SUPERFAMILY 1.75 HMM library and genome assignments server


Glycerol-3-phosphate (1)-acyltransferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Glycerol-3-phosphate (1)-acyltransferase [ 69592]
Superfamily:   Glycerol-3-phosphate (1)-acyltransferase [ 69593]
Families:   Glycerol-3-phosphate (1)-acyltransferase [ 69594]


Superfamily statistics
Genomes (2,978) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,483 27,887 2
Proteins 14,299 27,665 2


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process3.893e-080Least InformativeDirect
Biological Process (BP)single-organism metabolic process2.099e-110Least InformativeDirect
Biological Process (BP)multicellular organismal process0.25690.8837Least InformativeInherited
Biological Process (BP)localization0.9841Least InformativeInherited
Biological Process (BP)developmental process0.18250.8622Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)phosphate-containing compound metabolic process7.052e-140Moderately InformativeDirect
Biological Process (BP)lipid biosynthetic process00Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)cellular lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.052390.3677Moderately InformativeInherited
Biological Process (BP)organ development0.24810.09593Moderately InformativeInherited
Biological Process (BP)reproduction0.093080.2466Moderately InformativeInherited
Biological Process (BP)single-organism developmental process0.10420.5785Moderately InformativeInherited
Biological Process (BP)cell differentiation0.43041Moderately InformativeInherited
Biological Process (BP)tissue development0.00099070.04576Moderately InformativeInherited
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)glycerolipid metabolic process00InformativeDirect
Biological Process (BP)regulation of growth0.034940.0029InformativeInherited
Biological Process (BP)gland development0.0035478.39e-05InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.042530.009512InformativeInherited
Biological Process (BP)regulation of body fluid levels0.00131.67e-05InformativeInherited
Biological Process (BP)epithelium development0.10010.03161InformativeInherited
Biological Process (BP)epithelial cell development4.183e-051.067e-05Highly InformativeDirect
Biological Process (BP)lactation3.083e-051.169e-11Highly InformativeDirect
Biological Process (BP)regulation of multicellular organism growth0.00030257.558e-08Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.00024631.576e-10Highly InformativeDirect
Biological Process (BP)developmental maturation0.0026690.000208Highly InformativeInherited
Biological Process (BP)acylglycerol metabolic process0.14621.736e-06Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.011310.003352Highly InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)O-acyltransferase activity00Highly InformativeDirect
Cellular Component (CC)cytoplasmic part1.301e-060Least InformativeDirect
Cellular Component (CC)intracellular organelle part10.338Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.010581.937e-05Least InformativeInherited
Cellular Component (CC)membrane0.031180.0004335Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.00044923.731e-09Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.093321.367e-07Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane6.403e-081.521e-15InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8837 Least Informative Inherited
Biological Process (BP) developmental process 0.8622 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) lipid biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0001254 Moderately Informative Direct
Biological Process (BP) cellular lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) organic hydroxy compound metabolic process 0.6179 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3677 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.9817 Moderately Informative Inherited
Biological Process (BP) system process 0.6664 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.5785 Moderately Informative Inherited
Biological Process (BP) organ development 0.09593 Moderately Informative Inherited
Biological Process (BP) reproduction 0.2466 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.7522 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.04576 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 7.522e-05 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) gland development 8.39e-05 Informative Direct
Biological Process (BP) regulation of body fluid levels 1.67e-05 Informative Direct
Biological Process (BP) membrane organization 5.572e-06 Informative Direct
Biological Process (BP) alcohol metabolic process 0.3754 Informative Inherited
Biological Process (BP) regulation of growth 0.0029 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.1056 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.1856 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.492 Informative Inherited
Biological Process (BP) central nervous system development 0.2316 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.009512 Informative Inherited
Biological Process (BP) epithelium development 0.03161 Informative Inherited
Biological Process (BP) epithelial cell development 1.067e-05 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 1.736e-06 Highly Informative Direct
Biological Process (BP) lactation 1.169e-11 Highly Informative Direct
Biological Process (BP) developmental maturation 0.000208 Highly Informative Direct
Biological Process (BP) cell junction organization 0.000249 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 7.558e-08 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 9.667e-08 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 1.576e-10 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.002844 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.006768 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.003352 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) O-acyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.0004335 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1.937e-05 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.338 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 3.731e-09 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1.367e-07 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 1.521e-15 Informative Direct
Cellular Component (CC) microbody 1.854e-06 Informative Direct
Cellular Component (CC) microbody part 3.79e-08 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0.2006Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skeletal system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower limb0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of facial skeleton0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04679Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis4.604e-05Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)fruit2.273e-05InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.2919Moderately InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell membrane0.06214Moderately InformativeInherited
Cellular componentMitochondrion0.8605Moderately InformativeInherited
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion outer membrane3.747e-08InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)membrane lipid metabolism1Moderately InformativeInherited
UniPathway (UP)phospholipid metabolism0InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0.0002168InformativeDirect
UniPathway (UP)phospholipid biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycerol-3-phosphate (1)-acyltransferase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Glycerol-3-phosphate (1)-acyltransferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]