SUPERFAMILY 1.75 HMM library and genome assignments server

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MTH1598-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   MTH1598-like [ 69818]
Superfamily:   MTH1598-like [ 69819]
Families:   MTH1598-like [ 69820] (2)


Superfamily statistics
Genomes (503) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 544 891 2
Proteins 542 890 2


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular aromatic compound metabolic process0.0000810.0004203Least InformativeDirect
Biological Process (BP)heterocycle metabolic process0.000078060.0003769Least InformativeDirect
Biological Process (BP)organic cyclic compound metabolic process0.00015840.0006711Least InformativeDirect
Biological Process (BP)cellular macromolecule metabolic process0.0001990.003294Least InformativeInherited
Biological Process (BP)nitrogen compound metabolic process0.00042030.001251Least InformativeInherited
Biological Process (BP)gene expression0.00000010920.000003378Moderately InformativeDirect
Biological Process (BP)RNA metabolic process0.000000021360.000001712Moderately InformativeDirect
Biological Process (BP)RNA processing0.00000000037780.00000001593InformativeDirect
Biological Process (BP)ncRNA metabolic process0.000000000018190.0000000005431InformativeDirect
Biological Process (BP)RNA splicing0.00000000000057570.00000000002956Highly InformativeDirect
Cellular Component (CC)protein complex0.00025690.002191Least InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0004203 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0003769 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0006711 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.003294 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.001251 Least Informative Inherited
Biological Process (BP) gene expression 0.000003378 Moderately Informative Direct
Biological Process (BP) RNA metabolic process 0.000001712 Moderately Informative Direct
Biological Process (BP) RNA processing 0.00000001593 Informative Direct
Biological Process (BP) ncRNA metabolic process 0.0000000005431 Informative Direct
Biological Process (BP) RNA splicing 0.00000000002956 Highly Informative Direct
Cellular Component (CC) protein complex 0.002191 Least Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationChaperone0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002804 SSF69819 Protein matches
Abstract

Proteins in this entry are found in archaea, bacteria and eukaryotes. Their function is unknown, but alignment shows several conserved polar residues which are potential catalytic residues. The structure of one of these proteins has been determined and shows homolgy to heat shock protein 33, which is a chaperone protein that inhibits the aggregation of partially denatured proteins [PubMed11854485].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a MTH1598-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the MTH1598-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]