SUPERFAMILY 1.75 HMM library and genome assignments server


Tricorn protease domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Tricorn protease domain 2 [ 69322]
Families:   Tricorn protease domain 2 [ 69323]


Superfamily statistics
Genomes (932) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,317 5,130 2
Proteins 3,301 5,105 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.5132 Least Informative Inherited
Biological Process (BP) developmental process 0.3271 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01083 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.09807 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.04733 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.01413 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.3927 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.4732 Least Informative Inherited
Biological Process (BP) organelle organization 5.974e-05 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003678 Moderately Informative Direct
Biological Process (BP) cellular component biogenesis 0.008597 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.04937 Moderately Informative Inherited
Biological Process (BP) single-organism developmental process 0.208 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.007354 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.002523 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.04336 Moderately Informative Inherited
Biological Process (BP) gene expression 0.01449 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.04505 Moderately Informative Inherited
Biological Process (BP) organelle assembly 2.88e-07 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 8.381e-07 Informative Direct
Biological Process (BP) cell projection organization 9.829e-06 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 1.812e-05 Informative Direct
Biological Process (BP) microtubule-based process 8.374e-05 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0001684 Informative Direct
Biological Process (BP) cilium organization 0 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 7.252e-12 Highly Informative Direct
Biological Process (BP) cell projection assembly 1.019e-10 Highly Informative Direct
Biological Process (BP) regulation of translation 1.326e-08 Highly Informative Direct
Biological Process (BP) translational initiation 1.773e-07 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.004264 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.2621 Moderately Informative Inherited
Molecular Function (MF) RNA binding 3.546e-06 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 2.042e-08 Highly Informative Direct
Cellular Component (CC) protein complex 1.61e-07 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.9322 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) cell projection 9.57e-06 Moderately Informative Direct
Cellular Component (CC) intraflagellar transport particle 3.749e-11 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis3.337e-10InformativeDirect
Cellular componentCell projection3.288e-11Moderately InformativeDirect
Cellular componentCilium5.763e-05Highly InformativeDirect
DomainRepeat3.036e-15Least InformativeDirect
DomainCoiled coil9.668e-05Moderately InformativeDirect
DomainWD repeat0InformativeDirect
DomainTPR repeat9.051e-09Highly InformativeDirect
Molecular functionRNA-binding1.278e-06Moderately InformativeDirect
Post-translational modificationHydrolase0.6555Least InformativeInherited
Post-translational modificationDevelopmental protein2.87e-07Moderately InformativeDirect
Post-translational modificationProtease2.463e-05Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease8.909e-10InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tricorn protease domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Tricorn protease domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]