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Nuclear receptor coactivator interlocking domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Nuclear receptor coactivator interlocking domain [ 69124]
Superfamily:   Nuclear receptor coactivator interlocking domain [ 69125]
Families:   Nuclear receptor coactivator interlocking domain [ 69126] (3)


Superfamily statistics
Genomes (103) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 485 529 5
Proteins 485 529 5


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.0000000000001018 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.000000003789 Least Informative Direct
Biological Process (BP) developmental process 0.0000001674 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000001002 Least Informative Direct
Biological Process (BP) protein metabolic process 0.005576 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 0.02217 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5167 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.07362 Least Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of molecular function 0.0000000000006975 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0.000000869 Moderately Informative Direct
Biological Process (BP) reproduction 0.000005166 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0.0000275 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.00004356 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000214 Moderately Informative Direct
Biological Process (BP) organ development 0.2164 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.3427 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2052 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.003859 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.005164 Moderately Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.00000000312 Informative Direct
Biological Process (BP) chromosome organization 0.0000001183 Informative Direct
Biological Process (BP) positive regulation of gene expression 0.000002203 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.000003705 Informative Direct
Biological Process (BP) reproductive system development 0.00000712 Informative Direct
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.000009771 Informative Direct
Biological Process (BP) embryonic organ development 0.00001208 Informative Direct
Biological Process (BP) gland development 0.00001788 Informative Direct
Biological Process (BP) positive regulation of cellular biosynthetic process 0.00002893 Informative Direct
Biological Process (BP) growth 0.00005001 Informative Direct
Biological Process (BP) tube development 0.000271 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.000432 Informative Direct
Biological Process (BP) embryo development ending in birth or egg hatching 0.1937 Informative Inherited
Biological Process (BP) epithelium development 0.01687 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.002072 Informative Inherited
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.01025 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.001319 Informative Inherited
Biological Process (BP) internal protein amino acid acetylation 0.000000000000003741 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.00000000000008921 Highly Informative Direct
Biological Process (BP) histone modification 0.0000000001728 Highly Informative Direct
Biological Process (BP) branching morphogenesis of an epithelial tube 0.0000000009551 Highly Informative Direct
Biological Process (BP) placenta development 0.000000013 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.00000009567 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.0000462 Highly Informative Direct
Biological Process (BP) developmental growth 0.0004277 Highly Informative Direct
Biological Process (BP) development of primary female sexual characteristics 0.062 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000131 Least Informative Direct
Molecular Function (MF) transferase activity 0.0005304 Least Informative Direct
Molecular Function (MF) nucleic acid binding 0.00009901 Moderately Informative Direct
Molecular Function (MF) chromatin binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.000000000000146 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0.00000000001312 Informative Direct
Molecular Function (MF) DNA binding 0.000004976 Informative Direct
Molecular Function (MF) transcription factor binding 0 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0 Highly Informative Direct
Molecular Function (MF) acetyltransferase activity 0.00000000000000896 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 0.000005365 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.09527 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000007211 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.02944 Moderately Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.0003413Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0.00001398InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.05357Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1469Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1766Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.004328Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.009652Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.02233Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.0417Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.00008455InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0.0009478InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.003618InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.01006InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.0126InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.01388InformativeInherited
Mammalian Phenotype (MP)increased circulating leptin level0.0000105Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.00002688Highly InformativeDirect
Mammalian Phenotype (MP)abnormal megakaryocyte morphology0.0002174Highly InformativeDirect
Mammalian Phenotype (MP)increased lymphocyte cell number0.002999Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processBiological rhythms0.000000000001097InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0Least InformativeDirect
DomainBromodomain0.0000000000007937Highly InformativeDirect
Post-translational modificationTransferase0.0000644Least InformativeDirect
Post-translational modificationActivator0Moderately InformativeDirect
Post-translational modificationAcyltransferase0InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.000000000001686Least InformativeDirect
Post-translational modificationIsopeptide bond0.0000000004708Moderately InformativeDirect
Post-translational modificationMethylation0.0000001073Moderately InformativeDirect
Post-translational modificationUbl conjugation0.0000002053Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009110 SSF69125 Protein matches
Abstract

This entry represents the interlocking domain of various eukaryotic nuclear receptor coactivators, including CREBP, P300, Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.

Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein), P300 and ACTR (activator for thyroid and retinoid receptors) [PubMed11823864]. CBP and P300 both have histone acetyltransferase activity . CBP/P300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/P300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1 [PubMed11583620].

Ncoa1, Ncoa2 and Ncoa3 are all coactivators of various nuclear receptors. In addition, Ncoa1 and Ncoa3 both have histone acetyltransferase activity, but Ncoa2 does not [PubMed14757047, PubMed15145939].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Nuclear receptor coactivator interlocking domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Nuclear receptor coactivator interlocking domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]