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Glycerol-3-phosphate (1)-acyltransferase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Glycerol-3-phosphate (1)-acyltransferase [ 69592]
Superfamily:   Glycerol-3-phosphate (1)-acyltransferase [ 69593]
Families:   Glycerol-3-phosphate (1)-acyltransferase [ 69594]


Superfamily statistics
Genomes (3,019) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,175 55,804 2
Proteins 14,978 55,403 2


Functional annotation
General category Metabolism
Detailed category Transferases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biosynthetic process0.000000053230Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000000016810Least InformativeDirect
Biological Process (BP)multicellular organismal process0.13120.8133Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)developmental process0.075280.7654Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)phosphate-containing compound metabolic process0.000000000002660Moderately InformativeDirect
Biological Process (BP)organophosphate metabolic process00Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.10070.5464Moderately InformativeInherited
Biological Process (BP)organ development0.10190.06445Moderately InformativeInherited
Biological Process (BP)reproduction0.13970.3209Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.88570.2258Moderately InformativeInherited
Biological Process (BP)tissue development0.012780.09342Moderately InformativeInherited
Biological Process (BP)cell differentiation0.11341Moderately InformativeInherited
Biological Process (BP)phospholipid metabolic process00InformativeDirect
Biological Process (BP)glycerolipid metabolic process00InformativeDirect
Biological Process (BP)regulation of growth0.063370.00583InformativeInherited
Biological Process (BP)gland development0.0080320.000147InformativeInherited
Biological Process (BP)multicellular organismal reproductive process0.040990.01362InformativeInherited
Biological Process (BP)regulation of body fluid levels0.0026970.00003102InformativeInherited
Biological Process (BP)epithelium development0.10030.0316InformativeInherited
Biological Process (BP)epithelial cell development0.00009190.00002574Highly InformativeDirect
Biological Process (BP)lactation0.00002820.000000000008767Highly InformativeDirect
Biological Process (BP)regulation of multicellular organism growth0.00023010.0000001319Highly InformativeDirect
Biological Process (BP)phosphatidic acid metabolic process0.00020970.0000000001158Highly InformativeDirect
Biological Process (BP)acylglycerol metabolic process0.14250.000002071Highly InformativeInherited
Biological Process (BP)glycerophospholipid biosynthetic process0.0089390.003705Highly InformativeInherited
Molecular Function (MF)transferase activity00Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)O-acyltransferase activity00Highly InformativeDirect
Cellular Component (CC)membrane0.000010910.0000003015Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.000000009080Least InformativeDirect
Cellular Component (CC)intracellular organelle part10.7888Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.0017060.000002531Least InformativeInherited
Cellular Component (CC)endoplasmic reticulum00Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.00021210.00000000005487Moderately InformativeDirect
Cellular Component (CC)organelle membrane0.20340.0000003308Moderately InformativeInherited
Cellular Component (CC)endoplasmic reticulum membrane0.00000020InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.8133 Least Informative Inherited
Biological Process (BP) developmental process 0.7654 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) organophosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.0001216 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.2258 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.6252 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5464 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) system process 0.8054 Moderately Informative Inherited
Biological Process (BP) organ development 0.06445 Moderately Informative Inherited
Biological Process (BP) reproduction 0.3209 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.8856 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.09342 Moderately Informative Inherited
Biological Process (BP) cellular biogenic amine metabolic process 0.0001184 Informative Direct
Biological Process (BP) phospholipid metabolic process 0 Informative Direct
Biological Process (BP) glycerolipid metabolic process 0 Informative Direct
Biological Process (BP) gland development 0.000147 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.00003102 Informative Direct
Biological Process (BP) alcohol metabolic process 0.3642 Informative Inherited
Biological Process (BP) regulation of growth 0.00583 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2687 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.6155 Informative Inherited
Biological Process (BP) central nervous system development 0.3562 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.01362 Informative Inherited
Biological Process (BP) epithelium development 0.0316 Informative Inherited
Biological Process (BP) epithelial cell development 0.00002574 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.000002071 Highly Informative Direct
Biological Process (BP) lactation 0.000000000008767 Highly Informative Direct
Biological Process (BP) cell junction organization 0.0003643 Highly Informative Direct
Biological Process (BP) regulation of multicellular organism growth 0.0000001319 Highly Informative Direct
Biological Process (BP) ethanolamine-containing compound metabolic process 0.0000001513 Highly Informative Direct
Biological Process (BP) phosphatidic acid metabolic process 0.0000000001158 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.005101 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 0.007413 Highly Informative Inherited
Biological Process (BP) glycerophospholipid biosynthetic process 0.003705 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) O-acyltransferase activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.0000003015 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000002531 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.7888 Least Informative Inherited
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.00000000005487 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.0000003308 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) microbody 0.000004007 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0.2006Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the skull0Moderately InformativeDirect
Phenotypic Abnormality (PA)Growth abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lower limb0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of facial skeleton0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.04876Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00004649Moderately InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)fruit0.00002273InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Ligases0.2853Moderately InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0Moderately InformativeDirect
Biological processLipid biosynthesis0InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell membrane0.06762Moderately InformativeInherited
Cellular componentMitochondrion0.8662Moderately InformativeInherited
Cellular componentCell inner membrane0InformativeDirect
Cellular componentMitochondrion outer membrane0.00000004261InformativeDirect
Cellular componentLipid droplet0Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)alcohol metabolism0.0804Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)phospholipid metabolism0InformativeDirect
UniPathway (UP)glycerol metabolism0.01012InformativeInherited
UniPathway (UP)glycerolipid biosynthesis0.00000002489Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycerol-3-phosphate (1)-acyltransferase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Glycerol-3-phosphate (1)-acyltransferase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]