SUPERFAMILY 1.75 HMM library and genome assignments server


Quinohemoprotein amine dehydrogenase A chain, domain 3 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Streptavidin-like [ 50875] (8)
Superfamily:   Quinohemoprotein amine dehydrogenase A chain, domain 3 [ 69298]
Families:   Quinohemoprotein amine dehydrogenase A chain, domain 3 [ 69299]


Superfamily statistics
Genomes (34) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 36 65 2
Proteins 36 65 2


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR009111 SSF69298 Protein matches
Abstract

Quinoproteins are a class of amine-oxidising enzymes that catalyse the oxidation of biological amines, using quinone as a redox cofactor to store reducing equivalents. Quinohemoprotein amine dehydrogenase (QH-AmDH) from bacteria represents a new class of quinoproteins that contains both quinone and one or two hemes as redox active groups. The presence of extra redox active groups allows for intramolecular electron transfer.

QH-AmDH is a heterotrimeric enzyme containing alpha, beta and gamma chains encoded by separate genes. The alpha chain makes contact with both the beta and gamma chains. The small gamma chain forms three intra-chain cross-links via thioester bonds between cysteine and aspartic or glutamic acid residues, thereby encaging the cysteine tryptophylquinone cofactor [PubMed11704672]. The largest chain, alpha, contains two heme c groups. The alpha chain is folded into four domains, domain 1 forming a diheme cytochrome. Domains 2, 3 and 4 are antiparallel beta-barrel structures [PubMed11717396].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Quinohemoprotein amine dehydrogenase A chain, domain 3 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the Quinohemoprotein amine dehydrogenase A chain, domain 3 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]