SUPERFAMILY 1.75 HMM library and genome assignments server


alpha-ketoacid dehydrogenase kinase, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   alpha-ketoacid dehydrogenase kinase, N-terminal domain [ 69012]
Families:   alpha-ketoacid dehydrogenase kinase, N-terminal domain [ 69013] (2)


Superfamily statistics
Genomes (466) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,404 1,592 3
Proteins 1,402 1,589 3


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 2.125e-14 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0006769 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.8533 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.6379 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3616 Least Informative Inherited
Biological Process (BP) response to stimulus 0.004204 Least Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) homeostatic process 1.781e-07 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 2.163e-07 Moderately Informative Direct
Biological Process (BP) signal transduction 2.455e-06 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0005424 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.09283 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.002213 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2053 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.00568 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 0.03786 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.07832 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 3.77e-15 Informative Direct
Biological Process (BP) response to nutrient levels 9.763e-08 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 1.192e-06 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0004546 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0004726 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.002146 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.008939 Informative Inherited
Biological Process (BP) response to lipid 0.009589 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001579 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5436 Informative Inherited
Biological Process (BP) regulation of cellular ketone metabolic process 0 Highly Informative Direct
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 1.821e-11 Highly Informative Direct
Biological Process (BP) response to peptide hormone stimulus 2.086e-10 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 6.011e-09 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 1.498e-06 Highly Informative Direct
Biological Process (BP) response to hypoxia 1.898e-05 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.000321 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.08873 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) anion binding 3.216e-09 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 3.313e-13 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 5.883e-13 Informative Direct
Molecular Function (MF) nucleotide binding 2.395e-11 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.002514 Informative Inherited
Molecular Function (MF) ATP binding 4.58e-15 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0001425 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 3.867e-12 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 1.779e-09 Least Informative Direct
Cellular Component (CC) protein complex 0.002219 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2741 Least Informative Inherited
Cellular Component (CC) mitochondrial part 4.18e-09 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0001731 Moderately Informative Direct
Cellular Component (CC) mitochondrial matrix 1.017e-12 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skin0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein1.032e-06Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha-ketoacid dehydrogenase kinase, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the alpha-ketoacid dehydrogenase kinase, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]