SUPERFAMILY 1.75 HMM library and genome assignments server


Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (448) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 5,636 4,283 6
Proteins 5,573 4,248 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process1.028e-052.131e-10Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00066310.0003257Least InformativeDirect
Biological Process (BP)developmental process0.00024425.915e-05Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0026130.05136Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0040783.561e-05Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0052980.0002071Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.02221Least InformativeInherited
Biological Process (BP)macromolecule catabolic process7.701e-100Moderately InformativeDirect
Biological Process (BP)cell differentiation3.317e-050.0007197Moderately InformativeDirect
Biological Process (BP)cellular catabolic process8.662e-052.716e-09Moderately InformativeDirect
Biological Process (BP)single-organism developmental process0.00028070.0006133Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process1.399e-063.723e-05Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10681Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0054420.4769Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0013720.1657Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.041050.1359Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0041290.4455Moderately InformativeInherited
Biological Process (BP)proteolysis5.219e-051.749e-11InformativeDirect
Biological Process (BP)protein catabolic process2.845e-120InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process5.04e-070InformativeDirect
Biological Process (BP)regulation of cell cycle0.00020050InformativeDirect
Biological Process (BP)negative regulation of developmental process1.514e-070.03792InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process2.295e-110Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation2.046e-091.799e-05Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process1.887e-062.723e-06Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process2.84e-061.354e-12Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation2.143e-098.305e-05Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress2.746e-060.004439Highly InformativeInherited
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle2.218e-100.001524Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation6.465e-080.04205Highly InformativeInherited
Biological Process (BP)stem cell development2.082e-050.02079Highly InformativeInherited
Molecular Function (MF)binding0.00017426.407e-05Least InformativeDirect
Molecular Function (MF)protein dimerization activity0.017280.1007InformativeInherited
Molecular Function (MF)protein heterodimerization activity1.609e-072.131e-07Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 2.131e-10 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0003257 Least Informative Direct
Biological Process (BP) developmental process 5.915e-05 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 3.561e-05 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0002071 Least Informative Direct
Biological Process (BP) localization 0.0214 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05136 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3817 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.00675 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 7.337e-05 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.0007197 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 2.716e-09 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0006133 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 3.723e-05 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0004 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4769 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9748 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.05059 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5315 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1359 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1657 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.4455 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.431 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7348 Moderately Informative Inherited
Biological Process (BP) proteolysis 1.749e-11 Informative Direct
Biological Process (BP) cell death 0.0007156 Informative Direct
Biological Process (BP) vesicle-mediated transport 4.03e-05 Informative Direct
Biological Process (BP) cell cycle process 2.545e-09 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004219 Informative Direct
Biological Process (BP) regulation of cell cycle 0 Informative Direct
Biological Process (BP) organelle localization 0.009912 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.06082 Informative Inherited
Biological Process (BP) actin filament-based process 0.02669 Informative Inherited
Biological Process (BP) protein complex assembly 0.06936 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1808 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.1721 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.0456 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03792 Informative Inherited
Biological Process (BP) membrane organization 0.00357 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.5402 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) vesicle organization 6.555e-07 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 1.003e-08 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0001133 Highly Informative Direct
Biological Process (BP) mitotic cell cycle phase transition 0.000116 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 1.799e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 2.192e-08 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 2.723e-06 Highly Informative Direct
Biological Process (BP) cell division 1.222e-06 Highly Informative Direct
Biological Process (BP) establishment of vesicle localization 9.679e-05 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 1.354e-12 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 8.305e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.004439 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.001524 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.001408 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.04205 Highly Informative Inherited
Biological Process (BP) stem cell development 0.02079 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.2613 Highly Informative Inherited
Molecular Function (MF) binding 6.407e-05 Least Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.1007 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 2.131e-07 Highly Informative Direct
Cellular Component (CC) protein complex 2.283e-13 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.2228 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.9371 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.08265 Least Informative Inherited
Cellular Component (CC) cytosol 0.0003482 Moderately Informative Direct
Cellular Component (CC) cell projection 0.02168 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.7861 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.1611 Moderately Informative Inherited
Cellular Component (CC) endomembrane system 0.08414 Moderately Informative Inherited
Cellular Component (CC) organelle membrane 0.3107 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) Golgi apparatus 3.902e-06 Informative Direct
Cellular Component (CC) neuron projection 0.2993 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.01046 Informative Inherited
Cellular Component (CC) cell cortex 0.01456 Informative Inherited
Cellular Component (CC) Golgi membrane 4.883e-05 Highly Informative Direct
Cellular Component (CC) growth cone 7.194e-07 Highly Informative Direct
Cellular Component (CC) spindle 0.01322 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant6.128e-05Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004565Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.00134Moderately InformativeInherited
Worm Phenotype (WP)life span variant1.308e-06InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis4.848e-05InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased1.447e-06Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.01394Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.416Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.5587Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.7465Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue4.685e-08InformativeDirect
Plant ANatomical entity (PAN)root tip2.34e-06InformativeDirect
Plant ANatomical entity (PAN)root epidermis7.198e-05InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0001595InformativeDirect
Plant ANatomical entity (PAN)primordium0.0001787InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium4.248e-06Highly InformativeDirect
Plant ANatomical entity (PAN)root stele5.119e-05Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem5.294e-05Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.0001018Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05806Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle0.0001765Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processLipid transport7.297e-05InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processER-Golgi transport0.000289Highly InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.373e-16Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]