SUPERFAMILY 1.75 HMM library and genome assignments server

Tricorn protease domain 2 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Tricorn protease domain 2 [ 69322]
Families:   Tricorn protease domain 2 [ 69323]


Superfamily statistics
Genomes (933) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,324 5,130 2
Proteins 3,308 5,105 2


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0.0007479 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.8638 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.02597 Least Informative Inherited
Biological Process (BP) developmental process 0.3145 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.07243 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.1535 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.5017 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.7439 Least Informative Inherited
Biological Process (BP) single-organism organelle organization 0.000001541 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0.08497 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.001086 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.007352 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.01866 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.00391 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.01943 Moderately Informative Inherited
Biological Process (BP) gene expression 0.08323 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.0537 Moderately Informative Inherited
Biological Process (BP) microtubule-based process 0.0001056 Informative Direct
Biological Process (BP) posttranscriptional regulation of gene expression 0.0000004231 Informative Direct
Biological Process (BP) cell projection organization 0.00001504 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.0005035 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000363 Informative Direct
Biological Process (BP) organelle assembly 0.0000006813 Informative Direct
Biological Process (BP) translational initiation 0.0000002142 Highly Informative Direct
Biological Process (BP) regulation of translation 0.000000007752 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000000001525 Highly Informative Direct
Biological Process (BP) cell projection assembly 0.0000000001026 Highly Informative Direct
Biological Process (BP) cilium organization 0.00000000000233 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.004203 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 0.1976 Least Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.3271 Moderately Informative Inherited
Molecular Function (MF) RNA binding 0.0000004955 Informative Direct
Molecular Function (MF) peptidase activity 0.000007162 Informative Direct
Molecular Function (MF) translation factor activity, nucleic acid binding 0.000000002907 Highly Informative Direct
Cellular Component (CC) protein complex 0.0000002955 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.9841 Least Informative Inherited
Cellular Component (CC) cell projection 0.00001505 Moderately Informative Direct
Cellular Component (CC) intraciliary transport particle 0.00000000003818 Highly Informative Direct

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)preweaning lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Moderately InformativeDirect
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)immune system0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processProtein biosynthesis0.0000000003313InformativeDirect
Cellular componentCell projection0.00000000003485Moderately InformativeDirect
Cellular componentCilium0.00005423Highly InformativeDirect
DomainRepeat0.000000000000003027Least InformativeDirect
DomainCoiled coil0.00009826Moderately InformativeDirect
DomainWD repeat0InformativeDirect
DomainTPR repeat0.000000008969Highly InformativeDirect
Molecular functionRNA-binding0.000001295Moderately InformativeDirect
Post-translational modificationHydrolase0.6602Least InformativeInherited
Post-translational modificationDevelopmental protein0.0000002839Moderately InformativeDirect
Post-translational modificationProtease0.00002457Moderately InformativeDirect
Post-translational modificationInitiation factor0InformativeDirect
Post-translational modificationSerine protease0.0000000008874InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)tRNA modification0InformativeDirect
UniPathway (UP)N(7)-methylguanine-tRNA biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Tricorn protease domain 2 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Tricorn protease domain 2 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]