SUPERFAMILY 1.75 HMM library and genome assignments server


Cullin homology domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Cullin homology domain [ 75631]
Superfamily:   Cullin homology domain [ 75632]
Families:   Cullin homology domain [ 75633] (2)


Superfamily statistics
Genomes (496) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,532 3,707 4
Proteins 3,488 3,685 4


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 3.77e-15 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.281e-10 Least Informative Direct
Biological Process (BP) developmental process 1.178e-09 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.746e-09 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.000657 Least Informative Direct
Biological Process (BP) regulation of cellular process 1.958e-14 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.317e-06 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) response to stimulus 0.09706 Least Informative Inherited
Biological Process (BP) localization 0.546 Least Informative Inherited
Biological Process (BP) reproduction 4.216e-05 Moderately Informative Direct
Biological Process (BP) cell differentiation 1.558e-07 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 3.852e-10 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0001349 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 2.946e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 5.159e-05 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.5362 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3348 Moderately Informative Inherited
Biological Process (BP) system process 0.9546 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.005397 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.06849 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.9733 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.02114 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8641 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.4133 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1075 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.8005 Moderately Informative Inherited
Biological Process (BP) proteolysis 1.51e-12 Informative Direct
Biological Process (BP) apoptotic process 1.433e-08 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0001134 Informative Direct
Biological Process (BP) cell cycle process 1.858e-13 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of organelle organization 4.108e-08 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) single organism reproductive process 0.0005381 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 3.139e-06 Informative Direct
Biological Process (BP) organelle localization 7.647e-05 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.006033 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.001691 Informative Inherited
Biological Process (BP) actin filament-based process 0.0311 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.003089 Informative Inherited
Biological Process (BP) synaptic transmission 0.03773 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.0211 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.06496 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) generation of neurons 0.3617 Informative Inherited
Biological Process (BP) regulation of cell development 0.5329 Informative Inherited
Biological Process (BP) sexual reproduction 0.1683 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01166 Informative Inherited
Biological Process (BP) protein complex assembly 0.06993 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.2242 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2103 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.1107 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.004946 Informative Inherited
Biological Process (BP) cellular membrane organization 0.007248 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.006498 Informative Inherited
Biological Process (BP) chromosome organization 0.01206 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0.0008764 Highly Informative Direct
Biological Process (BP) chromosome segregation 2.484e-08 Highly Informative Direct
Biological Process (BP) regulation of mitosis 0.0009214 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.000352 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 1.302e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 7.327e-06 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 1.438e-05 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 3.813e-08 Highly Informative Direct
Biological Process (BP) stem cell development 0.0006415 Highly Informative Direct
Biological Process (BP) positive regulation of neurogenesis 1.792e-07 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 1.761e-06 Highly Informative Direct
Biological Process (BP) cell division 1.015e-10 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 2.118e-12 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.005272 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.06673 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2917 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.09348 Highly Informative Inherited
Biological Process (BP) mitosis 0.1337 Highly Informative Inherited
Molecular Function (MF) binding 2.201e-07 Least Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0575 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 3.497e-08 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.005826 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.425 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.01159 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0266 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.05815 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) Golgi apparatus 3.091e-06 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 6.03e-07 Informative Direct
Cellular Component (CC) nuclear ubiquitin ligase complex 1.037e-07 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 5.68e-05 Highly Informative Direct
Cellular Component (CC) spindle 0.005561 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0.5843Moderately InformativeInherited
Mammalian Phenotype (MP)embryonic lethality0.7795InformativeInherited
Mammalian Phenotype (MP)complete embryonic lethality between implantation and somite formation0.0004768Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.0002785Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001038Moderately InformativeInherited
Worm Phenotype (WP)gametogenesis variant0.5049Moderately InformativeInherited
Worm Phenotype (WP)life span variant4.34e-08InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis4.848e-05InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased4.147e-07Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect
Fly Anatomy (FA)epithelium0.1853Moderately InformativeInherited
Fly Anatomy (FA)epithelial cell0.005643InformativeInherited
Fly Anatomy (FA)ovariole0.008245InformativeInherited
Fly Anatomy (FA)germline cyst0.02011InformativeInherited
Fly Anatomy (FA)follicle cell0.0004024Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.8027Least InformativeInherited
Biological processCell cycle1.746e-10Moderately InformativeDirect
Biological processHost-virus interaction0.000158Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processMitosis3.093e-05InformativeDirect
Biological processER-Golgi transport1.923e-11Highly InformativeDirect
Cellular componentNucleus2.412e-09Least InformativeDirect
Cellular componentGolgi apparatus4.924e-08Moderately InformativeDirect
Coding sequence diversityAlternative splicing3.709e-05Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin homology domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Cullin homology domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]