SUPERFAMILY 1.75 HMM library and genome assignments server

Release factor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Release factor [ 75619]
Superfamily:   Release factor [ 75620]
Families:   Release factor [ 75621] (2)


Superfamily statistics
Genomes (3,075) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,667 41,441 5
Proteins 7,638 41,418 5


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00015540.00001676Least InformativeDirect
Biological Process (BP)protein metabolic process0.00015290.00006973Least InformativeDirect
Biological Process (BP)cellular component organization or biogenesis0.0018430.0005444Least InformativeInherited
Biological Process (BP)single-organism cellular process0.23970.2036Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0010390.001695Least InformativeInherited
Biological Process (BP)gene expression0.00000017490.00000177Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.00000080020.0000003469Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.023160.001065Moderately InformativeInherited
Biological Process (BP)cellular component disassembly0.00000000086670Highly InformativeDirect
Molecular Function (MF)binding0.30820.2904Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.000014210.000002376Moderately InformativeDirect
Molecular Function (MF)RNA binding0.0000006750.0000000001189InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding0.000000000020270.0000000003006Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.026720.0003962Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.029350.00001564Least InformativeInherited
Cellular Component (CC)plastid0.00093190.000001944InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00001676 Least Informative Direct
Biological Process (BP) protein metabolic process 0.00006973 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0005444 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.2036 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.001695 Least Informative Inherited
Biological Process (BP) gene expression 0.00000177 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0000003469 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.001065 Moderately Informative Inherited
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Molecular Function (MF) binding 0.2904 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.000002376 Moderately Informative Direct
Molecular Function (MF) RNA binding 0.0000000001189 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0.0000000003006 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.0003962 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001564 Least Informative Direct
Cellular Component (CC) plastid 0.000001944 Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Release factor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Release factor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]