SUPERFAMILY 1.73 HMM library and genome assignments server


RNase III domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (258)
Fold:   RNase III domain-like [ 69064]
  core: 5 helices; one helix is surrounded by the others
Superfamily:   RNase III domain-like [ 69065] (2)
Families:   RNase III catalytic domain-like [ 69066] (2)
  Pfam 00636
  PF0609-like [ 140675]
  specific to Thermococci; shares conserved carboxylic residues and similar dimerisation mode with the RNase III domain; contains integrated in the fold extra C-terminal helix, making it similar to the core fold of Ribosomal protein S7 (scop_cf 47972)


Superfamily statistics
Genomes (1,152) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 2,934 2,576 10
Proteins 2,443 2,270 10


Functional annotation
General category Information
Detailed category RNA processing

Function annotation of SCOP domain superfamilies
InterPro annotation
Cross references IPR000999 SSF69065 Protein matches
Abstract

Prokaryotic ribonuclease III (gene rnc) [PubMed3903434] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related [PubMed9241229] to the fission yeast pac1, a ribonuclease that probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development; yeast ribonuclease III (gene RNT1), a dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites; Caenorhabditis elegans hypothetical protein F26E4.13; Paramecium bursaria Chlorella virus 1 (PBCV-1) 1 protein A464R; Synechocystis sp. (strain PCC 6803) hypothetical protein slr0346; fission yeast hypothetical protein SpAC8A4.08c, a protein with a N-terminal helicase domain and a C-terminal RNase III domain; and C. elegans hypothetical protein K12H4.8, a protein with the same structure as SpAC8A4.08c.


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a RNase III domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the RNase III domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]