SUPERFAMILY 1.75 HMM library and genome assignments server


Arp2/3 complex 21 kDa subunit ARPC3 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Arp2/3 complex 21 kDa subunit ARPC3 [ 69059]
Superfamily:   Arp2/3 complex 21 kDa subunit ARPC3 [ 69060]
Families:   Arp2/3 complex 21 kDa subunit ARPC3 [ 69061]


Superfamily statistics
Genomes (444) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 596 611 1
Proteins 593 609 1


Functional annotation
General category Regulation
Detailed category Other regulatory function

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Molecular Function (MF)binding0.12520.4986Least InformativeInherited
Molecular Function (MF)cytoskeletal protein binding1.249e-062.539e-06InformativeDirect
Molecular Function (MF)actin binding3.552e-093.566e-08Highly InformativeDirect
Cellular Component (CC)intracellular non-membrane-bounded organelle5.407e-073.272e-05Least InformativeDirect
Cellular Component (CC)protein complex3.319e-050.0003794Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.0011130.00628Least InformativeInherited
Cellular Component (CC)cell projection2.622e-050.0002561Moderately InformativeDirect
Cellular Component (CC)cytoskeleton0.0011880.0009219Moderately InformativeInherited
Cellular Component (CC)actin cytoskeleton1.241e-121.127e-11InformativeDirect
Cellular Component (CC)cell leading edge2.334e-092.607e-08InformativeDirect
Cellular Component (CC)Arp2/3 protein complex00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Molecular Function (MF) binding 0.4986 Least Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 2.539e-06 Informative Direct
Molecular Function (MF) actin binding 3.566e-08 Highly Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 3.272e-05 Least Informative Direct
Cellular Component (CC) protein complex 0.0003794 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.00628 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0009219 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0002561 Moderately Informative Direct
Cellular Component (CC) actin cytoskeleton 1.127e-11 Informative Direct
Cellular Component (CC) cell leading edge 2.607e-08 Informative Direct
Cellular Component (CC) Arp2/3 protein complex 0 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Molecular functionActin-binding0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR007204 SSF69060 Protein matches
Abstract

The Arp2/3 complex is a seven-protein assembly that is critical for actin nucleation and branching in cells. Arp2/3 nucleates new actin filaments while bound to existing filaments, thus creating a branched network [PubMed15040784]. The complex consists of Arp2, Arp3, p41, p34, p21, p20 and p16. Subunits p34 and p20 constitute the core of the structure, with the remaining subunits located peripherally [PubMed11741539]. This entry describes the p21 subunit. Proteins such as WASp and Scar1 may mediate receptor signalling through interactions with p21-Arc, resulting in the activation of Arc2/3 complex activity [PubMed11162547].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Arp2/3 complex 21 kDa subunit ARPC3 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Arp2/3 complex 21 kDa subunit ARPC3 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]