SUPERFAMILY 1.75 HMM library and genome assignments server

Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (500) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,995 6,161 6
Proteins 6,880 6,107 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.000000044730.000000000000093Least InformativeDirect
Biological Process (BP)multicellular organismal process0.000006660.000001481Least InformativeDirect
Biological Process (BP)developmental process0.0000022270.000000466Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00069560.0000002098Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0032270.06559Least InformativeInherited
Biological Process (BP)positive regulation of biological process0.016460.08336Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.024450.991Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0077680.0202Least InformativeInherited
Biological Process (BP)cell differentiation0.000041780.000888Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.0000058330.0000006783Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.00036720.0000000007489Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.008020.03072Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0014680.00000002938Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.04950.1919Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0033070.3606Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0013710.1828Moderately InformativeInherited
Biological Process (BP)cellular protein modification process10.7678Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.062871Moderately InformativeInherited
Biological Process (BP)proteolysis0.00090240.000000005048InformativeDirect
Biological Process (BP)protein catabolic process0.0000010330InformativeDirect
Biological Process (BP)regulation of cell proliferation0.00056750.00007581InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.000011660.000000000000007248InformativeDirect
Biological Process (BP)protein modification by small protein conjugation or removal0.000016280InformativeDirect
Biological Process (BP)negative regulation of immune system process0.00000006570.003054InformativeInherited
Biological Process (BP)negative regulation of developmental process0.00000029130.0533InformativeInherited
Biological Process (BP)regulation of cell cycle process0.00000026990.07917InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.00000018020.07924InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.00000090440.06089InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.000000000025950Highly InformativeDirect
Biological Process (BP)protein ubiquitination0.0000017870Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation0.0000000018280.00001365Highly InformativeDirect
Biological Process (BP)positive regulation of mitotic cell cycle0.00000000035560.00004442Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process0.0000017360.00001456Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.0000020790.00000000000004551Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.0000000020010.00007207Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.0000031230.00589Highly InformativeInherited
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.00000000029160.03727Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.000000096190.04648Highly InformativeInherited
Biological Process (BP)stem cell development0.000017170.03125Highly InformativeInherited
Molecular Function (MF)binding0.00020080.0001645Least InformativeDirect
Molecular Function (MF)protein dimerization activity0.017150.1107InformativeInherited
Molecular Function (MF)protein heterodimerization activity0.00000017020.0000002855Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.000000000000093 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000001481 Least Informative Direct
Biological Process (BP) developmental process 0.000000466 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.0000002098 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.06559 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.005963 Least Informative Inherited
Biological Process (BP) localization 0.00119 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.08336 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.0202 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.991 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4068 Least Informative Inherited
Biological Process (BP) reproductive process 0.00005656 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000888 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.00000002938 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0000006783 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000000007489 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.3143 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.03072 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.5554 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.002195 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.624 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.1911 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1919 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3606 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1828 Moderately Informative Inherited
Biological Process (BP) organ development 0.3987 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.7678 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3819 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.1864 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) mitotic cell cycle 0.0003523 Informative Direct
Biological Process (BP) proteolysis 0.000000005048 Informative Direct
Biological Process (BP) apoptotic process 0.000003602 Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0004048 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00002596 Informative Direct
Biological Process (BP) cell cycle process 0.0000000005501 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0001032 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00007581 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000000000007248 Informative Direct
Biological Process (BP) single organism reproductive process 0.0001854 Informative Direct
Biological Process (BP) organelle fission 0.0009771 Informative Direct
Biological Process (BP) chromosome organization 0.0003611 Informative Direct
Biological Process (BP) cell division 0.0001086 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0004318 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.4787 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.008355 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.06712 Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.003054 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.0533 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.07917 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.07924 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0927 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.04745 Informative Inherited
Biological Process (BP) organelle localization 0.01067 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.228 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.2166 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.04945 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.08766 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.1428 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.06089 Informative Inherited
Biological Process (BP) locomotion 0.002037 Informative Inherited
Biological Process (BP) cellular component movement 0.02061 Informative Inherited
Biological Process (BP) localization of cell 0.004504 Informative Inherited
Biological Process (BP) central nervous system development 0.5137 Informative Inherited
Biological Process (BP) actin filament-based process 0.01842 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.6165 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) actin filament organization 0.000819 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.00000008251 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000008137 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) telencephalon development 0.0009992 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0001398 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00001365 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.00004442 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0000006458 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00001456 Highly Informative Direct
Biological Process (BP) positive regulation of cell division 0.00005039 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00000000000004551 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00007207 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0004497 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.00589 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.001717 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.03727 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis involved in cellular protein catabolic process 0.008397 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.04648 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.01475 Highly Informative Inherited
Biological Process (BP) stem cell development 0.03125 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.358 Highly Informative Inherited
Biological Process (BP) nuclear division 0.5445 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.008064 Highly Informative Inherited
Molecular Function (MF) binding 0.0001645 Least Informative Direct
Molecular Function (MF) transferase activity 0.009824 Least Informative Inherited
Molecular Function (MF) protein dimerization activity 0.1107 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0000002855 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) membrane 0.3282 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4419 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.2546 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.8819 Least Informative Inherited
Cellular Component (CC) cytosol 0.0003338 Moderately Informative Direct
Cellular Component (CC) transferase complex 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0.06126 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.9699 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4631 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0005048 Informative Direct
Cellular Component (CC) cell cortex 0.001051 Informative Inherited
Cellular Component (CC) neuron projection 0.265 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.01822 Informative Inherited
Cellular Component (CC) spindle 0.0002123 Highly Informative Direct
Cellular Component (CC) growth cone 0.0000005504 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00006128Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004565Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.00134Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.000001308InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.00004848InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.000001447Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.01394Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.416Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.5587Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.7465Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.00000004685InformativeDirect
Plant ANatomical entity (PAN)root tip0.00000234InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.00007198InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0001595InformativeDirect
Plant ANatomical entity (PAN)primordium0.0001787InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium0.000004248Highly InformativeDirect
Plant ANatomical entity (PAN)root stele0.00005119Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem0.00005294Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.0001018Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05806Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle0.000155Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processLipid transport0.0001295InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processER-Golgi transport0.0002813Highly InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.436e-16Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]