SUPERFAMILY 1.75 HMM library and genome assignments server

Arp2/3 complex 16 kDa subunit ARPC5 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   Arp2/3 complex 16 kDa subunit ARPC5 [ 69103]
Families:   Arp2/3 complex 16 kDa subunit ARPC5 [ 69104]


Superfamily statistics
Genomes (443) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 616 679 1
Proteins 614 676 1


Functional annotation
General category Other
Detailed category Viral proteins

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism cellular process0.036490.28Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0015960.01981Least InformativeInherited
Biological Process (BP)organelle organization0.0012220.003631Moderately InformativeInherited
Biological Process (BP)cytoskeleton organization0.0000015380.00002282InformativeDirect
Biological Process (BP)actin filament-based process0.00000036050.000001222InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle0.000000070290.000005006Least InformativeDirect
Cellular Component (CC)protein complex0.00000057240.00001009Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.00044630.001591Least InformativeInherited
Cellular Component (CC)cytoskeleton0.000000000022080.000000001616Moderately InformativeDirect
Cellular Component (CC)cell projection0.00000079510.000005651Moderately InformativeDirect
Cellular Component (CC)actin cytoskeleton0.0000000000000014340.00000000000002463InformativeDirect
Cellular Component (CC)cell leading edge0.0000000000021680.00000000001631InformativeDirect
Cellular Component (CC)Arp2/3 protein complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism cellular process 0.28 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.01981 Least Informative Inherited
Biological Process (BP) organelle organization 0.003631 Moderately Informative Inherited
Biological Process (BP) cytoskeleton organization 0.00002282 Informative Direct
Biological Process (BP) actin filament-based process 0.000001222 Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.000005006 Least Informative Direct
Cellular Component (CC) protein complex 0.00001009 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.001591 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.000000001616 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000005651 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 0.00000000000002463 Informative Direct
Cellular Component (CC) cell leading edge 0.00000000001631 Informative Direct
Cellular Component (CC) Arp2/3 protein complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell projection0.00000000000003892Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR006789 SSF69103 Protein matches
Abstract The Arp2/3 protein complex has been implicated in the control of actin polymerization. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3, and five others referred to as p41-Arc, p34-Arc, p21-Arc, p20-Arc, and p16-Arc. The precise function of p16-Arc is currently unknown. Its structure consists of a single domain containing a bundle of seven alpha helices [PubMed9230079, PubMed11721045].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Arp2/3 complex 16 kDa subunit ARPC5 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Arp2/3 complex 16 kDa subunit ARPC5 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]