SUPERFAMILY 1.75 HMM library and genome assignments server

C-terminal domain of adenylylcyclase associated protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Single-stranded right-handed beta-helix [ 51125] (8)
Superfamily:   C-terminal domain of adenylylcyclase associated protein [ 69340]
Families:   C-terminal domain of adenylylcyclase associated protein [ 69341]


Superfamily statistics
Genomes (484) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,012 1,079 3
Proteins 1,009 1,079 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0.0001083 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.00000005171 Least Informative Direct
Biological Process (BP) developmental process 0.002257 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.455 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.58 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.001266 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1517 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.06403 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1791 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0000003937 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.000001078 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000001256 Moderately Informative Direct
Biological Process (BP) single-organism organelle organization 0.000001902 Moderately Informative Direct
Biological Process (BP) nervous system development 0.01128 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5645 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01043 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.165 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.8453 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0015 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01609 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.006295 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03324 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.003048 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.0000001918 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00001529 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000006238 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000001937 Informative Direct
Biological Process (BP) actin filament-based process 0.00000000004107 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00000114 Informative Direct
Biological Process (BP) locomotion 0.000000002572 Informative Direct
Biological Process (BP) generation of neurons 0.000638 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000005044 Informative Direct
Biological Process (BP) cell projection organization 0.001252 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.2642 Informative Inherited
Biological Process (BP) localization of cell 0.003674 Informative Inherited
Biological Process (BP) chemotaxis 0.0002616 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.000007748 Highly Informative Direct
Biological Process (BP) neuron projection development 0.1224 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.9634 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3689 Highly Informative Inherited
Molecular Function (MF) binding 0.6196 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00002345 Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000007069 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.003016 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.8631 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000000001757 Moderately Informative Direct
Cellular Component (CC) cell projection 0.003298 Moderately Informative Inherited
Cellular Component (CC) cell cortex 0.000000006288 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.1632 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.0001477 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.000002684Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell membrane0.00000000000003711Moderately InformativeDirect
Cellular componentCytoskeleton0.000000001911Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationAcetylation0.0001273Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013912 SSF69340 Protein matches
Abstract

Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which binds to the cyclase in a different region. With its other domain, CAP can bind monomeric actin and therefore also carries a cytoskeletal function. The protein is thus involved in Ras/cAMP-dependent signal transduction and most likely serves as an adapter protein translocating the adenylyl cyclase complex to the actin cytoskeleton. [PubMed1550959, PubMed7962207].

Structurally, CAP is a protein of 474 to 551 residues. The N- and C-terminal domains of CAP are connected by an intermediate section which contains a proline-rich region. In the yeast protein, this domain has been further divided into the P1 and P2 regions. While the P1 region is constituted by a 14 amino-acid sequence of unknown function, the P2 region exhibits a consensus SH3-binding motif (PXXP) and is necessary to target CAP to cortical actin patches. Dictyostelium CAP is a phosphatidylinositol 4,5-biphosphate (PIP2) regulated G-actin sequestering protein, which is present in the cytosol and shows enrichment at plasma-membrane regions. The cortical translocation is mediated by the N-terminal domain [PubMed12351838].

The CARP domain has been found as a tandem repeat in the C-terminal of many CAPs and also in the X-linked retinitis pigmentosa 2 gene product.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal domain of adenylylcyclase associated protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal domain of adenylylcyclase associated protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]