 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)single-organism cellular process1.082e-050Least InformativeDirect
Biological Process (BP)regulation of cellular process4.438e-100Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)system process00Moderately InformativeDirect
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)regulation of localization0.84347.377e-15Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.17350.0002233Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.73161Moderately InformativeInherited
Biological Process (BP)homeostatic process0.12360Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)ion transport10.2431Moderately InformativeInherited
Biological Process (BP)organic substance transport10.8405Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process10.01868Moderately InformativeInherited
Biological Process (BP)gene expression11Moderately InformativeInherited
Biological Process (BP)RNA metabolic process11Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.21121.014e-06Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.67380Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)regulation of biosynthetic process0.87740.1984Moderately InformativeInherited
Biological Process (BP)response to organic substance10.0002702Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.071211Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.0013160Moderately InformativeInherited
Biological Process (BP)immune system process0.098040.003862Moderately InformativeInherited
Biological Process (BP)blood circulation0.00042160InformativeDirect
Biological Process (BP)response to wounding0.00042330InformativeDirect
Biological Process (BP)positive regulation of signal transduction3.453e-060InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade8.074e-050InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00012340InformativeDirect
Biological Process (BP)locomotion5.243e-051.272e-10InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00023760InformativeDirect
Biological Process (BP)regulation of secretion1.198e-070InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process8.32e-070InformativeDirect
Biological Process (BP)positive regulation of nitrogen compound metabolic process0.0098039.441e-08InformativeInherited
Biological Process (BP)positive regulation of transport0.074920InformativeInherited
Biological Process (BP)regulation of establishment of protein localization0.087031.781e-08InformativeInherited
Biological Process (BP)cellular cation homeostasis0.035671.108e-11InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.6291InformativeInherited
Biological Process (BP)response to lipid10.7288InformativeInherited
Biological Process (BP)response to cytokine stimulus0.072090.008286InformativeInherited
Biological Process (BP)nitrogen compound transport10.8935InformativeInherited
Biological Process (BP)metal ion homeostasis0.011969.131e-14InformativeInherited
Biological Process (BP)single-organism behavior0.010450.4992InformativeInherited
Biological Process (BP)regulation of hormone levels0.85681InformativeInherited
Biological Process (BP)secretion by cell0.85760.0239InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0010470InformativeInherited
Biological Process (BP)regulation of system process0.035240InformativeInherited
Biological Process (BP)transcription, DNA-dependent0.0059211InformativeInherited
Biological Process (BP)regulation of immune effector process0.13771InformativeInherited
Biological Process (BP)positive regulation of immune system process0.032031InformativeInherited
Biological Process (BP)regulation of immune response0.13931InformativeInherited
Biological Process (BP)regulation of cytokine production0.1262.383e-05InformativeInherited
Biological Process (BP)regulation of cell cycle process0.74971InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.021712.025e-11InformativeInherited
Biological Process (BP)regulation of body fluid levels0.72721.225e-05InformativeInherited
Biological Process (BP)response to light stimulus0.030910.001794InformativeInherited
Biological Process (BP)cellular component movement0.33761InformativeInherited
Biological Process (BP)sexual reproduction0.79991InformativeInherited
Biological Process (BP)single organism reproductive process11InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.85030.3749InformativeInherited
Biological Process (BP)cellular process involved in reproduction0.9961InformativeInherited
Biological Process (BP)localization of cell0.014014.953e-09InformativeInherited
Biological Process (BP)defense response0.57150InformativeInherited
Biological Process (BP)regulation of defense response0.078493.892e-05InformativeInherited
Biological Process (BP)regulation of growth11InformativeInherited
Biological Process (BP)cellular calcium ion homeostasis6.167e-060Highly InformativeDirect
Biological Process (BP)inflammatory response1.219e-060Highly InformativeDirect
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)sensory perception00Highly InformativeDirect
Biological Process (BP)regulation of blood pressure1.458e-050Highly InformativeDirect
Biological Process (BP)detection of light stimulus4.501e-080Highly InformativeDirect
Biological Process (BP)regulation of cyclic nucleotide metabolic process1.325e-070Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade2.043e-070Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion2.038e-050Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion0.05530Highly InformativeInherited
Biological Process (BP)regulation of cytokine secretion0.063553.349e-05Highly InformativeInherited
Biological Process (BP)response to carbohydrate stimulus11Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway0.79221Highly InformativeInherited
Biological Process (BP)response to drug11Highly InformativeInherited
Biological Process (BP)learning or memory0.73051Highly InformativeInherited
Biological Process (BP)hormone transport0.0038979.49e-12Highly InformativeInherited
Biological Process (BP)signal release0.041470.04918Highly InformativeInherited
Biological Process (BP)regulation of exocytosis0.55671Highly InformativeInherited
Biological Process (BP)transcription from RNA polymerase II promoter2.147e-051Highly InformativeInherited
Biological Process (BP)positive regulation of cell activation0.63771Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.54291Highly InformativeInherited
Biological Process (BP)regulation of cell division0.22280.4089Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.44471Highly InformativeInherited
Biological Process (BP)hemostasis0.046361Highly InformativeInherited
Biological Process (BP)wound healing0.95691Highly InformativeInherited
Biological Process (BP)coagulation0.46130.2021Highly InformativeInherited
Biological Process (BP)regulation of amine transport0.023819.009e-10Highly InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.26421Highly InformativeInherited
Biological Process (BP)regulation of acute inflammatory response0.066170.8047Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.15531Highly InformativeInherited
Biological Process (BP)positive regulation of response to external stimulus0.087867.938e-09Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.0018370.07166Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway11Highly InformativeInherited
Biological Process (BP)regulation of multicellular organism growth0.061640.01302Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)receptor activity00InformativeDirect
Molecular Function (MF)amide binding1.815e-050InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)lipid binding0.35680.0006963InformativeInherited
Molecular Function (MF)G-protein coupled receptor activity6.354e-070Highly InformativeDirect
Molecular Function (MF)odorant binding00Highly InformativeDirect
Molecular Function (MF)peptide binding9.19e-060Highly InformativeDirect
Molecular Function (MF)hormone binding2.079e-050Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.21730.003771Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)intrinsic to membrane00Moderately InformativeDirect
Cellular Component (CC)cell projection0.045415.036e-07Moderately InformativeInherited
Cellular Component (CC)organelle membrane11Moderately InformativeInherited
Cellular Component (CC)endosome0.00030579.612e-12InformativeDirect
Cellular Component (CC)integral to membrane1.636e-076.804e-14InformativeDirect
Cellular Component (CC)intrinsic to plasma membrane00InformativeDirect
Cellular Component (CC)integral to plasma membrane2.26e-071.693e-13Highly InformativeDirect
Cellular Component (CC)cilium part5.611e-149.081e-09Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.17010.9645Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) system process 0 Moderately Informative Direct
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.0002233 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0002702 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 7.377e-15 Moderately Informative Direct
Biological Process (BP) homeostatic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 1.014e-06 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of programmed cell death 0.3889 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.1984 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.2431 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01868 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8405 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) immune system process 0.003862 Moderately Informative Inherited
Biological Process (BP) organ development 0.1404 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03082 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 2.383e-05 Informative Direct
Biological Process (BP) defense response 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) positive regulation of cell proliferation 3.497e-05 Informative Direct
Biological Process (BP) response to wounding 0 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 2.44e-06 Informative Direct
Biological Process (BP) cellular cation homeostasis 1.108e-11 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 2.025e-11 Informative Direct
Biological Process (BP) regulation of defense response 3.892e-05 Informative Direct
Biological Process (BP) positive regulation of protein modification process 0.0003056 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) locomotion 1.272e-10 Informative Direct
Biological Process (BP) regulation of locomotion 4.007e-12 Informative Direct
Biological Process (BP) regulation of ion transport 1.184e-08 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 5.28e-09 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.225e-05 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 9.441e-08 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 3.368e-07 Informative Direct
Biological Process (BP) localization of cell 4.953e-09 Informative Direct
Biological Process (BP) metal ion homeostasis 9.131e-14 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 1.781e-08 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.0006178 Informative Direct
Biological Process (BP) regulation of nervous system development 0.0947 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.01123 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.9723 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) response to hormone stimulus 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 0.008286 Informative Inherited
Biological Process (BP) metal ion transport 0.006509 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.1924 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.4873 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) muscle tissue development 0.2384 Informative Inherited
Biological Process (BP) muscle structure development 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.3749 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.08691 Informative Inherited
Biological Process (BP) regulation of kinase activity 0.1393 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 0.002297 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.5759 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.8935 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) single-organism behavior 0.4992 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) transcription, DNA-dependent 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.3345 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.3041 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2549 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) response to lipid 0.7288 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.8156 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.134 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) lipid localization 0.4887 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) response to other organism 0.0696 Informative Inherited
Biological Process (BP) response to light stimulus 0.001794 Informative Inherited
Biological Process (BP) secretion by cell 0.0239 Informative Inherited
Biological Process (BP) protein transport 0.7854 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 1 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction 1 Informative Inherited
Biological Process (BP) cardiovascular system development 0.001737 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.8646 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.3798 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.007655 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) leukocyte activation 0.05128 Informative Inherited
Biological Process (BP) immune effector process 0.2297 Informative Inherited
Biological Process (BP) regulation of growth 1 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) angiogenesis 0.0003698 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 5.57e-11 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 8.921e-09 Highly Informative Direct
Biological Process (BP) calcium ion transport 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) regulation of muscle contraction 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) digestion 2.48e-11 Highly Informative Direct
Biological Process (BP) sensory perception 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 3.376e-09 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0 Highly Informative Direct
Biological Process (BP) hormone transport 9.49e-12 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.0006398 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 6.674e-08 Highly Informative Direct
Biological Process (BP) adult behavior 1.248e-07 Highly Informative Direct
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0.0009152 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 4.964e-12 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 7.938e-09 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.867e-12 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 1.944e-15 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 2.024e-07 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 1.071e-09 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0007472 Highly Informative Direct
Biological Process (BP) amide transport 4.918e-05 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 2.572e-09 Highly Informative Direct
Biological Process (BP) response to alkaloid 5.284e-14 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 1.642e-06 Highly Informative Direct
Biological Process (BP) regulation of angiogenesis 1.482e-08 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0001826 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 3.349e-05 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) regulation of behavior 0 Highly Informative Direct
Biological Process (BP) regulation of coagulation 0.0008735 Highly Informative Direct
Biological Process (BP) leukocyte migration 3.04e-13 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 1.784e-14 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 5.433e-11 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 1.553e-05 Highly Informative Direct
Biological Process (BP) regulation of amine transport 9.009e-10 Highly Informative Direct
Biological Process (BP) regulation of wound healing 0.0002658 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 2.901e-08 Highly Informative Direct
Biological Process (BP) regulation of hemostasis 0.0004363 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 4.812e-08 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 0.07564 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.2615 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.007621 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.007108 Highly Informative Inherited
Biological Process (BP) response to peptide hormone stimulus 0.3186 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.1345 Highly Informative Inherited
Biological Process (BP) response to carbohydrate stimulus 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.05643 Highly Informative Inherited
Biological Process (BP) MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.02638 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) muscle fiber development 0.006086 Highly Informative Inherited
Biological Process (BP) learning or memory 1 Highly Informative Inherited
Biological Process (BP) signal release 0.04918 Highly Informative Inherited
Biological Process (BP) placenta development 0.3949 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.3322 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.2152 Highly Informative Inherited
Biological Process (BP) response to drug 1 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 1 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1857 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.03582 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.007681 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 1 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.4089 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.08459 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) coagulation 0.2021 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.1267 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.05138 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.0951 Highly Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Highly Informative Inherited
Biological Process (BP) muscle organ development 0.6542 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 1 Highly Informative Inherited
Biological Process (BP) protein import 0.3506 Highly Informative Inherited
Biological Process (BP) protein localization to nucleus 0.2389 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.07436 Highly Informative Inherited
Biological Process (BP) nuclear import 0.08602 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) peptidyl-tyrosine modification 0.4584 Highly Informative Inherited
Biological Process (BP) purine ribonucleotide biosynthetic process 0.116 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.07104 Highly Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 0.8047 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.07166 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.6118 Highly Informative Inherited
Biological Process (BP) vascular process in circulatory system 0.01233 Highly Informative Inherited
Biological Process (BP) regulation of multicellular organism growth 0.01302 Highly Informative Inherited
Biological Process (BP) regulation of synaptic transmission 0.002915 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) lipid binding 0.0006963 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) receptor binding 0.3827 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 1 Informative Inherited
Molecular Function (MF) G-protein coupled receptor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 7.892e-06 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) drug binding 6.791e-14 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0.003771 Highly Informative Inherited
Molecular Function (MF) phosphoric diester hydrolase activity 0.05001 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.1495 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) intrinsic to membrane 0 Moderately Informative Direct
Cellular Component (CC) cell projection 5.036e-07 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) endosome 9.612e-12 Informative Direct
Cellular Component (CC) cell surface 0.0001017 Informative Direct
Cellular Component (CC) integral to membrane 6.804e-14 Informative Direct
Cellular Component (CC) intrinsic to plasma membrane 0 Informative Direct
Cellular Component (CC) synapse part 3.107e-06 Informative Direct
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) nuclear envelope 0.08555 Informative Inherited
Cellular Component (CC) integral to plasma membrane 1.693e-13 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.0005719 Highly Informative Direct
Cellular Component (CC) receptor complex 2.799e-13 Highly Informative Direct
Cellular Component (CC) cilium part 9.081e-09 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.9645 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.07115 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.7712Least InformativeInherited
Disease Ontology (DO)disease of mental health2.006e-07Moderately InformativeDirect
Disease Ontology (DO)lung disease6.82e-05Moderately InformativeDirect
Disease Ontology (DO)bone disease0.001632Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.003131Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.02975Moderately InformativeInherited
Disease Ontology (DO)central nervous system disease0.06901Moderately InformativeInherited
Disease Ontology (DO)overnutrition2.282e-06InformativeDirect
Disease Ontology (DO)migraine4.901e-05InformativeDirect
Disease Ontology (DO)arthritis0.0003579InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.2081InformativeInherited
Disease Ontology (DO)substance dependence0.3258InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.4773InformativeInherited
Disease Ontology (DO)eating disorder1.199e-05Highly InformativeDirect
Disease Ontology (DO)anxiety disorder0.0001772Highly InformativeDirect
Disease Ontology (DO)endocrine organ benign neoplasm0.01292Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.0001044Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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