SUPERFAMILY 1.75 HMM library and genome assignments server

Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (497) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,541 3,707 4
Proteins 3,496 3,685 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.00000000000001752 Least Informative Direct
Biological Process (BP) developmental process 0.00000000000167 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000000000007051 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00000000002106 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00001016 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.1318 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.04832 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.005259 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1224 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0.00000000003628 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000001464 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.00000003391 Moderately Informative Direct
Biological Process (BP) reproductive process 0.0000002021 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000002254 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0000007375 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001507 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.0005042 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.01618 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.7124 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1501 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.5723 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.00261 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1494 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8916 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.6078 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organ development 0.5624 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.5057 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.445 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.7811 Moderately Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cell cycle process 0.0000000000004112 Informative Direct
Biological Process (BP) proteolysis 0.00000000008704 Informative Direct
Biological Process (BP) apoptotic process 0.00000001296 Informative Direct
Biological Process (BP) cell division 0.00000002567 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0000001416 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000001815 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00000801 Informative Direct
Biological Process (BP) single organism reproductive process 0.00001289 Informative Direct
Biological Process (BP) localization of cell 0.0000217 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.00002734 Informative Direct
Biological Process (BP) organelle localization 0.00008034 Informative Direct
Biological Process (BP) mitotic cell cycle 0.0001516 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0001555 Informative Direct
Biological Process (BP) locomotion 0.0002859 Informative Direct
Biological Process (BP) single-organism membrane organization 0.009472 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1431 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.007059 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.1069 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.006509 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.001953 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.2297 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.262 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2465 Informative Inherited
Biological Process (BP) synaptic transmission 0.02923 Informative Inherited
Biological Process (BP) generation of neurons 0.3236 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.02223 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.001695 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.1356 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.005532 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.003998 Informative Inherited
Biological Process (BP) cellular component movement 0.01876 Informative Inherited
Biological Process (BP) central nervous system development 0.6875 Informative Inherited
Biological Process (BP) regulation of cell development 0.9143 Informative Inherited
Biological Process (BP) organelle fission 0.002306 Informative Inherited
Biological Process (BP) actin filament-based process 0.02878 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.002901 Informative Inherited
Biological Process (BP) chromosome organization 0.008617 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.000000000001867 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.00000002214 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00000003917 Highly Informative Direct
Biological Process (BP) regulation of nuclear division 0.00000005048 Highly Informative Direct
Biological Process (BP) positive regulation of cell division 0.000002505 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.000008189 Highly Informative Direct
Biological Process (BP) vesicle organization 0.000008544 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0.00001263 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.00001874 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00005986 Highly Informative Direct
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.0004073 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0004958 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.0007461 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.004282 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.001361 Highly Informative Inherited
Biological Process (BP) cytokinesis 0.4409 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.01501 Highly Informative Inherited
Biological Process (BP) telencephalon development 0.003793 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.1153 Highly Informative Inherited
Biological Process (BP) nuclear division 0.8569 Highly Informative Inherited
Molecular Function (MF) binding 0.00000005412 Least Informative Direct
Molecular Function (MF) transferase activity 0.0000001023 Least Informative Direct
Molecular Function (MF) protein dimerization activity 0.0627 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.00000003277 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0003075 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.004224 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3031 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.07851 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.01795 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 0.0000005604 Informative Direct
Cellular Component (CC) Golgi apparatus 0.00002871 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 0.000002312 Highly Informative Direct
Cellular Component (CC) spindle 0.00009295 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.5828Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.7798InformativeInherited
Mammalian Phenotype (MP)embryonic lethality between implantation and placentation0.002017Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0002785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001038Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.5049Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.0000000434InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.00004848InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.0000004147Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0.1845Moderately InformativeInherited
Fly Anatomy (FA)epithelial cell0.005777InformativeInherited
Fly Anatomy (FA)ovariole0.008129InformativeInherited
Fly Anatomy (FA)germline cyst0.01946InformativeInherited
Fly Anatomy (FA)follicle cell0.0004148Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8039Least InformativeInherited
Biological processCell cycle0.00000000015Moderately InformativeDirect
Biological processHost-virus interaction0.0001587Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis0.00002799InformativeDirect
Biological processER-Golgi transport0.0000000000191Highly InformativeDirect
Cellular componentNucleus0.000000002479Least InformativeDirect
Cellular componentCytoplasm0.7958Least InformativeInherited
Cellular componentGolgi apparatus0.00000005071Moderately InformativeDirect
Cellular componentCytoskeleton0.0001285Moderately InformativeDirect
Coding sequence diversityAlternative splicing0.00004937Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]