SUPERFAMILY 1.75 HMM library and genome assignments server

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Cullin repeat-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Cullin repeat-like [ 74788] (2)
Families:   Cullin repeat [ 74789] (2)
  Exocyst complex component [ 140851] (2)


Superfamily statistics
Genomes (499) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 6,987 6,161 6
Proteins 6,872 6,107 6


Functional annotation
General category Processes_IC
Detailed category Cell cycle, Apoptosis

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)protein metabolic process0.0000097950.0000000001749Least InformativeDirect
Biological Process (BP)multicellular organismal process0.00066640.0007817Least InformativeDirect
Biological Process (BP)developmental process0.0002480.0001451Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0028630.04995Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0040180.000004705Least InformativeInherited
Biological Process (BP)single-organism cellular process0.0054570.0004042Least InformativeInherited
Biological Process (BP)regulation of metabolic process0.020321Least InformativeInherited
Biological Process (BP)cellular catabolic process0.000085310.000000000866Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.0000015850.00006647Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.0000025820.000000000008033Moderately InformativeDirect
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.10181Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.0059990.1314Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0013780.183Moderately InformativeInherited
Biological Process (BP)cell differentiation0.000038990.001653Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.040370.1573Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process0.0045660.47Moderately InformativeInherited
Biological Process (BP)proteolysis0.000052110.00000000005624InformativeDirect
Biological Process (BP)protein catabolic process0.0000000000028810InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0006120.00007925InformativeDirect
Biological Process (BP)cellular macromolecule catabolic process0.00000048330InformativeDirect
Biological Process (BP)regulation of cell cycle process0.00000027990.08632InformativeInherited
Biological Process (BP)regulation of mitotic cell cycle0.00000013340.03488InformativeInherited
Biological Process (BP)negative regulation of developmental process0.00000019790.03955InformativeInherited
Biological Process (BP)ubiquitin-dependent protein catabolic process0.000000000023750Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation0.0000000018360.00001379Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process0.0000015930.000003476Highly InformativeDirect
Biological Process (BP)positive regulation of cell cycle process0.0000023010.00000000000003126Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.0000000020110.00006961Highly InformativeDirect
Biological Process (BP)regulation of cellular response to stress0.0000030220.005387Highly InformativeInherited
Biological Process (BP)regulation of G1/S transition of mitotic cell cycle0.00000000029440.0564Highly InformativeInherited
Biological Process (BP)negative regulation of cell differentiation0.000000069160.03987Highly InformativeInherited
Biological Process (BP)stem cell development0.000020670.02261Highly InformativeInherited
Molecular Function (MF)binding0.00019090.0002476Least InformativeDirect
Molecular Function (MF)protein dimerization activity0.017060.1019InformativeInherited
Molecular Function (MF)protein heterodimerization activity0.00000016940.0000002725Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0000000001749 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0007817 Least Informative Direct
Biological Process (BP) developmental process 0.0001451 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.000004705 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0004042 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00747 Least Informative Inherited
Biological Process (BP) localization 0.03241 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.04995 Least Informative Inherited
Biological Process (BP) response to stimulus 0.4 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.0001142 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000866 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00006647 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0004515 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000000000008033 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.9869 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.261 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.06674 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.7372 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.5986 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1573 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1314 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.183 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001653 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.47 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.3833 Moderately Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.00003444 Informative Direct
Biological Process (BP) proteolysis 0.00000000005624 Informative Direct
Biological Process (BP) apoptotic process 0.000003627 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00003736 Informative Direct
Biological Process (BP) cell cycle process 0.000000007023 Informative Direct
Biological Process (BP) protein catabolic process 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.00007925 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) cellular process involved in reproduction 0.0004375 Informative Direct
Biological Process (BP) chromosome organization 0.0003577 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.000000000000007347 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.08632 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.03488 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.03333 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.06761 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.06269 Informative Inherited
Biological Process (BP) actin filament-based process 0.02747 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1972 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.188 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.05072 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.03955 Informative Inherited
Biological Process (BP) organelle localization 0.009738 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.01677 Informative Inherited
Biological Process (BP) cellular membrane organization 0.02194 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.5156 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) chromosome segregation 0.0000001664 Highly Informative Direct
Biological Process (BP) positive regulation of organelle organization 0.0004317 Highly Informative Direct
Biological Process (BP) vesicle organization 0.0000008223 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) cell cycle phase 0.000008559 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0001408 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0.00001379 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.00000002537 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000003476 Highly Informative Direct
Biological Process (BP) cell division 0.000006211 Highly Informative Direct
Biological Process (BP) positive regulation of cell cycle process 0.00000000000003126 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.00006961 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.005387 Highly Informative Inherited
Biological Process (BP) regulation of G1/S transition of mitotic cell cycle 0.0564 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.001471 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.03987 Highly Informative Inherited
Biological Process (BP) stem cell development 0.02261 Highly Informative Inherited
Biological Process (BP) proteasomal protein catabolic process 0.3147 Highly Informative Inherited
Biological Process (BP) mitosis 0.1667 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle phase transition 0.003172 Highly Informative Inherited
Molecular Function (MF) binding 0.0002476 Least Informative Direct
Molecular Function (MF) ligase activity 0.000000000000973 Informative Direct
Molecular Function (MF) protein dimerization activity 0.1019 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) protein heterodimerization activity 0.0000002725 Highly Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) membrane 0.3275 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.2073 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.4507 Least Informative Inherited
Cellular Component (CC) cytosol 0.0005846 Moderately Informative Direct
Cellular Component (CC) cell projection 0.04915 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.6501 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.4702 Moderately Informative Inherited
Cellular Component (CC) ubiquitin ligase complex 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0.0001524 Informative Direct
Cellular Component (CC) cell cortex 0.0009514 Informative Direct
Cellular Component (CC) neuron projection 0.3031 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.01731 Informative Inherited
Cellular Component (CC) growth cone 0.0000006746 Highly Informative Direct
Cellular Component (CC) cullin-RING ubiquitin ligase complex 0.0004675 Highly Informative Direct
Cellular Component (CC) spindle 0.02314 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.00006128Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.0004565Moderately InformativeDirect
Worm Phenotype (WP)protein aggregation variant0.00134Moderately InformativeInherited
Worm Phenotype (WP)life span variant0.000001308InformativeDirect
Worm Phenotype (WP)protein aggregation induced paralysis0.00004848InformativeDirect
Worm Phenotype (WP)spontaneous mutation rate increased0.000001447Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)cell0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)reproductive system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root system0.01394Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.416Least InformativeInherited
Plant ANatomical entity (PAN)portion of meristem tissue0.5587Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.7465Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.00000004685InformativeDirect
Plant ANatomical entity (PAN)root tip0.00000234InformativeDirect
Plant ANatomical entity (PAN)root epidermis0.00007198InformativeDirect
Plant ANatomical entity (PAN)vascular system0.0001595InformativeDirect
Plant ANatomical entity (PAN)primordium0.0001787InformativeDirect
Plant ANatomical entity (PAN)lateral root primordium0.000004248Highly InformativeDirect
Plant ANatomical entity (PAN)root stele0.00005119Highly InformativeDirect
Plant ANatomical entity (PAN)root meristem0.00005294Highly InformativeDirect
Plant ANatomical entity (PAN)root hair cell0.0001018Highly InformativeDirect
Plant ANatomical entity (PAN)cortex0.05806Highly InformativeInherited

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processCell cycle0.000155Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processLipid transport0.0001295InformativeDirect
Biological processExocytosis0Highly InformativeDirect
Biological processER-Golgi transport0.0002813Highly InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle6.436e-16Moderately InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cullin repeat-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Cullin repeat-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]