SUPERFAMILY 1.75 HMM library and genome assignments server


Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (496) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,532 3,707 4
Proteins 3,488 3,685 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.936e-15 Least Informative Direct
Biological Process (BP) multicellular organismal process 5.407e-11 Least Informative Direct
Biological Process (BP) developmental process 5.626e-10 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.915e-10 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0006168 Least Informative Direct
Biological Process (BP) regulation of cellular process 4.447e-14 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 2.919e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.08435 Least Informative Inherited
Biological Process (BP) localization 0.5175 Least Informative Inherited
Biological Process (BP) reproduction 3.339e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.137e-07 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 6.56e-11 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0005669 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001006 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 8.694e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 5.183e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.6454 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3343 Moderately Informative Inherited
Biological Process (BP) system process 0.9542 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.004111 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.05373 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9726 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02076 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8679 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4141 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.0879 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7602 Moderately Informative Inherited
Biological Process (BP) proteolysis 1.558e-12 Informative Direct
Biological Process (BP) apoptotic process 1.234e-08 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0001077 Informative Direct
Biological Process (BP) cell cycle process 1.792e-13 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 2.221e-07 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.0005258 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 2.227e-06 Informative Direct
Biological Process (BP) organelle localization 7.479e-05 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.008307 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.002831 Informative Inherited
Biological Process (BP) actin filament-based process 0.03099 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.00308 Informative Inherited
Biological Process (BP) synaptic transmission 0.03791 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02146 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.06415 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 0.3619 Informative Inherited
Biological Process (BP) regulation of cell development 0.5335 Informative Inherited
Biological Process (BP) sexual reproduction 0.1664 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01178 Informative Inherited
Biological Process (BP) protein complex assembly 0.06992 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2214 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2075 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1103 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.004979 Informative Inherited
Biological Process (BP) cellular membrane organization 0.007212 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.006124 Informative Inherited
Biological Process (BP) chromosome organization 0.01186 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0008811 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.413e-08 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0003052 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 1.201e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 7.668e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 1.334e-05 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 3.549e-08 Highly Informative Direct
Biological Process (BP) stem cell development 0.0006484 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 1.635e-07 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.798e-06 Highly Informative Direct
Biological Process (BP) cell division 9.951e-11 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 1.268e-12 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.004842 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.06424 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2916 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.09346 Highly Informative Inherited
Biological Process (BP) mitosis 0.1346 Highly Informative Inherited
Molecular Function (MF) binding 1.56e-07 Least Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.05671 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.105e-08 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.005982 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.4214 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.009023 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.02644 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.05762 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) Golgi apparatus 3.066e-06 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 5.213e-07 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 8.585e-08 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 5.36e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.0055 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.5838Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.7782InformativeInherited
Mammalian Phenotype (MP)complete embryonic lethality between implantation and somite formation0.0004755Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0002785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001038Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.5049Moderately InformativeInherited
Worm Phenotype (WP)life span variant4.34e-08InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis4.848e-05InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased4.147e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0.1853Moderately InformativeInherited
Fly Anatomy (FA)epithelial cell0.005643InformativeInherited
Fly Anatomy (FA)ovariole0.008245InformativeInherited
Fly Anatomy (FA)germline cyst0.02011InformativeInherited
Fly Anatomy (FA)follicle cell0.0004024Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8027Least InformativeInherited
Biological processCell cycle1.746e-10Moderately InformativeDirect
Biological processHost-virus interaction0.000158Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis3.093e-05InformativeDirect
Biological processER-Golgi transport1.923e-11Highly InformativeDirect
Cellular componentNucleus2.412e-09Least InformativeDirect
Cellular componentGolgi apparatus4.924e-08Moderately InformativeDirect
Coding sequence diversityAlternative splicing3.709e-05Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]