SUPERFAMILY 1.75 HMM library and genome assignments server

alpha-ketoacid dehydrogenase kinase, N-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   alpha-ketoacid dehydrogenase kinase, N-terminal domain [ 69012]
Families:   alpha-ketoacid dehydrogenase kinase, N-terminal domain [ 69013] (2)


Superfamily statistics
Genomes (467) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 1,431 1,592 3
Proteins 1,429 1,589 3


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) protein metabolic process 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 0.00000000000008363 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.000966 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.3065 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5265 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.3914 Least Informative Inherited
Biological Process (BP) response to stimulus 0.004983 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0 Moderately Informative Direct
Biological Process (BP) phosphate-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0000002422 Moderately Informative Direct
Biological Process (BP) regulation of phosphorus metabolic process 0.000001977 Moderately Informative Direct
Biological Process (BP) signal transduction 0.000002165 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.0006245 Moderately Informative Direct
Biological Process (BP) response to abiotic stimulus 0.09615 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.2166 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.002329 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.01614 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002957 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.07304 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.006253 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.1127 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.000000000000001913 Informative Direct
Biological Process (BP) cellular response to external stimulus 0.00000001279 Informative Direct
Biological Process (BP) response to nutrient levels 0.0000002074 Informative Direct
Biological Process (BP) cation homeostasis 0.0000008009 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.0004622 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.0004982 Informative Direct
Biological Process (BP) cellular response to nitrogen compound 0.002135 Informative Inherited
Biological Process (BP) response to organonitrogen compound 0.001498 Informative Inherited
Biological Process (BP) response to acid chemical 0.00268 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.001207 Informative Inherited
Biological Process (BP) response to lipid 0.01007 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5635 Informative Inherited
Biological Process (BP) protein phosphorylation 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) peptidyl-serine modification 0.00000000002854 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000000003066 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.000000008052 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.000001901 Highly Informative Direct
Biological Process (BP) response to hypoxia 0.00002598 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0.0002147 Highly Informative Direct
Biological Process (BP) cellular response to peptide 0.0003147 Highly Informative Direct
Biological Process (BP) cellular response to acid chemical 0.0007264 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.1056 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.0000000004617 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.000000001785 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000000005646 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0000000000004784 Informative Direct
Molecular Function (MF) purine ribonucleoside binding 0.000000000000844 Informative Direct
Molecular Function (MF) nucleotide binding 0.00000000003934 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.002277 Informative Inherited
Molecular Function (MF) ATP binding 0.000000000000007683 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.0001305 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.000000000001404 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000000002887 Least Informative Direct
Cellular Component (CC) protein complex 0.002806 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.3134 Least Informative Inherited
Cellular Component (CC) mitochondrial part 0.000000008388 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.00006456 Moderately Informative Direct
Cellular Component (CC) oxidoreductase complex 0.00000000000000457 Informative Direct
Cellular Component (CC) mitochondrial matrix 0.000000000002967 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0InformativeDirect
Xenopus ANatomical entity (XAN)lung0InformativeDirect
Xenopus ANatomical entity (XAN)skin0InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionATP-binding0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationPhosphoprotein0.000001054Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha-ketoacid dehydrogenase kinase, N-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the alpha-ketoacid dehydrogenase kinase, N-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]