SUPERFAMILY 1.75 HMM library and genome assignments server


Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (445) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,601 4,283 6
Proteins 5,539 4,248 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of cellular process0.012070.05886Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.034961Least InformativeInherited
Biological Process (BP)protein metabolic process0.040581.386e-05Least InformativeInherited
Biological Process (BP)regulation of protein metabolic process3.788e-050.0001938Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process0.013040.6349Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.017662.096e-08Moderately InformativeInherited
Biological Process (BP)protein catabolic process2.815e-050InformativeDirect
Biological Process (BP)regulation of cell cycle process3.452e-070.05InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle1.535e-070.2847InformativeInherited
Biological Process (BP)positive regulation of cell cycle process3.248e-091.468e-11Highly InformativeDirect
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle3.557e-100.001592Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 1.386e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0009028 Least Informative Direct
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.01202 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.007758 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05886 Least Informative Inherited
Biological Process (BP) response to stimulus 0.6597 Least Informative Inherited
Biological Process (BP) localization 0.004811 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.004281 Least Informative Inherited
Biological Process (BP) developmental process 0.003353 Least Informative Inherited
Biological Process (BP) reproduction 6.869e-06 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 3.752e-07 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001938 Moderately Informative Direct
Biological Process (BP) cellular localization 2.864e-06 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 2.096e-08 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.6349 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.3297 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01769 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7654 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.3628 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.008437 Moderately Informative Inherited
Biological Process (BP) tissue development 0.45 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.02203 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.5341 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3706 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1.969e-08 Informative Direct
Biological Process (BP) proteolysis 1.035e-09 Informative Direct
Biological Process (BP) apoptotic process 2.582e-06 Informative Direct
Biological Process (BP) vesicle-mediated transport 3.538e-07 Informative Direct
Biological Process (BP) cell cycle process 2.312e-11 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 8.915e-13 Informative Direct
Biological Process (BP) single organism reproductive process 0.0002076 Informative Direct
Biological Process (BP) secretion 0.0009758 Informative Direct
Biological Process (BP) cellular process involved in reproduction 7.019e-05 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 2.357e-13 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.05 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2847 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.007236 Informative Inherited
Biological Process (BP) actin filament-based process 0.03229 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1397 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1384 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0294 Informative Inherited
Biological Process (BP) sexual reproduction 0.3097 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.1058 Informative Inherited
Biological Process (BP) epithelium development 0.5798 Informative Inherited
Biological Process (BP) cellular membrane organization 0.002701 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.5944 Informative Inherited
Biological Process (BP) nuclear division 0.000179 Highly Informative Direct
Biological Process (BP) exocytosis 5.479e-05 Highly Informative Direct
Biological Process (BP) vesicle organization 1.721e-06 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 3.439e-06 Highly Informative Direct
Biological Process (BP) regulation of Ras protein signal transduction 0.0008459 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 2.141e-07 Highly Informative Direct
Biological Process (BP) cell division 1.052e-08 Highly Informative Direct
Biological Process (BP) organelle localization 7.384e-06 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 1.468e-11 Highly Informative Direct
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.001592 Highly Informative Inherited
Biological Process (BP) negative regulation of signal transduction 0.0531 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.007574 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.6367 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.01755 Highly Informative Inherited
Biological Process (BP) germ cell development 0.00841 Highly Informative Inherited
Biological Process (BP) spermatogenesis 0.004669 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 0.1746 Highly Informative Inherited
Biological Process (BP) cell cycle phase transition 0.001686 Highly Informative Inherited
Molecular Function (MF) binding 0.03142 Least Informative Inherited
Molecular Function (MF) protein binding 1.259e-05 Moderately Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 4.552e-15 Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 2.632e-14 Least Informative Direct
Cellular Component (CC) membrane 0.9816 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.1933 Least Informative Inherited
Cellular Component (CC) cytosol 0.0001788 Moderately Informative Direct
Cellular Component (CC) cell projection 0.002303 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.5306 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2635 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) cell cortex 1.615e-05 Informative Direct
Cellular Component (CC) cell projection part 0.0009691 Informative Direct
Cellular Component (CC) neuron part 0.06674 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.02085 Informative Inherited
Cellular Component (CC) growth cone 1.941e-06 Highly Informative Direct
Cellular Component (CC) spindle 0.009523 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant6.128e-05Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004565Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.00134Moderately InformativeInherited
Worm Phenotype (WP)life span variant1.308e-06InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis4.848e-05InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased1.447e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root0.1964Least InformativeInherited
Plant ANatomical entity (PAN)plant cell0.6197Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue1Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue1.307e-07InformativeDirect
Plant ANatomical entity (PAN)root tip2.381e-06InformativeDirect
Plant ANatomical entity (PAN)stele4.777e-05InformativeDirect
Plant ANatomical entity (PAN)primordium0.0002653InformativeDirect
Plant ANatomical entity (PAN)root epidermal cell0.004688InformativeInherited
Plant ANatomical entity (PAN)lateral root primordium4.028e-06Highly InformativeDirect
Plant ANatomical entity (PAN)root stele4.834e-05Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem4.999e-05Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.0001542Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05406Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle9.302e-05Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processLipid transport3.351e-05InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processER-Golgi transport0.000152Highly InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle5.009e-15Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]