SUPERFAMILY 1.75 HMM library and genome assignments server


MTH1598-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MTH1598-like [ 69818]
Superfamily:   MTH1598-like [ 69819]
Families:   MTH1598-like [ 69820] (2)


Superfamily statistics
Genomes (504) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 545 891 2
Proteins 543 890 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process7.237e-050.0003847Least InformativeDirect
Biological Process (BP)heterocycle metabolic process6.914e-050.0003436Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00013950.0006119Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.00018780.003094Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.0003720.001136Least InformativeInherited
Biological Process (BP)gene expression1.057e-073.172e-06Moderately InformativeDirect
Biological Process (BP)RNA metabolic process2.062e-081.605e-06Moderately InformativeDirect
Biological Process (BP)RNA processing3.783e-101.505e-08InformativeDirect
Biological Process (BP)ncRNA metabolic process1.81e-115.043e-10InformativeDirect
Biological Process (BP)RNA splicing6.066e-132.873e-11Highly InformativeDirect
Cellular Component (CC)protein complex0.0002450.002079Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0003847 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003436 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0006119 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.003094 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.001136 Least Informative Inherited
Biological Process (BP) gene expression 3.172e-06 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 1.605e-06 Moderately Informative Direct
Biological Process (BP) RNA processing 1.505e-08 Informative Direct
Biological Process (BP) ncRNA metabolic process 5.043e-10 Informative Direct
Biological Process (BP) RNA splicing 2.873e-11 Highly Informative Direct
Cellular Component (CC) protein complex 0.002079 Least Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002804 SSF69819 Protein matches
Abstract

Proteins in this entry are found in archaea, bacteria and eukaryotes. Their function is unknown, but alignment shows several conserved polar residues which are potential catalytic residues. The structure of one of these proteins has been determined and shows homolgy to heat shock protein 33, which is a chaperone protein that inhibits the aggregation of partially denatured proteins [PubMed11854485].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MTH1598-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MTH1598-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]