SUPERFAMILY 1.75 HMM library and genome assignments server


Release factor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Release factor [ 75619]
Superfamily:   Release factor [ 75620]
Families:   Release factor [ 75621] (2)


Superfamily statistics
Genomes (3,074) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,659 41,441 5
Proteins 7,630 41,418 5


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00017971.837e-05Least InformativeDirect
Biological Process (BP)protein metabolic process0.00017678.642e-06Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0012830.002133Least InformativeInherited
Biological Process (BP)single-organism cellular process0.15520.2276Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0020290.0008347Least InformativeInherited
Biological Process (BP)gene expression1.567e-071.193e-06Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process8.518e-073.591e-07Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.011895.339e-05Moderately InformativeInherited
Biological Process (BP)translation1.334e-117.377e-15InformativeDirect
Biological Process (BP)cellular component disassembly1.136e-090Highly InformativeDirect
Molecular Function (MF)binding0.31830.3677Least InformativeInherited
Molecular Function (MF)nucleic acid binding9.747e-062.397e-06Moderately InformativeDirect
Molecular Function (MF)RNA binding3.002e-073.427e-11InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding2.325e-112.252e-09Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.039170.001769Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.037585.145e-05Least InformativeInherited
Cellular Component (CC)plastid0.00088121.694e-06InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 1.837e-05 Least Informative Direct
Biological Process (BP) protein metabolic process 8.642e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0008347 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.002133 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.2276 Least Informative Inherited
Biological Process (BP) gene expression 1.193e-06 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 3.591e-07 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 5.339e-05 Moderately Informative Direct
Biological Process (BP) translation 7.377e-15 Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Molecular Function (MF) binding 0.3677 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 2.397e-06 Moderately Informative Direct
Molecular Function (MF) RNA binding 3.427e-11 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 2.252e-09 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 5.145e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.001769 Least Informative Inherited
Cellular Component (CC) plastid 1.694e-06 Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Release factor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Release factor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]