SUPERFAMILY 1.75 HMM library and genome assignments server

Major surface antigen p30, SAG1 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Cupredoxin-like [ 49502] (2)
Superfamily:   Major surface antigen p30, SAG1 [ 74877]
Families:   Major surface antigen p30, SAG1 [ 74878]

Superfamily statistics
Genomes (5) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,193 0 4
Proteins 660 0 2

Functional annotation
General category Processes_EC
Detailed category Immune response

Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR007226 SSF74877 Protein matches
Abstract Toxoplasma gondii is a persistent protozoan parasite capable of infecting almost any warm-blooded vertebrate. The surface of T. gondii is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member. SRS proteins mediate attachment to host cells and interface with the host immune response to regulate the virulence of the parasite. The structure of the immunodominant SAG1 antigen reveals a homodimeric configuration [PubMed9418898]. This family of surface antigens is found in other apicomplexans.

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Major surface antigen p30, SAG1 domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Major surface antigen p30, SAG1 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]