SUPERFAMILY 1.75 HMM library and genome assignments server

Family A G protein-coupled receptor-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Membrane and cell surface proteins and peptides [ 56835] (58)
Fold:   Family A G protein-coupled receptor-like [ 81322]
Superfamily:   Family A G protein-coupled receptor-like [ 81321] (2)
Families:   Bacteriorhodopsin-like [ 81319] (5)
  Rhodopsin-like [ 81320]


Superfamily statistics
Genomes (548) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 78,018 118,221 43
Proteins 76,688 117,052 43


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.000000017910Least InformativeDirect
Biological Process (BP)single-organism cellular process10Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)positive regulation of biological process11Least InformativeInherited
Biological Process (BP)regulation of metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)signal transduction00Moderately InformativeDirect
Biological Process (BP)regulation of phosphorus metabolic process0.0000027250Moderately InformativeDirect
Biological Process (BP)positive regulation of response to stimulus0.00052580Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process10.04299Moderately InformativeInherited
Biological Process (BP)regulation of biological quality10.07929Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound11Moderately InformativeInherited
Biological Process (BP)response to organic substance10.000065Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus11Moderately InformativeInherited
Biological Process (BP)ion transport10.6926Moderately InformativeInherited
Biological Process (BP)organic substance transport10.9018Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.21290.0000007403Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process11Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.0076730.000000000001446Moderately InformativeInherited
Biological Process (BP)regulation of signal transduction0.13090.8465Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)RNA metabolic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular nitrogen compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity0.68750Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.81041Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.86451Moderately InformativeInherited
Biological Process (BP)regulation of localization0.70680.00000000000001071Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus11Moderately InformativeInherited
Biological Process (BP)gene expression11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)multi-organism process10.7379Moderately InformativeInherited
Biological Process (BP)reproductive process11Moderately InformativeInherited
Biological Process (BP)defense response0.5920Moderately InformativeInherited
Biological Process (BP)immune system process0.1060.004022Moderately InformativeInherited
Biological Process (BP)response to external stimulus11Moderately InformativeInherited
Biological Process (BP)regulation of secretion0.0000000069630InformativeDirect
Biological Process (BP)positive regulation of intracellular signal transduction0.00000013090InformativeDirect
Biological Process (BP)regulation of purine nucleotide metabolic process0.00000081670InformativeDirect
Biological Process (BP)regulation of MAPK cascade0.0000029140InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.0000095830InformativeDirect
Biological Process (BP)locomotion0.000066470.0000000002437InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00046610InformativeDirect
Biological Process (BP)blood circulation0.00052580InformativeDirect
Biological Process (BP)regulation of system process0.0009650InformativeDirect
Biological Process (BP)positive regulation of transport0.0071510InformativeInherited
Biological Process (BP)regulation of protein localization0.91740.343InformativeInherited
Biological Process (BP)regulation of vesicle-mediated transport11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.079240.000002055InformativeInherited
Biological Process (BP)positive regulation of multicellular organismal process0.0025930InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.6330InformativeInherited
Biological Process (BP)response to acid chemical11InformativeInherited
Biological Process (BP)response to cytokine0.12420.008139InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.81061InformativeInherited
Biological Process (BP)response to lipid10.6897InformativeInherited
Biological Process (BP)cation homeostasis0.081540.000004656InformativeInherited
Biological Process (BP)neurological system process00.001077InformativeInherited
Biological Process (BP)regulation of defense response0.099090.0001004InformativeInherited
Biological Process (BP)regulation of response to wounding0.0015590InformativeInherited
Biological Process (BP)secretion by cell0.60990.001503InformativeInherited
Biological Process (BP)regulation of hormone levels0.87751InformativeInherited
Biological Process (BP)negative regulation of nitrogen compound metabolic process11InformativeInherited
Biological Process (BP)regulation of immune effector process0.13521InformativeInherited
Biological Process (BP)regulation of immune response0.12811InformativeInherited
Biological Process (BP)regulation of cell activation11InformativeInherited
Biological Process (BP)regulation of cytokine production0.1630.00001492InformativeInherited
Biological Process (BP)regulation of cell cycle process0.74721InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)regulation of body fluid levels0.7410.00001194InformativeInherited
Biological Process (BP)response to light stimulus0.033140.001585InformativeInherited
Biological Process (BP)transcription, DNA-templated0.0061871InformativeInherited
Biological Process (BP)localization of cell0.016640.00000001216InformativeInherited
Biological Process (BP)cellular component movement0.069851InformativeInherited
Biological Process (BP)cellular process involved in reproduction in multicellular organism0.37041InformativeInherited
Biological Process (BP)sexual reproduction0.65881InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.80640.5734InformativeInherited
Biological Process (BP)single organism reproductive process11InformativeInherited
Biological Process (BP)positive regulation of immune system process0.07730.8646InformativeInherited
Biological Process (BP)response to nutrient levels0.82320.6856InformativeInherited
Biological Process (BP)nitrogen compound transport10.9238InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)sensory perception00.000000000000003707Highly InformativeDirect
Biological Process (BP)detection of light stimulus0.000000022950Highly InformativeDirect
Biological Process (BP)positive regulation of MAPK cascade0.000001150Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000014320Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0000054370Highly InformativeDirect
Biological Process (BP)cellular calcium ion homeostasis0.0000065740Highly InformativeDirect
Biological Process (BP)positive regulation of cyclic nucleotide metabolic process0.0000086510Highly InformativeDirect
Biological Process (BP)regulation of blood pressure0.000015330Highly InformativeDirect
Biological Process (BP)germ cell migration0.000029650.0004356Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.066830.00005064Highly InformativeInherited
Biological Process (BP)positive regulation of protein secretion0.74740.1078Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.8620.8002Highly InformativeInherited
Biological Process (BP)regulation of exocytosis0.97161Highly InformativeInherited
Biological Process (BP)cellular response to acid chemical0.36371Highly InformativeInherited
Biological Process (BP)response to carbohydrate11Highly InformativeInherited
Biological Process (BP)cytokine-mediated signaling pathway0.90311Highly InformativeInherited
Biological Process (BP)hormone transport0.0039930.00000000001307Highly InformativeInherited
Biological Process (BP)signal release0.048320.06251Highly InformativeInherited
Biological Process (BP)transcription from RNA polymerase II promoter0.000022771Highly InformativeInherited
Biological Process (BP)positive regulation of cell activation0.62731Highly InformativeInherited
Biological Process (BP)positive regulation of cell division0.09080.03587Highly InformativeInherited
Biological Process (BP)positive regulation of cell cycle process0.49951Highly InformativeInherited
Biological Process (BP)hemostasis0.046371Highly InformativeInherited
Biological Process (BP)wound healing0.19780.07184Highly InformativeInherited
Biological Process (BP)coagulation0.48060.2054Highly InformativeInherited
Biological Process (BP)regulation of amine transport0.031010.0000000007456Highly InformativeInherited
Biological Process (BP)regulation of myeloid leukocyte mediated immunity0.0022760.000002771Highly InformativeInherited
Biological Process (BP)regulation of acute inflammatory response0.067670.8205Highly InformativeInherited
Biological Process (BP)regulation of cytokine production involved in immune response0.0069180.005267Highly InformativeInherited
Biological Process (BP)positive regulation of production of molecular mediator of immune response0.11120.05102Highly InformativeInherited
Biological Process (BP)positive regulation of response to wounding0.014280.000001309Highly InformativeInherited
Biological Process (BP)positive regulation of defense response0.15981Highly InformativeInherited
Biological Process (BP)positive regulation of response to external stimulus0.16430.000001142Highly InformativeInherited
Biological Process (BP)immune response-activating signal transduction0.001940.07784Highly InformativeInherited
Biological Process (BP)immune response-regulating cell surface receptor signaling pathway11Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)small molecule binding11Moderately InformativeInherited
Molecular Function (MF)receptor activity00InformativeDirect
Molecular Function (MF)molecular transducer activity00InformativeDirect
Molecular Function (MF)amide binding0.000019390InformativeDirect
Molecular Function (MF)lipid binding0.17260.0001844InformativeInherited
Molecular Function (MF)odorant binding00Highly InformativeDirect
Molecular Function (MF)peptide binding0.0000098020Highly InformativeDirect
Molecular Function (MF)hormone binding0.000022120Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.050850.0001036Highly InformativeInherited
Molecular Function (MF)transmembrane signaling receptor activity0.0015280Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)intrinsic component of membrane00Moderately InformativeDirect
Cellular Component (CC)plasma membrane part00Moderately InformativeDirect
Cellular Component (CC)bounding membrane of organelle0.15561Moderately InformativeInherited
Cellular Component (CC)membrane region11Moderately InformativeInherited
Cellular Component (CC)cell projection0.050980.0000004889Moderately InformativeInherited
Cellular Component (CC)integral component of membrane00InformativeDirect
Cellular Component (CC)intrinsic component of plasma membrane00InformativeDirect
Cellular Component (CC)endosome0.00038140.000000000004242InformativeDirect
Cellular Component (CC)plasma membrane region0.13071InformativeInherited
Cellular Component (CC)integral component of plasma membrane00Highly InformativeDirect
Cellular Component (CC)ciliary part0.0000000000012590.000001069Highly InformativeDirect
Cellular Component (CC)cell projection membrane0.094740.8772Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) developmental process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 1 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000000001446 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000007403 Moderately Informative Direct
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00000000000001071 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.000065 Moderately Informative Direct
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.04299 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) nucleobase-containing small molecule metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organonitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.07929 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.7379 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.8465 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) reproductive process 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.6926 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9018 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organophosphate metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5672 Moderately Informative Inherited
Biological Process (BP) immune system process 0.004022 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of intracellular signal transduction 0 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0 Informative Direct
Biological Process (BP) regulation of MAPK cascade 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) locomotion 0.0000000002437 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0 Informative Direct
Biological Process (BP) blood circulation 0 Informative Direct
Biological Process (BP) regulation of system process 0 Informative Direct
Biological Process (BP) regulation of response to wounding 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) localization of cell 0.00000001216 Informative Direct
Biological Process (BP) single-organism behavior 0 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.000002055 Informative Direct
Biological Process (BP) cation homeostasis 0.000004656 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) regulation of defense response 0.0001004 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000000000005988 Informative Direct
Biological Process (BP) regulation of cytokine production 0.00001492 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000000005285 Informative Direct
Biological Process (BP) regulation of ion transport 0.000000003215 Informative Direct
Biological Process (BP) cardiovascular system development 0.0005233 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.000000311 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000006912 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0 Informative Direct
Biological Process (BP) metal ion transport 0.0006413 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00001194 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00000002474 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000001572 Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00000468 Informative Direct
Biological Process (BP) response to bacterium 0.0003716 Informative Direct
Biological Process (BP) regulation of cell development 0.119 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of protein localization 0.343 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1004 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.0485 Informative Inherited
Biological Process (BP) negative regulation of cell death 0.01891 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.009467 Informative Inherited
Biological Process (BP) protein transport 0.845 Informative Inherited
Biological Process (BP) response to organonitrogen compound 1 Informative Inherited
Biological Process (BP) response to acid chemical 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.003456 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 0.001377 Informative Inherited
Biological Process (BP) response to cytokine 0.008139 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cell proliferation 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) growth 1 Informative Inherited
Biological Process (BP) immune effector process 0.2421 Informative Inherited
Biological Process (BP) defense response to other organism 1 Informative Inherited
Biological Process (BP) regulation of intracellular transport 1 Informative Inherited
Biological Process (BP) neurological system process 0.001077 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 1 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.5734 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) regulation of protein phosphorylation 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.7404 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.5168 Informative Inherited
Biological Process (BP) negative regulation of nitrogen compound metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1234 Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9238 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure size 0.3878 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) regulation of immune effector process 1 Informative Inherited
Biological Process (BP) regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of cell activation 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.07554 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) response to lipid 0.6897 Informative Inherited
Biological Process (BP) anion transport 1 Informative Inherited
Biological Process (BP) organic acid transport 1 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 1 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of catalytic activity 0.1199 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) lipid localization 0.536 Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.9525 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) secretion by cell 0.001503 Informative Inherited
Biological Process (BP) transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) cellular process involved in reproduction in multicellular organism 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 1 Informative Inherited
Biological Process (BP) response to light stimulus 0.001585 Informative Inherited
Biological Process (BP) sexual reproduction 1 Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.0753 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) tissue morphogenesis 1 Informative Inherited
Biological Process (BP) embryonic morphogenesis 1 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.3458 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) muscle system process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) purine-containing compound biosynthetic process 0.531 Informative Inherited
Biological Process (BP) nucleotide biosynthetic process 1 Informative Inherited
Biological Process (BP) ribose phosphate biosynthetic process 0.4331 Informative Inherited
Biological Process (BP) purine ribonucleotide metabolic process 1 Informative Inherited
Biological Process (BP) positive regulation of immune system process 0.8646 Informative Inherited
Biological Process (BP) leukocyte activation 0.03642 Informative Inherited
Biological Process (BP) immune response 1 Informative Inherited
Biological Process (BP) response to nutrient levels 0.6856 Informative Inherited
Biological Process (BP) synaptic transmission 1 Informative Inherited
Biological Process (BP) reproductive structure development 1 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) sensory perception 0.000000000000003707 Highly Informative Direct
Biological Process (BP) detection of light stimulus 0 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0 Highly Informative Direct
Biological Process (BP) cellular calcium ion homeostasis 0 Highly Informative Direct
Biological Process (BP) positive regulation of cyclic nucleotide metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of blood pressure 0 Highly Informative Direct
Biological Process (BP) germ cell migration 0.0004356 Highly Informative Direct
Biological Process (BP) regulation of myeloid leukocyte mediated immunity 0.000002771 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0 Highly Informative Direct
Biological Process (BP) hormone transport 0.00000000001307 Highly Informative Direct
Biological Process (BP) leukocyte migration 0.0000000000003978 Highly Informative Direct
Biological Process (BP) positive regulation of response to wounding 0.000001309 Highly Informative Direct
Biological Process (BP) calcium ion transport 0.000000000000003707 Highly Informative Direct
Biological Process (BP) regulation of amine transport 0.0000000007456 Highly Informative Direct
Biological Process (BP) regulation of calcium ion transport 0.000002113 Highly Informative Direct
Biological Process (BP) angiogenesis 0.0004529 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.00000003333 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.0000000002035 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000000005821 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00005064 Highly Informative Direct
Biological Process (BP) regulation of phospholipase activity 0.0006985 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.0000000000879 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of ion transport 0.00000008603 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.000007096 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.000001142 Highly Informative Direct
Biological Process (BP) regulation of chemotaxis 0.00003209 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase activity 0.0001038 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0000000001522 Highly Informative Direct
Biological Process (BP) digestion 0.00000000002462 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.000000000005602 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0 Highly Informative Direct
Biological Process (BP) response to alkaloid 0.00000000000003735 Highly Informative Direct
Biological Process (BP) negative regulation of response to wounding 0.0000000001944 Highly Informative Direct
Biological Process (BP) positive regulation of behavior 0.0000000005978 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0.000000002051 Highly Informative Direct
Biological Process (BP) regulation of alcohol biosynthetic process 0.00000000449 Highly Informative Direct
Biological Process (BP) adult behavior 0.00000008162 Highly Informative Direct
Biological Process (BP) regulation of cellular amine metabolic process 0.000001284 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.000001471 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000002581 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.000003069 Highly Informative Direct
Biological Process (BP) behavioral fear response 0.000009001 Highly Informative Direct
Biological Process (BP) amide transport 0.00005867 Highly Informative Direct
Biological Process (BP) regulation of synaptic transmission 0.00009055 Highly Informative Direct
Biological Process (BP) female pregnancy 0.0007504 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.0009051 Highly Informative Direct
Biological Process (BP) negative regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of protein secretion 0.1078 Highly Informative Inherited
Biological Process (BP) regulation of exocytosis 1 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.003755 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 1 Highly Informative Inherited
Biological Process (BP) response to alcohol 1 Highly Informative Inherited
Biological Process (BP) cellular response to steroid hormone stimulus 0.01352 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.4683 Highly Informative Inherited
Biological Process (BP) cellular response to peptide 0.1305 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 1 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.1079 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.9598 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) negative regulation of protein transport 0.00633 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 1 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.04766 Highly Informative Inherited
Biological Process (BP) cardiac muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) response to virus 0.04741 Highly Informative Inherited
Biological Process (BP) signal release 0.06251 Highly Informative Inherited
Biological Process (BP) positive regulation of intracellular transport 0.1602 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.7254 Highly Informative Inherited
Biological Process (BP) placenta development 0.4032 Highly Informative Inherited
Biological Process (BP) regulation of muscle system process 1 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular catabolic process 0.03117 Highly Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.009371 Highly Informative Inherited
Biological Process (BP) regulation of cytokine biosynthetic process 0.1513 Highly Informative Inherited
Biological Process (BP) circadian rhythm 0.06804 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.2643 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 1 Highly Informative Inherited
Biological Process (BP) transcription from RNA polymerase II promoter 1 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.005507 Highly Informative Inherited
Biological Process (BP) vascular process in circulatory system 0.013 Highly Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 1 Highly Informative Inherited
Biological Process (BP) regulation of Rho protein signal transduction 0.005233 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.007452 Highly Informative Inherited
Biological Process (BP) positive regulation of cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.8002 Highly Informative Inherited
Biological Process (BP) positive regulation of cell division 0.03587 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.1143 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.7835 Highly Informative Inherited
Biological Process (BP) regulation of wound healing 1 Highly Informative Inherited
Biological Process (BP) hemostasis 1 Highly Informative Inherited
Biological Process (BP) coagulation 0.2054 Highly Informative Inherited
Biological Process (BP) monocarboxylic acid transport 0.135 Highly Informative Inherited
Biological Process (BP) small GTPase mediated signal transduction 1 Highly Informative Inherited
Biological Process (BP) protein targeting to nucleus 0.08214 Highly Informative Inherited
Biological Process (BP) single-organism nuclear import 0.08315 Highly Informative Inherited
Biological Process (BP) protein import 0.3773 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 1 Highly Informative Inherited
Biological Process (BP) regulation of acute inflammatory response 0.8205 Highly Informative Inherited
Biological Process (BP) regulation of cytokine production involved in immune response 0.005267 Highly Informative Inherited
Biological Process (BP) positive regulation of production of molecular mediator of immune response 0.05102 Highly Informative Inherited
Biological Process (BP) positive regulation of cell migration 0.06633 Highly Informative Inherited
Biological Process (BP) positive regulation of defense response 1 Highly Informative Inherited
Biological Process (BP) immune response-activating signal transduction 0.07784 Highly Informative Inherited
Biological Process (BP) immune response-regulating cell surface receptor signaling pathway 1 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) wound healing 0.07184 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 0.02144 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) cation binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) receptor activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) lipid binding 0.0001844 Informative Direct
Molecular Function (MF) receptor binding 0.4349 Informative Inherited
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) hormone binding 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) steroid binding 0.00001412 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0.0001036 Highly Informative Direct
Molecular Function (MF) drug binding 0.0000000000001336 Highly Informative Direct
Molecular Function (MF) phosphoric diester hydrolase activity 0.0598 Highly Informative Inherited
Molecular Function (MF) lipase activity 0.1507 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) plasma membrane part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0000004889 Moderately Informative Direct
Cellular Component (CC) membrane region 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) nuclear part 1 Moderately Informative Inherited
Cellular Component (CC) organelle envelope 1 Moderately Informative Inherited
Cellular Component (CC) integral component of membrane 0 Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Informative Direct
Cellular Component (CC) endosome 0.000000000004242 Informative Direct
Cellular Component (CC) cell surface 0.000535 Informative Direct
Cellular Component (CC) plasma membrane region 1 Informative Inherited
Cellular Component (CC) neuron projection 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) synapse 0.008556 Informative Inherited
Cellular Component (CC) nuclear envelope 0.08965 Informative Inherited
Cellular Component (CC) integral component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) ciliary part 0.000001069 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000000009663 Highly Informative Direct
Cellular Component (CC) nuclear membrane 0.000607 Highly Informative Direct
Cellular Component (CC) cell projection membrane 0.8772 Highly Informative Inherited
Cellular Component (CC) dendrite 0.008284 Highly Informative Inherited
Cellular Component (CC) trans-Golgi network 0.07994 Highly Informative Inherited

Document: GO annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.6324Least InformativeInherited
Disease Ontology (DO)disease of mental health0.000002498Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.05781Moderately InformativeInherited
Disease Ontology (DO)migraine0.00003683InformativeDirect
Disease Ontology (DO)overnutrition0.00004936InformativeDirect
Disease Ontology (DO)developmental disorder of mental health0.1958InformativeInherited
Disease Ontology (DO)substance dependence0.3374InformativeInherited
Disease Ontology (DO)eating disorder0.000007083Highly InformativeDirect
Disease Ontology (DO)anxiety disorder0.00002665Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)