SUPERFAMILY 1.75 HMM library and genome assignments server

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Release factor superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Multi-domain proteins (alpha and beta) [ 56572] (66)
Fold:   Release factor [ 75619]
Superfamily:   Release factor [ 75620]
Families:   Release factor [ 75621] (2)


Superfamily statistics
Genomes (3,074) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 7,659 41,441 5
Proteins 7,630 41,418 5


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.00015930.00001979Least InformativeDirect
Biological Process (BP)protein metabolic process0.00013820.000008195Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0010350.001997Least InformativeInherited
Biological Process (BP)single-organism cellular process0.13930.1522Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0017420.000424Least InformativeInherited
Biological Process (BP)gene expression0.00000011580.000001178Moderately InformativeDirect
Biological Process (BP)cellular macromolecule biosynthetic process0.00000080570.0000003498Moderately InformativeDirect
Biological Process (BP)macromolecular complex subunit organization0.011760.00005576Moderately InformativeInherited
Biological Process (BP)cellular component disassembly0.00000000087320Highly InformativeDirect
Molecular Function (MF)binding0.30220.2796Least InformativeInherited
Molecular Function (MF)nucleic acid binding0.0000088130.000001181Moderately InformativeDirect
Molecular Function (MF)RNA binding0.00000027460.00000000001461InformativeDirect
Molecular Function (MF)translation factor activity, nucleic acid binding0.000000000020180.000000002168Highly InformativeDirect
Cellular Component (CC)intracellular membrane-bounded organelle0.031530.000588Least InformativeInherited
Cellular Component (CC)cytoplasmic part0.030550.00001511Least InformativeInherited
Cellular Component (CC)plastid0.00087390.000001697InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0.00001979 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000008195 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000424 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.001997 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.1522 Least Informative Inherited
Biological Process (BP) gene expression 0.000001178 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.0000003498 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.00005576 Moderately Informative Direct
Biological Process (BP) cellular component disassembly 0 Highly Informative Direct
Molecular Function (MF) binding 0.2796 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.000001181 Moderately Informative Direct
Molecular Function (MF) RNA binding 0.00000000001461 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0.000000002168 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000588 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00001511 Least Informative Direct
Cellular Component (CC) plastid 0.000001697 Informative Direct

Document: GO annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Coding sequence diversityRibosomal frameshifting0Moderately InformativeDirect
Post-translational modificationMethylation0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Release factor domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Release factor superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]