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C-terminal domain of adenylylcyclase associated protein superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Single-stranded right-handed beta-helix [ 51125] (8)
Superfamily:   C-terminal domain of adenylylcyclase associated protein [ 69340]
Families:   C-terminal domain of adenylylcyclase associated protein [ 69341]


Superfamily statistics
Genomes (483) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,010 1,079 3
Proteins 1,007 1,079 3


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of cellular process 0.0003149 Least Informative Direct
Biological Process (BP) localization 0.0000864 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000000361 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.5259 Least Informative Inherited
Biological Process (BP) developmental process 0.002262 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.1848 Least Informative Inherited
Biological Process (BP) response to stimulus 0.1791 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.01835 Least Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.0000001064 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.0006586 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0.0000001578 Moderately Informative Direct
Biological Process (BP) regulation of catalytic activity 0.0000004247 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.9399 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.01052 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.02005 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.01609 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.03575 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.001868 Moderately Informative Inherited
Biological Process (BP) cellular component movement 0.000001393 Informative Direct
Biological Process (BP) cytoskeleton organization 0.00000000005112 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.0000002476 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000001048 Informative Direct
Biological Process (BP) actin filament-based process 0.0000000003526 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.000000306 Informative Direct
Biological Process (BP) locomotion 0.000000002605 Informative Direct
Biological Process (BP) generation of neurons 0.0003608 Informative Direct
Biological Process (BP) regulation of purine nucleotide metabolic process 0.00000000001521 Informative Direct
Biological Process (BP) cell projection organization 0.01597 Informative Inherited
Biological Process (BP) localization of cell 0.004069 Informative Inherited
Biological Process (BP) chemotaxis 0.0002626 Highly Informative Direct
Biological Process (BP) establishment or maintenance of cell polarity 0.00002016 Highly Informative Direct
Biological Process (BP) neuron projection development 0.1241 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.977 Highly Informative Inherited
Biological Process (BP) regulation of cyclic nucleotide metabolic process 0.009615 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.3875 Highly Informative Inherited
Molecular Function (MF) binding 0.4644 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.00002301 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.00001676 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01931 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.5026 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000001569 Moderately Informative Direct
Cellular Component (CC) cell cortex 0.000000006455 Informative Direct
Cellular Component (CC) actin cytoskeleton 0.05244 Informative Inherited
Cellular Component (CC) cortical cytoskeleton 0.00002394 Highly Informative Direct

Document: GO annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cell0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)gamete0Moderately InformativeDirect

Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0.000002684Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCell membrane0.00000000000003711Moderately InformativeDirect
Cellular componentCytoskeleton0.000000001911Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect
Post-translational modificationAcetylation0.0001273Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013912 SSF69340 Protein matches
Abstract

Cyclase-associated protein (CAP) is a conserved two-domain protein that helps to activate the catalytic activity of adenylyl cyclase in the cyclase-bound state through interaction with Ras, which binds to the cyclase in a different region. With its other domain, CAP can bind monomeric actin and therefore also carries a cytoskeletal function. The protein is thus involved in Ras/cAMP-dependent signal transduction and most likely serves as an adapter protein translocating the adenylyl cyclase complex to the actin cytoskeleton. [PubMed1550959, PubMed7962207].

Structurally, CAP is a protein of 474 to 551 residues. The N- and C-terminal domains of CAP are connected by an intermediate section which contains a proline-rich region. In the yeast protein, this domain has been further divided into the P1 and P2 regions. While the P1 region is constituted by a 14 amino-acid sequence of unknown function, the P2 region exhibits a consensus SH3-binding motif (PXXP) and is necessary to target CAP to cortical actin patches. Dictyostelium CAP is a phosphatidylinositol 4,5-biphosphate (PIP2) regulated G-actin sequestering protein, which is present in the cytosol and shows enrichment at plasma-membrane regions. The cortical translocation is mediated by the N-terminal domain [PubMed12351838].

The CARP domain has been found as a tandem repeat in the C-terminal of many CAPs and also in the X-linked retinitis pigmentosa 2 gene product.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal domain of adenylylcyclase associated protein domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the C-terminal domain of adenylylcyclase associated protein superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]