SUPERFAMILY 1.75 HMM library and genome assignments server


Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (445) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 3,188 2,602 4
Proteins 3,153 2,589 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 1.773e-14 Least Informative Direct
Biological Process (BP) protein metabolic process 2.397e-13 Least Informative Direct
Biological Process (BP) multicellular organismal process 9.559e-12 Least Informative Direct
Biological Process (BP) developmental process 1.306e-10 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 4.796e-08 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.098e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0009785 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.05689 Least Informative Inherited
Biological Process (BP) localization 0.461 Least Informative Inherited
Biological Process (BP) macromolecule catabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 4.263e-12 Moderately Informative Direct
Biological Process (BP) cell differentiation 2.636e-08 Moderately Informative Direct
Biological Process (BP) reproduction 2.222e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 4.767e-05 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 5.722e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0005188 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0008798 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.8345 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2496 Moderately Informative Inherited
Biological Process (BP) system process 0.9452 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.2511 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.00278 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9693 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7589 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.3542 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.06627 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7517 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.05369 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) proteolysis 3.746e-15 Informative Direct
Biological Process (BP) cell cycle process 5.993e-10 Informative Direct
Biological Process (BP) organelle localization 7.446e-05 Informative Direct
Biological Process (BP) cytoplasmic transport 8.284e-05 Informative Direct
Biological Process (BP) cell death 8.403e-05 Informative Direct
Biological Process (BP) single organism reproductive process 0.0003384 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0006957 Informative Direct
Biological Process (BP) actin filament-based process 0.02503 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.3797 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.02442 Informative Inherited
Biological Process (BP) cell-cell signaling 0.04991 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.01859 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.03362 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 0.3742 Informative Inherited
Biological Process (BP) regulation of cell development 0.5292 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01114 Informative Inherited
Biological Process (BP) sexual reproduction 0.1628 Informative Inherited
Biological Process (BP) protein complex assembly 0.06518 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.104 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1975 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2096 Informative Inherited
Biological Process (BP) membrane organization 0.02838 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.004774 Informative Inherited
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 2.6e-11 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 2.59e-08 Highly Informative Direct
Biological Process (BP) cell division 8.852e-07 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.831e-06 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 1.846e-06 Highly Informative Direct
Biological Process (BP) cell cycle phase 2.532e-06 Highly Informative Direct
Biological Process (BP) vesicle organization 3.027e-06 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 6.151e-06 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 8.244e-06 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0008154 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.1032 Highly Informative Inherited
Biological Process (BP) positive regulation of cell differentiation 0.09096 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.06283 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2782 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.07103 Highly Informative Inherited
Molecular Function (MF) binding 1.753e-07 Least Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.05555 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.244e-08 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.02882 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7554 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.5464 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.01231 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.0844 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.01214 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.04613 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) Golgi apparatus 1.119e-07 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0003854 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 8.746e-08 Highly Informative Direct
Cellular Component (CC) Golgi membrane 3.225e-07 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0002757 Highly Informative Direct
Cellular Component (CC) spindle 0.003061 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.5847Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.7748InformativeInherited
Mammalian Phenotype (MP)complete embryonic lethality between implantation and somite formation0.000485Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0002785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001038Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.5049Moderately InformativeInherited
Worm Phenotype (WP)life span variant4.34e-08InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis4.848e-05InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased4.147e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.02198Moderately InformativeInherited
Fly Anatomy (FA)egg chamber0.6995InformativeInherited
Fly Anatomy (FA)follicle cell0.0004169Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8024Least InformativeInherited
Biological processCell cycle1.823e-10Moderately InformativeDirect
Biological processHost-virus interaction0.0001595Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis3.097e-05InformativeDirect
Biological processER-Golgi transport1.968e-11Highly InformativeDirect
Cellular componentNucleus2.167e-09Least InformativeDirect
Cellular componentGolgi apparatus4.787e-08Moderately InformativeDirect
Coding sequence diversityAlternative splicing3.285e-05Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]