SUPERFAMILY 1.75 HMM library and genome assignments server


Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (499) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,987 6,161 6
Proteins 6,872 6,107 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process9.183e-061.212e-10Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00064390.0006276Least InformativeDirect
Biological Process (BP)developmental process0.00023680.0001169Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0025750.05049Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0042832.524e-05Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0050340.0002649Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.020331Least InformativeInherited
Biological Process (BP)cellular catabolic process8.525e-054.764e-09Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.374e-065.031e-05Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10271Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0055820.1182Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0013390.1753Moderately InformativeInherited
Biological Process (BP)cell differentiation3.82e-050.001464Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.039360.1413Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0043790.4619Moderately InformativeInherited
Biological Process (BP)proteolysis5.268e-054.442e-11InformativeDirect
Biological Process (BP)protein catabolic process2.701e-120InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process5.024e-070InformativeDirect
Biological Process (BP)regulation of cell cycle process2.789e-070.08341InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle1.332e-070.03318InformativeInherited
Biological Process (BP)negative regulation of developmental process1.586e-070.03953InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process2.442e-110Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation1.814e-091.453e-05Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process1.712e-062.993e-06Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process2.496e-063.801e-14Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation1.985e-097.583e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress2.691e-060.004888Highly InformativeInherited
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle2.898e-100.0595Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation5.387e-080.04016Highly InformativeInherited
Biological Process (BP)stem cell development1.947e-050.02265Highly InformativeInherited
Molecular Function (MF)binding0.00015860.000142Least InformativeDirect
Molecular Function (MF)protein dimerization activity0.017440.1044InformativeInherited
Molecular Function (MF)protein heterodimerization activity1.551e-072.5e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.212e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0006276 Least Informative Direct
Biological Process (BP) developmental process 0.0001169 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.524e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002649 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.005852 Least Informative Inherited
Biological Process (BP) localization 0.02735 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05049 Least Informative Inherited
Biological Process (BP) response to stimulus 0.439 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 9.885e-05 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 4.764e-09 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 5.031e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0004327 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9105 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.255 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06468 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7407 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5885 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1413 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1182 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1753 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001464 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4619 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.4024 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 3.344e-05 Informative Direct
Biological Process (BP) proteolysis 4.442e-11 Informative Direct
Biological Process (BP) apoptotic process 3.15e-06 Informative Direct
Biological Process (BP) vesicle-mediated transport 3.712e-05 Informative Direct
Biological Process (BP) cell cycle process 7.833e-09 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004097 Informative Direct
Biological Process (BP) chromosome organization 0.000322 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 7.377e-15 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.08341 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.03318 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.03082 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.06639 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.06432 Informative Inherited
Biological Process (BP) actin filament-based process 0.02775 Informative Inherited
Biological Process (BP) protein complex assembly 0.07516 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1937 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1838 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.04914 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03953 Informative Inherited
Biological Process (BP) organelle localization 0.01017 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01714 Informative Inherited
Biological Process (BP) cellular membrane organization 0.02171 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.5154 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 1.756e-07 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0004183 Highly Informative Direct
Biological Process (BP) vesicle organization 6.959e-07 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 9.738e-06 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 1.453e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 2.12e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 2.993e-06 Highly Informative Direct
Biological Process (BP) cell division 6.68e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 3.801e-14 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 7.583e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.004888 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.0595 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.001524 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.04016 Highly Informative Inherited
Biological Process (BP) stem cell development 0.02265 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.3134 Highly Informative Inherited
Biological Process (BP) mitosis 0.1654 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.003363 Highly Informative Inherited
Molecular Function (MF) binding 0.000142 Least Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.1044 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.5e-07 Highly Informative Direct
Cellular Component (CC) protein complex 2.779e-14 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.3036 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.5404 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.3513 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001933 Moderately Informative Direct
Cellular Component (CC) cell projection 0.02844 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.5042 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2264 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) Golgi apparatus 4.854e-05 Informative Direct
Cellular Component (CC) neuron projection 0.2946 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.01676 Informative Inherited
Cellular Component (CC) cell cortex 0.01466 Informative Inherited
Cellular Component (CC) growth cone 5.798e-07 Highly Informative Direct
Cellular Component (CC) spindle 0.01451 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant6.128e-05Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004565Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.00134Moderately InformativeInherited
Worm Phenotype (WP)life span variant1.308e-06InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis4.848e-05InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased1.447e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.01394Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.416Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.5587Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.7465Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue4.685e-08InformativeDirect
Plant ANatomical entity (PAN)root tip2.34e-06InformativeDirect
Plant ANatomical entity (PAN)root epidermis7.198e-05InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0001595InformativeDirect
Plant ANatomical entity (PAN)primordium0.0001787InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium4.248e-06Highly InformativeDirect
Plant ANatomical entity (PAN)root stele5.119e-05Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem5.294e-05Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.0001018Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05806Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle0.0001714Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processLipid transport0.0001305InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processER-Golgi transport0.0002832Highly InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.428e-16Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]